Journal
VIRULENCE
Volume 8, Issue 7, Pages 1160-1169Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2016.1276689
Keywords
anti-bacterial response; MORN2; planarians; S. aureus; Tim
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Funding
- CNRS (PEPS)
- Scientific Cooperation Foundation Infectiopole Sud
- Regional Council P.A.C.A
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Planarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the antimicrobial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle. Indeed, S. aureus infection leads to the expression of Smed-Tim, which in turn promotes Smed-Traf6 and Smed-morn2, but not Smed-p38 MAPK expression, 2 master regulators of planarian anti-microbial responses.
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