Article
Clinical Neurology
Nikolaos Mouchtouris, Fadi Al Saiegh, Breanna Valcarcel, Carrie E. Andrews, Evan Fitchett, David Nauheim, David Moskal, Nabeel Herial, Pascal Jabbour, Stavropoula Tjoumakaris, Ashwini D. Sharan, Robert H. Rosenwasser, M. Reid Gooch
Summary: The study identified hypertension, length of hospital stay, and hemorrhagic conversion as predictors of 30-day readmission in stroke patients after mechanical thrombectomy. Infection was the most common cause of readmission within 30 days, followed by cardiac and cerebrovascular diagnoses. These results are important in identifying patients requiring increased surveillance to reduce complications and unplanned readmissions.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Mei-Jun Shu, Jia-Rui Li, Yi-Cheng Zhu, Hang Shen
Summary: This study did not find significant associations between migraine and ischemic stroke and its subtypes, with the results being consistent with sensitivity analyses. Conducting a series of causal inference approaches supported the conclusion that there is no causal effect of migraine on ischemic stroke and its subtypes.
NEUROLOGY AND THERAPY
(2022)
Article
Clinical Neurology
Jenna Broman, Karoliina Aarnio, Anna But, Ivan Marinkovic, Jorge Rodriguez-Pardo, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
Summary: The study found that one-fourth of young adults initiated post-stroke antidepressant treatment within 1 year of ischemic stroke. Patients initiating antidepressant treatment had specific clinical characteristics associated with their condition, highlighting the importance of assessing the risk of post-stroke depression during follow-up.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Qiongbin Zhu, Lehui Chen, Qinglin Xu, Jiahui Xu, Lisan Zhang, Jin Wang
Summary: This study investigated the role of obstructive sleep apnea (OSA) in post-stroke anxiety (PSA) in noncardiogenic ischemic stroke patients. A total of 180 patients were enrolled and underwent polysomnography (PSG) to assess OSA severity. The prevalence of acute-phase and 6-month PSA were evaluated, and the associations between PSA and OSA were analyzed. The results showed that acute-phase PSA was associated with OSA severity, potentially through OSA-caused sleep discontinuity.
Article
Clinical Neurology
Gauthier Duloquin, Valentin Crespy, Pauline Jakubina, Maurice Giroud, Catherine Vergely, Yannick Bejot
Summary: The study found that minor ischemic stroke with large vessel occlusion is not uncommon, and its characteristics include severe symptom presentation, decreased consciousness, cortical signs, especially aphasia and altered item level of consciousness. Emergency arterial imaging is needed for patients suspected of acute stroke, including those with minor symptoms, due to the absence of obvious predictors of proximal occlusion.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Katie M. Linstra, Hendrikus J. A. van Os, Ynte M. Ruigrok, Paul J. Nederkoorn, Ewoud J. van Dijk, L. Jaap Kappelle, Peter J. Koudstaal, Marieke C. Visser, Michel D. Ferrari, Antoinette MaassenVanDenBrink, Gisela M. Terwindt, Marieke J. H. Wermer
Summary: Women with migraine have an increased risk of stroke at a young age, while men with migraine tend to have a higher incidence of stroke with other determined causes. Migraine does not significantly affect stroke outcome in women, but may increase the risk of poor outcomes in men.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Anesthesiology
Luca J. Wachtendorf, Maximilian Sebastian Schaefer, Peter Santer, Omid Azimaraghi, Salameh Sameh Obeidat, Sabine Friedrich, Liana Zucco, Albert Woo, Sarah Nabel, Eswar Sundar, Matthias Eikermann, Satya Krishna Ramachandran
Summary: The study showed that preoperative administration of gabapentinoids can reduce the risk of hospital readmission and postoperative respiratory complications in patients, partly due to lower intraoperative opioid utilization.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Clinical Neurology
Teng Hwee Tan, Huili Zheng, Timothy Cheo, Jeremy Tey, Yu Yang Soon
Summary: The study revealed a significantly increased risk of stroke in survivors of NPC, especially in stage 1 disease, compared to the general population; however, the risk of death within 30 days of stroke was not significantly higher for NPC survivors.
