Article
Medicine, Research & Experimental
Tomas Perecko, Zuzana Hoferova, Michal Hofer, Jana Pereckova, Martin Falk
Summary: Nitro-oleic acid (NO(2)OA) has shown to have protective effects against radiation-induced hematopoietic injury by increasing bone marrow cellularity and promoting recovery of white blood cells post irradiation.
Article
Biochemistry & Molecular Biology
Diaoyun Luo, Zhiqing Huang, Gang Jia, Hua Zhao, Guangmang Liu, Xiaoling Chen
Summary: The aim of this study was to investigate the effect of naringin on LPS-induced jejunum barrier function. Results showed that LPS disrupted the barrier function and resulted in changes in inflammatory response and oxidative stress. Naringin treatment attenuated LPS-induced damage by inhibiting inflammation, improving antioxidant function, and enhancing intestinal tight junctions.
Article
Immunology
Domonkos Czaran, Peter Sasvari, Adam Istvan Horvath, Krisztina Ella, Agnes Reka Sudy, Eva Borbely, Kitti Rusznak, Boldizsar Czeh, Attila Mocsai, Zsuzsanna Helyes, Roland Csepanyi-Komi
Summary: This study demonstrates that ARHGAP25 plays a crucial role in the pathomechanism of autoantibody-induced arthritis by regulating inflammation through the I-kappa B/NF-kappa B/IL-1 beta axis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Lydia Bensemmane, Claire Squiban, Christelle Demarquay, Noelle Mathieu, Marc Benderitter, Bernard Le Guen, Fabien Milliat, Christine Linard
Summary: The study demonstrates that stromal vascular fraction (SVF) derived from adipose tissue can effectively treat GIS after abdominal radiation by promoting intestinal regeneration and reducing mortality in mice through anti-inflammatory effects.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Andrea I. Luppi, Justine Y. Hansen, Ram Adapa, Robin L. Carhart-Harris, Leor Roseman, Christopher Timmermann, Daniel Golkowski, Andreas Ranft, Rudiger Llg, Denis Jordan, Vincent Bonhomme, Audrey Vanhaudenhuyse, Athena Demertzi, Oceane Jaquet, Mohamed Ali Bahri, Naji L. N. Alnagger, Paolo Cardone, Alexander R. D. Peattie, Anne E. Mantelow, Draulio B. de Araujo, Rudlger Ilg, Stefano L. Sensi, Adrian M. Owen, Lorina Naci, David K. Melon, Bratislav Misic, Emmanuel A. Stamatakis
Summary: In order to understand how pharmacological interventions affect brain function, this study investigates the relationship between the distribution of neurotransmitter receptors and transporters in the brain and the changes in functional connectivity induced by psychoactive drugs. The results show that there is a correlation between the effects of drugs on brain function and multiple neurotransmitter systems. Additionally, the effects of anesthetics and psychedelics are organized along hierarchical gradients of brain structure and function. The study also highlights the similarity between regional susceptibility to drug interventions and disorder-induced structural alterations.
Article
Chemistry, Multidisciplinary
Min-Sik Kim, Dong-Hwan Choi, In-Ho Lee, Wu-Sin Kim, Duhyuk Kwon, Myung-Ho Bae, Ju-Jin Kim
Summary: In this study, researchers report reversible electrical phase transitions in Mo0.67W0.33Se2 (MoWSe) materials, which can be tuned by gate voltage. Electrical current resumes flow in the gate-induced depletion region of the 2H phase when the temperature decreases between 150 K and 200 K. Additionally, the formation of conducting channels and negative differential transconductance were observed. Hysteresis measurements confirm the reversibility of the electrical phase transition behavior.
