Article
Biochemistry & Molecular Biology
Chen-Yi Tang, He Wang, Yan Zhang, Zhongliang Wang, Guochun Zhu, Abigail McVicar, Yi-Ping Li, Wei Chen
Summary: The GPCR125 gene is highly expressed in osteoclasts and positively regulates osteoclast formation and function through RANKL-stimulated MAPK and AKT-NF-kappa B signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Article
Pharmacology & Pharmacy
Hanan S. Althagafy, Fares E. M. Ali, Emad H. M. Hassanein, Zuhair M. Mohammedsaleh, Mohamed I. Kotb El-Sayed, Ahmed M. Atwa, Ahmed M. Sayed, Ayman A. Soubh
Summary: This study demonstrates that canagliflozin can effectively attenuate ulcerative colitis by regulating multiple pathways and targets, reducing inflammation, alleviating oxidative stress, and restoring colonic function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Panpan Chen, Rong Wang, Fangbin Liu, Shengnan Li, Yanqiu Gu, Lei Wang, Yongfang Yuan
Summary: Schizandrin C from Schisandra chinensis has been found to ameliorate liver fibrosis by regulating lipid metabolism and inflammation through nuclear factor kappa-B and p38/ERK MAPK signaling pathways, making it a potential drug for liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Yiwu Qin, Dezhi Song, Shijie Liao, Junchun Chen, Minglian Xu, Yuangang Su, Haoyu Lian, Hui Peng, Linhua Wei, Kai Chen, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: In this study, it was found that Isosinensetin (Iss) inhibits the formation and hyperactive bone resorption of osteoclasts by reducing intracellular reactive oxygen species (ROS) and activating the Nrf2 antioxidant pathway. Iss also demonstrated the potential to reduce bone loss in ovariectomized (OVX) mice. Therefore, Iss may be a preventive and therapeutic option for osteoporosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Jing Li, Haoran Du, Xin Ji, Yihan Chen, Yishuai Li, Boon Chin Heng, Jianguang Xu
Summary: This study demonstrated that overexpression of ETV2 significantly enhanced osteogenic markers expression, ALP activity, and matrix mineralization of hDPSCs. The mechanisms involved ERK/MAPK and PI3K-Akt signaling pathways, which were partially reversed by inhibitors of these pathways. In vivo studies also showed improved bone healing and ectopic bone formation due to ETV2 overexpression in animal models.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Pharmacology & Pharmacy
Zuoxing Wu, Chen Li, Yu Chen, Qian Liu, Na Li, Xuemei He, Weibin Li, Rong Shen, Li Li, Chenming Wei, Siyuan Shao, Fangsheng Fu, Jiaxin Ding, Xiaochen Sun, Dairong Wang, Guixin Yuan, Yiji Su, Jinmin Zhao, Jiake Xu, Ren Xu, Xin Xu, Feng Xu
Summary: Bone homeostasis relies on the balance between osteoblasts and osteoclasts. Excessive activation of osteoclasts leads to bone resorption diseases. Chrysin (CHR) has inhibitory effects on osteoclasts and may serve as a potential therapeutic agent for osteolytic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Yong Zhang, Zhengxia Zha, Wenhua Shen, Dan Li, Naixin Kang, Zhong Chen, Yanli Liu, Guoqiang Xu, Qiongming Xu
Summary: The study demonstrated that anemoside B4 ameliorated TNBS-induced colitis symptoms by inhibiting tissue damage, inflammatory cell infiltration, pro-inflammatory cytokine production, apoptosis, and slowed proliferation in colon. Quantitative proteomic analyses revealed that anemoside B4 significantly altered 56 proteins in TNBS-induced rats, with a focus on proteins related to TCA cycle and respiratory electron transport chain. S100A9, one of the most significantly down-regulated proteins, was associated with NF-kappa B and MAPK signaling pathways in UC pathogenesis.
Article
Anatomy & Morphology
Samaneh Abbasi, Reza Bazyar, Mohammad Ali Saremi, Gholamhoseen Alishiri, Nasrin Seyyedsani, Mahdieh Farhoudi Sefidan Jadid, Afshin Khorrami, Parisa Emami Golmarz, Gholamreza Jahangirzadeh, Ahmad Babazadeh Bedoustani, Alireza Isazadeh, Saba Hajazimian, Fatemeh Firouzi Amoodizaj
Summary: The study demonstrated that hWJSC-CM and hWJSC-CL inhibit the proliferation and viability of GC cell line AGS through induction of apoptosis, as well as modulation of NF-kappa B and MAPK signaling pathways.
