Article
Physiology
Eemu-Samuli Valiaho, Jukka A. Lipponen, Pekka Kuoppa, Tero J. Martikainen, Helena Jantti, Tuomas T. Rissanen, Maaret Castren, Jari Halonen, Mika P. Tarvainen, Tiina M. Laitinen, Tomi P. Laitinen, Onni E. Santala, Olli Rantula, Noora S. Naukkarinen, Juha E. K. Hartikainen
Summary: A study evaluated the feasibility of continuous photoplethysmogram (PPG) for atrial fibrillation (AF) detection. The results showed that continuous PPG can provide reliable AF identification during both daytime and nighttime, with better PPG data quality at night. Users had a positive experience with the device.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Chemistry, Analytical
Fangfang Jiang, Yihan Zhou, Tianyi Ling, Yanbing Zhang, Ziyu Zhu
Summary: Atrial fibrillation is a common cardiac arrhythmia that can lead to various cardiac conditions. As the morbidity and mortality of AF continue to increase, there is growing interest in unobtrusive methods for detecting AF in daily life. The use of cardiac dynamics signals for AF detection has garnered extensive attention in recent research.
Article
Genetics & Heredity
Bo Hu, Wen Ge, Yuliang Wang, Xiaobin Zhang, Tao Li, Hui Cui, Yongjun Qian, Yangyang Zhang, Zhi Li
Summary: Atrial fibrillation (AF) is associated with an increased risk of heart failure, dementia, and stroke. Proteomics and metabolomics analyses revealed distinct metabolite and protein profiles between valvular and non-valvular AF patients, indicating potential different mechanisms underlying the two types of AF. The study identified specific biomarkers and metabolic pathways associated with each type of AF, providing insights for prognosis and potential treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Biology
Gema Prats-Boluda, Maria S. Guillem, Miguel Rodrigo, Ye-Lin Yiyao, Javier Garcia-Casado
Summary: Due to the increasing prevalence of atrial fibrillation, accurate diagnosis and treatment are crucial. In this study, the use of body surface Laplacian potential mapping with BC-ECG signals showed better performance in detecting and quantifying atrial fibrillation activity compared to conventional unipolar signals.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Engineering, Biomedical
Zhihao Zhang, Simin Kang, Jifan Yu, Heyang Li, Gaohan Yin, Hongxing Zhang, Li Sun, Dangxiao Wang
Summary: This study proposes a quantitative approach for identifying ADHD tendency based on fingertip pressing force control paradigm with immersive visual feedback. By extracting nine behavioral features from reaction time and dynamic force fluctuation features, the proposed method can effectively capture the continuous changes in attention levels for ADHD diagnosis. The support vector machine (SVM) based classifier achieved an accuracy of 78.5% for ADHD diagnosis.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Jorge N. Dominguez, Valeria Lodde, Rachel Munk, Kotb Abdelmohsen, Myriam Gorospe, Veronica Jimenez-Sabado, Antonino Ginel, Leif Hove-Madsen, Amelia E. Aranega, Diego Franco
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. Recent research shows that the Pitx2 transcription factor plays a crucial role in regulating the expression of growth factors, microRNAs, and ion channels, which contribute to the onset of AF. Additionally, several lncRNAs have been discovered to be involved in AF development and are regulated by different signaling pathways.
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Neurosciences
Yingliang Zhao, Yanyun Che, Qiming Liu, Shenghua Zhou, Yichao Xiao
Summary: This study explores the role of m6A regulatory genes in atrial fibrillation (AF) and classifies AF patients into subtypes using genotyping methods. The research shows that m6A regulatory genes play a significant role in the development of AF, and a nomogram model using five feature genes can predict the incidence of AF. Two m6A modification patterns are identified and comprehensively evaluated, providing insights into the classification and treatment of AF patients.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Wen-Rui Shi, Shao-Hui Wu, Guang-Chen Zou, Kai Xu, Wei-Feng Jiang, Yu Zhang, Mu Qin, Xu Liu
Summary: This study used multiscale entropy (MSE) analysis to guide catheter ablation for persistent atrial fibrillation (PsAF) and predict ablation outcomes. The results showed that the RA < LA mMSE gradient before ablation could predict freedom from arrhythmia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Bader Aldughayfiq, Farzeen Ashfaq, N. Z. Jhanjhi, Mamoona Humayun
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia with significant health risks. This study focuses on using photoplethysmogram (PPG) time series data and deep learning to classify AF and non-AF cases, taking advantage of the accessibility and ease of use of non-invasive methods such as Electrocardiogram (ECG) and PPG. The hybrid 1D CNN and BiLSTM model achieved a high accuracy of 95% in identifying AF, demonstrating its strong performance and reliable predictive capabilities.
