Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 97, Issue -, Pages 356-376Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2015.01.021
Keywords
Benzofuran; Coumarone; Cancer; CNS; Diabetes; PET imaging
Categories
Funding
- FIST-DST, New Delhi
- UGC (SAP-DRS-II), New Delhi, India [SR/FST/CSII-002/2010]
- UGC (New Delhi)
- DST New Delhi
- Government of Gujarat Industries Commissionerate & Saurashtra University, Rajkot
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Benzofuran core is a highly versatile, presents in many important natural products and natural drugs. Many benzofuran containing synthetic drugs and clinical candidates have been derived from natural products. The present review will provide an insight on lead design-developments of the decade, clinical candidates and PET tracer radio-ligands containing benzofuran core along with brief target biology. Brief of the all approved drugs containing benzofuran core also have been enclosed. Main therapeutic areas covered are Cancer, Neurological disorders including anti-psychotic agent and diabetes. (C) 2015 Elsevier Masson SAS. All rights reserved.
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