Article
Biochemistry & Molecular Biology
Samprikta Manna, Colm J. J. Mc Elwain, Gillian M. M. Maher, Marta Giralt Martin, Andrea Musumeci, Fergus P. P. McCarthy, Cathal McCarthy
Summary: This study investigated the cellular senescence phenotypes of pre-eclampsia and intrauterine growth restriction (IUGR) pregnancies by measuring multiple biomarkers of senescence. The results showed signs of premature senescence in IUGR pregnancies, while pre-eclampsia activated cell cycle checkpoint regulators but with a phenotype of cell repair and proliferation rather than senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
A. Arias, J. A. Schander, M. Bariani, F. Correa, A. P. Dominguez Rubio, M. Cella, C. B. Cymeryng, M. L. Wolfson, A. M. Franchi, J. Aisemberg
Summary: Maternal dexamethasone administration during late gestation results in fetal and placental growth restriction, potentially due to altered placental angiogenesis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Acoustics
Farah Deeba, Ricky Hu, Victoria Lessoway, Jefferson Terry, Denise Pugash, Jennifer Hutcheon, Chantal Mayer, Septimiu Salcudean, Robert Rohling
Summary: Pregnancy complications such as pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are associated with changes in the structure and function of the placenta. Elastography techniques can assess the mechanical properties of the placenta and be used for detecting placenta abnormalities and predicting pregnancy outcomes.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Review
Medicine, General & Internal
Serena Resta, Gaia Scandella, Ilenia Mappa, Maria Elena Pietrolucci, Pavjola Maqina, Giuseppe Rizzo
Summary: The number of pregnancies achieved through IVF is increasing globally, with improved chances of success due to technological advances. However, pregnancies conceived through IVF have a higher risk of adverse maternal and perinatal outcomes, mainly related to hypertensive diseases, pre-eclampsia, and fetal growth restriction. Advances in ultrasound technology allow for the evaluation of placental volume and hemodynamics, with differences observed between fresh and frozen-thawed embryos.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Computer Science, Information Systems
Lola Gomez-Jemes, Andreea Madalina Oprescu, Angel Chimenea-Toscano, Lutgardo Garcia-Diaz, Maria del Carmen Romero-Ternero
Summary: The use of artificial intelligence in healthcare, especially in obstetrics and gynecology, has great potential. This study proposes a machine learning model to predict risk events in pregnancy, specifically pre-eclampsia and intrauterine growth restriction, using specific measurements. The variation of the decision tree classifier was found to be the best performing model.
Article
Obstetrics & Gynecology
Thi Truong, Alexandra J. Harvey, David K. Gardner
Summary: This study investigated the effect of combined antioxidants on mouse fetal gene expression. The results showed that both in-vitro culture in the presence of 20% oxygen and vitrification of blastocysts significantly perturbed fetal liver and placental gene expression. However, supplementation with A3 reduced the number of differentially expressed genes and altered biological processes, establishing a more in-vivo-like gene expression profile, particularly in the placenta. Additionally, A3 supplementation significantly reduced the expression of genes associated with pre-eclampsia and intrauterine growth restriction.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Kelsey McLaughlin, Sebastian R. Hobson, Anjana Ravi Chandran, Swati Agrawal, Rory C. Windrim, W. Tony Parks, Adrian W. Bowman, Ulla Sovio, Gordon C. Smith, John C. Kingdom
Summary: The study established a gestational age-specific reference range for placental growth factor levels and showed that low-molecular-weight heparin therapy can increase circulating placental growth factor levels in patients, prolonging pregnancy and reducing adverse pregnancy outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cell Biology
Carter Norton, Derek Clarke, Joshua Holmstrom, Isaac Stirland, Paul R. Reynolds, Tim G. Jenkins, Juan A. Arroyo
Summary: The objective of this study was to analyze methylation patterns in placental DNA from normal pregnancies, preeclampsia (PE) and intrauterine growth restriction (IUGR) affected pregnancies. DNA was extracted, bisulfite converted and hybridized for methylation array. Differentially methylated regions were identified using the USEQ program, and gene promoters were identified using UCSC's Genome browser and Stanford's GREAT analysis. Western blot confirmed differential protein expression of commonly regulated genes. The study found some common methylation alterations between PE and IUGR, which may explain the clinical similarities observed with these obstetric complications.
