Article
Oncology
Anne Sophie Lind Helligsoe, Line Kenborg, Louise Tram Henriksen, Aparna Udupi, Henrik Hasle, Jeanette Falck Winther
Summary: Incidence rates of childhood CNS tumors in Denmark remain stable but among the highest in the world. Despite improved survival rates in recent years for children aged 0-4 years, some subtypes still have a poor prognosis.
Article
Oncology
Meerim Park, Jiwon Lim, Jun Ah Lee, Hyeon Jin Park, Byung Kiu Park, Myong Cheol Lim, Sang-Yoon Park, Young-Joo Won
Summary: Malignant ovarian germ cell tumors (MOGCTs) in Korean women demonstrated a slight increase in prevalence, with a more pronounced growth among patients aged <19 years. Patients with dysgerminoma showed significantly higher survival rates compared to those with non-dysgerminoma. Following MOGCT diagnosis, the risk of developing subsequent malignancies doubled compared with the general population.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Micah K. Harris, Richard T. Graham, Andrea M. Cappellano, Ashley S. Margol, George Michaiel, John R. Crawford, Myrsini Ioakeim-Ioannidou, Joseph R. Stanek, Kevin X. Liu, Shannon M. MacDonald, Mohamed S. Abdelbaki
Summary: Patients with Down syndrome treated for central nervous system GCTs are at increased risk of treatment-related complications, with a higher rate of relapse or progression. Different therapeutic approaches may be needed to mitigate these risks and improve outcomes.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Kaishi Satomi, Hirokazu Takami, Shintaro Fukushima, Satoshi Yamashita, Yuko Matsushita, Yoichi Nakazato, Tomonari Suzuki, Shota Tanaka, Akitake Mukasa, Nobuhito Saito, Masayuki Kanamori, Toshihiro Kumabe, Teiji Tominaga, Keiichi Kobayashi, Motoo Nagane, Toshihiko Iuchi, Koji Yoshimoto, Kaoru Tamura, Taketoshi Maehara, Keiichi Sakai, Kazuhiko Sugiyama, Kiyotaka Yokogami, Hideo Takeshima, Masahiro Nonaka, Akio Asai, Toshikazu Ushijima, Masao Matsutani, Ryo Nishikawa, Koichi Ichimura
Summary: 12p gain may predict the presence of malignant components and poor prognosis of NGGCTs.
Article
Oncology
Ying L. Liu, Beryl L. Manning-Geist, Andrea Knezevic, Luxue Deng, Maria Bromberg, Samuel A. Funt, Jane L. Meisel, Oliver Zivanovic, Kara Long Roche, Yukio Sonoda, Ginger J. Gardner, Rachel N. Grisham, Roisin E. O'Cearbhaill, William P. Tew, Nadeem R. Abu-Rustum, Dennis S. Chi, Carol Aghajanian, Darren R. Feldman
Summary: The objective of this study was to validate the modified international male IGCCCG prognostic model in female patients with germ cell tumors (GCTs). The results demonstrated that the modified IGCCCG model accurately assessed the prognostic risk in female GCTs patients and was associated with clinical outcomes.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Inka Puhakka, Hanne Kuitunen, Pekka Jakala, Eila Sonkajarvi, Taina Turpeenniemi-Hujanen, Aino Ronka, Tuomas Selander, Miika Korhonen, Outi Kuittinen
Summary: This study provides the first population-based incidence rates and prognosis of primary central nervous system lymphoma (PCNSL) in Finland. The results show that PCNSL incidence in Finland is among the highest reported worldwide, with an annual increase of 2.4%. The prognosis is still poor, especially for elderly patients.
Review
Oncology
Mohammad H. Abu-Arja, Diana S. Osorio, Alvaro Lassaletta, Richard T. Graham, Scott L. Coven, Joseph R. Stanek, Eric Bouffet, Jonathan L. Finlay, Mohamed S. Abdelbaki
Summary: This study aimed to identify prognostic factors for relapsed central nervous system nongerminomatous germ cell tumors. Results showed that patients with lower serum/CSF AFP levels at initial diagnosis, achieved complete response/continued complete response by the end of therapy at relapse, and received marrow-ablative chemotherapy followed by autologous hematopoietic cell rescue had higher survival rates. Local relapse site, gross total surgical resection, and radiotherapy at relapse did not show significant associations with improved outcomes.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Hirokazu Takami, Christopher S. Graffeo, Avital Perry, Caterina Giannini, Yoichi Nakazato, Nobuhito Saito, Masao Matsutani, Ryo Nishikawa, Koichi Ichimura, David J. Daniels
Summary: This study investigates the optimal cut-offs for tumor markers in CNS germ cell tumors (GCTs) to specify non-germinomatous GCTs. It concludes that an integrated diagnosis based on tumor markers and histopathology is key to precise diagnosis and treatment strategies for this rare and heterogeneous tumor. The study also raises questions about the treatment approach for marker-positive germinomas or teratomas and optimal treatment strategy for marker-negative immature teratomas.
