Article
Psychology, Clinical
Guanmao Chen, Pan Chen, JiaYing Gong, Yanbin Jia, Shuming Zhong, Feng Chen, Jurong Wang, Zhenye Luo, Zhangzhang Qi, Li Huang, Ying Wang
Summary: This study investigated the shared and specific patterns of dynamic functional connectivity (dFC) variability of the striato-cortical circuitry in bipolar disorder (BD) and major depressive disorder (MDD). The results showed that both BD and MDD patients had common dFC alterations in the dorsal striatal-sensorimotor and ventral striatal-cognitive circuitries, while MDD patients had specific dFC alterations in the ventral striatal-affective circuitry.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Feng Chen, Jiaying Gong, Guanmao Chen, Pan Chen, Shuming Zhong, Guixian Tang, Jurong Wang, Zhenye Luo, Ting Su, Siying Fu, Shunkai Lai, Li Huang, Ying Wang
Summary: Comparing the brain blood flow and functional connectivity of patients with bipolar disorder and major depressive disorder can help us understand their pathophysiological mechanisms and find more effective treatments. The research found that patients with bipolar disorder and major depressive disorder shared common features of increased blood flow in the posterior lobe of the cerebellum and middle temporal gyrus. Additionally, only patients with bipolar disorder showed decreased functional connectivity between the posterior lobe of the cerebellum and the inferior frontal gyrus.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: Using the DRePS method, common and specific alterations in local functional connectivity patterns were found in patients with BDD and MDD. Patients with both disorders showed decreased DRePS values in multiple brain regions, with MDD patients exhibiting specific decreases in the left caudate. Voxel signals in these regions also contributed to the classification of the two diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: This study characterized the common and specific alterations in the dynamic local functional connectivity pattern in patients with bipolar depressive disorder (BDD) and major depressive disorder (MDD) using a newly developed method called dynamic regional phase synchrony (DRePS). The findings provided new insight into the neural mechanism of BDD and MDD patients and could potentially inform the diagnosis and treatment of these disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Zhenye Luo, Guanmao Chen, Yanbin Jia, Shuming Zhong, Jiaying Gong, Feng Chen, Jurong Wang, Zhangzhang Qi, Xia Liu, Li Huang, Ying Wang
Summary: This study revealed disrupted dynamic balance between segregation and integration within the default mode network in both Bipolar Disorder (BD) and Major Depressive Disorder (MDD) patients, with MDD patients showing specific abnormal brain dynamics in the putamen.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Yanzhuo Song, Jingyu Yang, Miao Chang, Yange Wei, Zhiyang Yin, Yue Zhu, Yuning Zhou, Yifang Zhou, Xiaowei Jiang, Feng Wu, Lingtao Kong, Ke Xu, Fei Wang, Yanqing Tang
Summary: Schizophrenia, bipolar disorder, and major depressive disorder have common neuroimaging characteristics. This study found different alterations in hippocampal subregions among these disorders, providing evidence for the different functions of these subregions in psychiatric pathology.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Fengmei Lu, Yanchi Chen, Qian Cui, Yuanhong Guo, Yajing Pang, Wei Luo, Yue Yu, Jiajia Chen, Jingjing Gao, Wei Sheng, Qin Tang, Yuhong Zeng, Kexing Jiang, Qing Gao, Zongling He, Huafu Chen
Summary: Abnormalities in thalamo-cortical functional connectivity were found in bipolar disorder during a depressive episode and major depressive disorder. Thalamo-cortical dynamic connectivity patterns were explored by dividing the thalamus into subregions and using a sliding-window approach. Both patient groups showed increased variability in dynamic connectivity between thalamus subregions and certain brain regions, with bipolar disorder displaying more extensive aberrant connectivity. The disrupted dynamic connectivity could accurately distinguish between bipolar disorder and major depressive disorder.