Article
Pharmacology & Pharmacy
Juan Duan, Xuantao Hu, Tao Li, Gen Wu, Pengcheng Dou, Zhengxiao Ouyang
Summary: The study demonstrates that CIM has the potential to inhibit RANKL-induced osteoclastogenesis by suppressing the NF-kappa B signaling pathway in vitro, and prevent periprosthetic osteolysis in vivo. These findings suggest the therapeutic potential of CIM in the treatment of ALP.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Qin Li, Yanqin Ju, Changlong Jin, Li Liu, Shouliang Zhao
Summary: The inhibition of NBCe1 significantly promotes odontogenic differentiation of DPSCs, which may be regulated by activating the NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF STEM CELLS
(2022)
Article
Fisheries
Ming Zhou, Xiaomeng Ren, Xiaolong Yan, Yuena Sun, Tianjun Xu
Summary: This study demonstrates the mechanism of how Rho-GDI γ negatively regulates the NF-κB signaling pathway mediated by TAK1, providing new experimental and theoretical basis for the innate immune regulation in teleost fish and mammals.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Wenkan Zhang, Guangyao Jiang, Xiaozhong Zhou, Leyi Huang, Jiahong Meng, Bin He, Yiying Qi
Summary: The study found that alpha-mangostin can inhibit the formation and function of osteoclasts and prevent inflammatory osteolysis by inhibiting the activation of the NF-kappa B/mitogen-activated protein kinase signaling pathways. This has potential clinical applications for treating osteoclast-related diseases.
Article
Biochemistry & Molecular Biology
Ziqiu Xiao, Yue Zhang, Yawei She, Guohua Yuan, Guobin Yang
Summary: The study found that IPO7 is highly expressed in pulpitis and plays an important regulatory role in the inflammatory response of human dental pulp. By inhibiting the p38 MAPK and NF-κB signaling pathways, IPO7 can suppress the production of inflammatory cytokines.
MOLECULAR IMMUNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Z. Luo, Z. Wang, X. He, N. Liu, B. Liu, L. Sun, J. Wang, F. Ma, H. Duncan, W. He, P. Cooper
INTERNATIONAL ENDODONTIC JOURNAL
(2018)
Article
Dentistry, Oral Surgery & Medicine
J. P. Robinson, R. G. Macedo, B. Verhaagen, M. Versluis, P. R. Cooper, L. W. M. van der Sluis, A. D. Walmsley
INTERNATIONAL ENDODONTIC JOURNAL
(2018)
Article
Cell Biology
A. A. Abdulkareem, R. M. Shelton, G. Landini, P. R. Cooper, M. R. Milward
CELL ADHESION & MIGRATION
(2018)
Article
Microscopy
R. Flight, G. Landini, I. B. Styles, R. M. Shelton, M. R. Milward, P. R. Cooper
JOURNAL OF MICROSCOPY
(2018)
Article
Dentistry, Oral Surgery & Medicine
R. Arruda-Vasconcelos, L. M. Louzada, M. Feres, P. L. Tomson, P. R. Cooper, B. P. F. A. Gomes
Summary: The microbial profile, and levels of endotoxin (LPS) and lipoteichoic acid (LTA), in infected dentine and root canals of teeth with irreversible pulpitis were investigated. Root canal preparation effectively reduced the levels of bacteria, LPS and LTA, while intracanal medication did not significantly reduce bacterial levels but led to a significant decrease in LTA levels.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kubra Aral, Michael R. Milward, Paul R. Cooper
Summary: This study aimed to investigate the potential regulatory pathways of IL-1 beta production by monitoring the effects of periodontal pathogens Fn and Pg on inflammasomes and their regulators in HGFs. The results showed that Fn and Pg, especially when combined with ATP exposure, could dysregulate NLRP3, AIM2, IL-1 beta, ASC, and other inflammasome components and regulators, ultimately affecting the production of IL-1 beta.
Article
Chemistry, Physical
David Yong, Joanne Jung Eun Choi, Peter Cathro, Paul R. Cooper, George Dias, Jeffrey Huang, Jithendra Ratnayake
Summary: The aim of this study was to develop an endodontic cement using bovine bone-derived hydroxyapatite (BHA), Portland cement (PC), and a radiopacifier. The results showed that the addition of 10% and 20% BHA improved the mechanical strength of the cement while maintaining similar radiopacity and biocompatibility to ProRoot MTA. This study is important for enhancing the properties of endodontic cements.
