Article
Chemistry, Multidisciplinary
Patricia Perez Schmidt, Katiuscia Pagano, Cristina Lenardi, Marta Penconi, Ruth Mateu Ferrando, Claudio Evangelisti, Luigi Lay, Laura Ragona, Marcello Marelli, Laura Polito
Summary: This study presents a simple photo-induced synthesis method for the production of Glyco-UAuNPs using a reliable microfluidic approach at room temperature. The method eliminates the need for chemical reductants, templating agents, or co-solvents and demonstrates good feasibility and stability. Using nuclear magnetic resonance spectroscopy, the study shows a linear correlation between the exposed thiol ligands on the UAuNPs and the ligand concentration in the initial mixture, providing a precise design method for engineered UAuNPs or smart hybrid nano-systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Balamurugan Subramani, Preeti Madhukar Chaudhary, Raghavendra Kikkeri
Summary: Nanoparticles embedded with bioactive ligands have become a potential tool to target biological processes. Inverted cell-culture assay is a flexible and accurate method to study cellular uptake and cytotoxicity, demonstrating that the glycosylation patterns and shapes of NPs can affect receptor binding affinity. This study highlights the importance of understanding the interaction between nanoparticles and cells for precise targeting and delivery in biological processes.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Szabolcs Czene, Nikoletta Jegenyes, Olga Krafcsik, Sandor Lenk, Zsolt Czigany, Gabor Bortel, Katalin Kamaras, Janos Rohonczy, David Beke, Adam Gali
Summary: Silicon carbide nanoparticles (SiC NPs) are potential inorganic molecular-sized fluorescent biomarkers, and researchers have developed a method to directly introduce amino groups into aqueous SiC NPs. The applicability of amino-terminated SiC NPs is demonstrated by attaching bovine serum albumin, and it is found that the fluorescence intensity is highly sensitive to surface termination, which may have implications for nanometer-sized SiC NPs with optically read electron spins.
Review
Chemistry, Physical
Palak Jethva, Munira Momin, Tabassum Khan, Abdelwahab Omri
Summary: This article introduces the applications of upconverting luminescent nanoparticles (UCNPs) in life sciences and healthcare, including bioimaging and drug delivery. By controlling the chemical composition and structure of UCNPs, enhanced imaging contrast, multiplexed detection, and low toxicity effects can be achieved. By surface modification and functionalization, a connection can be established between nanoparticles and biomolecules to expand the application of inorganic nanomaterials in biological environments.
Review
Chemistry, Inorganic & Nuclear
Shuting Yang, Wenjing Dai, Wei Zheng, Jie Wang
Summary: Sustained phototheranostics refers to the continuous diagnostic or therapeutic activity initiated by a single dosage of light stimulation. Recent advancements in non-UV-activated persistent luminescence phosphors (PLPs) have provided ideal optical agents for sustained phototheranostics, with improved tissue penetration ability and reduced photodamage.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Cong Cao, Guangshen Li, Yu Xie, Chang Hong, Yu Li
Summary: The article highlights the advantages of lanthanide doped nanoparticles in NIR-II imaging and proposes a potential new imaging probe. Experimental results have shown that the nanoparticles exhibit promising performance in in vivo imaging.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Yuanyuan Li, Xiaoyu Liu, Tianyuan Liang, Wenjie Liu, Jiyang Fan
Summary: The study shows that SiC quantum dots with small dimensions can naturally oxidize at a lower temperature to form core/shell and heteroepitaxial SiC/SiO2 quantum dots. The surface silica layer enhances the quantum efficiency by improving the carrier potential barrier and reducing the nonradiative transition rate, making it suitable for nanoscale electronic and photonic devices.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Afraz Subratti, Lorale J. Lalgee, Nigel K. Jalsa
