Article
Chemistry, Physical
Yacob Melman, Evgeny Katz, Oleh Smutok
Summary: This technology utilizes concatenated enzyme-based Boolean logic gates and analyzes them with a smartphone photo camera. It conveniently enables simultaneous detection of multiple input combinations and generates fluorescence with different intensities as outputs, offering an easy readout method for multi-channel logic systems.
Article
Chemistry, Multidisciplinary
Ran Liu, Yingmei Han, Feng Sun, Gyan Khatri, Jaesuk Kwon, Cameron Nickle, Lejia Wang, Chuan-Kui Wang, Damien Thompson, Zong-Liang Li, Christian A. Nijhuis, Enrique del Barco
Summary: This study presents a controllable ultra-minimalistic circuit element using single-molecule logic operations, which requires stable currents from multiple orthogonal inputs. By modulating the output current in real-time based on orthogonal input bias and gate voltages, reliable and low-voltage operations are achieved. Various logic gates are successfully implemented, demonstrating stable multilogic operations.
ADVANCED MATERIALS
(2022)
Article
Computer Science, Information Systems
Vipul Kumar Mishra, Mayank Dixit, Tejalal Choudhary, Anurag Goswami, Manjit Kaur, Omar Cheikhrouhou, Habib Hamam
Summary: This study presents a novel heuristic-driven tabular approach for majority logic synthesis, and introduces heuristic called matching difference and a circuit cost criterion. Additionally, an extended library based on five-input and three-input majority gates and a post-synthesis optimization method are proposed. Experimental results demonstrate significant improvements in delay and circuit cost reduction in both MCNC benchmarks and QCA case study.
Article
Nanoscience & Nanotechnology
Nikita Mahoviya, Prabhat Singh, Dharmendra Singh Yadav
Summary: This research focuses on the utilization of DE-DMG-CP-TFET for implementing various logic functions, employing two-dimensional device simulations for performance optimization. The simulations provide insights into the impact of design parameters, material properties, and device configurations on TFET functionality, highlighting its potential in compact logic implementation.
Article
Computer Science, Information Systems
Reza Akbari-Hasanjani, Reza Sabbaghi-Nadooshan, Majid Haghparast
Summary: This paper investigates the use of quantum-dot cellular automata (QCA) as an alternative to CMOS technology, which is simpler and more suitable for multi-valued logic due to its ability to implement fuzzy logic. The paper proposes a quaternary cell structure with two isolated layers and analyses its performance through simulations.
Article
Chemistry, Multidisciplinary
Ayan Chatterjee, Chiranjit Mahato, Dibyendu Das
Summary: Bioinspired by nature's ingenuity, short peptide-based cross-beta amyloid nanotubular hybrids were shown to promote various cascade reactions, while compartmentalizing enzymes within the cellular milieu. The ability to integrate different logic networks and access complex designs was achieved through the utilization of amyloid nanotubes with ordered arrays of imidazoles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Electrical & Electronic
Junbum Park, Sung Ho Cho
Summary: In this study, an improved and more efficient implementation method of the BTM antenna was proposed by improving the existing FPGA design.
IEEE INTELLIGENT TRANSPORTATION SYSTEMS MAGAZINE
(2022)
Article
Physics, Fluids & Plasmas
Ian Seet, Thomas E. Ouldridge, Jonathan P. K. Doye
Summary: Landauer's principle sets a lower limit on the work required for logically irreversible operations, which can be overcome by using logically reversible gates. This paper presents the design and simulation of molecular mechanical logic gates that approach the limits of thermodynamic reversibility, even in the presence of thermal noise. The study demonstrates the feasibility of constructing and simulating arbitrary combinatorial reversible circuits with these gates.
Article
Chemistry, Multidisciplinary
Yue Pang, Yaoqiang Zhou, Lei Tong, Jianbin Xu
Summary: This study presents a molybdenum disulfide (MoS2) asymmetric-dual-gate field-effect transistor (ADGFET) with independently controlled double gates, which can achieve logic function, nonvolatile memory, and tunable photoresponse. The multifunctional applications demonstrate that the ADGFET provides a feasible way to integrate logic, memory, and sensing into one device architecture.
