Article
Economics
Pierluigi Russo, Andrea Marcellusi, Matteo Zanuzzi, Angelica Carletto, Maria Elisabetta Fratto, Giampiero Favato, Tommaso Staniscia, Ferdinando Romano
Summary: This study evaluated the potential role of efficacy data and other information in defining oncology treatment costs in Italy during the price and reimbursement decision-making process. Results showed that the variation of progression-free survival was the only variable predictor statistically associated with treatment cost when confidential net prices were used.
Article
Oncology
Marc A. Rodwin, Julien Mancini, Segolene Duran, Anne-Celine Jalbert, Patrice Viens, Dominique Maraninchi, Anthony Goncalves, Patricia Marino
Summary: The study found a weak correlation between drug prices and added therapeutic benefit for drugs to treat solid tumors in France. Prices increased substantially even for drugs with no added benefit, but the correlation between benefit and prices was stronger for first indications.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Food Science & Technology
Francesco Bimbo, Emilio De Meo, Antonietta Baiano, Domenico Carlucci
Summary: This study aims to estimate the market value associated with craft beer attributes and support producers in detecting profitable marketing strategies. The results show that package type and cup have moderate effects on price, while gluten-free craft beers have a moderate premium price. Craft beers with organic labels and Italian origin do not benefit from higher prices. The beer style strongly affects the product price, with Barleywine and Italian Grape Ale having the highest premium prices.
Article
Environmental Sciences
Gyeongseon Shin, Hye-Young Kwon, SeungJin Bae
Summary: The skyrocketing prices of cancer drugs raise concerns about their commensurate value. Despite expedited reviews leading to approvals, only 20% of cancer drugs show overall survival gains in confirmatory trials. Small-scale studies with surrogate outcomes challenge economic evaluation. Health technology assessment bodies frequently reject expensive cancer drugs due to their high price and uncertain clinical value. To address this issue, cancer drug funds or risk-sharing schemes have been adopted. However, the lack of novel mechanisms of action and rising prices raise questions about whether newly marketed cancer therapies meet clinical needs and whether they are overpriced. A special approach for cancer medications harms transparency, equity, innovativeness, and sustainability. If early access is allowed, confirmatory trials and economic evaluations should be conducted within a certain time frame, and label changes or disinvestment should be based on these evaluations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Engineering, Industrial
Xiaoyue Zhang, Wenqiang Dai, Xiaoqiang Cai
Summary: This paper investigates the problem of inventory replenishment in a capacitated warehouse with uncertain procurement prices and market demands. The goal is to minimize the costs of procuring and holding inventory. A competitive analysis framework is used, and an efficient online real-time replenishment algorithm is developed. The algorithm does not rely on any distribution assumption and makes decisions based on past and present information. The paper also presents a theoretical performance guarantee and shows that the algorithm performs well in situations with high volatility uncertainty over time and exhibits risk-averse behavior. Numerical experiments further validate the effectiveness of the algorithm.
INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Jing Luo, Shunlong Ou, Hua Wei, Xiaoli Qin, Rui Peng, Song Wang, Qian Jiang
Summary: This study aimed to assess the value of new cancer drugs approved in China and explore the association between drug price and value. The results showed that not all approved drugs had meaningful value, and there was no significant correlation between drug price and clinical benefit.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Computer Science, Interdisciplinary Applications
Ting Jin, Xiangfeng Yang
Summary: This paper investigates the application of uncertain fractional differential equations in financial market modeling, presenting monotonicity theorems and an uncertain fractional mean-reverting model. Pricing formulas for European and American options are derived based on monotone function and present extreme values and time integral theorems. Numerical schemes are designed and illustrated for different parameters through the predictor-corrector method.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2021)
Review
Oncology
Zhenhuan Luo, Bishal Gyawali, Sheng Han, Luwen Shi, Xiaodong Guan, Anita Katharina Wagner
Summary: Facing the challenges posed by rapidly growing pharmaceutical expenditures and high drug prices, the Chinese government has focused on supporting local research and development of cancer medicines, leading to the development of locally produced me-too drugs. The introduction of a central reimbursement-linked drug price negotiation policy since 2016 aims to lower the prices of expensive medicines. Local me-too drugs marketed at lower prices have the potential to introduce price competition and facilitate negotiations for reduced prices of similar internationally-developed products.
