Correction
Cell Biology
Quan-Jun Deng, Xiao-Feng Xu, Jing Ren
Summary: There was an error in the positive control group of Figure 8 in the original version of the article.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Farzad Sadri, Zohreh Rezaei, Mohammad Fereidouni
Summary: This review summarizes the molecular signature of the SDF-1/CXCR4 pathway and explains how this axis is involved in normal events.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Orthopedics
Yuting Sun, Yanwen Fang, Xinle Li, Jie Li, Daquan Liu, Min Wei, Zhongcai Liao, Yao Meng, Lidong Zhai, Hiroki Yokota, Lei Yang, Ying Yu, Ping Zhang
Summary: This study aimed to investigate the therapeutic effects of static magnetic field (SMF) and its regulatory mechanism in the repair of osteoarthritic cartilage. The results showed that SMF significantly reduced the severity of osteoarthritis, promoted chondrogenesis, and improved cartilage extracellular matrix. SMF attenuated cartilage destruction by activating the Piezo1-mediated SDF-1/CXCR4 regulatory axis and promoting the migration of endogenous stem cells. These findings suggest the clinical value of SMF in the treatment of osteoarthritis.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Nanoscience & Nanotechnology
Ying Huang, Wenjuan Shen, Yong Zheng, Su Zheng, Yao Yao, Changjiang Lei
Summary: LNPs carrying miR-100 can effectively up-regulate miR-100 expression and inhibit the progression of gastric cancer cells by targeting TFF1 protein and regulating the SDF-1a/CXCR4 signaling pathway.
Article
Gastroenterology & Hepatology
Sara Abubakr, Noha M. Hazem, R. N. Sherif, Adel Abdelmohdy Elhawary, Kamal G. Botros
Summary: This study aimed to evaluate the relationship between CD34 + HPSCs, SDF-1a, and CXCR4 receptor expression and the percentage of hepatic fibrosis area. The results showed that in the liver injury group, hepatic enzymes, fibrosis area percentage, CXCR4 receptor expression, CD34 + cells, and SDF-1a levels were significantly increased with the progression of liver fibrosis.
BMC GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yizuo Song, Ruyi Li, Miaomiao Ye, Chunyu Pan, Lihong Zheng, Zhi-wei Wang, Xueqiong Zhu
Summary: This study found that MSCs from different tissues exhibit different chemotaxis towards cervical cancer cells, with chorion-derived MSC (CD-MSC) showing the strongest tropic capacity. The CXCL12/CXCR4 pathway was identified to contribute to the differential chemotaxis of MSCs to cervical cancer cells.
Article
Biology
Xing Feng, Ruifeng Sun, Moonyoung Lee, Xinyue Chen, Shangqin Guo, Huimin Geng, Marcus Muschen, Jungmin Choi, Joao Pedro Pereira
Summary: Acute lymphoblastic and myeloblastic leukemias (ALL and AML) modify the bone marrow microenvironment and disrupt non-malignant hematopoiesis. Leukemic cells express lymphotoxin alpha 1 beta 2 and activate lymphotoxin beta receptor (LT beta R) signaling in mesenchymal stem cells (MSCs), which turns off IL7 production and prevents non-malignant lymphopoiesis. Genetic or pharmacological disruption of LT beta R signaling in MSCs restores lymphopoiesis but not erythropoiesis, reduces leukemic cell growth, and extends the survival of transplant recipients.
Article
Oncology
F. Luo, Y. Su, Z. Zhang, J. Li
Summary: The study demonstrated the involvement of the SDF-1/CXCR4 axis in the homing and promotion of proliferation and migration of BMMSCs in prostate cancer. Increasing SDF-1 concentrations up-regulated CXCR4 expression, leading to enhanced proliferation and migration of BMMSCs. The presence of VECs in a non-contact co-culture model also facilitated BMMSC proliferation and migration.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi Ding, Rui Tan, Jian Gu, Puyang Gong
Summary: This study evaluated the stimulant effect of herpetin, derived from Herpetospermum caudigerum Wall. seeds, on bone marrow mesenchymal stem cells (BMSCs) to improve acute liver injury (ALI). The results showed that herpetin treatment enhanced liver-specific protein expression, cytochrome P450 activity, and glycogen-storage capacity of BMSCs. In a mouse model, coadministration of herpetin and BMSCs improved liver function and activated signaling pathways. This suggests that herpetin is a promising BMSC induction agent for the treatment of ALI.
