Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tiuri E. Kroese, Jelle P. Ruurda, Anne S. Bakker, Jasvir Jairam, Stella Mook, Sylvia van der Horst, Gert J. Meijer, Nadia Haj Mohammad, Peter S. N. van Rossum, Richard van Hillegersberg
Summary: This study investigated the feasibility of omitting PET/CT restaging after nCRT for esophageal cancer based on clinical stage and a prediction model. The results showed that the existing prediction model cannot accurately identify patients at risk for interval distant metastases. However, PET/CT restaging may be omitted in patients with clinical stage II esophageal cancer.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Ricarda Hinzpeter, Seyed Ali Mirshahvalad, Roshini Kulanthaivelu, Vanessa Murad, Claudia Ortega, Ur Metser, Zhihui Amy Liu, Elena Elimova, Rebecca K. S. Wong, Jonathan Yeung, Raymond W. Jang, Patrick Veit-Haibach
Summary: We investigated the prognostic value of sarcopenia measurements and metabolic parameters derived from F-18-FDG-PET/CT in patients with esophageal and gastroesophageal cancer. The results showed that sarcopenia status was significantly associated with survival prognosis, while standard metabolic parameters did not show significant correlation. Therefore, the combination of clinical parameters and sarcopenia status is a more effective indicator for predicting survival prognosis in patients with advanced gastroesophageal cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Article
Multidisciplinary Sciences
Ewa Burchardt, Agnieszka Bos-Liedke, Kamila Serkowska, Paulina Cegla, Adam Piotrowski, Julian Malicki
Summary: This study assessed the changes in metabolic, volumetric, statistical, and radiomic parameters of cervical cancer in response to chemotherapy, recurrence, and age using F-18 FDG PET/CT imaging and first-order statistical (FOS) and second-order texture analysis. The results showed significant differences in parameters such as SUVmax, SUVmean, TLG, MTV, ASP, E, COR, En, and H before and after chemotherapy, as well as in disease progression and treatment response. The study demonstrated the remarkable importance of pre- and post-treatment [F-18] FDG PET statistical and textural GLCM parameters in predicting recurrence and chemotherapy response in cervical cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: The systematic review and meta-analysis showed that F-18-FDG PET/CT has good diagnostic performance in detecting lymph node metastasis in penile cancer patients, with similar accuracy in detecting inguinal and pelvic lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Dae-Weung Kim, Soon-Ah Park, Myoung Hyoun Kim
Summary: A 77-year-old woman underwent F-18 FDG PET/CT for evaluation of fever focus. Diffuse and intense hepatosplenic uptake was noted, suggesting lymphoma or tuberculosis. Liver biopsy revealed chronic granulomatous inflammation with Langerhans-type giant cells and necrosis. A follow-up PET/CT after anti-tuberculosis treatment showed resolution of hepatosplenic uptake.
LIVER INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francois Lucia, Vincent Bourbonne, Clemence Pleyers, Pierre-Francois Dupre, Omar Miranda, Dimitris Visvikis, Olivier Pradier, Ronan Abgral, Augustin Mervoyer, Jean-Marc Classe, Caroline Rousseau, Wim Vos, Johanne Hermesse, Christine Gennigens, Marjolein De Cuypere, Frederic Kridelka, Ulrike Schick, Mathieu Hatt, Roland Hustinx, Pierre Lovinfosse
Summary: The study aims to predict para-aortic lymph node (PALN) involvement in patients with locally advanced cervical cancer (LACC) before chemoradiotherapy (CRT) using F-18-FDG PET/CT and MRI radiomics combined with clinical parameters. The results show that the radiomics combined model demonstrates high predictive ability in both the training and testing sets, outperforming clinical parameters.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang-Woo Lee, Shin Young Jeong, Keunyoung Kim, Seong-Jang Kim
Summary: The study aimed to compare F-18 FDG PET/CT and MRI in predicting pathologic responses to NAT in LARC patients. Results showed similar diagnostic performances between the two modalities, with FDG PET/CT having slightly lower sensitivity and MRI having slightly lower specificity. Both modalities can complement each other in predicting pathologic responses.
