Article
Food Science & Technology
Anatoly Skalny, Michael Aschner, Marina Sekacheva, Abel Santamaria, Fernando Barbosa, Beatriz Ferrer, Jan Aaseth, Monica M. B. Paoliello, Joao B. T. Rocha, Alexey A. Tinkov
Summary: The present study reviewed epidemiological and experimental toxicology studies on the association between mercury (Hg) exposure and carcinogenesis over the past two decades. It was found that Hg exposure levels were linked to cancer risk and mortality in some studies, and the mechanisms involved interference with cellular signaling pathways and DNA repair mechanisms. Furthermore, Hg exposure may also impact epigenetic effects and contribute to carcinogenic activity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Agronomy
Jiaqi Xu, Xudong Liu, Richard Napier, Liyao Dong, Jun Li
Summary: Halauxifen-methyl disrupts IAA homeostasis and stimulates overproduction of ethylene and ABA by inducing the overexpression of genes involved in their biosynthesis, ultimately leading to plant death.
Article
Environmental Sciences
Cansu Dagsuyu, Onur Derse, Murat Oturakci
Summary: This study analyzed different risk stages in the cold chain and proposed an integrated mathematical model to maximize risk reduction. Through scenario analyses and action plans, improvements were successfully made in 14 hazard situations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Agronomy
Yuan Gao, Jun Li, Guohui Shen, Zhihui Tian
Summary: Barnyardgrass and yerbadetajo are troublesome weeds in rice fields in China. This research found that the synthetic auxin herbicide florpyrauxifen-benzyl can effectively control both weeds. Yerbadetajo is more sensitive to florpyrauxifen-benzyl than barnyardgrass, and the herbicide induces different levels of ethylene and abscisic acid in the two weeds, leading to differences in phytotoxicity.
Article
Health Care Sciences & Services
Thomas Hongjie Zhang, Jen Sern Tham
Summary: The study analyzed cancer news articles with MI from selected Malaysian English and Chinese newspapers. Findings revealed unbalanced news distribution throughout the year, with some months receiving more attention than others. Significant differences were found between the two newspaper websites in terms of MI rates, types of MI, news sources interviewed, news focus, and mentioned cancer risks. Logistic regression results showed that online cancer news articles were more likely to provide MI when interviewing nongovernmental organizations, focusing on primary cancer prevention topics, and highlighting lifestyle risks.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xiaofei Shang, Huixin Yuan, Lixia Dai, Yang Liu, Jian He, Huan Chen, Hongyan Li, Xiuhui Li
Summary: Ruangan granules (RGGs) have been used for many years to treat liver fibrosis with good clinical efficacy. This study used network pharmacology and metabolomics to evaluate the quality, safety, and mechanism of action of RGGs. The results showed that RGGs contained active compounds and were able to improve liver function, decrease fibrosis markers, and alleviate oxidative stress and inflammatory response.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Guido Eibl, Enrique Rozengurt
Summary: Metformin has beneficial effects in pancreatic cancer, reducing the risk of developing the disease and improving survival in patients, mainly through its direct effects on transformed pancreatic epithelial cells and indirect effects on extra-pancreatic tissues.
CANCER AND METASTASIS REVIEWS
(2021)
Review
Cell Biology
Abdul Waheed Khan, Mariya Farooq, Muhammad Haseeb, Sangdun Choi
Summary: Despite advancements in conventional therapies, cancer remains a leading cause of death globally. Plant-based medicines have been used since ancient times and have shown promising results with minimal side effects. Discovery of more plant-derived bioactive compounds is encouraged to prevent and treat cancer without significant adverse effects.