Article
Obstetrics & Gynecology
Laura D. Brown, Claire Palmer, Lucas Teynor, Brit H. Boehmer, Jane Stremming, Eileen Chang, Alicia White, Amanda K. Jones, Sarah N. Cilvik, Stephanie R. Wesolowski, Paul J. Rozance
Summary: The study found that fetal sex does not have a widespread impact on experimental insults, with most outcomes showing no gender-based differences. The only exceptions were higher hormone concentrations in female fetuses.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sharon A. McCracken, Sean K. M. Seeho, Tamara Carrodus, Jenny H. Park, Narelle Woodland, Eileen D. M. Gallery, Jonathan M. Morris, Anthony W. Ashton
Summary: Preeclampsia and intrauterine growth restriction are major causes of maternal and fetal morbidity/mortality. This study reveals abnormal expression of hypoxia-inducible factors and identifies a significant mechanism driving maladaptive responses to hypoxia in pathological placentae from severe Preeclampsia and intrauterine growth restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Da Som Jeong, Ji-Yeon Lee, Myoung Hee Kim, Ji Hoon Oh
Summary: Our study investigated the effects of maternal LPS exposure on sex-specific placental adaptation. We found that LPS exposure induced placental inflammation in both sexes at GD 17.5. Prenatal infection resulted in growth retardation in both sexes of embryos, with males being more affected. Sex-specific impairments in placental development were observed, with LPS 400 μg/kg reducing the percentage area of the labyrinth in females and junctional zone in males. RNA sequencing revealed widespread sexually dimorphic transcriptional changes in placenta, particularly in processes such as trophoblast differentiation, nutrient/ion transport, pregnancy, and the immune system.
MOLECULAR MEDICINE
(2023)
Article
Biology
Tina Napso, Xiaohui Zhao, Marta Ibanez Lligona, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri
Summary: The study characterized secretory output of mouse placental endocrine cells and found that proteins secreted from the placenta are involved in metabolic, immune and growth modulation. These placental proteins could serve as new biomarkers for pregnancy complications, as demonstrated by increased levels of certain protein ratios in women prior to diagnosis of gestational diabetes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xing-Xing Gao, Shuai Lin, Pei-Ying Jiang, Meng-Ying Ye, Wei Chen, Chuan-Xiang Hu, Yuan-Hua Chen
Summary: This study revealed that gestational cholestasis induces apoptosis of trophoblast cells in the placenta, leading to placental insufficiency and IUGR. Furthermore, the activation of the IRE1α pathway was found in cholestasis cases.
Article
Environmental Sciences
Alison G. Paquette, James MacDonald, Samantha Lapehn, Theo Bammler, Laken Kruger, Drew B. Day, Nathan D. Price, Christine Loftus, Kurunthachalam Kannan, Carmen Marsit, W. Alex Mason, Nicole R. Bush, Kaja Z. LeWinn, Daniel A. Enquobahrie, Bhagwat Prasad, Catherine J. Karr, Sheela Sathyanarayana
Summary: This study examined the relationship between prenatal phthalate exposure and the placental transcriptome at birth, identifying numerous genes and lncRNAs associated with prenatal phthalate exposure. The findings provide insight into the biological pathways affected by phthalate exposure, contributing to a better understanding of the mechanisms of action during fetal development.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Reproductive Biology
C. Bertholdt, M. Dap, R. Pillot, P. Chavatte-Palmer, O. Morel, M. Beaumont
Summary: The study aimed to quantitatively characterize placental perfusion using contrast-enhanced ultrasound in pregnant rabbits and qualitatively assess the placental perfusion. The results showed that placental vascularization became gradually homogeneous as pregnancy progressed, and the wash-in and wash-out rates significantly increased. Contrast-enhanced ultrasound is feasible for qualitative and quantitative analysis of placental vascularization during pregnancy in animal models.
Article
Endocrinology & Metabolism
Sarah Louise Killeen, David F. Byrne, Aisling A. Geraghty, Mark T. Kilbane, Patrick J. Twomey, Malachi J. McKenna, Cara A. Yelverton, Radka Saldova, Douwe Van Sinderen, Paul D. Cotter, Eileen F. Murphy, Fionnuala M. McAuliffe
Summary: In women with obesity, the prevalence of metabolically unhealthy obesity (MUO) was lower using the cardiometabolic disease staging system (CMDS) than the Edmonton obesity staging system (EOSS). C3 and CRP may serve as useful clinical biomarkers for assessing risk and guiding treatment in these women.
