Article
Chemistry, Physical
Hedyeh Rahmani, Samira Mansouri Majd, Abdollah Salimi
Summary: Since the evaluation of CA 19-9 antigen level in human serum is important for the early diagnosis of various diseases, researchers developed a simple, rapid, and sensitive immunosensor using an electrolyte-gated field-effect transistor with MoS2 nanosheets. The immunosensor showed high selectivity and accurately detected trace amounts of the CA 19-9 antigen in real human serum samples. Its properties enable the early diagnosis of pancreatic cancer, increasing the chance of successful treatment.
Article
Oncology
Liva K. K. Stuhr, Kasper Madsen, Astrid Z. Z. Johansen, Inna M. M. Chen, Carsten P. P. Hansen, Lars H. H. Jensen, Torben F. F. Hansen, Kirstine Klove-Mogensen, Kaspar R. R. Nielsen, Julia S. S. Johansen
Summary: The CA 19-9 blood test has been widely used as a biomarker for pancreatic ductal adenocarcinoma (PDAC), but new biomarkers are needed to improve diagnosis. In this study, we found that combining the CA 19-9 test with the sCD163 blood test provided better diagnostic results compared to CA 19-9 alone. These findings suggest that sCD163 could be a valuable diagnostic marker for PDAC.
Article
Chemistry, Analytical
Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Vahid Rahmanian, Masoomeh Yari Kalashgrani, Ahmad Gholami, Navid Omidifar, Wei-Hung Chiang
Summary: This article discusses the application of surface-enhanced Raman spectroscopy (SERS) in COVID-19 virus detection. Flexible SERS substrates, known for their sensitivity and flexibility, are crucial for the development of high-quality virus detection platforms. The article also explores the potential impact of ultrasensitive detection methods based on flexible SERS substrates on disease diagnosis, control, and surveillance.
Article
Gastroenterology & Hepatology
Johannes F. Fahrmann, C. Max Schmidt, Xiangying Mao, Ehsan Irajizad, Maureen Loftus, Jinming Zhang, Nikul Patel, Jody Vykoukal, Jennifer B. Dennison, James P. Long, Kim-Anh Do, Jianjun Zhang, John A. Chabot, Michael D. Kluger, Fay Kastrinos, Lauren Brais, Ana Babic, Kunal Jajoo, Linda S. Lee, Thomas E. Clancy, Kimmie Ng, Andrea Bullock, Jeanine Genkinger, Michele T. Yip-Schneider, Anirban Maitra, Brian M. Wolpin, Samir Hanash
Summary: CA19-9 serves as an anchor marker for pancreatic cancer early detection, especially with exponentially increasing levels starting 2 years before diagnosis, providing significant value for early diagnosis.
Article
Biochemistry & Molecular Biology
Nima Sayyadi, Sareh Zhand, Sajad Razavi Bazaz, Majid Ebrahimi Warkiani
Summary: The study proposes a novel strategy of using Affibody functionalized microbeads (AffiBeads) for exosome detection with a high degree of efficiency. Results showed that the Affibody probe had a detection limit of 15.6 ng exosomes per mL (~12 exosomes per AffiBead), providing a basis for early-stage cancer diagnosis by sensitive detection of low expression level markers on tumor-derived exosomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Inseon Lee, Seok-Joon Kwon, Mirco Sorci, Peter S. Heeger, Jonathan S. Dordick
Summary: This study utilized CRISPR technology and immunoassay methods to detect the protein CXCL9 in the urine of kidney transplant recipients, demonstrating improved sensitivity and accuracy of detection through enhanced DNA barcode system and Cas12a enzyme trans-cleavage activity, while showing high selectivity.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Chaohui Zhou, Zhongyun Chu, Wenyue Hou, Xiuying Wang
Summary: Lanthanide-doped upconversion nanoparticles (UCNPs) have been widely studied for their excellent optical properties in biological detection. In this work, a UCNP-linked immunosorbent assay (ULISA) was developed for sensitive detection of carbohydrate antigen 19-9 (CA19-9). Compared with traditional ELISA, this ULISA system showed higher sensitivity and wider detection range, offering a potential new avenue for clinical applications using UCNPs as signal transducers.
FRONTIERS IN CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung-Seob Kim, Sunyoung Lee, Hee Seung Lee, Seungmin Bang, Kyunghwa Han, Mi-Suk Park
Summary: This study investigated the effectiveness of combined CT and carbohydrate antigen 19-9 (CA 19-9) evaluation at 8 weeks after first-line treatment for predicting overall survival (OS) in patients with nonmetastatic pancreatic ductal adenocarcinoma (PDAC). The results showed that integrated evaluation with CT and CA 19-9 response allowed more accurate stratification and prediction of survival in these patients.
