Article
Food Science & Technology
Hao Yue, Zhibing Leng, Yuying Bo, Yingying Tian, Ziyi Yan, Changhu Xue, Ping Dong, Jingfeng Wang
Summary: The effect of sea cucumber intestinal peptide (SCIP) on the differentiation fate of bone mesenchymal stem cells (BMSCs) was investigated in this study. It was found that SCIP promotes the proliferation and osteogenic differentiation of BMSCs, and maintains the phosphorylation of PPAR gamma Ser112 through the AMPK/ERK and TAZ signaling pathways, thereby inducing the osteogenic differentiation of BMSCs. These results suggest that SCIP has potential as a functional food to improve obesity and osteoporosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Cell Biology
Xinyun Xu, Ling Zhao, Paul D. Terry, Jiangang Chen
Summary: Mesenchymal stem cells from bone marrow can differentiate into either adipocytes or osteoblasts, and external stimuli such as environmental contaminants, heavy metals, dietary, and physical factors can influence this fate decision. Maintaining a balance between osteogenesis and adipogenesis is crucial for bone homeostasis, and disruptions in lineage commitment of these stem cells are associated with various bone disorders. This review focuses on understanding how external stimuli affect the fate of mesenchymal stem cells and calls for future studies to investigate the impact on bone health and underlying mechanisms of differentiation.
Article
Dentistry, Oral Surgery & Medicine
Shuzuo Zhou, Gang Zhang, Kun Wang, Zhong Yang, Yinghui Tan
Summary: This study revealed the critical role of METTL3 in osteogenic differentiation of BMSCs through the m(6)A/IGF2BP1/RUNX2 signaling axis. This finding provides a potential therapeutic target for maxillofacial bone defect treatment.
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Veterinary Sciences
Antonella Liza Pantaleoni Andrietti, Sushmitha S. Durgam, Brittany Naumann, Matthew Stewart
Summary: This study compared osteogenesis in equine bone marrow-, synovium- and adipose-derived cells and found that bone marrow-derived cells had higher basal expression of Osterix, indicating their higher osteogenic potential. In osteogenic medium, these cells quickly developed dense multicellular aggregates with strong mineralization and alkaline phosphatase activity. On the other hand, synovial and adipose cell cultures showed less matrix mineralization.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Medicine, Research & Experimental
Leiluo Yang, Qing Li, Junhong Zhang, Pengcheng Li, Pingjiang An, Chunqing Wang, Pingsheng Hu, Xue Zou, Xiaowei Dou, Lixin Zhu
Summary: The study investigated the role of Wnt7a in bone formation and demonstrated its key role in MSC differentiation into osteoblasts, offering a potential therapeutic target for bone-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Nan Wang, Luyao Wang, Jihao Yang, Zhihong Wang, Liangxing Cheng
Summary: The study reveals that quercetin promotes osteogenic differentiation and antioxidant responses of BMSCs by activating the AMPK/SIRT1 signaling pathway, showing potential as an effective treatment for osteoporosis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Linshan Xu, Yuyang Wang, Jianping Wang, Jianglong Zhai, Li Ren, Guoying Zhu
Summary: Cellular senescence and its associated secretory phenotype (SASP) are considered potential therapeutic targets for aging-related diseases. Inducing cellular senescence in osteocyte-like cells led to increased expression of senescence and SASP markers, disrupting the differentiation potential of bone marrow mesenchymal stem cells (BMSCs) through paracrine signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fatih Karadeniz, Jung Hwan Oh, Mi Soon Jang, Youngwan Seo, Chang-Suk Kong
Summary: Bone marrow adiposity is a complication in osteoporotic patients, and phytochemicals can alleviate it. This study evaluated the effect of libanoridin on the adipogenic differentiation of bone marrow-derived mesenchymal stromal cells. The results showed that libanoridin inhibited adipogenic differentiation through suppressing MAPK-mediated PPAR gamma signaling. Future studies will further explore the anti-adipogenic effects of libanoridin in vivo and elucidate its action mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Miguel Padial-Molina, Vicente Crespo-Lora, Clara Candido-Corral, Nati Martin-Morales, Dario Abril-Garcia, Pablo Galindo-Moreno, Pedro Hernandez-Cortes, Francisco O'Valle
Summary: The study revealed that MSI1 and RUNX2 expression increased over time during bone healing, while the expression of POSTN decreased. MSI1 was found to be expressed in mesenchymal stromal cells, osteoblasts, and osteocytes, suggesting a potential role in bone healing and osteogenic differentiation. The significant correlation between MSI1, POSTN, and RUNX2 after 14 days indicates the need for further research on MSI1 as a clinical biomarker for bone healing and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ping Liu, Yan Zhuang, Binfei Zhang, Hai Huang, Pengfei Wang, Hu Wang, Yuxuan Cong, Shuangwei Qu, Kun Zhang, Xing Wei
Summary: This study demonstrated that miR-140-3p promotes the osteogenic differentiation of BMSCs by interacting with Spred2, and revealed that Spred2-induced autophagic signaling accelerates this process.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Mengke Fan, Yurui Zhang, Huiying Shi, Lizhi Xiang, Hailing Yao, Rong Lin
Summary: This study explored the exact role and potential mechanism of bone marrow-derived mesenchymal stem cells (BMSCs) in the progression of gastric cancer (GC). The researchers found that TGF-ll1 was overexpressed in GC cells and tissues and was positively related to poor prognosis. TGF-ll1 from GCs activated the Smad2 pathway in BMSCs, promoting their differentiation into carcinoma-associated fibroblasts (CAFs) and TGF-ll1 expression. Simultaneously, TGF-ll1 secreted by CAFs activated Smad2 signaling in GC cells, inducing their epithelial-mesenchymal transition (EMT) and TGF-ll1 secretion. BMSCs significantly promoted the proliferation, migration, and invasion of GCs, and blocking the TGF-ll1/Smad2 positive feedback loop reversed these effects.
Article
Biotechnology & Applied Microbiology
Yi-Xuan Wang, Zhu-Li Peng, Zhi-Wen Sun, Yan-Jun Pan, Hong Ai, Zhi-Hui Mai
Summary: This study investigates the role of miR-20 in promoting osteogenic differentiation in BMSCs and accelerating bone formation in a rabbit maxillary sinus bone defect model. Overexpression of miR-20a increased the levels of osteogenic markers and enhanced calcified nodule deposition in BMSCs, while anti-miR-20a treatment had the opposite effect. In the rabbit model, miR-20a delivery significantly improved bone density, osteoblast numbers, and collagen type 1 secretion compared to Bio-Oss bone powder.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Xiaofeng Wang, Fanyuan Yu, Ling Ye
Summary: Recent studies have shown that MSCs play a vital role in bone regeneration, including osteogenic differentiation and providing seed cells. However, factors like drug intake and body senescence can affect MSCs' functions in bone regeneration. Epigenetic regulation has received attention for its heritable nature and involvement in bone metabolism disorders. This review focuses on the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs and its role in bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Jingbo Xue, Lulu Liu, Hao Liu, Zepeng Li
Summary: SNHG14 regulates Mef2c expression and activates autophagy through miR-493-5p, promoting osteogenic differentiation of BMSCs and consequently alleviating osteoporosis development.
COMMUNICATIONS BIOLOGY
(2023)