Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study proposed a novel way to classify and report surgical outcomes, integrating efficacy and safety at the patient level. By presenting results in four outcome groups ranging from good to poor, the study highlights the importance of balancing efficacy and complications in surgical interventions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: Transsphenoidal surgery is the standard treatment for hormone-secreting pituitary adenomas. This study proposes a novel way to classify and report surgical outcomes by integrating efficacy and safety at the patient level. The results show that surgical interventions can be presented in four categories, incorporating both efficacy and safety.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xuan Gong, Yang Zhuo, Huichun Yuan, Kui Yang, Chuntao Li, Songshan Feng, Mingyu Zhang, Zhenyan Li, Hongshu Zhou, Zhixiong Liu
Summary: The Knosp grade is an independent factor for GTR in endoscopic transsphenoidal surgery in patients with rrPAs. Previous transcranial surgery and non-functional PAs are risk factors for intraoperative CSF leakage in rrPAs patients. Despite longer hospital stays, rrPAs do not have lower GTR rates or more frequent postoperative complications compared to non-rrPAs cohort.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Chao Tao, Gang Cheng, Yunxiang Chen, Peiyuan Gu, Weixing Hu
Summary: This study retrospectively reviewed the tumor characteristics and surgical outcomes of a consecutive series of endoscopic endonasal approach pituitary adenomas resection mainly performed by a single author between March 2018 and June 2019. The results demonstrated that EEA is an effective and safe approach for resecting pituitary adenomas with satisfactory gross total resection rate, near-total resection rate, and endocrinological remission rate, while maintaining minimal nasal injury.
Article
Clinical Neurology
Ryan Delport, James King, Mendel Castle-Kirszbaum, Tony Goldschlager, Carmela Caputo, Yi Yuen Wang
Summary: This study aimed to determine if resection of pituitary adenomas via the endoscopic endo-nasal approach (EEA) improves headaches and investigate factors that may be associated with headaches in patients with pituitary adenoma. The results showed that surgery using this method can significantly improve headaches and patients with cavernous sinus invasion are more likely to experience improvement in headaches.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Huijian Zhang, Shuai Zhang, Mingchao Shang, Jiaxing Wang, Liangfeng Wei, Shousen Wang
Summary: This study aimed to investigate the MRI findings and clinical significance of pituitary stalk position and morphology changes following transsphenoidal surgery for pituitary adenoma (PA). A total of 108 patients who underwent transsphenoidal surgery were included, and the diameter, length, and coronal deviation of the pituitary stalk were measured pre-operatively, post-operatively, and in the mid-term postoperative period. The results showed that the pituitary stalk could be stretched to a normal state after surgery and its position tended to gradually center. The length of the pituitary stalk also gradually increased postoperatively. The presence of posterior pituitary bright spots (PPBS) in the early postoperative period was negatively correlated with postoperative diabetes insipidus (DI).