Article
Biochemical Research Methods
Rui Guan, Qi Yu, Junrong Li
Summary: The implementation of early cancer detection through the detection of rare circulating biomarkers in body fluids has greatly improved treatment outcomes and survival rates. Spectroscopic technologies, especially aggregation-enhanced fluorescence and Raman technologies, play a crucial role in sensitive biomarker measurements by outputting extremely strong signals, showing great promise for early cancer detection.
Article
Chemistry, Analytical
Hao Ji, Zhenhua Wang, Shun Wang, Chao Wang, Kai Zhang, Yu Zhang, Lin Han
Summary: In this study, a high-performance InSe-FET biosensor is developed for the detection of the CA125 biomarker in clinical samples. The biosensor is integrated with a homemade microfluidic channel, which provides good electrical stability during the liquid channel process. It is capable of quantitatively detecting the CA125 biomarker in breast cancer within the range of 0.01-1000 U/mL, with a detection time of 20 minutes. This work provides a universal detection tool for protein biomarker sensing and shows promising application in early screenings of major diseases.
Article
Chemistry, Analytical
Chun Dai, Kun Wang, Ming Tan, Zhaolai Hua, Lin Xia, Lei Qin
Summary: In this study, a capillary pump-driven surface-enhanced Raman scattering (SERS) microfluidic chip (LoC-SERS) platform was developed for the sensitive detection of colorectal cancer-associated (CRC) microRNA (miRNA). The platform achieved ultra-low detection limits of miR-122 (4.26 aM) and miR-192 (4.71 aM) within a linear range of 10 aM-10 pM. The results of the platform for clinical samples are highly consistent with those measured by qRT-PCR methods.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Multidisciplinary
Jie Liang, William G. G. Tong
Summary: The carbohydrate antigen 19-9 (CA 19-9) serves as a commonly used biomarker for diagnosing pancreatic cancer. Multiphoton nonlinear laser wave-mixing spectroscopy is proposed as an extremely sensitive detection method for CA 19-9. This method allows for the detection of CA 19-9 without labels or with labeled samples, offering advantages such as short optical path length and high spatial resolution. The wave-mixing signal exhibits a quadratic dependence on sample concentration, making it an ideal sensor for monitoring small changes in the sample. When combined with capillary electrophoresis, laser wave-mixing spectroscopy provides enhanced selectivity levels for protein detection, surpassing the detection limits of chemiluminescence- or ELISA-based methods.
Article
Chemistry, Analytical
Yuselis Castano-Guerrero, Yonny Romaguera-Barcelay, Felismina Teixeira Coelho Moreira, Walter Ricardo Brito, Elvira Fortunato, Maria Goreti Ferreira Sales
Summary: Polythionine (PTH) is an electroactive compound known for its excellent electron transfer capacity. It has been widely used in various fields, including electrochemical biosensors. This study explores the ability of PTH as an electrochemical probe to detect CA 19-9 on different substrates and provides analytical features and potential complementary information applications.
Article
Oncology
Timothy P. DiPeri, Timothy E. Newhook, Laura R. Prakash, Naruhiko Ikoma, Jessica E. Maxwell, Michael P. Kim, Jeffrey E. Lee, Matthew H. G. Katz, Ching-Wei D. Tzeng
Summary: This study compared the normalization of serum carbohydrate 19-9 (CA19-9) levels before and after surgery in patients with pancreatic adenocarcinoma (PDAC) who underwent neoadjuvant therapy (NT) versus surgery-first (SF). The results showed that normal pre/postoperative CA19-9 was associated with better recurrence-free survival (RFS) and overall survival (OS). Nearly 30% of SF patients failed to achieve postoperative CA19-9 normalization. NT should be considered for patients with elevated CA19-9 levels, and ideal SF patients may have normal CA19-9 levels at presentation.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Chemistry, Analytical
Hedyeh Rahmani, Samira Mansouri Majd, Abdollah Salimi, Foad Ghasemi
Summary: Measuring CA 19-9 antigen level plays a critical role in early diagnosis, treatment monitoring, and disease recurrence prediction of pancreatic cancer. This research assesses the application of few-layered TiS3 nanoribbons as a channel material in an immunosensor for rapid detection of CA 19-9 antigen. The results show the potential of the developed immunosensor for cancer diagnosis and therapeutic monitoring.
Review
Chemistry, Multidisciplinary
Qianfan Jiang, Chengyu Ji, D. Jason Riley, Fang Xie
Article
Nanoscience & Nanotechnology
Jing S. Pang, Ioannis G. Theodorou, Anthony Centeno, Peter K. Petrov, Neil M. Alford, Mary P. Ryan, Fang Xie
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Multidisciplinary
Miguel A. Gomez-Gonzalez, Mohamed A. Koronfel, Angela Erin Goode, Maryam Al-Ejji, Nikolaos Voulyoulis, Julia E. Parker, Paul D. Quinn, Thomas Bligh Scott, Fang Xie, Marian L. Yallop, Alexandra E. Porter, Mary P. Ryan
Article
Chemistry, Physical
Qianfan Jiang, Xiangyu Xie, D. Jason Riley, Fang Xie
JOURNAL OF CHEMICAL PHYSICS
(2020)
Review
Physics, Applied
Savita M. Sundaresan, S. M. Fothergill, Tanveer A. Tabish, Mary Ryan, Fang Xie
Summary: Early diagnosis of diseases is crucial for conservative treatment and better patient outcomes. Fluorescence biosensing, utilizing aptamers and metal enhanced fluorescence techniques, offers high sensitivity detection of biomarkers, showing great potential in clinical applications.
