Article
Biochemistry & Molecular Biology
Nan Wang, Guoli Gan, Jihao Yang, Luyao Wang
Summary: This study found that barbaloin promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells, possibly through the regulation of the Wnt/beta-catenin signaling pathway.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Lidi Deng, Siqi Yi, Xiaohui Yin, Yang Li, Qingxian Luan
Summary: This study reveals that MFN2 plays a role in regulating glycolysis and osteogenic differentiation of iPSC-MSCs through the Wnt/beta-catenin signaling pathway. Knockdown of MFN2 promotes the osteogenic differentiation of iPSC-MSCs through increased aerobic glycolysis, while overexpression of MFN2 has the opposite effect. These findings provide insights into the function of MFN2 in MSCs and offer a potential therapeutic target for alveolar bone repair and periodontal regenerative treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Orthopedics
Yue-wen Chang, Wen-Jun Zhu, Wei Gu, Jun Sun, Zhi-qiang Li, Xiao-en Wei
Summary: The study demonstrates that neohesperidin can promote osteogenic differentiation of bone mesenchymal stem cells, which is related to the activation of the Wnt/β-catenin pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jinwu Bai, Weijun Zhang, Chenwei Zhou, Guangfeng Zhao, Huiming Zhong, Kai Hang, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu, Deting Xue
Summary: MFG-E8 promotes osteogenic differentiation of BMSCs by regulating the GSK3 beta/beta-catenin signaling pathway and therefore, is a potential therapeutic target. This study has important clinical significance in addressing fracture nonunion and bone defects.
Article
Biochemistry & Molecular Biology
Yiqi Zhang, Long Zhou, Qin Fu, Ziyun Liu
Summary: This research explores the functions and molecular mechanism of ANKRD1 in bone marrow-derived mesenchymal stem cell (BMSC) osteogenesis. ANKRD1 promotes osteogenesis by activating Wnt/β-catenin signaling and modulating caveolin-3 (CAV3) expression. These findings suggest that ANKRD1 plays an important role in regulating BMSC osteogenesis and is a promising target for the treatment of osteoporosis and other bone diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Cell & Tissue Engineering
Hongwei Gao, Hui Dong, Jiachun Zheng, Xufeng Jiang, Mingzhi Gong, Le Hu, Jinshan He, Yongxiang Wang
Summary: The study identified LINC01119 as a negative regulator of osteogenic differentiation in MSCs, with its knockdown promoting calcification and osteogenic differentiation. It was revealed that LINC01119 negatively regulates osteogenesis through the Wnt pathway by targeting FZD4, with transcription factor EBF3 directly binding to LINC01119's promoter region.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Chemistry, Medicinal
Stefania Lama, Amalia Luce, Giuseppe Bitti, Pilar Chacon-Millan, Annalisa Itro, Pasquale Ferranti, Giovanni D'Auria, Marcella Cammarota, Giovanni Francesco Nicoletti, Giuseppe Andrea Ferraro, Chiara Schiraldi, Michele Caraglia, Evzen Amler, Paola Stiuso
Summary: This study investigated the potential application of polycaprolactone/polydatin (PCL/PD) nanofiber scaffold in bone tissue engineering. The results showed that osteosarcoma cells and mesenchymal stem cells cultured on PD-PCL nanofiber scaffold exhibited enhanced cell adhesion and osteogenic differentiation.
Article
Endocrinology & Metabolism
Shumin Rui, Takuo Kubota, Yasuhisa Ohata, Kenichi Yamamoto, Makoto Fujiwara, Shinji Takeyari, Keiichi Ozono
Summary: This study found that phosphate enhances osteogenic differentiation through up-regulation of the non-canonical Wnt signaling pathway in the early stage. These findings provide a new perspective on the role of phosphate and the non-canonical Wnt signaling pathway in osteogenic differentiation.