Article
Cardiac & Cardiovascular Systems
Alanna M. Chamberlain, Veronique L. Roger, Peter A. Noseworthy, Lin Y. Chen, Susan A. Weston, Ruoxiang Jiang, Alvaro Alonso
Summary: This study developed simple computable phenotypes for atrial fibrillation using electronic medical record data. However, using diagnostic codes to identify incident atrial fibrillation is prone to some misclassification. Further research is needed to determine if more complex phenotypes, including unstructured data sources or machine learning techniques, can improve the accuracy of identifying incident atrial fibrillation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Chemistry, Multidisciplinary
Yan Yu, Sheng Wang, Yang Luo, Chang Gu, Xin Shi, Feng Shen
Summary: Methylation is an essential epigenetic modification involved in regulating gene expression and maintaining genome stability. Current methods of methylation analysis face limitations of high cost, time-consuming workflows, and difficulty in accurate heterogeneity analysis and precise quantification. A droplet array SlipChip-based digital melting curve analysis (MCA) method was developed for accurate quantification of both methylation level and density. This method has been demonstrated to distinguish healthy individuals from patients with atrial fibrillation and holds potential for broader application in various research and clinical settings requiring methylation analysis.
Article
Genetics & Heredity
Yubin Chen, Tianyu Ouyang, Yue Yin, Cheng Fang, Can-E Tang, Jingmin Luo, Fanyan Luo
Summary: The synthesis of extracellular matrix and inflammatory response were found to be main processes involved in the development and progression of AF. Infiltration of immune cells was significantly different between patients with or without AF. Has_circ_0006314 and hsa_circ_0055387 were identified as potential predictive biomarkers for POAF.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Kai Huang, Xi Fan, Yuwen Jiang, Sheng Jin, Jiechun Huang, Liewen Pang, Yiqing Wang, Yuming Wu, Xiaotian Sun
Summary: This study identified EIF4E3, ZNF595, ZNF700, MATR3, ACKR4, ANXA3, SEPSECS-AS1, and RNF166 as hub genes significantly associated with AF-related stroke, and these genes have potential as novel biomarkers and therapeutic targets. Additionally, the hsa_circ_0018657/hsa-miR-198/EIF4E3 pathway was found to play an important role in regulating the development of AF-related stroke.
Article
Neuroimaging
Shin-Joe Yeh, Chih-Hao Chen, Yen-Heng Lin, Li-Kai Tsai, Chung-Wei Lee, Sung-Chun Tang, Jiann-Shing Jeng
Summary: Our findings demonstrate that plasma levels of SAA at an early stage are significant predictors for poor functional outcomes at 3 months in patients with stroke receiving EVT, indicating the substantial role of systemic inflammation in shaping stroke outcomes following EVT.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Chin-Feng Hsuan, Fang-Ju Lin, Thung-Lip Lee, Kai-Chien Yang, Wei-Kung Tseng, Yen-Wen Wu, Wei-Hsian Yin, Hung- Yeh, Jaw-Wen Chen, Chau-Chung Wu
Summary: The waist-to-BMI ratio may serve as a significant predictor for the risk of major adverse cardiovascular events (MACE) in patients with established ASCVD.
SCIENTIFIC REPORTS
(2022)
Article
Neuroimaging
Chun-Hsien Lin, Jeffrey L. Saver, Bruce Ovbiagele, Sung-Chun Tang, Meng Lee, David S. Liebeskind
Summary: This meta-analysis evaluated the effect of endovascular therapy (EVT) in mild acute ischemic stroke (AIS). The results showed that EVT was beneficial in proximal occlusions but not in distal occlusions.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Medicine, General & Internal
Tsung-Heng Lee, Chih-Ning Cheng, Chung-Wei Lee, Ching-Hua Kuo, Sung-Chun Tang, Jiann-Shing Jeng
Summary: This study aimed to investigate the relationship between plasma ceramides and sphingosine-1-phosphate levels in acute ischemic stroke patients undergoing endovascular thrombectomy (EVT) and their clinical outcomes. The results showed that long-chain ceramides were significantly elevated in AIS patients compared to controls, while the levels of sphingosine-1-phosphate were significantly lower. Additionally, specific types of ceramides could serve as early prognostic indicators for AIS patients undergoing EVT.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Yi-Hsing Chen, Sheng-Che Chou, Jing-Er Lee, Jui-Chang Tsai, Dar-Ming Lai, Yong-Kwang Tu, Sung -Tsang Hsieh, Kuo-Chuan Wang
Summary: The study investigated the relationship between continuous lumbar drain (LD) placement and malondialdehyde (MDA) level after aneurysmal subarachnoid hemorrhage (aSAH). The results showed that LD placement can decrease the intrathecal MDA level and improve the prognosis of patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Letter
Clinical Neurology
Chih-Hao Chen, Sung-Chun Tang
ANNALS OF NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Li-Ting Ho, Yen-Bin Liu, Yu-Fong Peng, Li-Kai Tsai, Chih-Fen Huang, Jiann-Shing Jeng
Summary: This study reports on the association between direct oral anticoagulant (DOAC) concentration and clinical outcomes in Asian patients with atrial fibrillation (AF). The proportion of DOAC concentrations falling outside the expected range was higher than reported in clinical trials. Low trough concentration was associated with increased risk of systemic thromboembolism (SSE), while high trough concentration was associated with major bleeding. Measurement of trough DOAC concentration should be considered for patients at risk of concentration deviations.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Clinical Neurology
Bo-Ching Lee, Hsin-Hsi Tsai, Chia-Ju Liu, Ya-Fang Chen, Li-Kai Tsai, Jiann-Shing Jeng, Ruoh-Fang Yen
Summary: This study found that cerebral venous reflux (CVR) is more closely associated with cerebral amyloid angiopathy (CAA) than hypertensive microangiopathy in intracerebral hemorrhage (ICH) survivors. The results suggest that venous drainage dysfunction potentially plays a role in CAA and cerebral amyloid deposition.