Article
Medicine, Legal
Chad M. Thompson, Christopher Kirman, Mark A. Harris
Summary: This article describes the presence of hexavalent chromium (Cr(VI)) in drinking water and the safety standards for its concentration. It explores the effects of different mechanisms on the carcinogenicity of Cr(VI). By using PBPK models and tumor incidence data, alternative safety standards for different Cr(VI) concentrations can be derived. Additionally, weaknesses in the rationale used by the U.S. EPA to discount in vivo genotoxicity studies are highlighted.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Lorrie Boisvert, Remco Derr, Torben Osterlund, Giel Hendriks, Inger Brandsma
Summary: ToxTracker is an in vitro mammalian stem cell-based reporter assay that can detect activation of specific cellular signaling pathways upon chemical exposure. This study used quantitative methods to analyze historical control data and dose-response data for potency ranking and mode-of-action determination. The results showed that different ToxTracker reporters have complementary functions and can indicate genotoxic stress or cellular stress. Dose-response modeling of multivariate ToxTracker data can be used for toxicological profiling and in vivo risk assessment.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Critical Care Medicine
Lori C. Sakoda, Amy Alabaster, Eric T. Sumner, Nancy P. Gordon, Charles P. Quesenberry Jr, Jeffrey B. Velotta
Summary: This study investigates the temporal changes in lung cancer incidence rates among adults who have never used tobacco. The overall lung cancer incidence rate has declined in recent years, while the incidence rate among adults who have never used tobacco remains relatively stable. However, it is worth noting that the incidence rate is higher and rising among Asian and Pacific Islander adults who have never used tobacco.
Article
Biochemistry & Molecular Biology
Irene Julca, Daniela Mutwil-Anderwald, Vaishnervi Manoj, Zahra Khan, Soak Kuan Lai, Lay. K. K. Yang, Ing. T. T. Beh, Jerzy Dziekan, Yoon. P. P. Lim, Shen. K. K. Lim, Yee. W. W. Low, Yuen. I. I. Lam, Seth Tjia, Yuguang Mu, Qiao. W. W. Tan, Przemyslaw Nuc, Le. M. M. Choo, Gillian Khew, Loo Shining, Antony Kam, James. P. P. Tam, Zbynek Bozdech, Maximilian Schmidt, Bjoern Usadel, Yoganathan Kanagasundaram, Saleh Alseekh, Alisdair Fernie, Hoi. Y. Y. Li, Marek Mutwil
Summary: This study reveals the biosynthetic pathway of active metabolites in the Oldenlandia group and the mode of action of ursolic acid in cancer cells, providing valuable resources for further characterization of active metabolite biosynthesis.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mark M. M. Aloysius, Sanskriti Shrivastava, Chaitanya Rojulpote, Raza Naseer, Hamza Hanif, Milos Babic, Kenneth Gentilezza, Pranjal K. K. Boruah, Samir Pancholy
Summary: This study investigated the clinical characteristics and cancer-specific survival rates of different races with primary malignant cardiac tumors (PMCTs) in the United States. The results showed that black and non-Hispanic patients had poorer cancer-specific survival rates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Eric M. Montminy, Meijiao Zhou, Lauren Maniscalco, Wesal Abualkhair, Michelle Kang Kim, Rebecca L. Siegel, Xiao-Cheng Wu, Steven H. Itzkowitz, Jordan J. Karlitz
Summary: The incidence rates of early-onset colorectal cancer are rising, with different histologic subtypes involved. Evaluating these subtypes independently can provide a better understanding of the factors driving changes in overall colorectal cancer incidence.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Seung-Gi Jin, Yingying Meng, Jennifer Johnson, Piroska E. Szabo, Gerd P. Pfeifer
Summary: This study provides detailed analysis of two types of oxidative DNA damage and its association with inflammation and cancer. The results show that the occurrence of oxidized guanines and oxidized thymines is dependent on specific DNA sequences and may lead to cancer-related mutations.
