4.7 Article

Analytical evidence of enamel hypomineralisation on permanent and primary molars amongst past populations

Journal

SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-01745-w

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Funding

  1. Institut Francais de Recherche Odontologique (IFRO)
  2. PRC CNRS-University of Melbourne [501911 GL]
  3. ANR [ANR-10-LABX-52]

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Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPM) involve prevalent qualitative structural developmental anomalies of tooth enamel affecting the first permanent molars (and often incisors) and the second primary molars, respectively. These demarcated hypomineralised lesions of enamel manifest as white-cream or yellow-brown opacities, with possible post-eruptive localised loss of enamel. Aetiological hypotheses have involved contemporary life factors (i.e. environmental pollutant exposure or early childhood medications) in contrast to factors not limited to a specific time period (i.e. hypoxia at birth or genetic predisposition). Evidence of MIH in ancient populations would reinforce aetiological factors present for many centuries. By means of microtomographic and X-ray fluorescence analyses the present study provides evidence that (i) two archaeological specimens: S407 (Sains-en-Gohelle, France, 12th-16th centuries) and B335 (Beauvais, France, 15th-18th centuries) were MIH-affected, and (ii) one individual S323 was affected by HSPM and MIH (Sains-en-Gohelle, France, 7th-11th centuries).

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