Article
Urology & Nephrology
Andrea Tubaro, Mark Speakman, Alexandre de la Taille, Louis Martinez-Pineiro, Richard Berges, Anup Patel, Anders Bjartell, Christien Caris, Wim Witjes
Summary: This study evaluated the effectiveness of pharmacological treatment for lower urinary tract symptoms-benign prostatic enlargement in a real-world setting, showing that 70% of previously untreated and 42% of previously treated patients experienced symptom improvement after 24 months. Patients with persistent symptoms (IPSS >= 8) remained in both untreated and treated groups at 59% and 61% respectively, with higher rates of symptom deterioration in the previously treated group compared to the previously untreated group.
JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas H. Sanford, Stephanie A. Harmon, Deepak Kesani, Sandeep Gurram, Nikhil Gupta, Sherif Mehralivand, Jonathan Sackett, Scott Wiener, Bradford J. Wood, Sheng Xu, Peter A. Pinto, Peter L. Choyke, Baris Turkbey
Summary: The study aimed to quantitatively assess prostate anatomy and its relation to lower urinary tract symptoms. Prostatic urethral length was found to be associated with worse urinary symptoms, along with urethral angle and transition zone volume. This demonstrates the potential of quantitative assessment of prostatic urethral anatomy in predicting lower urinary tract symptoms.
ACADEMIC RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Caihong Xin, Huaying Fan, Jing Xie, Jingcheng Hu, Xin Sun, Qiuchen Liu
Summary: This systematic review evaluated the impact of diabetes mellitus on lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH) patients. The results of the meta-analysis supported that LUTS in BPH patients were increased in patients with diabetes mellitus compared with controls, suggesting that physicians should pay more attention to BPH patients with diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Urology & Nephrology
Edoardo Pozzi, Luca Boeri, Paolo Capogrosso, Walter Cazzaniga, Luigi Candela, Giuseppe Fallara, Nicolo Schifano, Antonio Costa, Daniele Cignoli, Manuela Tutolo, Rayan Matloob, Costantino Abbate, Francesco Montorsi, Andrea Salonia
Summary: The Overactive Bladder questionnaire (OABq) can detect additional storage lower urinary tract symptoms (LUTS) in patients presenting solely with voiding LUTS according to the IPSS questionnaire. Moreover, the OABq is associated with worse quality of life in these patients regardless of the severity of voiding symptoms.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Urology & Nephrology
Patrick Curtin, Christopher Chang, Andre Uflacker
Summary: Prostatic artery embolization (PAE) is an emerging minimally invasive technique for lower urinary tract symptom reduction from benign prostatic hypertrophy (BPH). Recent findings from multiple meta-analyses indicate that PAE performs similarly to the gold standard transurethral resection of the prostate (TURP) in patient-driven measures and demonstrates favorable objective measurements. PAE also has shorter hospital stays and fewer adverse events compared to TURP.
CURRENT UROLOGY REPORTS
(2023)
Article
Medicine, General & Internal
Yang Xiong, Fuxun Zhang, Changjing Wu, Yangchang Zhang, Xiaoyingzi Huang, Feng Qin, Jiuhong Yuan
Summary: Circadian syndrome (CircS) was found to predict both incident and prevalent lower urinary tract symptoms/benign prostate hyperplasia (LUTS/BPH) better than metabolic syndrome (MetS) in a long-term study in China. The study showed higher prevalence rates for CircS and MetS in aging men, with CircS demonstrating a stronger predictive power for LUTS/BPH compared to MetS.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Charles Welliver, Lydia Feinstein, Julia B. Ward, Ziya Kirkali, Erline Martinez-Miller, Brian R. Matlaga, Kevin McVary
Summary: The study aimed to define costs related to lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) care. The findings showed that the medical expenses for LUTS/BPH increased over the years, with outpatient fees in healthcare facilities gradually rising while inpatient charges decreased. The estimated total direct costs for LUTS/BPH in 2013 were at least $1.9 billion.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Urology & Nephrology
Blayne J. Welk, Andrew McClure
Summary: Improvement in male lower urinary tract symptoms is associated with a reduced risk of death, which suggests that symptom treatment may be beneficial regardless of bother.
JOURNAL OF UROLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhinan Fan, Hongjin Shi, Jinsong Zhang, Haifeng Wang, Jiansong Wang
Summary: Lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) are common in middle-aged and elderly men. Different drug regimens have varying efficacy in treating BPH/LUTS, with combination therapy showing greater effectiveness in improving symptom scores and maximum flow rates compared to monotherapy. However, current treatment plans have no significant effect on reducing post-void residual urine.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Gallus B. Ineichen, Fiona C. Burkhard
Summary: Historically, prostate enlargement was believed to be the sole cause of male bladder problems. However, as our understanding of urine storage and voiding processes has deepened, we have realized that the issue is more complex, with different mechanisms capable of producing similar symptoms. Metabolic syndrome is an umbrella term associated with bladder and prostate issues, as well as other health problems. This review aims to synthesize interactions and evidence to enhance our understanding of the relationship between these two issues and lay the groundwork for personalized treatment.
