Article
Nutrition & Dietetics
Yair Lahav, Aviv Kfir, Yftach Gepner
Summary: This study evaluated the prevalence of excessive adiposity among normal-weight individuals and their cardiometabolic risk, and found that higher adiposity, even within normal weight, increases cardiometabolic risk.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Jamee Guerra Valencia, Willy Ramos, Liliana Cruz-Ausejo, Jenny Raquel Torres-Malca, Joan A. Loayza-Castro, Gianella Zulema Zenas-Trujillo, Norka Rocio Guillen Ponce, Fiorella E. Zuzunaga-Montoya, Mario J. Valladares-Garrido, Victor Juan Vera-Ponce, Jhony A. De La Cruz-Vargas
Summary: The study analyzed the association between fruit intake and body mass index (BMI) and waist circumference (WC) in a representative sample of Peruvians. Fruit intake per serving was found to be negatively related to general body adiposity and central fat distribution. However, the consumption of fruit in the form of juices was positively associated with a significant increase in BMI and WC.
Article
Multidisciplinary Sciences
Ban-Hock Khor, Sharmela Sahathevan, Ayesha Sualeheen, Mohammad Syafiq Md Ali, Sreelakshmi Sankara Narayanan, Karuthan Chinna, Abdul Halim Abdul Gafor, Bak-Leong Goh, Ghazali Ahmad, Zaki Morad, Zulfitri Azuan Mat Daud, Pramod Khosla, Kalyana Sundram, Tilakavati Karupaiah
Summary: TG monounsaturated fatty acids were associated with poor nutritional status, while TG n-3 PUFAs were associated with good nutritional status. Meanwhile, TG saturated fatty acids and TG n-6 PUFAs had both favorable and unfavorable associations with nutritional parameters.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Qinqiu Wang, Xiaoying Shi, Jinghua Wang, Juanwen Zhang, Chengfu Xu
Summary: This study found that a low serum vitamin D level is associated with NAFLD in obese participants but not in lean participants. Obese individuals with NAFLD had lower levels of serum vitamin D compared to obese individuals without NAFLD. Serum vitamin D level was negatively correlated with NAFLD prevalence in obese participants, and independently associated with NAFLD risk in this group.
Article
Pediatrics
Oskar Lundgren, Pontus Henriksson, Christine Delisle Nystrom, Kristin Silfvernagel, Marie Lof
Summary: This study investigated psychological strengths and difficulties in Swedish preschool children and found that hyperactivity scores were positively related to fat-free mass and moderate-to-vigorous physical activity, and negatively associated with sedentary behaviors, but not with fat mass. The findings suggest that the adverse health consequences of hyperactivity on obesity and obesity-related health behaviors may be established after the preschool period, raising questions about the time frame of contributing and modulating factors in obesity development.
Article
Endocrinology & Metabolism
Lijun Zhu, Zhengmei Fang, Yuelong Jin, Weiwei Chang, Mengyun Huang, Yan Chen, Yingshui Yao
Summary: This study found that ERBB3 levels are associated with hypertension in overweight patients, with gender and alcohol consumption potentially modulating the process.