Review
Environmental Sciences
Martyn T. Smith, Kathryn Z. Guyton, Catherine F. Gibbons, Jason M. Fritz, Christopher J. Portier, Ivan Rusyn, David M. DeMarini, Jane C. Caldwell, Robert J. Kavlock, Paul F. Lambert, Stephen S. Hecht, John R. Bucher, Bernard W. Stewart, Robert A. Baan, Vincent J. Cogliano, Kurt Straif
ENVIRONMENTAL HEALTH PERSPECTIVES
(2016)
Review
Environmental Sciences
Gary Ginsberg, Suryanarayana V. Vulimiri, Yu-Sheng Lin, Jayaram Kancherla, Brenda Foos, Babasaheb Sonawane
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2017)
Review
Toxicology
Jennifer Jinot, Jason M. Fritz, Suryanarayana V. Vulimiri, Nagalakshmi Keshava
TOXICOLOGY MECHANISMS AND METHODS
(2018)
Editorial Material
Environmental Sciences
Suryanarayana V. Vulimiri, Ofelia Olivero
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2019)
Review
Environmental Sciences
Channa Keshava, J. Allen Davis, John Stanek, Kristina A. Thayer, Audrey Galizia, Nagalakshmi Keshava, Jeff Gift, Suryanarayana V. Vulimiri, George Woodall, Carolyn Gigot, Kelly Garcia, Andrew Greenhalgh, Brittany Schulz, Savannah Volkoff, Krisa Camargo, Amanda S. Persad
ENVIRONMENT INTERNATIONAL
(2020)
Review
Environmental Sciences
Erin E. Yost, Audrey Galizia, Dustin F. Kapraun, Amanda S. Persad, Suryanarayana V. Vulimiri, Michelle Angrish, Janice S. Lee, Ingrid L. Druwe
Summary: The study summarized literature on naphthalene toxicity, indicating that animal studies are more suitable for deriving reference values.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Environmental Sciences
Kristina A. Thayer, Michelle Angrish, Xabier Arzuaga, Laura M. Carlson, Allen Davis, Laura Dishaw, Ingrid Druwe, Catherine Gibbons, Barbara Glenn, Ryan Jones, J. Phillip Kaiser, Channa Keshava, Nagalakshmi Keshava, Andrew Kraft, Lucina Lizarraga, Amanda Persad, Elizabeth G. Radke, Glenn Rice, Brittany Schulz, Rachel M. Shaffer, Teresa Shannon, Andrew Shapiro, Shane Thacker, Suryanarayana V. Vulimiri, Antony J. Williams, George Woodall, Erin Yost, Robyn Blain, Katherine Duke, Alexandra E. Goldstone, Pam Hartman, Kevin Hobbie, Brandall Ingle, Courtney Lemeris, Cynthia Lin, Alex Lindahl, Kristen McKinley, Parnian Soleymani, Nicole Vetter
Summary: This article describes the typical methods used to produce systematic evidence maps (SEMs) for the IRIS and PPRTV Programs. It provides examples of applications and workflows for rapid production of SEMs, as well as methods for literature search, screening, and data extraction. The article also presents approaches for study evaluation and offers interactive visual formats and downloadable data.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Kristina A. Thayer, Rachel M. Shaffer, Michelle Angrish, Xabier Arzuaga, Laura M. Carlson, Allen Davis, Laura Dishaw, Ingrid Druwe, Catherine Gibbons, Barbara Glenn, Ryan Jones, J. Phillip Kaiser, Channa Keshava, Nagalakshmi Keshava, Andrew Kraft, Lucina Lizarraga, Kristan Markey, Amanda Persad, Elizabeth G. Radke, Glenn Rice, Brittany Schulz, Teresa Shannon, Andrew Shapiro, Shane Thacker, Suryanarayana Vulimiri, George Woodall, Erin Yost
Summary: Systematic evidence maps (SEMs) are increasingly utilized in the environmental health field to enhance transparency and efficiency in data gathering, and to promote coordination and sharing among the community.
ENVIRONMENT INTERNATIONAL
(2022)
Meeting Abstract
Environmental Sciences
Channa Keshava, Vulimiri V. Suryanarayana, Suna Nicolai, Florenz A. Cruz, Ariane Lenzner, Patrick Tarnow, Narges Ghoreishi, Sven Knueppel, Amanda S. Persad, Kristina A. Thayer, Antony J. Williams, Nancy Baker, Jens T. Vanselow, Ralph Pirow
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Meeting Abstract
Environmental Sciences
Nagalakshmmi Keshava, Brittany Schulz, Suryanarayana V. Vulimiri, Jeff Gift, Geoffrey Peterson, Catheryne Chiang, Chelsea A. Weitekamp, David M. Lehmann, Amanda S. Persad, Yu-Sheng Lin, Anuradha Mudipalli, Michelle Angrish, Andrew Hotchkiss, Kristina A. Thayer
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Meeting Abstract
Environmental Sciences
C. Keshava, A. Davis, J. Stanek, K. Thayer, A. Galizia, N. Keshava, J. Gift, S. V. Vulimiri, G. Woodall, C. Gigot, A. Greenhalgh, Z. B. Schult, S. Volkoff, K. Camargo, A. S. Persad
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2019)
Meeting Abstract
Environmental Sciences
S. V. Vulimiri
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2016)