Article
Immunology
Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun, Yuchen Zhou, Patrick P. McDonald, Walter R. Perkins, David C. Cipolla
Summary: Neutrophil serine proteases (NSPs) released by neutrophils have been implicated in systemic lupus erythematosus and lupus nephritis. In this study, a DPP1 inhibitor called brensocatib was found to reduce kidney damage and improve renal function in a mouse model, suggesting the potential for DPP1 inhibition in the treatment of lupus nephritis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Physiology
Sydney Weber Boutros, Benjamin Zimmerman, Sydney C. Nagy, Joanne S. Lee, Ruby Perez, Jacob Raber
Summary: The study assessed the potential of amifostine to mitigate cognitive injury induced by simulated GCRs. The results showed that amifostine could alleviate radiation-induced cognitive effects in male mice, but had different impacts on females.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Food Science & Technology
Siyu Wei, Jiaojiao Wang, Cheng Wang, Yizhen Wang, Mingliang Jin
Summary: Inulin alleviates obesity and metabolic disorders induced by high fructose through modulating gut microbiota and serum metabolites.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Dhafer Y. Alhareth, Abdulrazaq Alanazi, Wael A. Alanazi, Mushtaq A. Ansari, Mahmoud N. Nagi, Sheikh F. Ahmad, Mohamed S. M. Attia, Ahmed Nadeem, Saleh A. Bakheet, Sabry M. Attia
Summary: This study found that the proteasome inhibitor carfilzomib can protect against acute liver failure (ALF) induced by LPS/GalN/DMSO in mice by inhibiting NF-kB, reducing inflammatory mediators, oxidative stress, and apoptosis, suggesting its potential as a therapeutic agent for ALF.
Article
Food Science & Technology
Fangfang Min, Jielun Hu, Yadong Zhong, Tao Huang, Yousheng Huang, Shaoping Nie, Tao Xiong, Mingyong Xie
Summary: A previous study found that L. plantarum NCU1125, derived from fermented Nanfeng mandarin, survived in vitro simulated gastrointestinal digestion, suggesting potential probiotic properties. The current study demonstrated that L. plantarum NCU1125 could repair the intestinal physical barrier, strengthen the immunologic barrier, and reshape the microbial barrier. It also activated the TLR4/MyD88/NF-kappa B pathway and controlled intestinal inflammation.
Article
Behavioral Sciences
Yue Zhang, Jianguo Feng, Cehua Ou, Xue Zhou, Yonghong Liao
Summary: Neuropathic pain-induced cognitive impairment is associated with decreased expression of AQP4 protein and mRNA. AQP4 overexpression can restore cognitive deficits in mice. Furthermore, AQP4 overexpression also reduces the concentration of A beta 1-42 in the serum and hippocampus. In conclusion, AQP4 in astrocytes plays an important role in mitigating cognitive impairment caused by chronic neuropathic pain.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff, Hong Chen
Summary: By using ultrasound to activate specific neurons in the hypothalamus, researchers have successfully induced a torpor-like state in rodents, characterized by hypothermia and reduced metabolic rate. This noninvasive technique involves closed-loop feedback control of ultrasound stimulation and automated detection of body temperature. The study identifies TRPM2 as an ultrasound-sensitive ion channel in the hypothalamus preoptic area, and demonstrates the feasibility of ultrasound-induced hypothermia and hypometabolism in non-torpid animals.
Article
Cell Biology
Yuanyang Zhang, Yinping Dong, Ping Lu, Xinyue Wang, Wenxuan Li, Hui Dong, Saijun Fan, Deguan Li
Summary: UroA, a metabolite of ellagitannin from fruits like pomegranates, shows radioprotective effects by improving survival rates in irradiated mice, enhancing intestinal morphology and regeneration, and reducing apoptosis of enterocytes induced by radiation. Additionally, UroA helps in the recovery of intestinal microbiota changes caused by ionizing radiation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Qing Shen, Guo Zhang
Summary: This study demonstrates the important role of neuroinflammation involving microglia in obesity-related cerebrovascular dysfunction, with PLX3397 treatment improving brain artery function in mice, and excessive IL-18 leading to vascular dysfunction in the mouse brain.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Chemistry, Medicinal
Jayadev Joshi, Manali Dimri, Subhajit Ghosh, Nitisha Shrivastava, Rina Chakraborti, Neeta Sehgal, Jharna Ray, Indracanti Prem Kumar
CURRENT COMPUTER-AIDED DRUG DESIGN
(2015)
Article
Immunology
Subhajit Ghosh, Namita Indracanti, Jayadev Joshi, Prem Kumar Indraganti
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Engineering, Environmental
Anasuya Roy, Mangala Joshi, B. S. Butola, Subhajit Ghosh
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Oncology
Jian L. Campian, Subhajit Ghosh, Vaishali Kapoor, Ran Yan, Sukrutha Thotala, Arijita Jash, Tong Hu, Anita Mahadevan, Kasem Rifai, Logan Page, Byung Ha Lee, Sara Ferrando-Martinez, Alexandra A. Wolfarth, Se Hwan Yang, Dennis Hallahan, Milan G. Chheda, Dinesh Thotala
Summary: In this study, NT-17 was found to prevent systemic lymphopenia in GBM patients receiving radiotherapy and temozolomide, while improving survival. Furthermore, NT-17 increased cytotoxic CD8 T lymphocytes in lymphoid organs and tumor.
CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Subhajit Ghosh, Jiayi Huang, Matthew Inkman, Jin Zhang, Sukrutha Thotala, Ekaterina Tikhonova, Natalia Miheecheva, Felix Frenkel, Ravshan Ataullakhanov, Xiaowei Wang, David DeNardo, Dennis Hallahan, Dinesh Thotala
Summary: Severe and prolonged lymphopenia often occurs in glioblastoma patients after standard chemoradiotherapy, and it is associated with worse survival. A correlative study was conducted on 20 patients with glioblastoma to investigate the underlying biological mechanism of lymphopenia. The study revealed an elevated concentration of myeloid-derived suppressor cell (MDSC) regulatory genes in patients with lymphopenia after chemoradiotherapy. Further analysis confirmed increased numbers of circulating MDSC in these patients, and preclinical models demonstrated a causal relationship between radiation-induced MDSC and systemic lymphopenia. Pharmacological inhibition of MDSC effectively prevented radiation-induced lymphopenia and improved survival in the models, suggesting the potential of CB1158 and tadalafil as drugs for reducing lymphopenia in glioblastoma patients.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Liyun Chen, Victoria Shi, Songyan Wang, Lulu Sun, Rebecca Freeman, Jasmine Yang, Matthew J. Inkman, Subhajit Ghosh, Fiona Ruiz, Kay Jayachandran, Yi Huang, Jingqin Luo, Jin Zhang, Pippa Cosper, Clifford J. Luke, Catherine S. Spina, Perry W. Grigsby, Julie K. Schwarz, Stephanie Markovina
Summary: Patients with high levels of SERPINB3 in their serum commonly experience treatment resistance and poor prognosis in cancer. The role of SERPINB3 in tumor immunity is not well understood. Through experiments on human primary cervical tumors and mouse models, it was found that SERPINB3 promoted myeloid cell infiltration and inhibited T cell function, leading to treatment resistance. Inhibition of SERPINB3 enhanced cytotoxic T cell function and improved the response to radiotherapy. These findings suggest that targeting SERPINB3 may be a potential strategy to counteract immunosuppression and improve treatment response in tumors.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Meeting Abstract
Oncology
Subhajit Ghosh, Matthew Inkman, Jin Zhang, Sukrutha Thotala, Ekaterina Tikhonova, Natalia Miheecheva, Felix Frenkel, Ravshan Ataullakhanov, Xiaowei Wang, Dennis Hallahan, Jiayi Huang, Dinesh Thotala
Meeting Abstract
Oncology
Subhajit Ghosh, Ran Yan, Sukrutha Thotala, Arijita Jash, Anita Mahadevan, Tong Hu, Byung Lee, Se Hwan Yang, Dennis Hallahan, Milan Chheda, Dinesh Thotala, Jian Campian
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Meeting Abstract
Oncology
Subhajit Ghosh, Ran Yan, Sukrutha Thotala, Arijita Jash, Anita Mahadevan, Tong Hu, Byung Ha Lee, Se Hwan Yang, Dennis Hallahan, Milan Chheda, Dinesh Thotala, Jian Campian
Article
Chemistry, Medicinal
Jayadev Joshi, Tapan K. Barik, Nitisha Shrivastava, Manali Dimri, Subhajit Ghosh, Rahul S. Mandal, Srinivasan Ramachandran, Indracanti P. Kumar
CURRENT COMPUTER-AIDED DRUG DESIGN
(2013)