Article
Multidisciplinary Sciences
Jeremy J. McGuire, Jeremy S. Frieling, Chen Hao Lo, Tao Li, Ayaz Muhammad, Harshani R. Lawrence, Nicholas J. Lawrence, Leah M. Cook, Conor C. Lynch
Summary: The authors demonstrate that MSC-derived IL-28 induces apoptosis in prostate cancer cells via IL-28R alpha -STAT1 signaling, while acquired resistance to apoptosis is associated with a shift in signaling pathway from STAT1 to STAT3 in IL-28R alpha.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Chi Zhang, Wei Zhang, Dashuai Zhu, Zhenhua Li, Zhenzhen Wang, Junlang Li, Xuan Mei, Wei Xu, Ke Cheng, Biao Zhong
Summary: This study proposes a method using cell-mimicking and targeted therapeutic nanoparticles to replace stem cells. The results show that in a rat model of osteoporosis, this treatment can accumulate in bone, inhibit osteoclast differentiation, and promote osteogenic proliferation. Additionally, this treatment reduces bone mass attenuation in rats with ovariectomy-induced bone loss.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Andong Zhao, Manhon Chung, Yi Yang, Xiaohua Pan, Yu Pan, Sa Cai
Summary: This study investigates the mechanisms underlying the migration of bone marrow-derived mesenchymal stem cells (MSCs) to the injured spinal cord. It was found that the stromal cell-derived factor 1 (SDF-1)/CXCR4 axis plays an important role in recruiting MSCs to the spinal cord, promoting neural regeneration and functional recovery.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Karla Montalban-Hernandez, Cesar Casado-Sanchez, Jose Avendano-Ortiz, Jose Carlos Casalvilla-Duenas, Gloria C. Bonel-Perez, Julia Prado-Montero, Jaime Valentin-Quiroga, Roberto Lozano-Rodriguez, Veronica Terron-Arcos, Fatima Ruiz de la Bastida, Laura Cordoba, Fernando Laso-Garcia, Luke Diekhorst, Carlos del Fresno, Eduardo Lopez-Collazo
Summary: This study successfully generated a new hybrid cell population, named foam hybrid cell (FHC), through co-culture. The FHC exhibited enhanced motility, proliferation, immunomodulation properties, and maintained stemness features. This finding is of great significance for stem cell therapy and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Yifan Zhang, Xinle Li, Jie Li, Daquan Liu, Lidong Zhai, Xuetong Wang, Abdusami Abdurahman, Hiroki Yokota, Ping Zhang
Summary: In this study, it was found that knee loading promoted the migration of adipose-derived stem cells (ASCs) and accelerated the repair of osteoarthritis (OA) damaged sites. The mechanical loading enhanced the migration ability of ASCs through the SDF-1/CXCR4 regulatory axis, thus improving the joint-protective effect of ASCs.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Xiaosong Li, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: Sequential transplantation of exosomes and pretreated MSCs can effectively promote cardiac repair post-AMI. Among them, the combination of pretreatment with hypoxia and TXL significantly enhances the CXCR4 level of MSCs, promotes recruitment, improves cardiac function, reduces infarct size, and enhances angiogenesis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Supinder Kour, Manasa G. Garimella, Divya A. Shiroor, Suhas T. Mhaske, Snehal R. Joshi, Kanupriya Singh, Subhashis Pal, Monika Mittal, Hari B. Krishnan, Naibedya Chattopadhyay, Anil H. Ulemale, Mohan R. Wani
JOURNAL OF IMMUNOLOGY
(2016)
Article
Nanoscience & Nanotechnology
