Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-05372-3
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Funding
- National Natural Foundation of China [81402803]
- Research Foundation for the Educational Commission of Sichuan Province [15TD0048]
- Applied Basic Research of Sichuan Province [2014JY0125]
- Fundamental Research Funds for the Central Universities [2682015ZT04]
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Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C-20-diterpenoid alkaloids (anthriscifolsines A-C, 1-3), six new C-19-diterpenoid alkaloids (anthriscifolrines A-F, 4-9), and five know compounds (10-14). Among them, anthriscifolsine A represents a novel C-20-diterpenoid alkaloid characterized by a seco C-ring. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including HR-ESI-MS, X-ray, and 1D and 2D NMR experiments. Bioactivity of compounds 3-6 was evaluated for their cytotoxicity against the MCF-7, HepG2 and H460 cancer cell lines.
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