Article
Pharmacology & Pharmacy
Si-Chun Gu, Qing Ye, Chang-De Wang, Shao-Rong Zhao, Jie Zhou, Chen Gao, Yu Zhang, Zhen-Guo Liu, Can-Xing Yuan
Summary: Pingchan granule (PCG) has a long-lasting and extensive symptomatic efficacy for both motor and non-motor symptoms of Parkinson's disease (PD) with good tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Muhammad Kashif, Ashfaq Ahmad, Muhammad Ali Mohseni Bandpei, Hafiza Aroosa Syed, Ali Raza, Vishal Sana
Summary: This study demonstrates that the combination of virtual reality and motor imagery techniques with routine physical therapy can significantly improve motor function in individuals with Parkinson's disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Maria Francesca De Pandis, Margherita Torti, Rossella Rotondo, Lanfranco Iodice, Maria Levi Della Vida, Miriam Casali, Laura Vacca, Fabio Viselli, Valeria Servodidio, Stefania Proietti, Fabrizio Stocchi
Summary: This study evaluated the efficacy of an education program for Parkinson's disease patients. It found that the program significantly improved motor and non-motor symptoms, particularly in reducing daily OFF hours. The long-term efficacy of the program was also confirmed.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Lubos Brabenec, Patricia Klobusiakova, Patrik Simko, Milena Kostalova, Jiri Mekyska, Irena Rektorova
Summary: This study evaluated the long-term effects of repetitive transcranial magnetic stimulation on hypokinetic dysarthria in Parkinson's disease, showing that real stimulation led to improvements in speech articulation compared to sham stimulation. The neural mechanisms of these improvements involve activation increases in specific brain regions and enhanced intrinsic connectivity.
Article
Integrative & Complementary Medicine
Si-chun Gu, Jie Zhou, Qing Ye, Can-xing Yuan
Summary: The study demonstrated that treatment with Pingchan Granule significantly improved depressive symptoms in Parkinson's disease patients, as well as motor and other non-motor symptoms.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Clinical Neurology
Sanne Broeder, Britt Vandendoorent, Pauline Hermans, Evelien Nackaerts, Geert Verheyden, Raf Meesen, Jean-Jacques Orban de Xivry, Alice Nieuwboer
Summary: This study investigated the effects of combining writing training with anodal transcranial direct current stimulation (atDCS) on consolidation of writing skills in Parkinson's disease (PD) patients. The results showed that atDCS improved retention of writing skills compared to sham stimulation, especially in the presence of medication.
JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Multidisciplinary
Timo Marcel Buchwitz, Franziska Maier, Andrea Greuel, Franziska Thieken, Kenan Steidel, Viktoria Jakobs, Carsten Eggers
Summary: This study evaluated the feasibility and effects of a newly developed mindfulness intervention tailored to the specific needs of patients with Parkinson's disease. Although it did not reduce impaired self-awareness of motor symptoms in PD patients, the intervention appears to be a feasible and effective concept for supporting mental health in the mid-term.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Ying-Jia Li, Ian-I Leong, Jing-Qi Fan, Ming-Yue Yan, Xin Liu, Wei-Jing Lu, Yuan-Yuan Chen, Wei-Qiang Tan, Yu-Ting Wang, Li-Xing Zhuang
Summary: This study evaluated the efficacy of acupuncture in treating Parkinson's disease-related constipation (PDC) through a randomized, controlled trial. The results showed that acupuncture treatment significantly increased the number of complete spontaneous bowel movements per week and the effect lasted for 4 weeks.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Plant Sciences
Si-Chun Gu, Rong Shi, Chen Gaoag, Xiao-Lei Yuan, You Wu, Yu Zhang, Chang De Wang, Rui-Dong Fan, Xiqun Chen, Can-Xing Yuan, Qing Ye
Summary: This study aimed to evaluate the efficacy and safety of the traditional Chinese medicine, Pingchan granule (PCG), for motor symptoms, gait impairments, and quality of life in patients with Parkinson's disease (PD). The results showed that PCG significantly improved motor symptoms, gait, and quality of life in PD patients, with good tolerance. PCG might be a viable alternative in the management of PD.