Article
Biochemistry & Molecular Biology
Jingzhe Zhang, Kaili Wang, Yilu Sun
Summary: A versatile mono-Schiff compound ABJ-MS was synthesized easily using a one-step reaction. ABJ-MS exhibited diverse fluorescence responses to Zn2+/Al3+/Fe3+/Ag+ addition, with the maximum fluorescence emission undergoing a hypsochromic shift and fluorescence enhancement. However, Cu2+ addition resulted in fluorescence quenching. ABJ-MS also displayed distinct absorption changes and had the potential to mimic versatile logic circuits based on metal ion-mediated optical responses.
Review
Biochemistry & Molecular Biology
Nikolai I. Georgiev, Ventsislav V. Bakov, Vladimir B. Bojinov
Summary: The progress in fluorescent probes and sensing materials has led to the development of more complex molecular logic gates capable of multiple sensing functions. These gates can calculate results without human intervention. The goal now is to create more complicated molecular logic circuits. This study discusses the construction of molecular comparators and presents recent achievements in this field.
Article
Nanoscience & Nanotechnology
Jiaxuan Li, Cong Xiao, Wenting Wei, Ruiqi Xiao, Huiqin Yao, Hongyun Liu
Summary: In this study, fluorescent gold nanoclusters (AuNCs) and horseradish peroxidase (HRP) were embedded into self-assembled dipeptide supramolecular films on ITO electrodes, forming a smart film electrode system that can be regulated by Cu(II)/EDTA in solution to control fluorescence signal quenching/dequenching and UV-vis signal generation. The coordinated Cu(II) in the films enhanced the electrocatalytic capacity toward the reduction of H2O2 and a biomolecular logic circuit was built based on this system. Various logic devices were fabricated, demonstrating the potential for designing sophisticated biologic functions and multianalyte biosensing through a simple film system.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Sofia Zanella, Miguel A. Hernandez-Rodriguez, Lianshe Fu, Luis D. Carlos, Rute A. S. Ferreira, Carlos D. S. Brites
Summary: The miniaturization of silicon chips is nearing its physical limits and the small size of transistors causes current leakage, becoming an insurmountable problem. The world's excessive dependence on silicon is highlighted by the current chip shortage, emphasizing the need for silicon-free computing strategies. Quantum computing and computation using individual molecules are proposed as alternatives, with potential advantages in terms of miniaturization, performance enhancement, and energy efficiency. Molecular logics and the unique photonic characteristics of trivalent lanthanide ions have the potential to play a crucial role in the future of the computer industry.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Xianjing Zhou, Gerwin Koolstra, Xufeng Zhang, Ge Yang, Xu Han, Brennan Dizdar, Xinhao Li, Ralu Divan, Wei Guo, Kater W. Murch, David I. Schuster, Dafei Jin
Summary: This study presents an experimental realization of a qubit platform based on isolated single electrons trapped on an ultraclean solid neon surface. By integrating an electron trap in a circuit quantum electrodynamics architecture, strong coupling between a single electron and a single microwave photon is achieved. The results indicate that the electron-on-solid-neon qubit performs near the state of the art for a charge qubit.
Article
Chemistry, Multidisciplinary
Darlene Sammut, Nathalie Bugeja, Konrad Szacilowski, David C. Magri
Summary: Several hybrid molecular logic gates were designed and synthesized, achieving photoinduced electron transfer through different substituents. Computational and experimental results showed differences in the electron transfer dynamics between two of the substituents. These compounds in solution exhibited a polarity-tunable internal charge transfer mechanism and colorful solvatochromatism.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Minyang Zhao, Xiaodong Lin, Xiao Zhou, Yujie Zhang, Haotian Wu, Yaqing Liu
Summary: A novel chemical-tongue sensor array using TMB as a single probe was developed for the identification and sterilization of multiple bacteria. By reading the absorbance intensity of oxTMB at four feature peaks, nine kinds of bacteria, including drug-resistant ones, can be successfully distinguished. Additionally, oxTMB exhibits excellent photothermal properties and can effectively kill bacteria under near-infrared laser irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Analytical
Binfeng Yin, Xinhua Wan, A. S. M. Muhtasim Fuad Sohan, Xiaodong Lin
Summary: This article discusses the application of microfluidic chips combined with POCT in COVID-19 testing, and how it better meets the diagnostic needs in the current pandemic.