Summary: Lipophosphoramidates are a class of tunable amphiphilic molecules that enhance the bioavailability and selectivity of drug molecules. This study reports the synthesis of novel glyco-lipophosphoramidates and investigates their surface activity and aggregation behavior in aqueous solution using various techniques. The results demonstrate the potential for drug delivery or nanocarrier applications of these molecules.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Chemistry, Multidisciplinary
Qiang Luo, Wenjie Wang, Jie Tan, Quan Yuan
Summary: Persistent luminescence materials (PLMs) have great potential for biological applications but require surface modification to overcome stability, selectivity, and biocompatibility issues in biological systems.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Analytical
Xu Zhao, Xue-Mei Gao, Tian-Yue Gu, Ke-Lin Chen, Zhu-Ying Yan, Li-Jian Chen, Xiu-Ping Yan
Summary: This review summarizes the design strategies and research progress of responsive PLNPs-based sensors for food analysis, biosensing, and bioimaging. The advantages of these sensors include not needing in-situ excitation and background fluorescence-free, making them ideal for low-background and high-sensitivity detection. The challenges and opportunities of responsive PLNPs-based sensing systems to promote the development of highly sensitive detection technologies are also discussed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Manoj Kumar Mahata, Ranjit De, Kang Taek Lee
Summary: The article reviews the progress and potential of lanthanide-doped upconverting nanoparticles in biomedical applications, focusing on their applications in optogenetics, oncotherapy, bioimaging, etc. The unique properties of UCNPs make them accurate, sensitive, multifunctional nanoprobes, leading to significant advancements in therapy and diagnosis. Emerging bioapplications and challenges in clinical translation of UCNP-based nanotechnology research are also discussed.
Article
Chemistry, Applied
Yurong Wei, Chengxu Gong, Min Zhao, Lei Zhang, Shaodan Yang, Peixu Li, Zhao Ding, Quan Yuan, Yanbing Yang
Summary: This review summarizes the research progress in the synthesis of lanthanide-based persistent luminescence nanoparticles (PLNPs), outlines several typical synthesis methods, discusses the advantages, drawbacks, current challenges, and potential solutions. The review aims to provide strategies for designing lanthanide-based PLNPs with desired properties and promoting their applications in biomedicine, energy, and information science.
JOURNAL OF RARE EARTHS
(2022)
Review
Chemistry, Multidisciplinary
Hengxin Shen, Shiyi Liao, Zhe Li, Youjuan Wang, Shuangyan Huan, Xiao-Bing Zhang, Guosheng Song
Summary: Organic afterglow nanoparticles are optical materials that emit light long after excitation. They have been widely used in various fields such as cell tracking, biosensing, cancer diagnosis, and therapy due to their advantages of no need for real-time excitation, low background, deep tissue penetration, and high sensitivity. This review summarizes the recent progress of organic afterglow imaging, focusing on the mechanism and biological application of these materials. The potential challenges and future directions of this field are also discussed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Engineering, Biomedical
Alexander N. Baker, Asier R. Muguruza, Sarah-Jane Richards, Panagiotis G. Georgiou, Stephen Goetz, Marc Walker, Simone Dedola, Robert A. Field, Matthew Gibson
Summary: Lateral flow immuno-assays using glycosylated polymer-coated nanoparticles show potential for rapid and sensitive detection of lectins, providing unique biosensing opportunities. Optimization of the system allows for detection of lectins at subnanomolar concentrations, comparable to antibody-based systems.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Mausam Kalita, Macy M. Payne, Stefan H. Bossmann
Summary: Glycans regulate cellular signaling through glycan-protein and glycan-glycan crosstalk. Glyco-nanotechnology enables the manipulation of this crosstalk for the diagnosis, therapeutics, and analysis of human diseases.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Guillermo Moreno-Alcantar, Alessandro Aliprandi, Remi Rouquette, Luca Pesce, Klaus Wurst, Claudio Perego, Peter Bruggeller, Giovanni M. Pavan, Luisa De Cola