Review
Medicine, General & Internal
Seong Hyeon Yu, Seung Il Jung
Summary: Historically, urine was believed to be sterile, but recent studies have shown the presence of bacteria and microbial DNA in urine. This article focuses on the evidence of a microbial presence in urine and its association with lower urinary tract symptoms, particularly in men with benign prostate hyperplasia (BPH).
Article
Andrology
Vineet Gauhar, Ee Jean Lim, Tan Yung Khan, Yu Xi Terence Law, Zen Wei Choo, Daniele Castellani, Jeremy Yuen-Chun Teoh, Naeem Bhojani, Bilal Chughtai, Kevin Zorn, Dean Elterman
Summary: The aim of this study is to report the short-term outcomes of re-treatment intervention for recurrent lower urinary tract symptoms after prior surgical treatment for benign prostate enlargement. The results showed that after a 3-month follow-up of Rezum treatment, patients experienced significant improvement in symptoms and quality of life, and none of them required medication for benign prostate enlargement.
Article
Medicine, General & Internal
Giulio Milanese, Edoardo Agostini, Maria Vittoria De Angelis, Eugenio Pretore, Andrea Benedetto Galosi, Daniele Castellani
Summary: The study aimed to evaluate the impact of Cavacurmin(R) on prostate volume (PV), lower urinary tract symptoms (LUTS), and micturition parameters in men after 1 year of therapy. The retrospective comparison of 20 men receiving alpha 1-adrenoceptor antagonists plus Cavacurmin(R) with 20 men receiving only alpha 1-adrenoceptor antagonists revealed that the combination therapy led to significantly lower PV, PSA, and IPSS levels, as well as higher Qmax values.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Linlin Yang, Xin Chen, Zhiqi Liu, Wei Sun, Dexin Yu, Haiqin Tang, Zhiqiang Zhang
Summary: This study revealed that there is a correlation between the severity of LUTS in BPH patients and depressive symptoms as well as illness perceptions. Different subscales of illness perceptions were found to be associated with depressive symptoms. The study also suggested that illness consequences, concern, and emotion may mediate the relationship between LUTS and depressive symptoms.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Urology & Nephrology
Yi Lu, Shujun Fan, Yuxuan Song, Kang Liu, Kechong Zhou, Jiaqi Kang, Shangren Wang, Yongjiao Yang, Xiaoqiang Liu
Summary: The study found that a longer anogenital distance is associated with more severe BPH-related symptoms. It is recommended to consider anogenital distance as a marker for BPH-LUTS. Further research is needed to explore this interesting issue.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Endocrinology & Metabolism
D. Malandrino, A. Berni, B. Fibbi, B. Borellini, D. Cozzi, D. Norello, F. Fattirolli, F. Lavorini, I Olivotto, C. Fumagalli, C. Zocchi, L. Tassetti, L. Gozzi, N. Marchionni, M. Maggi, A. Peri
Summary: This study aimed to investigate whether early hyponatremia is a predictor of long-term sequelae in COVID-19 patients. The findings suggest that early hyponatremia is associated with pulmonary and right-sided heart involvement at follow-up.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Environmental Sciences
Costanza Calamai, Oumaima Ammar, Sara Marchiani, Selene Degl'Innocenti, Marisa Fino, Lorenzo Righi, Sara Dabizzi, Mario Maggi, Elisabetta Baldi, Linda Vignozzi, Monica Muratori
Summary: In March 2020, the Italian government implemented a national lockdown, which resulted in a significant reduction in air pollutants and an improvement in sperm motility and DNA quality of male infertility patients after the lockdown period.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Environmental Sciences
Giulia Guarnieri, Matteo Becatti, Roberta Squecco, Paolo Comeglio, Rachele Garella, Lara Tamburrino, Sara Marchiani, Linda Vignozzi, Gabriella Barbara Vannelli, Mario Maggi, Annamaria Morelli
Summary: The neuroendocrine control of reproduction is regulated by the pulsatile release of GnRH by hypothalamic neurons. BaP, a pollutant, can disrupt endocrine function and affect gonadal function and gamete maturation. This study found that BaP alters the phenotype and function of GnRH neurons by interfering with KISS1R signaling and GnRH secretion, highlighting its importance in the central neuroendocrine control of reproduction.
ENVIRONMENTAL POLLUTION
(2023)
Article
Andrology
Arcangelo Barbonetti, Giulia Rastrelli, Clotilde Sparano, Chiara Castellini, Linda Vignozzi, Mario Maggi, Giovanni Corona
Summary: A study found that male cannabis users are younger, have fewer comorbidities, and have better sexual performance compared to non-users. Cannabis use is associated with a more unstable relationship and a higher frequency of masturbation. Cannabis use may improve anthropometric and lipid profiles as well as penile arterial response in patients with sexual dysfunction.