ANNALS OF NUTRITION AND METABOLISM
(2022)
Editorial Material
Obstetrics & Gynecology
Divya Gautam, Gillian A. Ryan, Fionnuala M. McAuliffe, Nikhil Purandare
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Helena C. Bartels, Jennifer M. Walsh, Clare O'Connor, Peter McParland, Stephen Carroll, Shane Higgins, Karen M. Mulligan, Paul Downey, David Brophy, Gabrielle Colleran, Claire Thompson, Tom Walsh, Donal J. O'Brien, Donal J. Brennan, Ruaidhri McVey, Fionnuala M. McAuliffe, Jennifer Donnelly, Siobhan M. Corcoran
Summary: The objective of this study was to evaluate fetal growth in pregnancies complicated by placenta accreta spectrum (PAS) and compare fetal growth between different ultrasound stages of PAS. The results showed that the diagnosis of PAS was not associated with fetal growth restriction.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Nursing
Sharleen L. O'Reilly, Marie C. Conway, Eileen C. O'Brien, Eva Molloy, Hannah Walker, Eimear O'Carroll, Fionnuala M. McAuliffe
Summary: This study aims to explore the barriers and enablers to breastfeeding among women with high body mass indices and identify specific behaviors suitable for intervention. The research found that women with high body mass indices face limitations in terms of knowledge, support, and self-efficacy in breastfeeding. A multifactorial intervention is needed to provide comprehensive support for successful breastfeeding.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Obstetrics & Gynecology
Fiona Cody, Julia Unterscheider, Sean Daly, Michael Geary, Mairead Kennelly, Fionnuala McAuliffe, John Morrison, Keelin O'Donoghue, Alyson Hunter, Patrick Dicker, Elizabeth Tully, Rachel Fhearaigh, Fergal Malone
Summary: A total of 17% of fetuses with initial fetal growth restriction (FGR) outgrew their diagnosis, and this was more common in healthy mothers. Antenatal surveillance could be decreased once the fetus exceeded the 10th centile.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Pediatrics
Helena C. Bartels, Linda M. O'Keeffe, Cara A. Yelverton, Kate N. O'Neill, Aisling A. Geraghty, Eileen C. O'Brien, Sarah Louise Killeen, Ciara McDonnell, Fionnuala M. McAuliffe
Summary: This study aimed to examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age. Data from the ROLO study were analyzed, and no strong evidence of associations between maternal metabolic parameters and fetal to childhood weight and abdominal circumference trajectories was found.
Article
Environmental Sciences
Doireann Roche, Anthony Rafferty, Sinead Holden, Sarah Louise Killeen, Maria Kennelly, Fionnuala M. McAuliffe
Summary: This study aimed to examine the association between early pregnancy well-being and stage of behavior change during an antenatal lifestyle intervention. The results showed that both maternal well-being and the study group significantly influenced the positive stage of behavior change, highlighting the potential importance of well-being in promoting women's engagement in a healthy lifestyle.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Obstetrics & Gynecology
Catherine McNestry, Sarah L. Killeen, Rachel K. Crowley, Fionnuala M. McAuliffe
Summary: There is an increasing recognition of the association between pregnancy complications and the development of chronic diseases later in life. Pregnancy can be seen as a stress test that reveals underlying predispositions to disease. However, healthcare providers lack awareness of these risks. A narrative literature review shows that various pregnancy complications are associated with increased risk of cardiovascular disease, diabetes, venous thromboembolism, chronic kidney disease, postnatal depression, and mental health disorders. It is important to offer counseling and risk reduction advice for women in the postnatal period following a complicated pregnancy. Further research is needed to determine optimal screening intervals for cardiovascular disease and diabetes after a complicated pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Sarah Louise Killeen, Shauna L. Callaghan, Sharleen L. O'Reilly, Fionnuala M. McAuliffe
