Effect of opicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity and motor fluctuations in patients with Parkinson's disease

Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations

(2014) José-Francisco Rocha et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Medicinal Chemistry of Catechol O-Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility

(2014) László E. Kiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

(2013) José Francisco Rocha et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor

(2013) M.J. Bonifácio et al.   NEUROPHARMACOLOGY

Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects

(2012) Luis Almeida et al.   CLINICAL PHARMACOKINETICS

Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson's disease

(2012) J. J. Ferreira et al.   EUROPEAN JOURNAL OF NEUROLOGY

Computation of the binding affinities of catechol-O-methyltransferase inhibitors: Multisubstate relative free energy calculations

(2012) P. Nuno Palma et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase

(2010) László E. Kiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Levodopa in the treatment of Parkinson’s disease

(2009) A. H. V. Schapira et al.   EUROPEAN JOURNAL OF NEUROLOGY

Bimodal administration of entacapone in Parkinson’s disease patients improves motor control

(2008) L. Bet et al.   EUROPEAN JOURNAL OF NEUROLOGY