Article
Clinical Neurology
Fabian Schaible, Franziska Maier, Timo Marcel Buchwitz, Frank Schwartz, Marius Hoock, Eckhard Schoenau, Miriam Libuda, Anke Hordt, Thilo van Eimeren, Lars Timmermann, Carsten Eggers
Summary: This study demonstrated that Lee Silverman Voice Treatment (LSVT) BIG, intensified and personalized physiotherapy (INTENSIVE), and conventional physiotherapy (NORMAL) are all effective techniques to improve non-motor symptoms as well as motor function in Parkinson's disease. The INTENSIVE program showed superior results compared to the NORMAL program.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Clinical Neurology
Elisa Frisaldi, Piero Bottino, Margherita Fabbri, Marco Trucco, Alessandra De Ceglia, Nadia Esposito, Diletta Barbiani, Eleonora Maria Camerone, Federico Costa, Cristina Destefanis, Edoardo Milano, Giuseppe Massazza, Maurizio Zibetti, Leonardo Lopiano, Fabrizio Benedetti
Summary: The study demonstrated that the DArT method was more effective than conventional physiotherapy in improving motor impairment in mild PD patients, and was found to be safe and well accepted. The experimental group showed significant improvements in MDS-UPDRS-III scores and upper body subscores, while conventional physiotherapy had better effects on reducing trait anxiety levels.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Michelle S. Troche, James A. Curtis, Jordanna S. Sevitz, Avery E. Dakin, Sarah E. Perry, James C. Borders, Alessandro A. Grande, Yuhan Mou, Nora Vanegas-Arroyave, Karen W. Hegland
Summary: Disorders of airway protection are common in Parkinson's disease (PD) and can lead to aspiration pneumonia and death. This study compared expiratory muscle strength training (EMST) and sensorimotor training for airway protection (smTAP) to improve cough-related outcomes in PD patients. The results showed that smTAP was more effective than EMST in improving cough function.
MOVEMENT DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Frank C. Church
Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.
Article
Clinical Neurology
Martin E. Johansson, Ian G. M. Cameron, Nicolien M. Van der Kolk, Nienke M. de Vries, Eva Klimars, Ivan Toni, Bastiaan R. Bloem, Rick C. Helmich
Summary: This study conducted a clinical trial and found that aerobic exercise can improve motor symptoms and cognitive control in patients with Parkinson's disease. It also showed positive effects on the structural and functional changes in the brain, suggesting that aerobic exercise can stabilize disease progression in the corticostriatal sensorimotor network.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Konstantin G. Heimrich, Aline Schonenberg, Hannah M. Muehlhammer, Sarah Mendorf, Diego Santos-Garcia, Tino Prell
Summary: This study aimed to determine the impact of non-motor symptoms on the progression of Parkinson's disease and revealed that the depressive symptoms of anhedonia and feeling sad had the strongest influence on the overall pattern of non-motor symptoms in PD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Emanuela Formaggio, Michele Tonellato, Angelo Antonini, Leonora Castiglia, Laura Gallo, Paolo Manganotti, Stefano Masiero, Alessandra Del Felice
Summary: This study aims to explore the pathophysiological mechanisms of Parkinson disease (PD) by examining changes in EEG rhythms after transcranial magnetic stimulation (TMS). The study found that TMS can temporarily normalize brain oscillations in PD patients, providing a theoretical basis for the development of practical, portable techniques to treat PD symptoms.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Clinical Neurology
Andrew Lees, Eduardo Tolosa, Fabrizio Stocchi, Joaquim J. Ferreira, Olivier Rascol, Angelo Antonini, Werner Poewe
Summary: There is a resurgence of levodopa as the initial treatment for Parkinson's disease, while the addition of adjuvant treatments is an established strategy to reduce motor complications. Improving levodopa delivery to the brain and combining agents earlier in the disease course can leverage the full potential of this strategy.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Marta Campagnolo, Luca Weis, Carmelo Fogliano, Valeria Cianci, Michela Garon, Eleonora Fiorenzato, Miryam Carecchio, Florinda Ferreri, Patrizia Bisiacchi, Angelo Antonini, Roberta Biundo