Review
Andrology
Giovanni Corona, Walter Vena, Alessandro Pizzocaro, Linda Vignozzi, Alessandra Sforza, Mario Maggi
Summary: Type 2 diabetes mellitus and pre-diabetes are associated with reduced levels of circulating testosterone, but the role of testosterone replacement therapy in these patients is still uncertain.
Article
Andrology
Dimitri Yannas, Elena Zago, Elena Cavallini, Tommaso Todisco, Linda Vignozzi, Giovanni Corona, Mario Maggi, Giulia Rastrelli
Summary: This study found that the level of education is closely associated with erectile dysfunction and cardiovascular risk in men. Men with lower education level are more likely to have erectile dysfunction and metabolic syndrome, as well as a higher risk of cardiovascular events.
Review
Urology & Nephrology
G. Corona, G. Rastrelli, N. Bianchi, C. Sparano, A. Sforza, L. Vignozzi, M. Maggi
Summary: The present paper aims to analyze and discuss the relationship between male sexual function and elevated prolactin (PRL) levels (HPRL) using clinical data and meta-analytic approach. 4.2% of patients seeking medical care for sexual dysfunction showed PRL levels above the normal range. HPRL was found to have a negative influence on male sexual desire. Treating HPRL can improve libido, but its effect on erection is limited. The role of HPRL in erectile dysfunction remains inconclusive. Overall, the paper provides important evidence on the relationship between PRL levels and male sexual function.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Livio Tarchi, Giuseppe Pierpaolo Merola, Ottone Baccaredda-Boy, Francesca Arganini, Emanuele Cassioli, Eleonora Rossi, Mario Maggi, David S. Baldwin, Valdo Ricca, Giovanni Castellini
Summary: The purpose of this systematic review was to investigate the adverse effects of SSRIs on sexual function and determine if these effects persist after discontinuation. The review found limited evidence of sexual dysfunction following SSRI discontinuation and was unable to establish a cause-effect relationship. However, it highlighted the need for further research to explore the relationship between SSRI exposure and persistent sexual dysfunction and to develop new treatment options.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Review
Endocrinology & Metabolism
Serena Martinelli, Francesca Amore, Letizia Canu, Mario Maggi, Elena Rapizzi
Summary: Pheochromocytomas and Paragangliomas (Pheo/PGL) are rare catecholamine-producing tumors derived from adrenal medulla or from the extra-adrenal paraganglia respectively. This review provides an overview of the roles of tumor microenvironment (TME) cells and non-cellular components on Pheo/PGL growth and progression. Understanding the complex effects of TME on Pheo/PGL could suggest novel therapeutic targets for further clinical treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Clotilde Sparano, Virginia Adornato, Matteo Puccioni, Elena Zago, Giuliano Perigli, Benedetta Badii, Roberto Santoro, Mario Maggi, Luisa Petrone
Summary: This study aimed to investigate the prognostic role of pre-operative and early calcitonin levels in patients with medullary thyroid carcinoma without distant metastases. The results showed that patients with higher pre-operative and early calcitonin levels were more likely to have persistent disease. The early calcitonin level six months after surgery can serve as an effective predictor of persistent disease in medullary thyroid carcinoma without distant metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Costanza Calamai, Oumaima Ammar, Viktoria Rosta, Ginevra Farnetani, Salvatore Zimmitti, Lisa Giovannelli, Linda Vignozzi, Csilla Krausz, Monica Muratori
Summary: Cancer significantly increases sperm DNA fragmentation (sDF) and oxidative stress levels. The induction of viable oxidative stress is even higher in cancer patients compared to normozoospermic subfertile patients and healthy donors. There is a correlation between sDF and viable oxidative stress in all subjects, but not in cancer patients alone. Detecting oxidative stress could help manage the reproductive issues of cancer patients.
Article
Endocrinology & Metabolism
Giulia Cantini, Giovanni Quartararo, Niccolo Ghezzi, Diego Assis Goncalves, Laura Fei, Arianna Pia Propato, Luca Galtarossa, Marcello Lucchese, Mario Maggi, Michaela Luconi
Summary: This study investigates the predictive value of adiponectin in abdominal visceral tissue for excess weight loss after bariatric surgery, and finds that adiponectin in abdominal visceral tissues is the only marker significantly correlated with weight loss in females.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Medicine, General & Internal
Sara Marchiani, Selene Degl'Innocenti, Sara Dabizzi, Lara Tamburrino, Maria Grazia Fino, Giulia Traini, Costanza Calamai, Mario Maggi, Linda Vignozzi, Elisabetta Baldi, Francesco Lotti
Summary: Sperm cryopreservation is recommended for male fertility preservation in cancer patients or other medical conditions. The recovery rates of motility and viability vary depending on the medical condition. Our study showed that lower sperm quality led to lower recovery rates, and donor samples had the highest recovery rates. Cut-off values for motility recovery were established based on initial semen quality. Overall, our results emphasize the importance of considering intrinsic sperm characteristics in cryopreservation.
JOURNAL OF CLINICAL MEDICINE
(2023)