Article
Medicine, General & Internal
Jiamei Ji, Yating Li, Lei Fan, Hua Lu, Xiaoyan Qu
Summary: This report highlights a rare case of pure erythroid leukemia which may present a diagnostic challenge.
Review
Genetics & Heredity
Weijia Fu, Aijie Huang, Hui Cheng, Yanrong Luo, Lei Gao, Gusheng Tang, Jianmin Yang, Jianmin Wang, Xiong Ni
Summary: The NUP98-PMX1 fusion gene, resulting from t(1;11)(q23;p15), is rare in acute myeloid leukemia (AML) patients. This report represents the first case of de novo AML carrying the NUP98-PMX1 fusion gene, contributing to a more comprehensive understanding of this rearrangement. Mechanistic studies are needed to fully elucidate the role of the NUP98-PMX1 fusion gene in leukemia pathogenesis.
BMC MEDICAL GENOMICS
(2021)
Article
Pathology
Marietya I. S. Lauw, Zhongxia Qi, Lauren Eversmeyer, Sonam Prakash, Kwun Wah Wen, Jingwei Yu, Sara A. Monaghan, Nidhi Aggarwal, Linlin Wang
Summary: This study described 12 cases of myeloid neoplasms with t(v; 11p15); NUP98 rearrangement and characterized their pathological features. The study found that NUP98-rearranged myeloid neoplasms are clinically, morphologically, and cytogenetically distinct, and should be considered as a separate entity in the WHO classification.
Article
Oncology
Wei Xie, Philipp W. Raess, Jennifer Dunlap, Cristina Magallanes Hoyos, Hongmei Li, Peng Li, Ronan Swords, Susan B. Olson, Fei Yang, Tauangtham Anekpuritanang, Shimin Hu, Joanna Wiszniewska, Guang Fan, Richard D. Press, Stephen R. Moore
Summary: Adult AML-NUP98 is associated with an unfavorable outcome, often accompanied by cryptic translocations. Our study suggests that incorporating the NUP98 probe into AML FISH panels are warranted to improve clinical management.
LEUKEMIA & LYMPHOMA
(2022)
Article
Oncology
Karen M. M. Chisholm, Jenny Smith, Amy E. E. Heerema-McKenney, John K. K. Choi, Rhonda E. E. Ries, Betsy A. A. Hirsch, Susana C. C. Raimondi, Yi-Cheng Wang, Alice Dang, Todd A. A. Alonzo, Lillian Sung, Richard Aplenc, Alan S. S. Gamis, Soheil Meshinchi, Samir B. B. Kahwash
Summary: This study analyzed the different fusion genes and chromosomal abnormalities in pediatric acute myeloid leukemia (AMkL) and evaluated the 5-year event-free survival (EFS), overall survival (OS), and relapse rate in these subtypes. The results showed that CBFA2T3::GLIS2 and KMT2A rearrangements were associated with worse prognosis compared to other AMkL, while RBM15::MRTFA or AMkl-MRC subtypes had better outcomes. NUP98 fusion genes were associated with poor prognosis in the AAML1031 trial.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Pathology
Yannan Jia, Dong Lin, Zhe Wang, Chengwen Li, Huijun Wang, Jianxiang Wang, Yingchang Mi
Summary: This case presented a rare MPAL with T/myeloid lineages accompanied by t(3;3). The flow cytometry analysis supported the diagnosis, while cytogenetics revealed AML with t(3;3) and achieved complete morphological remission after treatment with an AML-like regimen.
DIAGNOSTIC PATHOLOGY
(2022)
Article
Medicine, General & Internal
So-Yeon Jeon, Na-Ri Lee, Seungah Cha, Ho-Young Yhim, Jae-Yong Kwak, Kyu Yun Jang, Namsu Kim, Yong Gon Cho, Chang-Hoon Lee
Summary: The therapeutic effect of decitabine in a patient with concurrent acute myeloid leukemia (AML) and T-lymphoblastic lymphoma (T-LBL) was reported. Complete remission of both AML and T-LBL was achieved after treatment with decitabine and dexamethasone.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Plant Sciences
Francesco Aloi, Rossana Parlascino, Sebastiano Conti Taguali, Roberto Faedda, Antonella Pane, Santa Olga Cacciola
Summary: A dieback was observed on three-year-old pot-grown plants of Cycas revoluta in Sicily (Italy), and Phytophthora species were identified as the causal agent. Among the three Phytophthora species isolated, P. pseudocryptogea was found to be the most virulent, while P. multivora was the least virulent. The pathogenicity tests confirmed that P. pseudocryptogea was responsible for the decline of C. revoluta.