Article
Biophysics
Binfeng Yin, Changcheng Qian, Xinhua Wan, A. S. M. Muhtasim Fuad Sohan, Xiaodong Lin
Summary: This article introduces a Tape-based key valve microfluidic chip (KVMC) that utilizes commercially available 3M tapes to detect disease biomarkers in serum ranging from pg mL(-1) to mu g mL(-1). The system allows for automated, multiplexed, simultaneous bioassays of clinically relevant inflammatory biomarkers, offering a desirable strategy for early clinical diagnosis of sepsis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Food Science & Technology
Biao Zhang, Ruofan Zhou, Huiqi Zhang, Danfeng Cai, Xiaodong Lin, Yihan Lang, Yulou Qiu, Xuping Shentu, Zihong Ye, Xiaoping Yu
Summary: A smartphone colorimetric sensor based on the Pt@Au nanozyme was developed for the visual and quantitative detection of omethoate in fruit and vegetables. The sensor showed high accuracy and reliability in detecting the target analyte. This sensor provides a technical reference and potential strategy for hazard factor immunoassay in resource-scarce laboratories.
Article
Chemistry, Analytical
Xiaodong Lin, Bergoi Ibarlucea, Tao Peng, Ren Shen, Peiyue Li, Pan Zhang
Summary: This study synthesized vancomycin-modified copper selenide nanoparticles that can be used for photothermal determination and hyperthermal inactivation of bacteria. The strategy provides a sensitive point-of-care testing method for bacterial determination and efficient bacterial inactivation.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Materials Science, Biomaterials
Binfeng Yin, Wenkai Yue, A. S. M. Muhtasim Fuad Sohan, Xinhua Wan, Teng Zhou, Liuyong Shi, Changcheng Qian, Xiaodong Lin
Summary: In this study, the mixing characteristics of hyperbolic micromixers were investigated, and the effects of different hyperbolic curvatures, Reynolds numbers, and channel widths on the mixing performance were explored. An optimal micromixer was integrated into a microfluidic chip to fabricate a desirable hyperbolic microfluidic chip (DHMC) for the sensitive determination of inflammation marker PCT. The DHMC achieved a low limit of detection (LOD) of 0.17 ng mL(-1) using a chemiluminescence signal, making it a promising real-time platform for early clinical diagnosis.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biophysics
Xiaodong Lin, Haotian Wu, Shiyu Zeng, Tao Peng, Pan Zhang, Xinhua Wan, Yihan Lang, Biao Zhang, Yanwei Jia, Ren Shen, Binfeng Yin
Summary: A lanthanide-based ratiometric fluorescent probe was designed and integrated into a self-designed microfluidic chip for the automated determination of DPA. The platform showed high selectivity and sensitivity, with a detection limit as low as 10.11 nM. The device could achieve rapid detection in only 1 minute and was used for point-of-care testing using a smartphone app, simplifying complex processes and reducing testing times.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Haotian Wu, Xiaodong Lin, Minyang Zhao, Xiao Zhou, Yaqing Liu
Summary: Great progress has been made in DNA computing for cancerous diagnosis, but errors in data transmission are inevitable and directly impact computational reliability, which has been neglected in DNA computing-based diagnosis. Here, a conceptual DNA logic circuit with error correction function for liver cancer diagnosis was constructed by integrating redundant modules to trace logic operation results and judge the correctness of the final result. Furthermore, photothermal treatment function was integrated in the DNA logic circuit for targeted therapy in time. This strategy significantly improves diagnosis accuracy and reliability, with instructive application in biomedical engineering and clinic diagnosis and therapy.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Xinghui Yu, Yongqiang Ma, Siyuan Liu, Chunchun Qi, Weiqi Zhang, Wen Xiang, Zhaoxian Li, Kai Yang, Shaoxian Duan, Xinrao Du, Jian Yu, Yan Xie, Zicheng Wang, Wentao Jiang, Li Zhang, Xiaodong Lin