BMC ENDOCRINE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Yu-Cheng Cheng, Wei-Chun Ma, Yu-Hsuan Li, Junyi Wu, Kae-Woei Liang, Wen-Jane Lee, Hsiu-Chen Liu, Wayne Huey-Herng Sheu, I-Te Lee
Summary: In this study, it was found that plasma AhR concentrations were higher in individuals with obesity compared to healthy controls. Moreover, plasma AhR levels were positively correlated with epicardial adipose tissue thickness on the free wall of the right ventricle. These findings suggest a relationship between AhR and epicardial adipose tissue and further research is needed to understand the causal effects and underlying mechanisms.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Biochemistry & Molecular Biology
A-Ra Cho, Eunkyung Suh, Hyoju Oh, Baek Hwan Cho, Minchan Gil, Yun-Kyong Lee
Summary: This study aimed to investigate the association between body fat and muscle percentages and natural killer cell activity (NKA). The study conducted a cross-sectional analysis on 8058 subjects in a medical center in Korea. The results showed that low NKA was significantly associated with low muscle mass and muscle percentage in both men and women, while high fat percentage was associated with low NKA in men.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Ye Jiang, Bai Ma Kang Zhuo, Bing Guo, Pei-Bin Zeng, Yu-Ming Guo, Gong-Bo Chen, Jing Wei, Rui-Feng He, Zhi-Feng Li, Xue-Hui Zhang, Zi-Yun Wang, Xuan Li, Lei Wang, Chun-Mei Zeng, Lin Chen, Xiong Xiao, Xing Zhao
Summary: This study aimed to explore the association between living near green spaces and bone strength, and to determine the potential mediating roles of ambient air pollution, physical activity, and body mass index. A cross-sectional analysis was conducted among 66,053 Chinese adults recruited from the China Multi-Ethnic Cohort.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Beruk Berhanu Desalegn, Tona Zema Diddana, Alemneh Kabeta Daba, Tagel Alemu Tafese
Summary: This study aimed to determine the magnitude and determinants of overnutrition among school-going adolescents in Dale District of Ethiopia. The results showed that the prevalence of overnutrition was 7.2%, and it was positively associated with factors such as lack of sufficient play area within the school, being an urban resident, positive energy balance, consuming fast foods and snacks, and having low physical activity levels.
Article
Psychology, Multidisciplinary
Xiaomei Zhang, Yanqing Li, Yueping Zhong, Ziheng Wang
Summary: The study found that patients with acromegaly have significant body image concerns, which are exacerbated by the stigma associated with the disease, leading to a reduced quality of life.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Nutrition & Dietetics
Saori Onishi, Akira Fukuda, Masahiro Matsui, Kosuke Ushiro, Tomohiro Nishikawa, Akira Asai, Soo Ki Kim, Hiroki Nishikawa
Summary: The study aimed to investigate the relationship between body composition and the Suita score in Japanese health check-up subjects. The results showed that parameters of body composition, such as waist circumference, fat mass to fat-free mass ratio, and water mass index, were associated with the Suita score.
Article
Public, Environmental & Occupational Health
Gao-Xiang Wang, Bao-Li Huang, Jun-Tong Li, Ze-Bin Fang, Le-Yi Feng, Heng-Xia Zhao, Shu-Fang Chu, De-Liang Liu, Hui-Lin Li
Summary: A correlation was found between urinary nickel levels and BMI and WC in adult males, suggesting the need for reducing nickel exposure, especially in obese men.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, Research & Experimental
Jiacheng Wang, Yi Zheng, Yawen Wang, Chengjun Zhang, Yanfeng Jiang, Chen Suo, Mei Cui, Tiejun Zhang, Xingdong Chen, Kelin Xu
Summary: This study investigated the association between lifetime body mass index (BMI) trajectories and bone loss. The results showed that rapid and excess weight gain during adulthood is associated with a higher risk of osteoporosis, but this association varies by skeletal sites. Maintaining stable overweight and obesity at an early stage may have potentially beneficial effects on bone health.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Nursing
Yong Kang Cheah, Kuang Kuay Lim, Hasimah Ismail, Ruhaya Salleh, Chee Cheong Kee, Kuang Hock Lim, Yoon Ling Cheong
Summary: This study explores the correlates of sociodemographic factors, smoking, and caloric knowledge to body mass index awareness with a focus on Malaysia. The findings suggest that age, education, smoking, and caloric knowledge are associated with body mass index awareness.
NURSING & HEALTH SCIENCES
(2022)
Article
Peripheral Vascular Disease
Susana Martin-Vano, Alejandra Miralles-Abella, Pascual Castano, Gema Hurtado-Genoves, Maria Aguilar-Ballester, Andrea Herrero-Cervera, Angela Vinue, Sergio Martinez-Hervas, Herminia Gonzalez-Navarro
Summary: This study explores the involvement of the tumor necrosis factor superfamily (TNFSF) ligands in the gene expression signature associated with vascular smooth muscle cell plasticity. The results indicate that these ligands play a crucial role in maintaining the identity of vascular smooth muscle cells and preventing them from acquiring a genetic expression signature compatible with functional cellular plasticity.