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Iyan Younus, Mina Gerges, Theodore H. Schwartz, Rohan Ramakrishna
Summary: Patients with Medicaid insurance undergoing endonasal endoscopic transsphenoidal surgery for pituitary adenoma tend to have larger tumor diameter, longer postoperative length of stay, higher rate of complications, and increased likelihood of long-term cranial neuropathy. However, there were no statistically significant differences in baseline comorbidities, apoplexy, endocrine outcome, vision outcome, or 30-day readmission.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Xiaoyu Ji, Xinyu Zhuang, Siyuan Yang, Kai Zhang, Xiaozhe Li, Kun Yuan, Xiaofeng Zhang, Xuebo Sun
Summary: The purpose of this study was to analyze and predict the likelihood of visual field recovery after endoscopic transsphenoidal surgery (ETSS) in patients with pituitary adenoma. The study investigated factors that affect the improvement of visual field defects (VFD) and built a predictive nomogram model based on these risk factors. The study also identified specific recovery regions of the visual field associated with VFD improvement.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Mingjian Lin, Wenbo Wang, Lejian Tang, Yunxiang Zhou, Wencai Li, Jing Xiao, Zhizhu Peng, Xuewei Xia
Summary: The suprasellar extension (SSE) value on sagittal MRI can predict the risk of intracranial infection in patients with suprasellar extended pituitary adenoma after endoscopic endonasal transsphenoidal resection (EETA). Neurosurgeons should pay attention to the imaging characteristics of pituitary adenomas and select appropriate treatment plans based on intraoperative conditions to reduce the incidence of intracranial infection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Juan Manuel Canelo Moreno, Elena Dios Fuentes, Eva Venegas Moreno, Pablo Jesus Remon Ruiz, Cristina Munoz Gomez, Ana Pinar Gutierrez, Eugenio Cardenas Valdepenas, Ariel Kaen, Alfonso Soto Moreno
Summary: This study aimed to investigate the prevalence and predictive factors of water and electrolyte disturbances in patients undergoing surgery with an extended endoscopic endonasal approach. The study found a high prevalence of electrolyte disturbances, with most cases being transient hypotonic polyuria and a smaller proportion being transient or permanent diabetes insipidus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Otorhinolaryngology
Zaid Al-Qurayshi, Douglas M. Bennion, Jeremy D. W. Greenlee, Scott M. Graham
Summary: This study provides a national epidemiological perspective on transsphenoidal approach for pituitary tumors surgery in the United States. The risk of postoperative cerebrospinal fluid (CSF) leak appears to be associated with intrinsic patient factors rather than hospital volume and teaching status.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Clinical Neurology
Hyung-Chul Lee, Hyun-Kyu Yoon, Jung Hee Kim, Yong Hwy Kim, Hee-Pyoung Park
Summary: The study suggests that preoperative steroid administration may not be necessary for patients without adrenal insufficiency undergoing endoscopic transsphenoidal surgery for nonfunctioning pituitary adenomas, as it does not affect the pituitary hormone levels postoperatively. However, further large-scale studies are needed to determine the impact of preoperative steroid administration on clinically meaningful events such as perioperative AI and postoperative 3-month ACTH deficiency in these patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Vicki M. Butenschoen, Nina Schwendinger, Alexander von Werder, Stefanie Bette, Maximilian Wienke, Bernhard Meyer, Jens Gempt
Summary: Transsphenoidal surgery is the preferred treatment for pituitary adenoma resection, leading to significant improvements in visual function postoperatively. Age is identified as the strongest predictor for visual function recovery after surgery.
NEUROSURGICAL REVIEW
(2021)
Article
Endocrinology & Metabolism
Rob A. Vergeer, Robin E. P. Theunissen, Theodora van Elk, Iris Schmidt, Mark R. Postma, Katalin Tamasi, J. Marc C. van Dijk, Jos M. A. Kuijlen
Summary: The use of fluorescent agents in pituitary surgery for distinguishing tumor tissue from normal tissue shows potential, although more evidence is needed to support their efficacy in improving total tumor resection.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Neurosciences
Chuan Shao, Junwei Wang, Pan Wang, Nan Wu
Summary: Retrospective analysis was conducted on patients with Cushing's disease (CD) who underwent endoscopic transsphenoidal surgery (ETS) with a layered peel strategy. The study found a low rate of surgical complications postoperatively and no recurrence events during follow-up. However, further studies are needed to confirm the effectiveness and safety of this approach due to the limited number of cases.
Article
Clinical Neurology
Joshua Materi, David Mampre, Jeff Ehresman, Jordina Rincon-Torroella, Kaisorn L. Chaichana
Summary: This study aimed to identify predictors of recurrence and high growth rate following subtotal resection of intracranial meningiomas. Analysis revealed that patients with large preoperative tumor volume, falcine or tentorial location, and African American race were more likely to experience recurrence after surgery. Additionally, residual volume was associated with higher postoperative growth rates.