Article
Public, Environmental & Occupational Health
Yuxuan Lu, Weiping Sun, Zhiyuan Shen, Wei Sun, Ran Liu, Fan Li, Junlong Shu, Liwen Tai, Guozhong Li, Huisheng Chen, Guiru Zhang, Lei Zhang, Xuwen Sun, Jinhua Qiu, Yan Wei, Haiqiang Jin, Yining Huang
Summary: Studies on the regional differences in hospital costs of acute ischemic stroke (AIS) in China are scarce. The research revealed significant disparities in hospital costs among different regions, with similar proportion size order of components but unique determinants of costs in each region.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Zhen Lin, Hedong Han, Cheng Wu, Xin Wei, Yiming Ruan, Chenxu Zhang, Yang Cao, Jia He
Summary: The study evaluated the relationship between DAMA and 30-day unplanned readmissions in AIS patients, finding that DAMA was associated with higher rates of all-cause and recurrent stroke-specific readmissions.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Jussi O. T. Sipila, Jori O. Ruuskanen, Paivi Rautava, Ville Kyto
Summary: Survival rate of ICH in Finland has continued to decrease over the years, with patient age, sex, and comorbidities being significant factors affecting prognosis.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Adalia H. Jun-O'Connell, Eliza Grigoriciuc, Brian Silver, Kimiyoshi J. Kobayashi, Marcey Osgood, Majaz Moonis, Nils Henninger
Summary: The study aimed to evaluate the effectiveness of the LACE+ index in predicting the risk of 30-day readmission in stroke patients. The results showed that the LACE+ index was associated with the risk of 30-day readmission, with the high-risk group having the highest readmission rate. This indicates that the LACE+ scoring system has some validity in predicting readmission in stroke patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Rehabilitation
Janet K. Freburger, Aileen Chou, Tracey Euloth, Beth Matcho, Andrew Bilderback
Summary: This study found an inverse relationship between the number of physical and occupational therapist visits received in acute care hospital and the risk of hospital readmission or death for stroke patients. The effects differed by time to the event, discharge location, and mobility limitations on admission.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Emily C. McKinley, Christine L. Lay, Robert S. Rosenson, Ligong Chen, Victoria Chia, Lisandro D. Colantonio, Paul Muntner, Robert Urman, Michael E. Farkouh
Summary: Older adults with migraine are at increased risk for ischemic stroke. The risk for ischemic stroke among older adults with migraine may differ by migraine medication classes.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Felipe A. A. Oliveira, Mario G. G. Dourado-Filho, Pedro A. A. Sampaio Rocha-Filho
Summary: The study aimed to assess whether migraine affects the divergence between the areas of diffusion and perfusion in ischemic stroke and the prognosis after the stroke. The results showed that there was no association between migraine and the absence or volume of the ischemic penumbra, as well as the stroke prognosis.
Article
Surgery
Denys Shay, Pauline Y. Ng, David M. Dudzinski, Stephanie D. Grabitz, John D. Mitchell, Xinling Xu, Timothy T. Houle, Deepak L. Bhatt, Matthias Eikermann
Summary: The study aimed to identify undertreated subgroups of heart failure patients who would benefit from better perioperative optimization. Patients with heart failure have increased risks of postoperative cardiac complications after noncardiac surgery. In this analysis of hospital registry data, it was found that heart failure patients had significantly higher risks of cardiac complications. Clinicians often make insufficient attempts to optimize the clinical condition of lower-risk heart failure patients preoperatively, but appropriate preoperative preventive treatment can significantly reduce their risk of postoperative cardiac complications.
Article
Clinical Neurology
Hebun Erdur, Joachim E. Weber, Anselm Angermaier, Stephan Kinze, Ali Sotoodeh, Claudia Gorski, Kerstin Bollweg, Stefanie Ernst, Farid Kandil, Janina Behrens, Ramanan Ganeshan, Anne Keysers, Malgorzata Kotlarz-Boettcher, Daniel Peters, Ludwig Schlemm, Kirsten Stangenberg-Gliss, Carl Witt, Beata Hennig, Katrin C. Reber, Udo Schneider, Christiana Franke, Ingo Schmehl, Hans-Beatus Straub, Agnes Floeel, Sarah Theen, Matthias Endres, Tobias Kurth, Heinrich J. Audebert
Summary: Implementing a multicomponent system-of-care can reduce the risk of poor outcomes in stroke patients.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ana Sofia Oliveira Goncalves, Jessica L. Rohmann, Marco Piccininni, Tobias Kurth, Martin Ebinger, Matthias Endres, Erik Freitag, Peter Harmel, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Reinhard Busse, Heinrich J. Audebert
Summary: The study assessed the cost-utility and cost-effectiveness of additional mobile stroke unit (MSU) dispatch in ischemic stroke patients eligible for recanalizing treatments. Results showed that MSU dispatch increased costs but also improved quality-adjusted life years (QALYs), and it was considered cost-effective according to internationally accepted thresholds.
ANNALS OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Tobias Kurth, Jessica L. Rohmann
Review
Economics
Ana Sofia Oliveira Goncalves, Sophia Werdin, Tobias Kurth, Dimitra Panteli
Summary: This review aimed to identify how studies deal with methodological challenges of repeated measurements in mapping algorithms using patient responses to questionnaires. The inconsistent use of methods to account for interdependent observations indicates a need for mapping guidelines and journal updates.