Article
Psychology, Clinical
S. Rupprechter, A. Stankevicius, Q. J. M. Huys, P. Series, J. D. Steele
Summary: The study focused on reward valuation and decision-making processes in individuals with major depressive disorder. Results showed abnormal reward value encoding in depression, leading to impaired decision-making processes and increased activity in the rostral anterior cingulate cortex. Additionally, decreased event-related connectivity between the anterior mid-cingulate cortex and rostral cingulate regions was observed in depression, indicating impaired communication between neural substrates related to expected value estimation and decision-making.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Shunkai Lai, Shuming Zhong, Ying Wang, Yiliang Zhang, Ying Xue, Hui Zhao, Hanglin Ran, Shuya Yan, Yange Luo, Jiali He, Yunxia Zhu, Sihui Lv, Zijing Song, Haofei Miao, Yilei Hu, Xiaosi Huang, Xiaodan Lu, Jiansong Zhou, Yanbin Jia
Summary: This study investigated the prevalence and characteristics of cognitive impairment in patients with bipolar disorder and major depressive disorder. The results showed that both groups had significantly reduced cognitive performance compared to the healthy control group. The cognitive impairments in both groups were clinically significant, but more common in patients with bipolar disorder. These findings suggest the importance of cognitive screening and intervention strategies for patients with mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Hao Chen, Longxi Wang, Hong Li, Huihui Song, Xiaobin Zhang, Dong Wang
Summary: This study found that euthymic bipolar disorder patients have poorer cognitive performance and abnormal brain activity. Compared to healthy controls, patients showed decreased activity in certain regions of the brain. These findings are important for understanding the neurobiology and cognitive impairment mechanisms of bipolar disorder.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Yang Yang, Qian Cui, Fengmei Lu, Yajing Pang, Yuyan Chen, Qin Tang, Di Li, Ting Lei, Zongling He, Shan Hu, Jiaxin Deng, Huafu Chen
Summary: The study revealed abnormal functional connectivity patterns of DMN subsystems in patients with bipolar disorder during major depressive episodes, and these abnormalities were associated with high levels of pessimism, highlighting the importance of pathological mechanisms in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Zhenghua Hou, Youyong Kong, Yingying Yin, Yuqun Zhang, Yonggui Yuan
Summary: Using the dCAP analysis approach, distinct pretreatment features of the DMN and reward network can effectively differentiate MDD patients from healthy controls, potentially serving as indicators for individual diagnosis and prediction of antidepressant response in the early stage.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Danielle A. Goldman, Anjali Sankar, Alexandra Rich, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
Summary: This study aimed to identify functional connectivity differences between depressions of bipolar disorder (BD-Dep) and depressions of major depressive disorder (MDD-Dep). The results showed that there were significant differences in functional connectivity patterns between these two groups, suggesting the potential for early diagnosis and treatment strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Shuming Zhong, Nan Chen, Shunkai Lai, Yanyan Shan, Zhinan Li, Junhao Chen, Aiming Luo, Yiliang Zhang, Sihui Lv, Jiali He, Ying Wang, Zhijun Yao, Yanbin Jia
Summary: By investigating the dynamics of overlapping brain sub-networks, we found that the mechanisms of cognitive impairments in patients with MDD may differ depending on the frequency bands. The aberrant dynamics of overlapping neural sub-networks revealed by frequency-specific MEG signals may provide new information on the mechanism of cognitive impairments resulting from MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neuroimaging
Yi-Bing Guo, Wei-Jia Gao, Zhi-Liang Long, Wei-Fang Cao, Dong Cui, Yong-Xin Guo, Qing Jiao, Jian-Feng Qiu, Lin-Yan Su, Guang-Ming Lu
Summary: This study found that in both manic and euthymic pediatric BD patients, there were significant decreases in cortical thickness of the left middle frontal gyrus and bilateral superior frontal gyrus, as well as decreases in volume of the left thalamus and cortical thickness of the right middle frontal gyrus in manic BD patients. Additionally, hyperconnectivity with the middle frontal gyrus was observed in manic BD patients, while hypoconnectivity with the precentral gyrus/SFG was found in euthymic BD patients.
BRAIN IMAGING AND BEHAVIOR
(2021)