Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera

Therapeutic opportunities for targeting cold pain pathways

(2015) Kathleen Yin et al.   BIOCHEMICAL PHARMACOLOGY

Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models

(2015) Jessica O'Neill et al.   JOURNAL OF PHYSIOLOGY-LONDON

Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat

(2015) W. Rahman et al.   NEUROSCIENCE

The Nav1.9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia

(2015) Stéphane Lolignier et al.   Cell Reports

Involvement of both sodium influx and potassium efflux in ciguatoxin-induced nodal swelling of frog myelinated axons

(2014) César Mattei et al.   NEUROPHARMACOLOGY

Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception

(2014) Vanessa Pereira et al.   PAIN

Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: A comparison with topical menthol

(2014) Ryan Patel et al.   PAIN

Significant Determinants of Mouse Pain Behaviour

(2014) Michael S. Minett et al.   PLoS One

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

(2014) Cruz Morenilla-Palao et al.   Cell Reports

The Ion Channel TRPA1 Is Required for Chronic Itch

(2013) S. R. Wilson et al.   JOURNAL OF NEUROSCIENCE

Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition

(2013) I. Vetter et al.   JOURNAL OF NEUROSCIENCE

A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia

(2013) W. M. Knowlton et al.   JOURNAL OF NEUROSCIENCE

Neurotoxicity and Reactive Astrogliosis in the Anterior Cingulate Cortex in Acute Ciguatera Poisoning

(2013) Xu Zhang et al.   NEUROMOLECULAR MEDICINE

Analgesic treatment of ciguatoxin-induced cold allodynia

(2013) Katharina Zimmermann et al.   PAIN

Neural coding of nociceptive stimuli—from rat spinal neurones to human perception

(2013) Shafaq Sikandar et al.   PAIN

A role for Piezo2 in EPAC1-dependent mechanical allodynia

(2013) N Eijkelkamp et al.   Nature Communications

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

(2012) Irina Vetter et al.   EMBO JOURNAL

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

(2012) Shannon D. Shields et al.   PAIN

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

Topical High-Concentration (40%) Menthol—Somatosensory Profile of a Human Surrogate Pain Model

(2011) Andreas Binder et al.   JOURNAL OF PAIN

Evidence for Thalamic Involvement in the Thermal Grill Illusion: An fMRI Study

(2011) Fredrik Lindstedt et al.   PLoS One

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal Processing of Noxious and Innocuous Cold Information: Differential Modulation by the Periaqueductal Gray

(2010) J. L. Leith et al.   JOURNAL OF NEUROSCIENCE

TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats

(2010) Steve McGaraughty et al.   Molecular Pain

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

(2010) Wendy M. Knowlton et al.   PAIN

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

(2009) Jacques Noël et al.   EMBO JOURNAL

Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells

(2009) Kaoru Yamaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels

(2009) R. Madrid et al.   JOURNAL OF NEUROSCIENCE

TRPA1 acts as a cold sensor in vitro and in vivo

(2009) Y. Karashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

(2008) B. Abrahamsen et al.   SCIENCE