Article
Pediatrics
Stefanie Theuring, Mascha Kern, Franziska Hommes, Marcus A. A. Mall, Joachim Seybold, Frank P. P. Mockenhaupt, Toivo Glatz, Tobias Kurth
Summary: During the COVID-19 pandemic, children and adolescents worldwide have been disproportionately affected in their psychological health and wellbeing. A cohort study in Germany found that anxiety symptoms among school children decreased from June to August 2021, but increased again in September 2021. Factors such as gender, school type, household education and income level, and COVID-19 vaccination were significantly associated with reporting anxiety symptoms.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Jessica L. Rohmann, Rodrigo Huerta-Gutierrez, Heinrich J. Audebert, Tobias Kurth, Marco Piccininni
Summary: This study demonstrates the potential bias in using unadjusted stacked bar graphs to compare functional outcomes after stroke. By using IPT weighting to account for measured confounding, the researchers were able to present more accurate results.
EUROPEAN STROKE JOURNAL
(2023)
Article
Infectious Diseases
Annemarie Pantke, Christian Kollan, Barbara Gunsenheimer-Bartmeyer, Bjoern-Erik Ole Jensen, Christoph Stephan, Olaf Degen, Dirk Schuermann, Tobias Kurth, Viviane Bremer, Uwe Koppe
Summary: This study aimed to examine the incidence rates and predictive utility of established prognostic factors for the progression to AIDS among people living with HIV under clinical care. The study used data from two observational cohorts of people living with HIV in Germany and found that the rates of a first AIDS event have continuously declined, and health outcomes depend on CD4 count, viral load, and age but not on transmission mode.
Article
Genetics & Heredity
Corinna Grasemann, Jakob Hoppner, Peter Burgard, Michael M. Schundeln, Nora Matar, Gabriele Mueller, Heiko Krude, Reinhard Berner, Min Ae Lee-Kirsch, Fabian Hauck, Kerstin Wainwright, Sylvana Baumgarten, Janet Atinga, Jens J. Bauer, Eva Manka, Julia Korholz, Cordula Kiewert, Andre Heinen, Tanita Kretschmer, Tobias Kurth, Janna Mittnacht, Christoph Schramm, Christoph Klein, Holm Graessner, Olaf Hiort, Ania C. Muntau, Annette Grueters, Georg F. Hoffmann, Daniela Choukair
Summary: The transition process from paediatric/adolescent to adult medical care settings is crucial for the future health of adolescents with chronic diseases, especially in the context of rare diseases. This study presents a patient-focused transition pathway that can be adopted for different rare diseases, aiming to improve patients' health literacy and empower them through individualized training and counselling.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Marco Piccininni, Tobias Kurth, Heinrich J. Audebert, Jessica L. Rohmann
Summary: The B_PROUD study aimed to evaluate the impact of mobile stroke unit (MSU) dispatch on ischemic stroke and transient ischemic attack (TIA) patients. However, a large proportion of patients did not receive MSU care despite being dispatched. The study found that receiving additional MSU care was associated with better functional outcomes compared to conventional care.
Article
Cardiac & Cardiovascular Systems
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, Tobias Kurth
Summary: Adding information on migraine with aura (MA) to cardiovascular disease (CVD) risk prediction models can improve risk prediction accuracy, but does not significantly improve risk stratification among women.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Kurth, Pamela M. Rist
Summary: The connection between migraine and cardiovascular disease is intricate and involves overlapping mechanisms like endovascular disturbances. Challenges in measuring migraine, differentiating causation from prediction, and understanding clinical implications emphasize the importance of further research to guide treatment and cardiovascular risk assessment for migraine sufferers.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Clinical Neurology
Marco Piccininni, Ralph Brinks, Jessica L. Rohmann, Tobias Kurth
Summary: This study used modern epidemiological methods to estimate the prevalence of never, active, and inactive migraine. The transition rate from active to inactive migraine increased after age 22.5 for women and 27.5 for men in Germany. The estimated prevalence of inactive migraine at age 60 was 25.7% for women in Germany and 16.5% globally, and 10.4% for men in Germany and 7.1% globally.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Health Care Sciences & Services
Vanessa Voelskow, Claudia Messner, Tobias Kurth, Amelie Busam, Toivo Glatz, Natalie Ebert
Summary: During the COVID-19 pandemic in Germany, telephone hotlines of local health authorities were overwhelmed with information requests. This study evaluated the use of a COVID-19-specific voicebot (CovBot) in these authorities and found that while it provided some relief to staff, it could not fully replace human assistance.
Article
Clinical Neurology
Eugen Schwabauer, Marco Piccininni, Erik Freitag, Martin Ebinger, Frederik Geisler, Peter Harmel, Annegret Hille, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Tobias Kurth, Jessica L. Rohmann, Matthias Endres, Frieder Schlunk, Joachim Weber, Matthias Wendt, Heinrich J. Audebert
Summary: The study found that dispatching Mobile Stroke Units (MSUs) led to a reduction in systolic blood pressure (sBP) and shorter dispatch-to-imaging time compared to conventional ambulance care for patients with acute intracerebral haemorrhage (ICH). However, there was no significant difference in other outcomes, including 7-day mortality and favorable outcome.
EUROPEAN STROKE JOURNAL
(2023)