Article
Medicine, Research & Experimental
Ochuko L. Erukainure, Motlalepula G. Matsabisa, Veronica F. Salau, Kolawole A. Olofinsan, Sunday O. Oyedemi, Chika I. Chukwuma, Adeline Lum Nde, Md. Shahidul Islam
Summary: Reduced glucose uptake and utilization has been linked to obesity and its complications. This study found that cannabinoid-stimulated glucose uptake increased antioxidative activities, modulated cholinergic and purinergic dysfunctions, and improved glucose-lipid homeostasis in adipose tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Marine & Freshwater Biology
Jiangong Jiang, Bingying He, Yimu Wei, Jingna Cui, Qiang Zhang, Xueke Liu, Donghui Liu, Peng Wang, Zhiqiang Zhou
Summary: This study investigated the potential toxic interactions of chlorpyrifos and p,p'-DDE on zebrafish. The results showed that the co-exposure of these pesticides resulted in significant additive acute toxic effects on adult zebrafish, as well as altered activity of antioxidant enzymes and decreased activity of certain enzymes related to detoxification. The bioaccumulation of these pesticides in co-exposure was significantly different from single exposure.
AQUATIC TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Jeonghyeon Kwon, Chungho Lee, Sungbaek Heo, Bobae Kim, Chang-Kee Hyun
Summary: The study reveals a potential molecular mechanism linking colitis, hepatic steatosis, and dyslipidemia, suggesting disrupted metabolic processes as a key factor in the comorbidity of NAFLD and IBD.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Marina Chaves de Oliveira, Ana Leticia Malheiros Silveira, Amanda Carla Clemente de Oliveira, Jaqueline Pereira Lana, Katia Anunciacao Costa, Erica Leandro Marciano Vieira, Vanessa Pinho, Mauro Martins Teixeira, Fatiha Merabtene, Genevieve Marcelin, Karine Clement, Adaliene Versiani Matos Ferreira
Summary: This study evaluated the participation of eosinophils in metabolic and adipose tissue homeostasis in mice and humans, showing that eosinophils play a role in controlling systemic and adipose tissue metabolic homeostasis by modulating glucose metabolism, inflammation, and visceral fat expansion. These findings provide important insights into the pathogenesis of obesity and metabolic-related diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Engineering, Environmental
Ho Ting Shiu, Xiaohan Pan, Qing Liu, KeKao Long, Kenneth King Yip Cheng, Ben Chi-Bun Ko, James Kar-Hei Fang, Yuyan Zhu
Summary: The health concerns of microplastics (MPs) and nanoplastics (NPs) have been increasing, but there is still a lack of key indicators to evaluate the adverse risks of MPs/NPs. This study demonstrates that fluorescent polystyrene nanoplastics (nPS) can distribute in white adipose tissue (WAT) of mice and reduce lipolysis under stimulation in vitro and ex vivo. Chronic oral exposure to nPS at relevant concentrations impairs lipid mobilization in obese mice, leading to larger adipocytes in WAT. Additionally, nPS exposure induces macrophage infiltration in the small intestine and increases lipid accumulation in the liver, disrupting systemic metabolism. These findings highlight the potential obesogenic role of nPS via diminishing lipid mobilization in WAT and suggest using lipolysis relevant parameters for evaluating the adverse effect of MPs/NPs in clinics.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Sang Joon Ahn, Elizabeth Le Master, James C. Lee, Shane A. Phillips, Irena Levitan, Ibra S. Fancher
Summary: Obesity-induced endothelial dysfunction varies in different adipose arteries, and disruption of the glycocalyx and loss of Kir channel flow sensitivity may contribute to the differences observed.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Iva Kladnicka, Miroslava Cedikova, Jan Jedlicka, Michaela Kohoutova, Ludek Muller, Iveta Plavinova, Michaela Kripnerova, Monika Bludovska, Jitka Kuncova, Dana Mullerova
Summary: This study evaluated the impact of exposure to p,p'-DDE on mitochondrial function in adipocytes, finding that low concentrations of p,p'-DDE increased basal mitochondrial respiration and ATP-linked oxygen consumption, while higher concentrations slowed down the normal increase in oxygen consumption during adipogenesis.
Article
Environmental Sciences
Annalise N. VonderEmbse, Sarah E. Elmore, Kyle B. Jackson, Beth A. Habecker, Katherine E. Manz, Kurt D. Pennell, Pamela J. Lein, Michele A. La Merrill
Summary: Exposure to DDTs or p,p'-DDE during the perinatal period impairs thermogenesis by interfering with sympathetic regulation of brown adipose tissue. This effect leads to long-term metabolic dysfunction in female mice. Additionally, alterations in synaptic connectivity in sympathetic circuits that regulate BAT were observed in mice exposed to DDTs or p,p'-DDE.