Article
Oncology
Tomotaka Suzuki, Rui Yokomori, Takaomi Sanda, Takaki Kikuchi, Yoshiaki Marumo, Shiori Kinoshita, Tomoko Narita, Ayako Masaki, Asahi Ito, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Hiroshi Inagaki, Shinsuke Iida
Summary: We present a case of a 69-year-old female with human T-cell leukemia virus type 1 carrier who developed three hematological malignancies within a short period: diffuse large B-cell lymphoma (DLBCL), chronic myelomonocytic leukemia (CMMoL), and acute myeloid leukemia (AML). The AML cells showed features of acute promyelocytic leukemia (APL) but lacked the RAR alpha gene fusion, leading to initial diagnosis of APL-like leukemia (APLL). Genomic sequencing revealed a chromosomal rearrangement between KMT2A and ACTN4 in both CMMoL and APLL samples, suggesting their clonal relationship. Additionally, the APLL sample exhibited NRAS G12 mutation, suggesting its contribution to leukemic transformation. This report emphasizes the importance of sequencing analysis in understanding therapy-related leukemia.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Zhibo Zhang, Yiyan Zhu, Zheng Wang, Zhao Zeng, Lijun Wen, Ling Zhang, Suning Chen
Summary: This study identified a novel FGFR1 fusion gene in myeloproliferative syndrome using RNA sequencing and confirmed its protein expression. Despite initial treatment success, the patient eventually relapsed and became resistant to chemotherapy. These findings expand the range of translocations in myeloproliferative syndrome and demonstrate the potential of RNA sequencing in clinical practice.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Min-Yu Zhang, Yue Zhao, Ji-Hong Zhang
Summary: This case report describes a rare t(4;11) AML with hyperdiploid karyotype, showing a negative MLL-AF4 fusion gene result. The patient died within 5 days, highlighting the poor prognosis associated with hyperdiploid karyotype in AML.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Oncology
Emmanuella Oyogoa, Lukas Streich, Philipp W. Raess, Theodore Braun
Summary: This is a case report on a 27-year-old female with chronic myeloid leukemia (CML) who developed kinase-independent resistance and disease progression. The patient initially had chronic phase (CP) CML and acquired mutations in ASXL1 and RUNX1. Due to uncontrolled disease, she progressed to a chronic myelomonocytic leukemia-like (CMML) accelerated phase (AP) disease and obtained an IDH1 mutation. The disease progression was associated with the development of an inflammatory serositis, a phenomenon not typically observed in AP-CML.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Giovanna Scarfone, Monica Fumagalli, Martina Imbimbo, Tommaso Ceruti, Fulvia Milena Cribiu, Eugenia Di Loreto, Maurizio D'Incalci, Federica Facchin, Camilla Fontana, Marina C. Garassino, Fedro A. Peccatori, Nicola Persico, Diego Signorelli, Massimo Zucchetti
Summary: This case report presents a female patient with ALK-rearranged metastatic lung adenocarcinoma who became pregnant while receiving alectinib treatment. With the collaborative effort of a multidisciplinary team, the patient continued the study drug throughout pregnancy and delivered a healthy baby girl. Both maternal and fetal parameters remained normal during the pregnancy, and the baby showed no developmental anomalies during the first 20 months of life. After 32 months from diagnosis, the mother is doing well and in partial remission.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Oncology
Jingying Zhang, Heping Shen, Hua Song, Diying Shen, Chan Liao, Meixin Fang, Yan Wang, Yongmin Tang, Honghu Zhu
Summary: This study introduces the first case of pediatric AML with RARG-NUP98, which shows resistance to common drugs. Currently, there is no standardized treatment for this AML subtype.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Review
Oncology
Qin Hu, Yunfei Li, Ying Zhang, Shusen Sun, Hui Wang, Zhiping Jiang, Sheng Deng
Summary: This case report describes a rare case of T-LGLL with a rare gamma delta type and fusion gene NPL-DHX9 rearrangement. The patient was successfully treated with cladribine, indicating that this regimen could be a promising therapeutic strategy for aggressive T-LGLL.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Hyeon-Ho Lim, Shuhua Li, Gyu-Dae An, Kwang-Sook Woo, Kyeong-Hee Kim, Jeong-Man Kim, Moo-Hyun Kim, Jin-Yeong Han
ANNALS OF LABORATORY MEDICINE
(2018)
Article
Medical Laboratory Technology
Hyeon-Ho Lim, In-Hwa Jeong, Gyu-Dae An, Kwang-Sook Woo, Kyeong-Hee Kim, Jeong-Man Kim, Jae-Kwan Cha, Jin-Yeong Han
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2019)
Article
Hematology
Kwang-Sook Woo, In-Hwa Jeong, Gyu-Dae An, Hyeon-Ho Lim, Jin-Yeong Han
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2019)
Article
Medical Laboratory Technology
Hyeon-Ho Lim, In-Hwa Jeong, Gyu-Dae An, Kwang-Sook Woo, Kyeong-Hee Kim, Jeong-Man Kim, Seong-Hoon Yun, Joo-In Park, Jae-Kwan Cha, Moo-Hyun Kim, Jin-Yeong Han
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Letter
Hematology
Kwang-Sook Woo, Gyu-Dae An, Hyeon-Ho Lim, Jin-Yeong Han
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2020)
Letter
Medical Laboratory Technology
In Hwa Jeong, Gyu Dae An, Hyeon Ho Lim, Kwang Sook Woo, Kyeong Hee Kim, Jeong Man Kim, Ji Hyun Lee, Jin Yeong Han
ANNALS OF LABORATORY MEDICINE
(2019)
Article
Hematology
Shuhua Li, Hyeon-Ho Lim, Kwang-Sook Woo, Sung-Hyun Kim, Jin-Yeong Han