JOURNAL OF NEUROSURGERY
(2021)
Article
Engineering, Biomedical
Bin Sheng Wong, Sagar R. Shah, Christopher L. Yankaskas, Vivek K. Bajpai, Pei-Hsun Wu, Deborah Chin, Brent Ifemembi, Karim ReFaey, Paula Schiapparelli, Xiaobin Zheng, Stuart S. Martin, Chen-Ming Fan, Alfredo Quinones-Hinojosa, Konstantinos Konstantopoulos
Summary: A microfluidic assay has been shown to successfully categorize patients with glioblastoma based on progression-free survival, predict time to recurrence, and classify patients accurately with an 86% accuracy rate. RNA sequencing of highly motile cells revealed differentially expressed genes associated with poor prognosis.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Oncology
Montserrat Lara-Velazquez, Natanael Zarco, Anna Carrano, Jordan Phillipps, Emily S. Norton, Paula Schiapparelli, Rawan Al-Kharboosh, Jordina Rincon-Torroella, Stephanie Jeanneret, Teresa Corona, Jose Segovia, Mark E. Jentoft, Kaisorn L. Chaichana, Yan W. Asmann, Alfredo Quinones-Hinojosa, Hugo Guerrero-Cazares
Summary: This study investigated the effect of CSF on GBM gene expression and the role of CSF-induced SERPINA3 gene in GBM malignancy in vitro and in vivo. The results showed that SERPINA3 plays a key role in GBM malignancy and its inhibition leads to a better outcome for patients.
Article
Medicine, General & Internal
Johan L. Heemskerk, Ricardo A. Domingo, Rabih G. Tawk, Tito G. Vivas-Buitrago, Josephine F. Huang, Ashley Rogers, Alfredo Quinones-Hinojosa, Kingsley Abode-Iyamah, William D. Freeman
Summary: This study analyzed prehospital time for patients with suspected stroke transported to treatment centers in Florida in 2018, finding that dispatch notification and stroke assessment scales can reduce EMS time. Adoption of these interventions may improve stroke systems of care.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Clinical Neurology
Elird Bojaxhi, Christopher Louie, Karim ReFaey, Shaun E. Gruenbaum, Bruce J. Leone, Perry Bechtel, Maria P. Barbosa, Kaisorn L. Chaichana, Alfredo Quinones-Hinojosa
Summary: Frontotemporal craniotomies conducted awake under regional anesthesia provide better pain control, reduced opioid use, and less somnolence in the early postoperative period compared to surgeries done under general anesthesia.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Ali Karadag, Pinar Gokdogan Kirgiz, Baran Bozkurt, Baris Kucukyuruk, Karim ReFaey, Erik H. Middlebrooks, Mehmet Senoglu, Necmettin Tanriover
Summary: Removal of the JT via EETCA improves exposure along the lower third of the cerebellopontine and upper cerebellomedullary cisterns, providing a better surgical field for operating.
ACTA NEUROCHIRURGICA
(2021)
Review
Oncology
Jordina Rincon-Torroella, Harmon Khela, Anya Bettegowda, Chetan Bettegowda
Summary: Despite current limitations in detecting brain tumor biomarkers in blood or cerebrospinal fluid, disrupting the blood-brain barrier with MRI-guided focused ultrasound (MRgFUS) shows promise in enhancing the presence of these biomarkers. The non-invasive nature of liquid biopsies can provide valuable insights into tumor evolution and treatment response, offering new possibilities for future management of brain tumor patients.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Ann Liu, Jordina Rincon-Torroella, Matthew T. Bender, Cameron G. McDougall, Anthony P. Tufaro, Nyall R. London, Alexander L. Coon, Douglas D. Reh, Gary L. Gallia
Summary: This study discusses the use of a combined Pipeline embolization device (PED) and endoscopic endonasal repair to treat an iatrogenic ICA pseudoaneurysm, with long-term radiographic follow-up reported. Further research is needed to explore the utility of directed endoscopic endonasal repair for iatrogenic pseudoaneurysms initially treated with PED.