APPLIED PHYSICS REVIEWS
(2021)
Article
Physics, Applied
Jiamin Xu, William Morton, Daniel Jones, Tanveer A. Tabish, Mary P. Ryan, Fang Xie
Summary: This study presents a unique silica template method for synthesizing cetrimonium bromide free silver nanorods (AgNRs), and explores the application of AgNRs in metal enhanced fluorescence (MEF). The results demonstrate that AgNRs can significantly increase the quantum yield and enhance the fluorescence intensity of visible/near-infrared fluorescent dyes.
APPLIED PHYSICS REVIEWS
(2022)
Article
Chemistry, Physical
William Morton, Caoimhe Joyce, Jonny Taylor, Mary Ryan, Stefano Angioletti-Uberti, Fang Xie
Summary: The research findings suggest that the geometric properties of gold nanostars can be referenced, similar to the way a nanosphere can be described by its radius, instead of solely relying on the local surface plasmon resonance (LSPR) of the structure. The suggested average tip approximation simplifies the complex nature of nanostars in simulations. By comparing the characteristics of modeled nanostars to synthesized nanostars, the volume, surface area, and number of tips can be approximated without the need for extensive characterization. Understanding the nanoparticle geometry can have implications for drug delivery capacity, identification of hot spots for electron microscopy imaging, and the interaction of particles with cells.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Physical
Hao Zhang, Jiefeng Diao, Mengzheng Ouyang, Hossein Yadegari, Mingxuan Mao, Mengnan Wang, Graeme Henkelman, Fang Xie, D. Jason Riley
Summary: In this study, trimetallic heterostructured core-shell nanoboxes based on Prussian blue analogues (Ni-Co@Fe-Co PBA) were synthesized and showed remarkable electrocatalytic performance for the hydrogen evolution reaction (HER) in alkaline freshwater and simulated seawater.
Article
Chemistry, Physical
Tian Tian, Jiamin Xu, Ying Xiong, Nitya Ramanan, Mary Ryan, Fang Xie, Camille Petit
Summary: Study finds that metal-organic frameworks can serve as precursors for metal-functionalized porous boron nitride, expanding the potential of porous boron nitride in catalysis and optical applications. The type of metal in the MOF precursor also impacts the purity of the porous boron nitride.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Multidisciplinary
Darinka Primc, Luca Indrizzi, Elena Tervoort, Fang Xie, Markus Niederberger
Summary: Mesocrystals are superstructures of crystallographically aligned nanoparticles displaying advanced morphologies and properties beyond those from size and shape alone. The first synthesis of Cu3N mesocrystals with structure-directing agents and subtle tuning of reaction parameters is reported. Detailed structural characterizations reveal non-classical crystallization of Cu3N mesocrystals and variations in sizes and morphologies traced back to distinct attachment scenarios of subunits. Conversion processes of Cu3N mesocrystals into multicomponent/heterostructured Cu3N-Cu2O mesocrystals and subsequently into Cu2O nanocages involve a two-step mechanism driven by nanoscale Kirkendall effect.
Article
Materials Science, Multidisciplinary
C. Joyce, S. M. Fothergill, F. Xie
MATERIALS TODAY ADVANCES
(2020)
Article
Chemistry, Multidisciplinary
Rosalia Lopes Rodrigues, Fang Xie, Alexandra E. Porter, Mary P. Ryan
NANOSCALE ADVANCES
(2020)
Article
Chemistry, Multidisciplinary
Ke Wang, Chang Li, Zheng Li, Huizeng Li, An Li, Kaixuan Li, Xintao Lai, Qing Liao, Fang Xie, Mingzhu Li, Yanlin Song
Article
Chemistry, Multidisciplinary
Pakatip Ruenraroengsak, Darya Kiryushko, Ioannis G. Theodorou, Michal M. Klosowski, Erik R. Taylor, Thisa Niriella, Carlo Palmieri, Ernesto Yague, Mary P. Ryan, R. Charles Coombes, Fang Xie, Alexandra E. Porter
Article
Chemistry, Multidisciplinary
Ioannis G. Theodorou, Pakatip Ruenraroengsak, Daniel A. Gonzalez-Carter, Qianfan Jiang, Ernesto Yague, Eric O. Aboagye, R. Charles Coombes, Alexandra E. Porter, Mary P. Ryan, Fang Xie