Review
Medicine, General & Internal
Michal Pruc, Frank William Peacock, Zubaid Rafique, Damian Swieczkowski, Krzysztof Kurek, Monika Tomaszewska, Burak Katipoglu, Maciej Koselak, Basar Cander, Lukasz Szarpak
Summary: This study suggests that the platelet-to-lymphocyte ratio (PLR) may have a potential prognostic role in patients presenting with suspected acute coronary syndromes (ACS).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Mi Su, Xiaoxiao Ouyang, Yongyan Song
Summary: This meta-analysis supports the association between depression and inflammation, with NLR being a potential indicator of depression. However, no significant differences were found in PLR and MLR values between depressed subjects and controls. Further large-scale studies are needed to evaluate the role of PLR and MLR in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Brody H. Foy, Thoralf M. Sundt, Jonathan C. T. Carlson, Aaron D. Aguirre, John M. Higgins
Summary: The study examines the recovery process of inflammation caused by trauma, ischemia, and infection by tracking the longitudinal dynamics of clinical laboratory measurements in hospitalized patients. The findings reveal a universal recovery trajectory characterized by exponential white blood cell decay and delayed linear growth of platelet count. The co-regulation of white blood cells and platelet dynamics provides a generic approach for identifying high-risk patients and predicting adverse outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Pengyu Gong, Yukai Liu, Yachi Gong, Gang Chen, Xiaohao Zhang, Siyu Wang, Feng Zhou, Rui Duan, Wenxiu Chen, Ting Huang, Meng Wang, Qiwen Deng, Hongchao Shi, Junshan Zhou, Teng Jiang, Yingdong Zhang
Summary: NLR, PLR, and LMR were shown to be associated with post-thrombolysis early neurological outcomes, with NLR and PLR potentially predicting early neurological deterioration, and NLR related to early neurological improvement.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Sai Luo, Wen-Song Yang, Yi-Qing Shen, Ping Chen, Shu-Qiang Zhang, Zhen Jia, Qi Li, Jian-Ting Zhao, Peng Xie
Summary: This study aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and D-dimer-to-fibrinogen ratio (DFR) as predictors of pneumonia and poor outcomes in patients with acute intracerebral hemorrhage (ICH). The results showed that NLR and PLR were independent predictors of pneumonia, while NLR and DFR were independent predictors of poor 90-day outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Dario Bongiovanni, Nina Schreiner, Rosanna Gosetti, Katharina Mayer, Dominick J. Angiolillo, Dirk Sibbing, Stefan Holdenrieder, Aida Anetsberger, Moritz von Scheidt, Heribert Schunkert, Karl-Ludwig Laugwitz, Stefanie Schuepke, Adnan Kastrati, Isabel Fegers-Wustrow, Isabell Bernlochner
Summary: This study aimed to evaluate immature or reticulated platelets as a predictive biomarker for adverse cardiovascular events in patients with acute coronary syndrome treated with potent P2Y(12) receptor inhibitors. The findings showed that immature platelets were significantly associated with the incidence of the primary endpoint, indicating their potential as a predictive marker for adverse cardiovascular events in these patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoteng Ma, Kangning Han, Lixia Yang, Qiaoyu Shao, Qiuxuan Li, Zhijian Wang, Yueping Li, Fei Gao, Zhiqiang Yang, Dongmei Shi, Yujie Zhou
Summary: The monocyte to high-density lipoprotein cholesterol ratio (MHR) is significantly associated with adverse cardiovascular outcomes in ACS patients undergoing PCI, and can improve the predictive ability of the GRACE risk score based prognostic models.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Sarah Soh, Yu Rim Shin, Jong-Wook Song, Jun Hyug Choi, Young-Lan Kwak, Jae-Kwang Shim
Summary: This study investigated the association between preoperative platelet reactivity to P2Y(12) antagonists and ischemic and hemorrhagic complications in ACS patients undergoing coronary surgery. The results showed no correlation between platelet inhibitory response to P2Y(12) antagonists and ischemic or hemorrhagic complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Wei Fu, Weixia Ye, Xianqiang Liu, Sirui Zhu, Hu Fu, Rui Zhu, Hongmin Li, Haoyun Zeng, Qin Wang
Summary: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are valuable biomarkers for assessing the clinical significance of Henoch-Schonlein purpura (HSP) and its complications, with NLR particularly useful in predicting gastrointestinal complications and renal involvement in HSP patients. Further well-designed and large cohort studies are needed to confirm these findings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Psychiatry
Yanwei Cheng, Yiwen Wang, Xiangyi Wang, Zhuoya Jiang, Lijun Zhu, Shaokuan Fang
Summary: This study found that the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are significantly higher in patients with depression. However, the monocyte-to-lymphocyte ratio (MLR) is slightly higher but not significantly different. Sensitivity and subgroup analysis revealed differences in inflammatory ratios in different regions and in patients with post-stroke depression (PSD).
FRONTIERS IN PSYCHIATRY
(2022)
Article
Hematology
Amaya Llorente-Chavez, Eduardo Martin-Nares, Carlos Nunez-Alvarez, Gabriela Hernandez-Molina
Summary: In this study, we assessed the performance of MPV, PLR, NLR, and MPV-to-lymphocyte ratio in APS patients and found that baseline MPV and PLR may help identify APS patients according to their thrombotic or thrombocytopenic phenotype. These variables change during acute events and may reflect physiopathological or compensatory mechanisms in APS.
THROMBOSIS RESEARCH
(2021)
Review
Oncology
Jiali Leng, Fei Wu, Lihui Zhang
Summary: This meta-analysis found that pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may serve as biomarkers for predicting poor prognosis in patients with endometrial cancer, while monocyte-lymphocyte ratio (MLR) is not associated with prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Fatma Ozpamuk Karadeniz, Yusuf Karadeniz, Emine Altuntas
Summary: This study investigated the association between hematological parameters (SII, NLR, and PLR) and clinical outcomes in acute coronary syndrome (ACS) patients. The results showed that SII was significantly associated with major adverse cardiac events and had a greater predictive power than PLR and NLR.
CARDIOVASCULAR JOURNAL OF AFRICA
(2023)
Article
Medicine, General & Internal
Yu-Cheng Liu, Tzu- Yang, Shu-Wei Huang, Yi-Jie Kuo, Yu-Ping Chen
Summary: Osteoporosis is characterized by low bone mass and increased bone fragility. Inflammation has been suggested to play a role in its development. This study found that both the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were significantly higher in the osteoporosis group compared to the normal bone mineral density group. NLR was also significantly higher in postmenopausal women with osteoporosis. These findings suggest that NLR and PLR could be potential targets for osteoporosis screening.
Article
Cardiac & Cardiovascular Systems
Ahmed Mohammed Shumilah, Arwa Mohammed Othman, Anwar Kasim Al-Madhagi
Summary: Inflammation plays a key role in atherosclerosis and ACS. NLR was found to be the strongest predictive marker of ACS, indicating its potential as an auxiliary biomarker in ACS diagnosis.
BMC CARDIOVASCULAR DISORDERS
(2021)