Summary: The International Parkinson's and Movement Disorder Society (MDS) criteria has expanded the clinical spectrum of progressive supranuclear palsy (PSP) and established phenotypic characterization based on the predominant manifestation at onset. This study aimed to describe the clinical/cognitive and imaging features of a monocentric cohort of PSP patients, highlighting different patterns of functional disability according to the assigned phenotype. The findings support the concept of discrete patterns of Tau pathology within the PSP spectrum and emphasize the importance of tailored approaches in terms of follow-up and treatment.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Biochemistry & Molecular Biology
Aron Emmi, Aleksandar Tushevski, Alessandro Sinigaglia, Silvia Barbon, Michele Sandre, Elena Stocco, Veronica Macchi, Angelo Antonini, Luisa Barzon, Andrea Porzionato, Raffaele De Caro
Summary: Angiotensin-converting enzyme 2 receptor (ACE2R) is a transmembrane protein that plays a key role in blood pressure regulation. It has gained attention for its involvement in the pathogenesis of COVID-19. This study investigated the expression of ACE2R and TMPRSS2 in the brainstem and found that they are expressed in neuronal and glial cells, particularly in specific nuclei. These findings help to understand the neurological manifestations of COVID-19.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Clinical Neurology
Valentina Leta, Lisa Klingelhoefer, Katherine Longardner, Marta Campagnolo, Hafize Cotur Levent, Federico Aureli, Vinod Metta, Roongroj Bhidayasiri, Guy Chung-Faye, Cristian Falup-Pecurariu, Fabrizio Stocchi, Peter Jenner, Tobias Warnecke, K. Ray Chaudhuri
Summary: Levodopa is the gold standard treatment for Parkinson's disease, but it often leads to motor and non-motor fluctuations. Gastrointestinal barriers, such as dysphagia, delayed gastric emptying, and gut dysbiosis, can affect levodopa absorption and response. Managing gastrointestinal dysfunction is crucial for optimizing levodopa therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patricia Lyra, Vanessa Machado, Silvia Rota, Kallol Ray Chaudhuri, Joao Botelho, Jose Joao Mendes
Summary: The development of neurodegenerative disorders, such as Parkinson's Disease, is closely linked to inflammation and dysbiosis. Understanding the mechanistic pathways of alpha-synucleinopathies and the impact of microbial dysbiosis on alpha-Syn can provide insights into the management and prevention of these conditions, with a focus on inflammatory mitigation and microbial balance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
K. Ray Chaudhuri, Valentina Leta, Kirsty Bannister, David J. J. Brooks, Per Svenningsson
Summary: In Parkinson disease (PD), some patients have non-motor symptoms that are related to abnormalities in noradrenergic function. Research suggests the existence of a noradrenergic subtype of PD, characterized by specific non-motor symptoms such as rapid eye movement sleep behavior disorder, pain, anxiety, and dysautonomia. Understanding this subtype could lead to personalized treatments for PD.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Behavioral Sciences
Sara Pisani, Brandon Gunasekera, Yining Lu, Miriam Vignando, Dominic Ffytche, Dag Aarsland, K. Ray Chaudhuri, Clive Ballard, Jee-Young Lee, Yu Kyeong Kim, Latha Velayudhan, Sagnik Bhattacharyya
Summary: This study conducted a meta-analysis of MRI studies to explore the neuroanatomical alterations underlying psychosis in Parkinson's Disease (PDP). The results revealed widespread grey matter volume loss in the parieto-temporo-occipital regions of PDP patients, which was associated with the expression of serotonergic receptor genes (5-HT1a and 5-HT2a), but not dopaminergic receptors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Stefanie T. Jost, Agni Konitsioti, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Anna Sauerbier, Maria Gabriela dos Santos Ghilardi, Franz Rosenkranz, Lena Strobel, Alexandra Gronostay, Michael T. Barbe, Julian Evans, Veerle Visser-Vandewalle, Christopher Nimsky, Gereon R. Fink, Monty Silverdale, Rubens G. Cury, Erich T. Fonoff, Angelo Antonini, K. Ray Chaudhuri, Lars Timmermann, Pablo Martinez-Martin, Haidar S. Dafsari