Article
Biochemistry & Molecular Biology
Yang Zheng, Panyang Shen, Mengsha Tong, Hangchao Li, Conglin Ren, Fengqing Wu, Hanyu Li, Huan Yang, Bingbing Cai, Weibin Du, Xing Zhao, Shasha Yao, Renfu Quan
Summary: This study reveals the important role of bone marrow mesenchymal stem cells (BMSCs) in congenital scoliosis (CS). CS-BMSCs showed decreased osteogenic differentiation ability compared to BMSCs from healthy donors. The downregulation of WISP2 was associated with the impaired osteogenic differentiation of CS-BMSCs, and overexpression of WISP2 can promote osteogenesis in CS-BMSCs via the Wnt/beta-catenin pathway. These findings provide new insights into the pathogenesis of CS.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Faezeh Sahebdel, Azita Parvaneh Tafreshi, Ehsan Arefian, Eleni Roussa, Samad Nadri, Bahman Zeynali
Summary: The study found that trabecular meshwork-derived mesenchymal stem cells (TM-MSCs) have higher neurogenic differentiation potential compared to adipose tissue-derived mesenchymal stem cells (AD-MSCs) and bone marrow-derived stem cells (BMSCs). The activation of the Wnt/beta-catenin pathway directs the neurally induced TM-MSCs towards a dopaminergic fate.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Anatomy & Morphology
Kai Wang, Zhiping Zhao, Xiangyu Wang, Yongtao Zhang
Summary: BRD4 plays a role in the osteogenic differentiation of BMSCs through the Wnt/beta-catenin signaling pathway. This finding contributes to a better understanding of the mechanism behind BMSC osteogenic differentiation.
Article
Biochemistry & Molecular Biology
Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang, Minghai Wang
Summary: This study found that MFAP5 regulates osteogenesis in BMSCs through the Wnt/beta-catenin and AMPK signaling pathways, and may serve as a therapeutic target for patients with osteoporosis.
MOLECULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Maorui Zhang, Yujin Gao, Qing Li, Huayue Cao, Jianghua Yang, Xiaoxiao Cai, Jingang Xiao
Summary: This study investigates the impact of the diabetic environment on the osteogenic potential of adipose-derived stem cells (ASCs) and explores the role of DNA methylation and the Wnt/beta-catenin signaling pathway. The findings suggest that downregulating Dnmt3a rescues the poor osteogenic potential of ASCs in diabetic osteoporosis and provides a possible approach for bone tissue regeneration in these patients.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang, Limin Rong
Summary: The study demonstrates that melatonin enhances the hypertrophic differentiation of MSC-derived chondrocytes through the Wnt signaling pathway, increasing chondrocyte cell volume and type X collagen expression while decreasing type II collagen expression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Weiqiang Zhan, Juanhua Quan, Zhuming Chen, Tianfeng Liu, Mingzhu Deng, Ziquan Zhao, Xuyang Wu, Zhuolan Zhong, Feifei Gao, Jiaqi Chu
Summary: This study uncovered the mechanism by which Toxoplasma gondii excretory/secretory proteins (TgESPs) regulate the energy metabolism and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yuna Qian, Linhao Li, Chao Jiang, Wei Xu, Yonggang Lv, Li Zhong, Kaiyong Cai, Li Yang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Article
Engineering, Biomedical
Zhenbei Wang, Yuna Qian, Linhao Li, Lianhong Pan, Lucy W. Njunge, Lili Dong, Li Yang
JOURNAL OF BIOMATERIALS APPLICATIONS
(2016)
Article
Materials Science, Biomaterials
Linhao Li, Yuna Qian, Chongwen Lin, Haibin Li, Chao Jiang, Yonggang Lv, Wanqian Liu, Kaiyong Cai, Oliver Germershaus, Li Yang
JOURNAL OF MATERIALS CHEMISTRY B
(2015)
Article
Engineering, Biomedical
Jin Zhou, Danyu Yao, Zhiyong Qian, Sen Hou, Linhao Li, A. Tobias A. Jenkins, Yubo Fan
Article
Engineering, Biomedical
Yuna Qian, Linhao Li, Yang Song, Lili Dong, Peixing Chen, Xiaoming Li, Kaiyong Cai, Oliver Germershaus, Li Yang, Yubo Fan
Article
Multidisciplinary Sciences
Linhao Li, Yanbing Liang, Guohang Wang, Peng Xu, Lingbing Yang, Sen Hou, Jin Zhou, Lizhen Wang, Xiaoming Li, Li Yang, Yubo Fan
Article
Engineering, Biomedical
Shengzhao Xiao, Linhao Li, Jie Yao, Lizhen Wang, Kaimin Li, Chongshi Yang, Chao Wang, Yubo Fan
Summary: This study using a rat orthodontic model revealed the biological mechanisms of root resorption caused by microcracks, showing changes in protein and signaling pathways involved in the root resorption process.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Lingbing Yang, Xubo Lin, Jin Zhou, Sen Hou, Yunnan Fang, Xuewei Bi, Li Yang, Linhao Li, Yubo Fan
Summary: The cell membrane-biomimetic coating developed by immobilizing liposomes on electrospun fibers is effective in reducing the foreign-body reaction and enhancing tissue-scaffold integration. This method improves liposome stability and fusion rate, effectively inhibiting the foreign-body reaction and promoting neovascularization.