Article
Biochemistry & Molecular Biology
Shelly Arora, Paul R. Cooper, Lara T. Friedlander, Benedict Seo, Shakila B. Rizwan, Alison M. Rich, Haizal Mohd Hussaini
Summary: This study successfully isolated and cultured cHDPCs and ncHDPCs from healthy and inflamed dental pulp tissue respectively. The growth characteristics and differentiation abilities were not significantly different between the two types of HDPCs. However, the expression of certain genes such as TLR-2 and IL-6 was significantly higher in cHDPCs, indicating an inflammatory phenotype in the inflamed dental pulp.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zohaib Khurshid, Mohammed Farhan Alfarhan, Javed Mazher, Yasmin Bayan, Paul R. Cooper, George J. Dias, Necdet Adanir, Jithendra Ratnayake
Summary: In this study, camel bone-based hydroxyapatite (CBHA) was extracted and characterized. The CBHA exhibited favorable mechanical properties, porous structure, and stability in simulated body fluid, making it a promising material for bone tissue regeneration applications.
Article
Biochemistry & Molecular Biology
Michaela Kearney, Paul R. Cooper, Anthony J. Smith, Henry F. Duncan
Summary: Exciting opportunities exist within regenerative endodontics for the development of targeted biomaterials that harness epigenetic machinery to control pulpitis and stimulate repair. In this study, small RNA sequencing and bioinformatic analysis were used to establish a miRNA expression profile for mineralising dental pulp cells (DPCs) and examine their interaction with histone deacetylase inhibitors and DNA methyltransferase inhibitors. The results showed that these inhibitors induced mineralisation but reduced cell growth, suggesting an increased and dynamic interaction between miRNA and epigenetic modifiers during DPC reparative processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Dentistry, Oral Surgery & Medicine
Rabia Majeed, Hoda Mohamed Elnawawy, Muralithran Govindan Kutty, Noor Azlin Yahya, Noor Hayati Azami, Noor Hayaty Abu Kasim, Mohamed Shady Nabhan, Paul Roy Cooper, Josette Camilleri, Hany Mohamed Aly Ahmed
Review
Dentistry, Oral Surgery & Medicine
Rabia Majeed, Hoda Mohamed Elnawawy, Muralithran Govindan Kutty, Noor Azlin Yahya, Noor Hayati Azami, Noor Hayaty Abu Kasim, Mohamed Shady Nabhan, Paul Roy Cooper, Josette Camilleri, Hany Mohamed Aly Ahmed
Summary: This systematic review examined the effects of nano-sized cement particles on the properties of calcium silicate-based cements. A literature search was conducted and 17 eligible studies were included. The results showed that nano-calcium silicate-based cements have better physical, mechanical, and biological properties compared to commonly used cements. However, there were deficiencies in characterizing and verifying the nano-particle size, and the presence of additives may have influenced the properties.
Review
Dentistry, Oral Surgery & Medicine
Eisha Imran, Paul R. Cooper, Jithendra Ratnayake, Manikandan Ekambaram, May Lei Mei
Summary: This article provides a contemporary review of the potential beneficial effects of nanosized hydroxyapatite (nHAP) on caries lesions demonstrated in in vitro studies. Data showed that nHAP has the potential to promote mineralization in initial caries and has antimicrobial effects through metal substitution. Metal-substituted fluorhydroxyapatite nanoparticles can potentially possess dual action property and enhanced chemical stability and bioactivity, providing a promising synergistic strategy for the development of dental therapeutics.
Article
Dentistry, Oral Surgery & Medicine
Satnam S. Virdee, Nasir Z. Bashir, Milan Krstic, Josette Camilleri, Melissa M. Grant, Paul R. Cooper, Phillip L. Tomson
Summary: This study identified optimized parameters for periapical tissue fluid (PTF) paper point sampling and compared the proteomes of PTF from teeth with normal apical tissues (NAT) and asymptomatic apical periodontitis (AAP) using high-throughput proteomic analysis. The results showed that some proteins were closely associated with AAP and had good diagnostic performance. The findings provide a potential biomarker network for clinical applications and further validation is needed.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hannah Serrage, Vladimir Heiskanen, William M. Palin, Paul R. Cooper, Michael R. Milward, Mohammed Hadis, Michael R. Hamblin
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2019)