ANNALS OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Falko Ensle, Jan A. Schaab, Florentia Dimitriou, Martin W. Huellner, Alexander Maurer
Summary: We report the F-18-FDG PET/CT findings of an internal thoracic vein tumor thrombus in a 76-year-old woman with melanoma. The restaging F-18-FDG PET/CT revealed disease progression with an internal thoracic vein tumor thrombus associated with sternal bone metastasis. Although cutaneous malignant melanoma can metastasize to any organ, direct tumor invasion of veins leading to tumor thrombus formation is an extremely rare complication.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Thierry Galvez, Ikrame Berkane, Simon Thezenas, Marie-Claude Eberle, Nicolas Flori, Sophie Guillemard, Alina Diana Ilonca, Lore Santoro, Pierre-Olivier Kotzki, Pierre Senesse, Emmanuel Deshayes
Summary: F-18-FDG PET-CT is commonly used for the initial staging of various cancers. This study found a significant association between F-18-FDG uptake in the brain and initial weight loss in patients with esophageal cancer, providing new insights for the diagnosis and treatment of anorexia in cancer patients.
Article
Nutrition & Dietetics
Emanuele Rinninella, Alberto Biondi, Marco Cintoni, Pauline Raoul, Francesca Scialanga, Eleonora Persichetti, Gabriele Pulcini, Roberto Pezzuto, Roberto Persiani, Domenico D'Ugo, Antonio Gasbarrini, Maria Cristina Mele
Summary: The NutriCatt protocol resulted in significant improvements in body composition and clinical outcomes for elderly patients undergoing colorectal surgery while also reducing length of hospital stay and severe complications compared to standard ERAS protocol.
Article
Gastroenterology & Hepatology
Maurizio Degiuli, Ugo Elmore, Raffaele De Luca, Paola De Nardi, Mariano Tomatis, Alberto Biondi, Roberto Persiani, Leonardo Solaini, Gianluca Rizzo, Domenico Soriero, Desiree Cianflocca, Marco Milone, Giulia Turri, Daniela Rega, Paolo Delrio, Corrado Pedrazzani, Giovanni D. De Palma, Felice Borghi, Stefano Scabini, Claudio Coco, Davide Cavaliere, Michele Simone, Riccardo Rosati, Rossella Reddavid
Summary: This retrospective multicentre study aimed to assess the anastomotic leak rate after restorative surgery for rectal cancer, identify independent risk factors, and develop a clinical prediction model. The study found that factors such as sex, body mass index, tumour location, type of approach, and number of cartridges employed were independent risk factors for anastomotic leak. While a stoma did not reduce the leak rate, it significantly decreased the severity of leaks and reoperation rate.
COLORECTAL DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carmelo Caldarella, Fabrizio Cocciolillo, Silvia Taralli, Margherita Lorusso, Valentina Scolozzi, Daniele Antonio Pizzuto, Maria Lucia Calcagni, Vittoria Rufini, Davide Guido, Fernando Palluzzi, Luciano Giaco, Alessandro Giordano, Lucia Leccisotti
Summary: The study found a significant increase in advanced cancer patients at FDG PET/CT staging in 2020 compared to 2019 due to the COVID-19 pandemic and national lockdown, with a notable increase in the number of patients with N or M involvement. Targeted health interventions are needed to address the impact of the pandemic on patient outcomes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Annamaria Agnes, Alberto Biondi, Roberto Persiani, Antonio Laurino, Rossella Reddavid, Maurizio De Giuli, Federico Sicoli, Ferdinando Cananzi, Stefano De Pascale, Uberto Fumagalli, Federica Galli, Stefano Rausei, Laura Lorenzon, Domenico D'Ugo
Summary: Two risk models (PERI-Gastric 1 and 2) were developed to assess the risk of peritoneal recurrence after curative-aim gastrectomy, based on multivariable logistic regression results and discrimination evaluation using the area under the receiver operating curve. These models could guide the use of prophylactic treatments.
Letter
Oncology
Francesco Malfona, Anna Maria Testi, Maria Luisa Moleti, Luigi Petrucci, Maurizio Martelli, Alice Di Rocco, Lucia Leccisotti
LEUKEMIA & LYMPHOMA
(2022)
Article
Oncology
Elisa Meldolesi, Giuditta Chiloiro, Roberta Giannini, Roberta Menghi, Roberto Persiani, Barbara Corvari, Claudio Coco, Stefania Manfrida, Carlo Ratto, Viola De Luca, Luigi Sofo, Sara Reina, Antonio Crucitti, Valeria Masiello, Nicola Dinapoli, Vincenzo Valentini, Maria Antonietta Gambacorta
Summary: This retrospective study analyzed the efficacy of simultaneous integrated boost-intensity modulated radiation therapy and determined the optimal dose of radiotherapy for locally advanced rectal cancer patients with clinically positive lateral pelvic lymph nodes. Excellent results in terms of oncological outcomes were observed, suggesting a potential alternative to surgery without significant side effects or disabilities.