JOURNAL OF NEUROLOGICAL SURGERY REPORTS
(2021)
Review
Neurosciences
Anudeep Yekula, Jovanna Tracz, Jordina Rincon-Torroella, Tej Azad, Chetan Bettegowda
Summary: Single-cell sequencing of cells in cerebrospinal fluid offers promising insights into the diagnosis, molecular characterization, and monitoring of neurological diseases. It provides information about rare cell populations and gene expression heterogeneity at a single-cell resolution. The development of standardized protocols for collection, preprocessing, isolation, and analysis is crucial for comprehensive single-cell sequencing analysis.
Article
Clinical Neurology
Tej D. Azad, Emily Rodriguez, Divyaansh Raj, Yuanxuan Xia, Joshua Materi, Jordina Rincon-Torroella, L. Fernando Gonzalez, Jose I. Suarez, Rafael J. Tamargo, Henry Brem, Elliott R. Haut, Chetan Bettegowda
Summary: This study aimed to demonstrate that patient safety indicator (PSI) 04 is not an appropriate measure for capturing failure to rescue (FTR) within neurosurgery. A retrospective cohort study was conducted, identifying that only 43.2% of cases attributed to PSI 04 were the primary cause of death, and complications during neurosurgical procedures were not the main reason for PSI 04. Therefore, a subspecialty-specific measure is needed to capture FTR in neurosurgery.
Review
Oncology
Kurt R. Lehner, Kelly Jiang, Jordina Rincon-Torroella, Ranjan Perera, Chetan Bettegowda
Summary: Central nervous system (CNS) tumors are the leading cause of cancer death in pediatric patients. Liquid biopsy of cerebrospinal fluid (CSF) presents a potential noninvasive method for detecting CNS malignancy. A literature review identified molecular biomarkers associated with CNS tumors for further analysis and development of detection tools.
Article
Clinical Neurology
Andrew M. Hersh, Ann Liu, Jordina Rincon-Torroella, Haris I. Sair, Daniel Lubelski, Chetan Bettegowda, Nir Shimony, Sheng-Fu Larry Lo, Daniel M. Sciubba, George I. Jallo
Summary: Recognition of the ribbon sign on preoperative MRI can improve surgical decision-making and patient counseling for IMSC subependymomas.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Megan Parker, Kelly Jiang, Jordina Rincon-Torroella, Joshua Materi, Tej D. Azad, David O. Kamson, Lawrence R. Kleinberg, Chetan Bettegowda
Summary: This study investigated the incidence and survival of synchronous brain metastases (sBM) in patients with malignancies. The incidence rate of sBM from 2015 to 2019 was 7.1 per 100,000 people. Lung and bronchus cancers had the highest incidence of sBM, followed by melanoma and breast cancers. White patients had better survival rates compared to nonwhite patients.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Clinical Neurology
Wuyang Yang, Jordina Rincon-Torroella, James Feghali, Adham M. Khalafallah, Wataru Ishida, Alexander Perdomo-Pantoja, Alfredo Quinones-Hinojosa, Michael Lim, Gary L. Gallia, Gregory J. Riggins, William S. Anderson, Sheng-Fu Larry Lo, Daniele Rigamonti, Rafael J. Tamargo, Timothy F. Witham, Ali Bydon, Alan R. Cohen, George Jallo, Alban Latremoliere, Mark G. Luciano, Debraj Mukherjee, Alessandro Olivi, Lintao Qu, Ziya L. Gokaslan, Daniel M. Sciubba, Betty Tyler, Henry Brem, Judy Huang
Summary: This study aimed to quantify the academic output of international research fellows at The Johns Hopkins University School of Medicine's Department of Neurosurgery and found that these fellows have made substantial contributions to academic neurosurgery.
JOURNAL OF NEUROSURGERY
(2022)
Letter
Clinical Neurology
Joshua Materi, David Mampre, Jeff Ehresman, Jordina Rincon-Torroella, Kaisorn L. Chaichana
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)