Article
Engineering, Biomedical
Yang Song, Linhao Li, Weikang Zhao, Yuna Qian, Lili Dong, Yunnan Fang, Li Yang, Yubo Fan
Summary: The study introduced a novel short peptide, mechano-growth factor (MGF), to modify a synthetic polymeric scaffold to direct macrophage phenotype transition and mitigate foreign-body reaction (FBR). In vitro and in vivo experiments demonstrated that MGF-modified scaffold can promote macrophage polarization towards an anti-inflammatory phenotype and prevent tissue adhesion.
BIOACTIVE MATERIALS
(2021)
Article
Cell Biology
Yuanyuan Zheng, Linhao Li, Xuewei Bi, Ruyue Xue
Summary: In this study, the researchers constructed a HuMSCs-seeded SF-SIS scaffold and investigated its potential for repairing damaged endometrium in an IUA mouse model. They found that the scaffold increased gland count and reduced ulcer area in the model. They also identified circPTP4A2 as a key regulator in stabilizing mitochondrial metabolism through the miR-330-5p-PDK2 signaling pathway. These findings highlight the therapeutic potential of HuMSCs-seeded SF-SIS scaffolds for IUA treatment.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Nanoscience & Nanotechnology
Guohang Wang, Yilin Zhang, Shudong Zhao, Zhijun Zhao, Meili Liu, Yawei Wang, Xiao Liu, Sen Hou, Linhao Li, Yubo Fan
Summary: In this study, a freestanding graphene substrate with micropatterned surfaces and internal hollow structure was developed using a simple templating method. It was found that the formation of the hollow structures was influenced by the width of the template microgrooves and the size of the graphene nanosheets. The delamination and interlayer movement of the graphene nanosheets triggered by evaporation-induced capillary force were identified as the main formation mechanism. Furthermore, the controlled release of loaded microparticles and promotion of neuron orientation were achieved by applying an electric field to the hollow micropatterns. This capillarity-induced self-assembly strategy has potential for clinical application in nerve injury repair.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Lingbing Yang, Yilin Zhang, Zeyun Xiao, Wenbo Zhang, Linhao Li, Yubo Fan
Summary: Hollow polymer microcapsules are advantageous as drug carriers for their ability to protect, store, and release drugs in a controlled manner. When combined with tissue engineering scaffolds like electrospun microfibers, they can improve long-term local drug retention. However, the methods of combining microcapsules and fibers require further exploration.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Biomaterials
Zhiyong Qian, Yating Bai, Jin Zhou, Linhao Li, Jing Na, Yubo Fan, Ximin Guo, Haifeng Liu
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Materials Science, Biomaterials
Xuewei Bi, Linhao Li, Zhinan Mao, Bo Liu, Lingbing Yang, Wei He, Yubo Fan, Xiaoming Li
BIOMATERIALS SCIENCE
(2020)