Jyoti V. Kumbhar, Sachin H. Jadhav, Dhananjay S. Bodas, Amruta Barhanpurkar-Naik, Mohan R. Wani, Kishore M. Paknikar, Jyutika M. Rajwade
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Article
Immunology
Kanupriya Singh, Vikrant Piprode, Suhas T. Mhaske, Amruta Barhanpurkar-Naik, Mohan R. Wani
JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Amruta P. Barhanpurkar, Navita Gupta, Rupesh K. Srivastava, Geetanjali B. Tomar, Sameer P. Naik, Snehal R. Joshi, Satish T. Pote, Gyan C. Mishra, Mohan R. Wani
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2012)
Article
Biochemistry & Molecular Biology
Tanveer Ahmad, Shravani Mukherjee, Bijay Pattnaik, Manish Kumar, Suchita Singh, Manish Kumar, Rakhshinda Rehman, Brijendra K. Tiwari, Kumar A. Jha, Amruta P. Barhanpurkar, Mohan R. Wani, Soumya S. Roy, Ulaganathan Mabalirajan, Balaram Ghosh, Anurag Agrawal
Article
Nanoscience & Nanotechnology
Jay R. Dave, Ankush M. Dewle, Suhas T. Mhaske, Prashant T. Phulpagar, Vikas L. Mathe, Supriya E. More, Ayesha A. Khan, Appala Venkata Ramana Murthy, Suwarna S. Datar, Ajay J. Jog, Megha Page, Geetanjali B. Tomar
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Immunology
Anil Kumar, Lekha Rani, Suhas T. Mhaske, Satish T. Pote, Shubhanath Behera, Gyan C. Mishra, Mohan R. Wani
JOURNAL OF IMMUNOLOGY
(2020)
Article
Acoustics
Rahul Kumar Agrawal, Vaibhav Pandey, Amruta Barhanpurkar-Naik, Mohan R. Wani, Kausik Chattopadhyay, Vakil Singh
Article
Genetics & Heredity
Shubham Shrivastava, Harshad P. Patil, Suhas T. Mhaske, Sonali Palkar, Sanjay Lalwani, Akhilesh Chandra Mishra, Vidya A. Arankalle
Summary: Two isolates of SARS-CoV-2 were characterized from Indian patients, showing similarities to Italian strains. The fully characterized virus isolates will assist in the development of neutralization/virological assays for vaccine and antiviral evaluation.
Article
Infectious Diseases
Nandini Malshe, Suprabha K. Patnaik, Sanjay Lalwani, Pradeep Suryawanshi, Ruta Kulkarni, Suhas Mhaske, Akhilesh Chandra Mishra, Vidya Arankalle
Summary: The study found a low rate of perinatal transmission, lower transfer of maternal antibodies in SARS-CoV-2-RNA+ mothers compared to SARS-CoV-2-RNA-negative mothers, but the majority of neonates demonstrated neutralizing potential against SARS-CoV-2.
Article
Virology
Shubham Shrivastava, Suhas T. Mhaske, Meera S. Modak, Rashmi G. Virkar, Shamburaje S. Pisal, Akhilesh Chandra Mishra, Vidya A. Arankalle
Summary: This study examines the prevalence of SARS-CoV-2 variants in India, highlighting the emergence of Kappa and Delta variants and the subsequent dominance of the Delta variant. The study emphasizes the importance of continuous monitoring of new mutations.
ARCHIVES OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Jay R. Dave, Sayali S. Chandekar, Shubhanath Behera, Kaushik U. Desai, Pradnya M. Salve, Neha B. Sapkal, Suhas T. Mhaske, Ankush M. Dewle, Parag S. Pokare, Megha Page, Ajay Jog, Pankaj A. Chivte, Rupesh K. Srivastava, Geetanjali B. Tomar
Summary: Aging negatively affects the quantity and quality of mesenchymal stem cells (MSCs) derived from gingival tissues, limiting their therapeutic potential. This study demonstrates that these MSCs exhibit decreased adipogenesis and osteogenesis with age, but their neurogenic potential remains unaffected. Importantly, regardless of donor age, these cells display immunoregulatory and regenerative abilities, making them promising candidates for cell-based therapies in acute inflammatory conditions.