Article
Oncology
Lucia Leccisotti, Daria Maccora, Rosalia Malafronte, Francesco D'Alo, Elena Maiolo, Salvatore Annunziata, Vittoria Rufini, Alessandro Giordano, Stefan Hohaus
Summary: This study aimed to investigate the predictive value of baseline total metabolic tumour volume (TMTV) and whole-body total lesion glycolysis (WB-TLG) for time to treatment (TTT) in patients with follicular lymphoma (FL) undergoing watchful waiting (WW). The results showed that these metabolic tumour volume parameters, in combination with clinical scores, can better predict TTT and stratify patients for interventional studies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Luca Tagliaferri, Ilaria Giarrizzo, Bruno Fionda, Mario Rigante, Monica Maria Pagliara, Calogero Casa, Claudio Parrilla, Valentina Lancellotta, Elisa Placidi, Alessandra Salvati, Gabriella Macchia, Stefano Gentileschi, Maria Antonietta Blasi, Alessio Giuseppe Morganti, Francesco Bussu, Ketty Peris, Gaetano Paludetti, Vincenzo Valentini
Summary: This study retrospectively analyzed 40 patients with periorificial face cancer and found that interstitial high-dose-rate interventional radiotherapy showed good local control and high patient satisfaction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Savino Cilla, Pietro Viola, Carmela Romano, Maurizio Craus, Milly Buwenge, Gabriella Macchia, Vincenzo Valentini, Francesco Deodato, Alessio G. Morganti
Summary: This study presents different machine learning models based on log files analysis and complexity indexes to predict and classify the dosimetric accuracy of VMAT plans. The results show that machine learning can accurately predict and classify the dosimetric accuracy, and serve as an efficient tool for patient-specific quality assurance.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Medicine, General & Internal
Riccardo Rinaldi, Mattia Basile, Carmine Salzillo, Domenico Luca Grieco, Andrea Caffe, Carlotta Masciocchi, Livia Lilli, Andrea Damiani, Giulia La Vecchia, Giulia Iannaccone, Alice Bonanni, Gennaro De Pascale, Rita Murri, Massimo Fantoni, Giovanna Liuzzo, Tommaso Sanna, Massimo Massetti, Antonio Gasbarrini, Vincenzo Valentini, Massimo Antonelli, Filippo Crea, Rocco Antonio Montone
Summary: This study found that myocardial injury during hospitalization for COVID-19 is associated with mortality and cardiovascular sequelae in survivors. Patients with myocardial injury had higher rates of all-cause mortality, major adverse cardiovascular events, arrhythmias, and inflammatory heart disease during follow-up. Myocardial injury, age, and chronic kidney disease were independent predictors of death, while myocardial injury, age, and diabetes were independent predictors of major adverse cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Roberto Iezzi, Alessandro Posa, Cosimo Tommaso Caputo, Davide De Leoni, Fabio Sbaraglia, Marco Rossi, Giampaolo Tortora, Luca Tagliaferri, Vincenzo Valentini, Cesare Colosimo
Summary: Interventional Oncology treatments provide low-risk minimally invasive alternatives to surgery for cancer patients. Among these, electrochemotherapy is a newly emerging percutaneous ablative therapy for liver cancer patients. Improvements in analgesia and sedation now make it a safe and effective option without the need for general anesthesia.
Proceedings Paper
Computer Science, Information Systems
Carlotta Masciocchi, Benedetta Gottardelli, Mariachiara Savino, Luca Boldrini, Antonella Martino, Ciro Mazzarella, Mariangela Massaccesi, Vincenzo Valentini, Andrea Damiani
Summary: The Cox Proportional Hazards regression model is widely used in personalized medicine research to explore the relationship between time-to-event outcomes and multiple predictors. Feature selection techniques and federated learning are necessary when including a large number of variables in the prediction model. In this study, we propose an adapted algorithm for federated learning of the Cox Proportional Hazards regression model with LASSO regularization as a feature selector, and demonstrate its efficacy on real and simulated datasets in a distributed environment without patient-level data sharing.
2022 IEEE 35TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS)
(2022)
Article
Oncology
Laura Lorenzon, Alberto Biondi, Annamaria Agnes, Ottavio Scrima, Roberto Persiani, Domenico D'Ugo
Summary: This study analyzed GC surgical volumes and 30-day postoperative mortality in Italy and modeled centralization of GC resections based on district case volumes. The results showed a correlation between hospital volume and postoperative mortality, and most Italian districts can achieve a high-volume threshold. However, discrepancies in mortality rates are alarming.
JOURNAL OF GASTRIC CANCER
(2022)