ENVIRONMENTAL HEALTH
(2021)
Article
Endocrinology & Metabolism
Ines Castela, Juliana Morais, Ines Barreiros-Mota, Marta P. Silvestre, Claudia Marques, Catarina Rodrigues, Shamila Ismael, Joao R. Araujo, Miguel angelo-Dias, Catarina Martins, Luis Miguel Borrego, Rosario Monteiro, Silvia Ribeiro Coutinho, Conceicao Calhau, Catia Martins, Ana Faria, Diogo Pestana, Diana Teixeira
Summary: This study found that the adiponectin/leptin ratio (AdipoQ/Lep) can be used as a biomarker of adipose tissue and metabolic function in adults with obesity and without diabetes. AdipoQ/Lep is associated with insulin resistance and correlates with obesity indices and anti-insulin hormone levels in the blood. These data highlight the role of adipocyte dysfunction in the pathogenesis of insulin resistance and suggest that AdipoQ/Lep may be a promising early marker of insulin resistance in adults with obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ningning Bai, Xuhong Lu, Li Jin, Miriayi Alimujiang, Jingyuan Ma, Fan Hu, Yuejie Xu, Jingjing Sun, Jun Xu, Rong Zhang, Junfeng Han, Cheng Hu, Ying Yang
Summary: CLSTN3 gene is routinely expressed in human white adipose tissue (WAT), predominantly enriched in the adipocyte fraction. The variant rs7296261 in the CLSTN3 locus is associated with a high risk of obesity, and its risk allele is linked to an increase in CLSTN3 expression in human WAT. Overexpression of CLSTN3 in inguinal WAT of mice results in dysfunctional expansion, liver steatosis, and systemic metabolic deficiency.
MOLECULAR METABOLISM
(2022)
Article
Cell & Tissue Engineering
Mengle Shao, Chelsea Hepler, Qianbin Zhang, Bo Shan, Lavanya Vishvanath, Gervaise H. Henry, Shangang Zhao, Yu A. An, Yibo Wu, Douglas W. Strand, Rana K. Gupta
Summary: Regional differences in adipose precursor cells' response to obesity are driven by HIF alpha-induced PDGFR beta signaling, leading to inhibitory phosphorylation of PPAR gamma. Suppression of HIF alpha promotes adipogenesis and improves metabolic health in obesity, with potential for pharmacological targeting of APCs to enhance metabolic health.
Article
Biochemistry & Molecular Biology
Clara Lefranc, Malou Friederich-Persson, Fabienne Foufelle, Aurelie Nguyen Dinh Cat, Frederic Jaisser
Summary: The study demonstrates that overexpression of MR in adipocytes can lead to mitochondrial dysfunction and cellular senescence, triggered by increased mitochondrial oxidative stress. This imbalance in mitochondrial dynamics and regeneration in the visceral adipose tissue results in aging and dysfunction, revealing new insights into the role of MR in adipose tissue dysfunction in obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Wojciech Myslinski
Summary: PVAT plays a significant role in regulating vascular tone, thermoregulation, and VSMC proliferation. Obesity-induced dysfunction can be improved by physical activity and diet interventions.
Review
Biochemistry & Molecular Biology
Valentina Annamaria Genchi, Erica Rossi, Celeste Lauriola, Rossella D'Oria, Giuseppe Palma, Anna Borrelli, Cristina Caccioppoli, Francesco Giorgino, Angelo Cignarelli
Summary: Obesity is associated with metabolic derangements and comorbidities, leading to impaired testicular function. Multiple mechanisms may negatively affect hypothalamic-pituitary-gonadal health. In addition, androgen deficiency may worsen obesity and exacerbate hypogonadism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marcelo V. Topete, Sara Andrade, Raquel L. Bernardino, Marta Guimaraes, Ana M. Pereira, Sofia B. Oliveira, Madalena M. Costa, Mario Nora, Mariana P. Monteiro, Sofia S. Pereira
Summary: Obesity is associated with changes in energy metabolism in adipose tissue. This study aimed to compare the energy metabolism and substrate preferences in visceral adipose tissue (VAT) between individuals with obesity class 2 and class 3. VAT from patients with obesity class 2 showed a higher dependence on glucose/pyruvate and glutamine metabolism, while VAT from patients with obesity class 3 had higher non-mitochondrial oxygen consumption. These findings suggest that patients with obesity class 2 may respond better to interventions targeting energy substrate modulation for obesity treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ines Castela, Juliana Morais, Ines Barreiros-Mota, Marta P. Silvestre, Claudia Marques, Catarina Rodrigues, Shamila Ismael, Joao R. Araujo, Miguel angelo-Dias, Catarina Martins, Luis Miguel Borrego, Rosario Monteiro, Silvia Ribeiro Coutinho, Conceicao Calhau, Catia Martins, Ana Faria, Diogo Pestana, Diana Teixeira
Summary: This study found that the adiponectin/leptin ratio (AdipoQ/Lep) can be used as a biomarker of adipose tissue and metabolic function in adults with obesity and without diabetes. AdipoQ/Lep is associated with insulin resistance and correlates with obesity indices and anti-insulin hormone levels in the blood. These data highlight the role of adipocyte dysfunction in the pathogenesis of insulin resistance and suggest that AdipoQ/Lep may be a promising early marker of insulin resistance in adults with obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Pediatrics
Isaac Barroso, Elisabete Ramos, Vanda Craveiro, Jao Tiago Guimaraes
Summary: This study examined the relationship between leukocytes and social and environmental determinants of health in adolescents. The results showed that adolescents with better socioeconomic conditions and those who participated in sports had lower levels of white blood cells, while those with chronic diseases or allergies had higher levels of white blood cells. In addition, an increase in body mass index and systemic inflammation was associated with higher levels of white blood cells.