SEMINARS IN ONCOLOGY
(2021)
Article
Management
Adam N. Elmachtoub, Vishal Gupta, Michael L. Hamilton
Summary: Increased availability of high-quality customer information has led to a growing interest in personalized pricing strategies, which can potentially offer greater value compared to simple single-price strategies. By analyzing statistical data and customer features, the potential benefits of personalized pricing over traditional pricing models are examined to provide insights for different markets.
MANAGEMENT SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Yuka Kadomatsu, Shota Nakamura, Harushi Ueno, Masaki Goto, Naoki Ozeki, Koichi Fukumoto, Takayuki Fukui, Yuka Suzuki, Toyofumi Fengshi Chen-Yoshikawa
Summary: In this study, the researchers evaluated the R(un) category proposed by the IASLC for NSCLC and found that various factors led to the reclassification of patients into the R(un) group. The study also revealed that the R(un) classification was associated with poor overall survival in node-positive patients. Therefore, careful consideration is required to determine whether the R(un) classification can be used as an indicator of lymph node dissection quality, and for advanced cases, the R(un) definition may be useful in predicting poor prognosis.
ANNALS OF THORACIC SURGERY
(2022)
Article
Dermatology
Christine M. Thomas, Whitney Shae, Devin Koestler, Terese DeFor, Nathan C. Bahr, Jonathan D. Alpern
Summary: This study examines the trends in antifungal drug prices and identifies the factors contributing to these price changes. The results show that antifungal drugs have experienced significant price increases, and atypical routes of administration and compounded formulations are associated with higher price increases. The findings support the development of policies to curb price increases for important medications.
Article
Pharmacology & Pharmacy
Tiansheng Cao, Hongsheng Wu, Tengfei Ji
Summary: This study investigated the role of gene methylation in pancreatic adenocarcinoma (PAAD) using bioinformatics. It identified differentially methylated genes (DMGs) and differentially expressed genes (DEGs) that were mainly associated with olfactory transduction, natural killer cell mediated cytotoxicity pathway, and cytokine-cytokine receptor interaction. The study also screened potential anti-cancer small molecule drugs and constructed a prediction model for PAAD prognosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
History & Philosophy Of Science
Patryk Dziurosz-Serafinowicz, Dominika Dziurosz-Serafinowicz
Summary: The article explores the value of waiting for cost-free uncertain evidence before making decisions, extending the classical value of evidence theorem to a new update method. By focusing on this new method, the study shows that gathering uncertain evidence can maximize expected pragmatic utility while minimizing expected epistemic disutility.
Article
Multidisciplinary Sciences
Miriam Gold, Seth Binder, Christoph Nolte
Summary: This paper presents an estimation approach at the county and parcel level to improve the accuracy of estimating the market value of undeveloped land in the United States. By considering factors that affect agricultural productivity and demand for undeveloped land, such as median home value, climatic variables, and soil type, the predictive power is substantially increased. Expanding the set of predictors and the geographical scale of modeling further improves accuracy and extends coverage to more counties.
Article
Health Care Sciences & Services
Hana Althobaiti, Enrique Seoane-Vazquez, Lawrence M. Brown, Marc L. Fleming, Rosa Rodriguez-Monguio
Summary: This study evaluated the factors associated with the differences in treatment cost between new orphan and non-orphan drugs approved by the FDA from 2017 to 2021. The results showed that orphan drugs have significantly higher treatment costs compared to non-orphan drugs.