Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 90, Issue -, Pages 491-496Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.11.060
Keywords
Anti-angiogenesis; Antitumor activity; Antiviral activity; Sesquiterpene lactones; Xanthatin; Xanthium spinosum L
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Funding
- Ministerio de Ciencia e Innovacion [CTQ2011-29285-C02-01]
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The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L favours the conversion of xanthinin (1) to xanthatin (2) via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction. (C) 2014 Elsevier Masson SAS. All rights reserved.
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