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2023)
Article
Biochemistry & Molecular Biology
Marta Galvez-Fernandez, Zulema Rodriguez-Hernandez, Maria Grau-Perez, F. Javier Chaves, Ana Barbara Garcia-Garcia, Nuria Amigo, Daniel Monleon, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, Laisa S. Briongos-Figuero, Jose L. Perez-Castrillon, Josep Redon, Maria Tellez-Plaza, Juan C. Martin-Escudero
Summary: This study evaluated the association between plasma metabolic patterns and bone fragility, taking into account redox balance and genetic variants. The results showed that metabolic patterns were related to bone fractures and bone mineral density. Participants with exposure to certain metal elements had increased risk of fractures. Genetic variants may also influence the relationship between metabolism and bone fragility.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ana Flores-Chova, Olga Martinez-Arroyo, Angela L. L. Riffo-Campos, Ana Ortega, Maria J. J. Forner, Raquel Cortes
Summary: This study analyzed the non-coding RNA (ncRNA) profile of plasma exosomes in patients with lupus nephritis (LN), a serious complication of systemic lupus erythematosus (SLE), using next-generation sequencing. The study identified a unique ncRNA signature associated with LN, with microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and piwi-interacting RNAs (piRNAs) being the most abundant differentially expressed transcripts. Furthermore, the study identified potential therapeutic targets for renal damage in SLE, including transforming growth factor-beta (TGF-beta) superfamily binding proteins, WNT/beta-catenin signaling, and fibroblast growth factors (FGFs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ana Palanca, F. Javier Ampudia-Blasco, Jose Miguel Calderon, Inmaculada Sauri, Sergio Martinez-Hervas, Jose Luis Trillo, Josep Redon, Jose T. Real
Summary: The study aimed to assess the impact of GLP-1RA treatment in obese adults with type 2 diabetes and compare it with other glucose-lowering agents. The results showed that GLP-1RA users had lower persistence but higher medication adherence. Within 2 years, persistent GLP-1RA users showed better reduction in HbA1c. However, therapeutic inertia was observed in the study population.
Editorial Material
Biochemistry & Molecular Biology
Francisco Lara-Hernandez, Luis Alvarez, Javier Chaves, Ana-Barbara Garcia-Garcia
Article
Biology
Olga Martinez-Arroyo, Ana Flores-Chova, Belen Sanchez-Garcia, Josep Redon, Raquel Cortes, Ana Ortega
Summary: Diabetic nephropathy is a major complication in diabetic patients, and the Rab3A/Rab27A system plays a key role in podocyte injury and vesicular traffic regulation in this condition. Silencing RAB3A and RAB27A decreases podocyte differentiation and cytoskeleton organization while increasing apoptosis. The pattern distribution of CD63-positive vesicles also changes. Rab3A/Rab27A silencing improves some detrimental processes under high glucose, suggesting a differential influence depending on cellular stress.