Summary: The objective of this study was to develop a core outcome set for pregnancy nutrition. Candidate outcomes were identified from a systematic review and additional data were collected through interviews with women with pregnancy experience. A modified Delphi survey and consensus meeting were conducted to finalize the core outcome set. The set includes critical outcomes for both pregnant women and newborns, providing important guidance for researchers and healthcare professionals.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Multidisciplinary Sciences
Conor Feehily, Ian J. O'Neill, Calum J. Walsh, Rebecca L. Moore, Sarah Louise Killeen, Aisling A. Geraghty, Elaine M. Lawton, David Byrne, Rocio Sanchez-Gallardo, Sai Ravi Chandra Nori, Ida Busch Nielsen, Esther Wortmann, Elizabeth Matthews, Roisin O'Flaherty, Pauline M. Rudd, David Groeger, Fergus Shanahan, Radka Saldova, Fionnuala M. McAuliffe, Douwe Van Sinderen, Paul D. Cotter
Summary: The authors combine isolation and sequencing of bacteria from both mothers and infants to investigate microbial strain transfer, particularly in the genus Bifidobacterium. They reveal that strain transfer occurs in almost 50% of dyads, with factors such as vaginal birth and avoidance of intrapartum antibiotics being important. Dual approaches, combining cultivation and metagenomic sequencing, are necessary for a comprehensive understanding of this transfer process.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Obstetrics & Gynecology
Long Nguyen-Hoang, Graeme N. Smith, Lina Bergman, Fionnuala M. McAuliffe, Liona C. Poon
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Microbiology
Cara A. Yelverton, Sarah Louise Killeen, Conor Feehily, Rebecca L. Moore, Shauna L. Callaghan, Aisling A. Geraghty, David F. Byrne, Calum J. Walsh, Elaine M. Lawton, Eileen F. Murphy, Douwe Van Sinderen, Paul D. Cotter, Fionnuala M. Mcauliffe
Summary: This study explored the relationships among maternal well-being during pregnancy, breastfeeding, and the infant gut microbiome. The results showed that maternal well-being during pregnancy was not associated with infant microbial diversity. However, exclusive breastfeeding at discharge from hospital was associated with infant microbial beta diversity, and any breastfeeding at 1 month postpartum was associated with infant microbial alpha diversity, observed species, and beta diversity. Exclusive breastfeeding at 1 month postpartum was also associated with infant alpha diversity and number of observed microbial species.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Sharleen L. O'Reilly, Rachel Laws, Helle Terkildsen Maindal, Helena Teede, Cheryce Harrison, Fionnuala M. McAuliffe, Aisling Geraghty, Cristina Campoy, Mercedes G. Bermudez, Laura Pirhonen, Christy Burden, Anna Davies, Ditte Hjorth Laursen, Timothy Skinner
Summary: This study aims to explore the feasibility and implementation of the B2B&Me intervention and investigate its effectiveness in women at risk of gestational diabetes.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Obstetrics & Gynecology
Rebecca L. Moore, Conor Feehily, Sarah Louise Killeen, Cara A. Yelverton, Aisling A. Geraghty, Calum J. Walsh, Ian J. O'Neill, Ida Busch Nielsan, Elaine M. Lawton, Rocio Sanchez-Gallardo, Sai Ravi Chandra Nori, Fergus Shanahan, Eileen F. Murphy, Douwe Van Sinderen, Paul D. Cotter, Fionnuala M. McAuliffe
Summary: This study aimed to investigate if maternal probiotic supplementation in pregnancy can affect the infant gut microbiome. The results showed that direct mother-to-infant strain transfer of the supplemented probiotic occurred, albeit infrequently. This study highlights the potential for maternal supplementation to introduce microbial strains into the infant microbiome.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Nutrition & Dietetics
May Loong Tan, Izz Amirah Mohd Shukri, Jacqueline J. Ho, Elizabeth J. O'Sullivan, Amal Omer-Salim, Fionnuala M. McAuliffe
Summary: A breastfeeding-friendly city is a city that provides an enabling environment to support breastfeeding throughout a child's first 2 years or more. However, there are currently no established indicators for defining a breastfeeding-friendly city. This study identified common criteria such as policy, training & education, skilled breastfeeding support, and physical infrastructure, which could be developed into indicators. Further research is needed to determine the importance of these criteria and how they can be measured.
MATERNAL AND CHILD NUTRITION
(2023)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)