ARCHIVES DE PEDIATRIE
(2023)
Article
Sport Sciences
Ivone Carneiro, Peter Krustrup, Carlo Castagna, Magni Mohr, Jose Magalhaes, Rita Pereira, Rute Santos, Sandra Martins, Joao Tiago Guimaraes, Eduardo Coelho, Susana Povoas
Summary: This study aimed to examine the dose-response of a recreational team handball exercise-based programme on cardiometabolic health and physical fitness in inactive middle-aged-to-elderly males without TH experience. The results showed that performing three 60-minute team handball exercise sessions per week can improve aerobic performance in middle-aged-to-elderly men, and it is more effective than training with a lower weekly frequency.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Sonia Soares, Francisca Rodrigues, Cristina Delerue-Matos
Summary: Honey is a widely consumed natural product with health benefits, and its environmental and ethical aspects influence consumer decision-making. Various methods, including DNA markers, have been developed to assess the quality and authenticity of honey. DNA metabarcoding has become particularly important for studying environmental and biodiversity aspects in honey.
Article
Horticulture
Catarina Macedo, Ana Margarida Silva, Ana Sofia Ferreira, Maria de la Luz Cadiz-Gurrea, Alvaro Ferandez-Ochoa, Antonio Segura-Carretero, Cristina Delerue-Matos, Paulo Costa, Francisca Rodrigues
Summary: Actinidia arguta fruit, also known as kiwiberry, is a promising source of bioactive compounds for health applications. This study aimed to determine the optimal extraction conditions of antioxidant/antiradical compounds from kiwiberry using the Response Surface Methodology. The optimal extract exhibited outstanding antioxidant, antiradical, and antimicrobial activities, and decreased the viability of human carcinoma cell lines.
SCIENTIA HORTICULTURAE
(2023)
Article
Biochemistry & Molecular Biology
Maria Luz Maia, Clara Grosso, M. Fatima Barroso, Aurora Silva, Cristina Delerue-Matos, Valentina Fernandes Domingues
Summary: This study characterized shrimp shell waste from Palaemon serratus and Palaemon varians from the Portuguese coast. The waste showed antioxidant and antimicrobial activities, as well as high levels of carotenoids. These findings are important in recognizing the potential value of shrimp shell waste as colorants and preservatives with antioxidant protection capacity in the food industry.
Article
Chemistry, Analytical
Shayesteh Bazsefidpar, Maria Freitas, Clara R. Pereira, Gemma Gutierrez, Esther Serrano-Pertierra, Henri P. A. Nouws, Maria Matos, Cristina Delerue-Matos, Maria Carmen Blanco-Lopez
Summary: In this paper, a method for effectively controlling Escherichia coli (E. coli) O157:H7 in milk samples was developed. Monodisperse Fe3O4@Au magnetic nanoparticles were synthesized and used in an electrochemical sandwich-type magnetic immunoassay for rapid and accurate analysis. The assay showed a linear range from 20 to 2 x 10(6) CFU/mL, with a limit of detection of 20 CFU/mL for E. coli O157:H7. The selectivity of the assay was tested and the applicability was demonstrated by analyzing a commercial milk sample.
Review
Chemistry, Analytical
Mariana Lamas, Francisca Rodrigues, Maria Helena Amaral, Cristina Delerue-Matos, Virginia Cruz Fernandes
Summary: Environmental pollution is a significant issue in our society, and it is important to understand its consequences, including increased contaminant cocktails in the environment. The contamination of honeybees can lead to contamination of their products, such as honey. Controlling the quality and safety of honey, including evaluating contaminants and following legislation, is crucial.
