Article
Multidisciplinary Sciences
Weiping Xia, Xiang Chen, Zewu Zhu, Hequn Chen, Bingsheng Li, Kangning Wang, Li Huang, Zhi Liu, Zhi Chen
Summary: The study found that lncRNA MALAT1 promotes the process of renal interstitial fibrosis through the miR-124-3p/ITGB1 signaling pathway, suggesting its potential as a therapeutic target for RIF.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Kefeng Lv, Yuhua Liu, Yanbing Zheng, Shaowen Dai, Peifeng Yin, Haifeng Miao
Summary: The study revealed that MALAT1 regulates cell proliferation and apoptosis in MPP+-stimulated cell model of PD through the miR-135b-5p/GPNMB axis, suggesting MALAT1 as a potential biomarker and therapeutic target for PD.
BIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xin Geng, Shipeng Li, Jinghui Li, Renli Qi, Lianmei Zhong, Hualin Yu
Summary: This study found that MDMA promoted the expression of MALAT1 and inhibited the targeted downregulation of MEKK3 by miR-124, resulting in upregulation of MEKK3 expression and jointly promoting the progression of PD.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Bin Liu, Xinli Zhan, Chong Liu
Summary: The study reveals that in osteosarcoma, overexpression of MALAT1 can modulate SphK1 by interacting with miR-124-3p, thus affecting tumor proliferation and migration.
JOURNAL OF ONCOLOGY
(2021)
Article
Immunology
Shitao Zhang, Dong Dong, Yuan Zhang, Jia Wang, Lei Liu, Yulin Zhao
Summary: The study revealed that miR-124-3p modulates the development of allergic rhinitis by targeting DPP4. Upregulation of miR-124-3p alleviated nasal symptoms, reduced pathological changes and cell apoptosis, and lowered inflammation factor levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Chenyi Zhang, Lai Pan, Haizheng Zhang, Ting Ke, Yuxuan Yang, Lan Zhang, Lili Chen, Jingyi Tan
Summary: The study investigated the role of lncRNA MALAT1 and miRNA-124 in osteoclast differentiation, providing new clues for the pathogenesis of periodontitis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Neurosciences
Hongyu Cheng, Haikang Zhao, Xin Xiao, Qian Huang, Wen Zeng, Bo Tian, Tao Ma, Dan Lu, Yulong Jin, Yuqian Li
Summary: The high expression of MALAT1 in glioma is associated with poor prognosis, and its silencing inhibits tumor cell proliferation and induces apoptosis. MALAT1 regulates glioma development through the miR-124/ZEB2 pathway, providing a new potential strategy for future therapy.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Oncology
Tian Liang, Tong Lu, Weiwei Jia, Runze Li, Min Jiang, Yu Jiao, Yuchen Wang, Shanshan Cong, Xinyan Jiang, Lina Dong, Yingyu Zhou, Guangmei Zhang, Dan Xiao
Summary: This study elucidated the role and downstream mechanism of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the process of pyroptosis in cervical cancer cells. The findings demonstrated that lncRNA MALAT1 was upregulated in cervical carcinoma cells and its knockdown induced pyroptosis-mediated cell death, while its overexpression blocked lipopolysaccharide-induced pyroptosis. The study also identified the involvement of the microRNA-124/sirtuin 1 axis in mediating the effects of lncRNA MALAT1 on cervical cancer cell pyroptosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Oncology
Baocheng Zhu, Hengguan Cui, Weiqiang Xu
Summary: Hydrogen gas treatment significantly inhibits proliferation and migration of gastric cancer cells, while affecting the expression of related genes, showing potential therapeutic effects. In addition, the lncRNA MALAT1/miR-124-3p/EZH2 axis may serve as an important target for intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Orthopedics
Rigbat Rozi, Yubo Zhou, Kai Rong, Pingbo Chen
Summary: This study aimed to investigate the role of miR-124-3p in chondrocyte pyroptosis and cartilage injury in osteoarthritis (OA). The results showed that overexpression of miR-124-3p could alleviate cartilage injury and inhibit chondrocyte pyroptosis. Further investigations revealed that miR-124-3p exerted its function by regulating the expression of factors such as MALAT1 and KLF5.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, Research & Experimental
Qi Li, Xiaoxia Liu, Weifang Liu, Yang Zhang, Mengying Wu, Zhirui Chen, Yin Zhao, Li Zou
Summary: In early-onset preeclampsia (EOPE), decreased expression of MALAT1 and PFKFB3 is associated with endothelial cell dysfunction. PFKFB3 modulates the proliferation, migration, and tube formation of ECs by regulating glycolysis, while MALAT1 regulates PFKFB3 expression by sponging miR-26a/26b. MALAT1 knockdown reduces EC angiogenesis by inhibiting PFKFB3-mediated glycolysis flux, suggesting that strategies targeting PFKFB3-driven glycolysis may be a promising approach for EOPE treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Qiang Sun, Yueliang Zhang, Songlin Wang, Fang Yang, Hongxia Cai, Yu Xing, Liping Zhou, Sen Chen, Yunfu Wang
Summary: The study aimed to investigate the role of long non-coding RNA HOTAIR in Parkinson's disease (PD) and its underlying mechanism. The results showed that HOTAIR attenuated MPP+-induced SH-SY5Y cell injury via the miR-221-3p/alpha-synuclein axis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yuluan Wang, Charlotte Soneson, Anna L. Malinowska, Artur Laski, Souvik Ghosh, Alexander Kanitz, Luca F. R. Gebert, Mark D. Robinson, Jonathan Hall
Summary: The study introduced a new class of miR-CLIP probes to capture targetomes of miR-124 and miR-132, revealing overlapping targetomes between isoforms and potential synergistic effects of isomirs. Interestingly, it was found that pre-miR-124 processed into isomiRs can repress targets more strongly than individual treatments with miR-124 and iso-miR-124. Mining the miR-CLIP targetome identified G-bulged target-sites regulated at the protein level by miR-124 but not isomiR-124, proposing a model involving AGO2 helix-7 for site engagement.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Yinying Qin, Junqiang Huang, Xiangyou Zhao
Summary: This study reveals the important role of Mst1 in regulating neuronal cell death in Parkinson's disease models, and suggests that the miR-135a-5p/Mst1 axis could be a potential therapeutic target for PD treatment.
CELLULAR SIGNALLING
(2022)
Article
Immunology
Zijun Yang, Dongxu Song, Yulin Wang, Lin Tang
Summary: This study investigates the role of MALAT1 in diabetic nephropathy (DN) and reveals that MALAT1 knockdown alleviates high glucose-induced damage in HK-2 cells through the inhibition of the miR-15b-5p/TLR4 axis. MALAT1 may serve as a potential biomarker and therapeutic target for DN.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)