Summary: Self-assembly relies on the ability of smaller entities to arrange into organized systems, with the design of the media playing a crucial role. The media determines the self-assembly pathway and can control the wrapping process of supramolecular homo-aggregates by a different crystal lattice component. This reverse coating process is controlled by the media composition and could lead to the construction of hierarchical supramolecular structures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Biomedical
Aaron Lee, Dedy Septiadi, Patricia Taladriz-Blanco, Mauro Almeida, Laetitia Haeni, Miguel Spuch-Calvar, Wildan Abdussalam, Barbara Rothen-Rutishauser, Alke Petri-Fink
Summary: The text discusses how physical and chemical features influence cellular surface recognition and behavior, particularly through particle-cell interactions. It highlights that particles with varying degrees of rigidity have different effects on cell behavior, and the adsorption of particles can impact the topographical recognition of the surface, offering a novel approach to controlling cell-surface recognition and response.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Manuela Estermann, Giovanni Spiaggia, Dedy Septiadi, Irini Magdelina Dijkhoff, Barbara Drasler, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: By evaluating the applicability of hydrophilic PTFE membranes as vessel-like constructs and PDMS chips as perfusion bioreactors, stable and leakproof tubes were successfully formed. Endothelial cells adhered to the tube's wall, expressed VE-cadherin, resisted perfusion for 48 hours, significantly delayed the diffusion of fluorescently labeled molecules, reducing diffusion velocity by twofold.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Laura Talamini, Pierre Picchetti, Lorena Maria Ferreira, Giovanni Sitia, Luca Russo, Martina B. Violatto, Leana Travaglini, Jennifer Fernandez Alarcon, Lucrezia Righelli, Paolo Bigini, Luisa De Cola
Summary: This study evaluates the biocompatibility of novel organosilica nanoparticles in vivo, finding that they have the potential to be used as nanotools for modulating biological processes, impacting tumor cell extravasation and hepatic immune functions.
Article
Chemistry, Multidisciplinary
Hugo Hernandez-Toledo, Hugo Torrens, Marcos Flores-alamo, Luisa De Cola, Guillermo Moreno-Alcantar
Summary: Luminescent copper(I)-based compounds with high emission quantum yields have attracted attention for their potential in self-assembling supramolecular systems. This study demonstrates that the emissive profile of Cu(I) derivatives in water is sensitive to solvent composition, leading to changes in both emission characteristics and aggregate morphology. These findings suggest the construction of smart supramolecular systems based on dynamic coordinative metal centers.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Pierre Picchetti, Guillermo Moreno-Alcantar, Laura Talamini, Adrien Mourgout, Alessandro Aliprandi, Luisa De Cola
Summary: This study demonstrates the use of redox-responsive nanocontainers to control the dynamic self-assembly pathway of luminescent platinum compounds, allowing for the release of trapped species on demand and stabilization of out-of-equilibrium states. The application of nanocontainers inside living cells highlighted the potential for controlling self-assembly pathways in complex media.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Multidisciplinary
Joana Kraemer, Rui Kang, Laura M. Grimm, Luisa De Cola, Pierre Picchetti, Frank Biedermann
Summary: Combining synthetic molecular probes, chemosensors, and nanosensors with innovative assay protocols can lead to the development of robust, low-cost, and fast-responding sensors applicable in biofluids. This review focuses on the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions, and the monitoring and analysis of metabolic and signaling networks in cells and organisms. The review highlights the potential applications of sensing systems that provide optical signals through dynamic covalent chemistry, supramolecular host-guest interactions, or plasmonic effects, and also encourages the development of more advanced systems.