Summary: Post-operative pathogenic infections in liver transplantation pose a serious threat to human health. Researchers have developed a chemiluminescence-based method for the rapid and sensitive detection of Staphylococcus aureus. By integrating specific capture and separation techniques, this portable device, integrated with a smartphone, enables specific detection of S. aureus with high antibacterial efficiency. The method is simple to use and cost-effective, demonstrating great potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biophysics
Binfeng Yin, Xinhua Wan, Wenkai Yue, Teng Zhou, Liuyong Shi, Songbai Wang, Xiaodong Lin
Summary: Abusive use of 13-agonists can harm human health and food safety. Conventional assays cannot meet the demand for automated, high throughput, and rapid quantitative analysis of multiple 13-agonists in real samples. A portable automated chip system (PACS) was developed in this study to provide simultaneous point-of-care testing of multiple 13-agonists in the field, simplifying complex manual methods, shortening assay times, and improving sensitivity. The PACS enables sensitive and rapid detection of multiple 13-agonists in farms or markets lacking advanced laboratory facilities.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Applied
Xiaodong Lin, Minyang Zhao, Tao Peng, Pan Zhang, Ren Shen, Yanwei Jia
Summary: Pathogenic bacteria can be a major threat to food safety and human health, making it crucial to develop a rapid, portable, and sensitive method for their detection and discrimination. Nanomaterials have emerged as desirable nanoprobes, offering extraordinary properties for optical signal-enabled detection and identification of bacteria. This review focuses on the recent application of nanomaterial-based optical biosensors for the detection and discrimination of pathogenic bacteria in food safety, with particular emphasis on noble metal nanomaterials, fluorescent nanomaterials, and point-of-care testing (POCT). It also discusses future trends in bacterial detection and discrimination, including the role of machine learning in intelligent rapid detection and accurate identification of bacteria.
Article
Chemistry, Analytical
Wenhui Li, Xuecheng Zhang, Haojie Zhang, Cheng Zhang, Yingjie Chen, Cong Li, Yonghong Hu, Xiaoping Yu, Biao Zhang, Xiaodong Lin
Summary: A novel colorimetric immunoassay was developed using Pt@Au nanozymes and catalytic signal probes for the simultaneous detection of DMP and DBP. The method showed high sensitivity and accuracy and can be applied for quantitative analysis of DMP and DBP in baijiu and plastic bottled drinks.
Article
Food Science & Technology
Yuan Fang, Shusen Ding, Weiran Li, Jingjing Zhang, Hui Sun, Xiaodong Lin
Summary: In this study, a dual-channel nanosensor was developed for the detection of Ag+ using synthesized nanomaterials with specific response to Ag+. The sensor combines fluorescence and colorimetric analysis to improve the sensitivity and accuracy of detection, and has shown satisfactory results in real samples.
Article
Chemistry, Applied
Biao Zhang, Jingyi Zhang, Yihan Lang, Zicheng Wang, Danfeng Cai, Xiaoping Yu, Xiaodong Lin
Summary: A novel dual-mode nanoplatform based on sea urchin-shaped Pt@Au NPs with high peroxidase-like activity is developed for sensitive detection of histamine. The colorimetric-based UV-vis nanoplatform allows for sensitive detection of histamine with a linear range of 0.5-100 ng/mL and a low limit of detection (LOD) of 0.3 ng/mL. Additionally, a smartphone-loaded color picker APP can intelligently detect histamine based on the R/B ratio in the color channels, achieving a detection range of 0.5-1000 ng/mL and a LOD as low as 0.15 ng/mL, significantly expanding the detection range. This easy-to-use and sensitive detection system shows great potential in ensuring the safety of protein-rich meat food.
Article
Chemistry, Analytical
Shiyu Zeng, Xiaocheng Sun, Xinhua Wan, Changcheng Qian, Wenkai Yue, A. S. M. Muhtasim Fuad Sohan, Xiaodong Lin, Binfeng Yin
Summary: The highly sensitive detection of cancer cells is crucial for improving the accuracy of early clinical diagnosis. In this study, a novel microfluidic mixer chip combined with fluorescence sensors was fabricated to detect and differentiate cancer cells from normal cells with excellent sensitivity and selectivity.