Article
Cardiac & Cardiovascular Systems
Vin- Cent Wu, Chieh-Kai Chan, Jeff S. Chueh, Yung-Ming Chen, Yen- Hung Lin, Chin-Chen Chang, Po-Chih Lin, Shiu-Dong Chung, TAIPAI grp
Summary: A study found that targeted treatment with MRAs or adrenalectomy in patients with PA leads to a decline in estimated glomerular filtration rate. However, the changes in biomarkers of kidney tubule health are still unclear.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Chih-Hao Chen, Yuan-Chang Chao, Chih-Fen Huang, Jiann-Shing Jeng
Summary: This study aimed to investigate the association between DOAC concentration and stroke outcomes in patients with acute IS or ICH. It found that low DOAC concentration at hospital presentation predicted poor outcomes in IS patients at 3 months. Furthermore, the DOAC concentration was not associated with reversal therapy or hematoma growth in ICH patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Clinical Neurology
Hung-Jen Lin, Chih-Hao Chen, Ming-Wei Su, Chien-Wei Lin, Yu-Wen Cheng, Sung-Chun Tang, Jiann-Shing Jeng
Summary: This study investigated the effects of the NOTCH3 R544C variant and associated vascular risk factors on stroke in the Taiwanese population. The results showed that the NOTCH3 R544C variant alone increased the risk of stroke, but modifiable vascular risk factors also played a role in the occurrence of stroke in Taiwanese individuals carrying the NOTCH3 variant.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Neurosciences
Shin-Joe Yeh, Chih-Hao Chen, Yen-Heng Lin, Li-Kai Tsai, Chung-Wei Lee, Sung-Chun Tang, Jiann-Shing Jeng
Summary: This study found that plasma ferroptosis biomarkers at the hyperacute stage are associated with long-term outcomes in patients with acute ischemic stroke undergoing EVT. The severity of stroke at admission is correlated with levels of 4-hydroxynonenal (4-HNE) and soluble transferrin receptor (sTfR). Moreover, plasma homocysteine levels are associated with functional outcome and mortality at 3 months post-EVT.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Wan-Ting Hsu, Yu-Ting Lee, Jasmine Tan, Yung-Han Chang, Frank Qian, Kuei-Yu Liu, Jo-Ching Hsiung, Chia-Hung Yo, Sung-Chun Tang, Xia Jiang, Chien-Chang Lee
Summary: Hsu et al. conducted a genome-wide association study on headaches in East Asians, which revealed that a single-nucleotide polymorphism (rs8072917) of the RNF213 gene is the causal variant for broadly defined headaches. This study also found associations between the causal variant and other medical conditions such as cellulitis, neck and face abscesses, and muscular symptoms. This research sheds light on the genetic architecture of headaches in individuals of East Asian ancestry and has potential implications for the development of genetic tests and treatments.
BRAIN COMMUNICATIONS
(2023)
Article
Medical Laboratory Technology
Huai-Hsuan Chiu, Shin-Yi Lin, Chen-Guang Zhang, Chuan-Ching Tsai, Sung-Chun Tang, Ching-Hua Kuo
Summary: Metabolomics has emerged as a promising approach for understanding pathological mechanisms. This study compared plasma (PLS) and dried blood spot (DBS) samples to investigate the correlation between their metabolites. It was found that approximately 47% of the samples showed a strong correlation, 19% showed a moderate correlation, and 34% showed a low or negligible correlation. Additionally, two significant metabolites were identified in both PLS and DBS samples from diabetes mellitus (DM) patients.
CLINICA CHIMICA ACTA
(2024)