Review
Engineering, Biomedical
Eko Adi Prasetyanto, Hutomo Suryo Wasisto, Dedy Septiadi
Summary: Cellular lasers, which utilize biomaterials to generate laser emissions, have shown great potential in various applications such as cell imaging, tracking, and biosensing. However, challenges in probe fabrication and biocompatibility need to be addressed for further development.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Andrea Mosseri, Maria Sancho-Albero, Marilisa Leone, Donatella Nava, Francesco Secundo, Daniela Maggioni, Luisa De Cola, Alessandra Romanelli
Summary: This study reports the formation of homogeneous chiral fibers through self-assembly of peptide nucleic acids. Nucleobases play a key role in determining the morphology and chirality of the fibers. By spectroscopic characterization and microscopy studies, a structural model consistent with the experimental evidence was obtained.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Physical
Phattadon Yajan, Nursidik Yulianto, Matthias Saba, Agus Budi Dharmawan, Mauro Sousa de Almeida, Patricia Taladriz-Blanco, Hutomo Suryo Wasisto, Barbara Rothen-Rutishauser, Alke Petri-Fink, Dedy Septiadi
Summary: The generation of amplified stimulated emission inside mammalian cells has opened up new possibilities for bioimaging and cell sensing. This study investigates the possibility of triggering amplified spontaneous emission inside different cell types and enhancing the emission properties using plasmonic nanoparticles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Aaron Lee, Mauro Sousa de Almeida, Daela Milinkovic, Dedy Septiadi, Patricia Taladriz-Blanco, Celine Loussert-Fonta, Sandor Balog, Amelie Bazzoni, Barbara Rothen-Rutishauser, Alke Petri-Fink
Summary: Cells respond to mechanical forces by altering their behavior and substrate stiffness can regulate cellular endocytosis of particles. Altering surface characteristics can also affect the biomechanical changes that occur within cells.
Article
Nanoscience & Nanotechnology
Giovanni Spiaggia, Patricia Taladriz-Blanco, Dedy Septiadi, Roberto Diego Ortuso, Aaron Lee, Veronique Trappe, Barbara Rothen-Rutishauser, Alke Petri-Fink
Summary: This study successfully fabricated collagen hydrogels with aligned and oriented fibers doped with gold nanoparticles and carbon nanotubes using a microfluidic device. The doped hydrogels exhibited greater rigidity and stiffness compared to native collagen, with the stiffest formulations found in the presence of carbon nanotubes. In vitro experiments with NIH-3T3 fibroblasts showed directional cell growth on carbon nanotube-doped collagen fibers, as well as increased fibroblast proliferation and secretion of TGF-beta 1.
ACS APPLIED BIO MATERIALS
(2021)
Article
Multidisciplinary Sciences
Rathosivan Gopal, Alex Zhen Kai Lo, Noor Masuriani Masrol, Chian-Hui Lai, Norhidayu Muhamad Zain, Syafiqah Saidin
Summary: Wound healing and management present challenging clinical problems despite advancements in medical technology. Honey, a natural product synthesized by honey bees, possesses strong antibacterial properties. Honey cellulose hydrogels show potential as an alternative treatment for wound infections, with variations in efficacy depending on the type of honey used. Among the honey hydrogels tested, those incorporating giant bee honey showed the highest antibacterial activity, while stingless bee honey demonstrated susceptibility to E. coli and Asian bee honey showed susceptibility to S. aureus. Additionally, in-vitro cytocompatibility analyses showed that stingless bee honey hydrogels supported greater cell viability and migration compared to other types of honey hydrogels and control hydrogels.
MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES
(2021)
Article
Materials Science, Biomaterials
Angel Tan, Qingtao Liu, Dedy Septiadi, Shuiling Chu, Tianqing Liu, Sarah-Jane Richards, Barbara Rothen-Rutishauser, Alke Petri-Fink, Matthew Gibson, Ben J. Boyd
Summary: This work explores the selectivity of metabolic glycan labelling in cancer versus normal cells, demonstrating the potential to recruit nanotherapeutics using metabolic labelling while minimizing non-specific targeting of surrounding tissues.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Jessica Caldwell, Roman Lehner, Sandor Balog, Christian Rheme, Xin Gao, Dedy Septiadi, Christoph Weder, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: With the increasing prevalence of plastic micro- and nanoparticles in the environment, the risk of human exposure and uptake is elevated, yet little is known about their potential adverse effects. This study successfully created fluorescently labeled plastic nanoparticles of heterogeneous shapes, and found differences in their uptake and compatibility within different cell types.
ENVIRONMENTAL SCIENCE-NANO
(2021)