Review
Biochemistry & Molecular Biology
Ana Margarida Silva, Marco Preto, Clara Grosso, Monica Vieira, Cristina Delerue-Matos, Vitor Vasconcelos, Mariana Reis, Lillian Barros, Rosario Martins
Summary: Alzheimer's disease is a neurodegenerative disease that causes a decline in cognitive functions. It is the most common form of dementia and has no well-defined cause. Current treatments only manage to reduce symptoms, and there are only two drugs that can partially halt its progression. Natural compounds from mushrooms have been studied for their potential use in AD treatment due to their beneficial effects on various AD-related mechanisms such as enzyme inhibition, prevention of protein aggregation and neurotoxicity, and antioxidant and anti-inflammatory potential. While there have been studies linking mushrooms to neurodegenerative diseases, there is currently no publication summarizing the data specifically focused on AD. This review aims to fill that gap by compiling the potential anti-AD effects of mushroom extracts or compounds that target known AD-related mechanisms.
Article
Environmental Sciences
Sara Sousa, Diogo Pestana, Gil Faria, Cristina Delerue-Matos, Conceicao Calhau, Valentina Fernandes Domingues
Summary: This study found the presence of pollutants such as polychlorinated biphenyls, brominated flame retardants, and synthetic musks in the adipose tissue of obese women. These pollutants were found to be associated with various biochemical parameters related to metabolic processes. Synthetic musks behave differently than other pollutants and their impact on human health is still poorly understood.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Stephanie L. Morais, Julia M. C. S. Magalhaes, Valentina F. Domingues, Cristina Delerue-Matos, Joilson Ramos-Jesus, Hygor Ferreira-Fernandes, Giovanny R. Pinto, Marlene Santos, M. Fatima Barroso
Summary: Cardiovascular diseases are a significant cause of death and illness. Warfarin is commonly used to treat these conditions, but its dosage variability can lead to complications such as hemorrhage or thromboembolism. The Cytochrome P450 (CYP) 2C9*3 genetic polymorphism contributes to this variability by modifying the enzymatic activity and plasmatic concentration of warfarin. Therefore, it is crucial to have a selective, rapid, low-cost, and real-time detection device before prescribing warfarin. In this study, a disposable electrochemical DNA-based biosensor capable of detecting CYP2C9*3 polymorphism was developed.
Article
Biochemistry & Molecular Biology
Filipa Teixeira, Ana Margarida Silva, Stefania Sut, Stefano Dall'Acqua, Cristina Delerue-Matos, Berta Estevinho, Paulo C. Costa, Francisca Rodrigues
Summary: The aim of this study was to produce polymeric particles of Actinidia arguta leaves extract by spray-drying to improve the condition of oral mucositis. The results showed that the extract microparticles had good antioxidant and antiradical activities, and no adverse effects on oral cells, highlighting their potential applications in the pharmaceutical and nutraceutical industries.
Article
Food Science & Technology
Elsa F. Vieira, Ana Q. Fontoura, Cristina Delerue-Matos
Summary: Chayote seed protein isolates were prepared using alkaline extraction and ultrasonic-assisted extraction. The ultrasonic-assisted extraction significantly improved the protein extraction yield and functional properties. Chayote seed protein isolates obtained by ultrasonic-assisted extraction showed high nutritional and commercial value.
Article
Biology
Isabella Bracchi, Juliana Guimaraes, Catarina Rodrigues, Rui Azevedo, Claudia Matta Coelho, Catia Pinheiro, Juliana Morais, Ines Barreiros-Mota, Virginia Cruz Fernandes, Cristina Delerue-Matos, Edgar Pinto, Andre Moreira-Rosario, Luis Filipe Ribeiro de Azevedo, Claudia Camila Dias, Jorge Lima, Ines Sapinho, Carla Ramalho, Conceicao Calhau, Joao Costa Leite, Agostinho Almeida, Diogo Pestana, Elisa Keating
Summary: This study aimed to evaluate the role of essential trace elements in pregnancy health. The findings suggest that high urinary zinc levels increase the risk of pre-eclampsia, but decrease the risk of small head circumference at birth.
Article
Environmental Sciences
Luisa Correia-Sa, Virginia C. Fernandes, Maria Luz Maia, Edgar Pinto, Sonia Norberto, Agostinho Almeida, Cristina Santos, Cristina Delerue-Matos, Conceicao Calhau, Valentina F. Domingues
Summary: This study evaluated the exposure of Portuguese children to environmental chemicals through urine analysis and identified predictors of exposure. The results showed that region, age, diet, and weight group were significant predictors of urinary concentrations of certain elements.