Review
Medical Laboratory Technology
Daniel F. Marker, Thomas M. Pearce
Summary: Germ cell tumors of the central nervous system (GCT-CNS) primarily occur in midline locations, affect young patients, and present with symptoms of ventricular obstruction or compression. Diagnosis relies on morphology and immunohistochemistry, while treatment is challenging and requires accurate pathological diagnosis.
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2023)
Article
Oncology
Hideo Nakamura, Hirokazu Takami, Takaaki Yanagisawa, Toshihiro Kumabe, Takamitsu Fujimaki, Yoshiki Arakawa, Katsuyuki Karasawa, Keita Terashima, Hideaki Yokoo, Kohei Fukuoka, Yukihiko Sonoda, Kaori Sakurada, Yohei Mineharu, Toshinori Soejima, Motoaki Fujii, Naoki Shinojima, Junichi Hara, Kai Yamasaki, Junya Fujimura, Fumiyuki Yamasaki, Mayu Takahashi, Tomonari Suzuki, Iori Sato, Ryo Nishikawa, Kazuhiko Sugiyama
Summary: Primary CNS germ cell tumors are rare neoplasms primarily seen in children and young adults. While treatment standardization remains challenging due to low case volume, advancements have been made in recent years through modified radiation and chemotherapy methods. In order to provide clinical management recommendations, the Japan Society for Neuro-Oncology established a multidisciplinary task force to create an evidence-based guideline for CNS GCTs.
Article
Clinical Neurology
Narendra Kumar, Renu Madan, Chinna Babu Dracham, Divya Khosla, Namrata Das, Treshita Dey, Arun Elangovan, Manjul Tripathi, Kirti Gupta, Chirag K. Ahuja, Rakesh Kapoor
Summary: CNS GCTs, relatively rare and heterogeneous neoplasms, commonly occur in the pineal and suprasellar locations. A combination of chemotherapy and radiotherapy has shown excellent treatment outcomes for these tumors.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Oncology
Alexandra L. Farrall, Justine R. Smith
Summary: This study analyzed the incidence and survival outcomes of primary central nervous system lymphoma (PCNSL) in Australia using data from the Australian Cancer Database. The incidence of PCNSL has been increasing at an average annual rate of 6.8% over the past four decades, with an overall low survival rate of only 33% at 5 years after diagnosis. Additionally, the study found that the increase in PCNSL incidence was driven by the diffuse large B-cell lymphoma (DLBCL) type, with survival outcomes improving but still lower than for non-CNS lymphoma.
Article
Oncology
Danny R. Youlden, Chloe Henshaw, Nicholas G. Gottardo, Timothy Hassall, Joanne F. Aitken
Summary: The study found that the incidence rate of childhood CNS tumors increased by 29% between 1983 and 2016, with high-grade tumors on the rise. Among various diagnostic subtypes, astrocytoma and embryonal tumors were the most common. The overall 5-year survival rate was 72%, and although survival rates improved for some tumors over time, patients with high-grade astrocytoma still had poor outcomes.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Huy Gia Vuong, Tam N. M. Ngo, Ian F. Dunn
Summary: This study investigated the incidence, prognostic indicators, and survival trend of tumors emanating from the pineal gland. Findings revealed that older age, male gender, non-germ cell tumor, and chemotherapy were significantly associated with poor survival. The study also showed an increased survival of pineal gland tumors over the years.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Annamaria D'Alessandro, Domenico Ciavardelli, Anna Pastore, Germana Giannone, Giada Del Baldo, Andrea Carai, Angela Mastronuzzi, Andrea Onetti Muda, Ottavia Porzio
Summary: This study evaluated the suitability of an analytical method certified for use on serum and/or amniotic fluid for quantifying hCG and AFP in cerebrospinal fluid. The results showed that the automated immunochemical method can accurately quantify hCG and AFP in CSF for selective and specific diagnosis of secreting germ cell tumors.