Article
Endocrinology & Metabolism
Enrique Ozcariz, Montse Guardiola, Nuria Amigo, Gemma Rojo-Martinez, Sergio Valdes, Pere Rehues, Lluis Masana, Josep Ribalta
Summary: The aim of this study was to combine nuclear magnetic resonance-based metabolomics and machine learning to identify a glucose-independent molecular signature associated with future type 2 diabetes development. A metabolomic analysis was performed on serum samples from individuals in the Di@bet.es study, revealing lipoprotein and glycoprotein profiles as well as 15 low molecular weight metabolites that were related to the development of type 2 diabetes. Machine learning models also highlighted the roles of inflammation and muscle as independent factors in the development of type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Sergio Valdes, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Eva Garcia-Escobar, Sara Garcia-Serrano, Wasima Oualla-Bachiri, Marta Garcia-Vivanco, Juan Luis Garrido, Victoria Gil, Fernando Martin-Llorente, Alfonso Calle-Pascual, Luis Castano, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbes, F. Javier Chaves, Jose L. Galan-Garcia, Gabriel Aguilera-Venegas, Joan Carles Vallve, Nuria Amigo, Montse Guardiola, Josep Ribalta, Gemma Rojo-Martinez
Summary: The study aimed to assess the associations between exposure to air pollutants and lipoprotein measures in the adult population of Spain. The results showed that exposure to particulate matter and nitrogen dioxide was associated with lower levels of high-density lipoprotein cholesterol and particles, as well as increased risk of low high-density lipoprotein cholesterol and particles. Subgroup analysis further revealed that the effects of particulate matter and nitrogen dioxide were more pronounced in men and individuals with obesity.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Olga Martinez-Arroyo, Ana Ortega, Ana Flores-Chova, Belen Sanchez-Garcia, Ana B. Garcia-Garcia, Felipe J. Chaves, Juan C. Martin-Escudero, Maria Jose Forner, Josep Redon, Raquel Cortes
Summary: Elevated plasma microRNA levels, particularly miR-126-3p, are associated with albuminuria in hypertensive patients, and may serve as prognostic markers for cardiovascular events. Further studies are needed to assess the potential role of miR-126-3p in evaluating endothelial dysfunction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Rebeca Melero, Maria Elena Quiroz-Rodriguez, Francisco Lara-Hernandez, Josep Redon, Guillermo Saez, Laisa S. Briongos-Figuero, Jessica Abadia-Otero, Juan Carlos Martin-Escudero, F. Javier Chaves, Guillermo Ayala, Ana-Barbara Garcia-Garcia
Summary: This study found a significant association between genetic polymorphisms related to oxidative stress parameters and the risk of developing Type 2 Diabetes Mellitus in a general population from Spain, indicating the important role of genetic variations and their interaction with oxidative stress parameters in the risk of developing T2D.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Nutrition & Dietetics
Blanca Alabadi, Miguel Civera, Adrian De la Rosa, Sergio Martinez-Hervas, Mari Carmen Gomez-Cabrera, Jose T. Real
Summary: Body composition changes during aging, particularly loss of lean mass, can contribute to the development of age-associated diseases such as type 2 diabetes (T2D). T2D is also associated with increased oxidative stress (OS) that negatively affects skeletal muscle. This study aimed to investigate the differences in clinical and nutritional parameters, disease control, and OS in older patients with T2D based on their amount of lean mass. The findings indicate that older women with low fat-free mass and muscle mass have poorer T2D metabolic control, and those with low muscle mass exhibit higher levels of OS. Thus, low lean mass in geriatric T2D patients is associated with worse glycemic control and increased OS.
Article
Biology
Soraya Garcia-Sorribes, Francisco Lara-Hernandez, Iris Manzano-Blasco, Jessica Abadia-Otero, Eliseo Albert, Alba Mulet, Laisa Socorro Briongos-Figuero, Miriam Gabella-Martin, Ignacio Torres, Jaime Signes-Costa, David Navarro, Juan-Carlos Martin-Escudero, Ana-Barbara Garcia-Garcia, Felipe Javier Chaves
Summary: The novel coronavirus SARS-CoV-2 emerged at the end of 2019, causing the COVID-19 pandemic. Current detection techniques, such as RT-qPCR, are sensitive but time-consuming and expensive. To address this, rapid tests like antibody-antigen tests have been developed but with lower sensitivity. In this study, a faster and more sensitive COVID-19 diagnostic test based on RT-LAMP was developed, allowing diagnosis in 40 minutes and colorimetric detection in non-specialized centers.
Article
Education, Scientific Disciplines
A. Lopez-Prado, P. Miramontes-Gonzalez, J. C. Martin-Escudero, J. L. Perez-Castrillon, A. Duenas-Laita, M. J. Rollan, L. Corral-Gudino
Summary: This study assessed the effectiveness of using Twitter threads in improving medical students' skills in reading electrocardiograms (ECG). The results showed that using Twitter threads led to an improvement in students' interpretation of ECGs, especially in the final years of medical school when basic skills had already been acquired.
MEDICAL SCIENCE EDUCATOR
(2023)