Summary: This study suggests that patients with 'postural instability and gait difficulty' (PIGD) may experience more beneficial non-motor effects compared to patients with 'tremor-dominant' symptoms undergoing deep brain stimulation (DBS) for Parkinson's disease (PD). These differences in clinical efficacy on non-motor aspects should be taken into consideration when advising and monitoring PD patients undergoing DBS.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Chemistry, Analytical
Mariana H. G. Monje, Sylvie Grosjean, Martin Srp, Laura Antunes, Raquel Bouca-Machado, Ricardo Cacho, Sergio Dominguez, John Inocentes, Timothy Lynch, Argyri Tsakanika, Dimitrios Fotiadis, George Rigas, Evzen Ruzicka, Joaquim Ferreira, Angelo Antonini, Norberto Malpica, Tiago Mestre, Alvaro Sanchez-Ferro
Summary: The healthcare model is shifting towards integrated care approaches that involve patients more closely. The iCARE-PD project aims to develop a technology-enabled, home-based, and community-centered integrated care paradigm to address this need. The project's central focus is the codesign process of the care model, with active patient participation in designing and iteratively evaluating sensor-based technological solutions. The results show the usefulness of this approach in testing usability and acceptability, as well as incorporating patients' feedback into the development.
Article
Clinical Neurology
Glynn Harrison-Jones, Xiaocong Li Marston, Francesca Morgante, K. Ray Chaudhuri, Guillermo Castilla-Fernandez, Valentina Di Foggia
Summary: This study found that initiating COMT inhibition with opicapone is likely to decrease healthcare resource utilization compared to initiation with entacapone in people with Parkinson's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Marta Campagnolo, Aron Emmi, Roberta Biundo, Eleonora Fiorenzato, Lucia Batzu, K. Ray Chaudhuri, Angelo Antonini
Summary: Behavioural symptoms in Parkinson's disease, including depression, anxiety, impulse control disorders, hallucinations, psychosis, and cognitive dysfunction, are often overlooked and not adequately addressed in many patients. Current literature suggests refraining from using dopamine agonists without considering their potential benefits on motor complications.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Clinical Neurology
Andrea Guerra, Valentina D'Onofrio, Florinda Ferreri, Matteo Bologna, Angelo Antonini
Summary: Although clinician-based assessment is the gold standard for quantifying motor impairment in Parkinson's disease, there are limitations such as variability and approximation. Objective motion analyses can complement clinical assessment and provide more accurate evaluations of motor symptoms and complications in PD.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Alessandro Padovani, Angelo Antonini, Paolo Barone, Giuseppe Bellelli, Andrea Fagiolini, Luigi Ferini Strambi, Sandro Sorbi, Fabrizio Stocchi
Summary: This Delphi study aims to reach a shared point of view among Italian specialists on depression in Alzheimer's disease (AD). Consensus was achieved in most cases (86%), with 80% of statements receiving positive consensus and 6% receiving negative consensus. The study also highlights the strong link between depression and AD, as well as specific features of depression in AD compared to major depressive disorder (MDD).
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garri, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffaele De Caro, Gabor G. Kovacs, Angelo Antonini
Summary: This study investigated the alterations of alpha-synuclein and glial responses in duodenum biopsies of Parkinson's disease (PD) patients. The findings provide evidence of synuclein pathology and gliosis in the duodenum of PD patients, including early cases, suggesting the important role of the gut in PD pathogenesis.
MOVEMENT DISORDERS
(2023)