Article
Oncology
Sen Liu, Xu Chen, Tianxin Lin
Summary: The article summarizes the molecular mechanisms of lymphatic metastasis in bladder cancer, including lymphangiogenesis, noncoding RNAs, and microenvironment-associated molecules. Newly discovered radiomics and genomics approaches have improved the preoperative diagnostic accuracy of lymph node metastasis, potentially leading to promising therapeutic strategies.
Article
Peripheral Vascular Disease
Anqi Li, Linyu Zhu, Ningjing Lei, Jiajia Wan, Xixi Duan, Shuangqing Liu, Yanru Cheng, Ming Wang, Zhuoyu Gu, Huilei Zhang, Yueyue Bai, Li Zhang, Fazhan Wang, Chen Ni, Zhihai Qin
Summary: The expression of S100A4 in lymphatic endothelial cells promotes lymphatic vessel sprouting in growing tumors by regulating glycolysis. S100A4 plays a crucial role in the position and motility of tip cells, and its expression is upregulated under hypoxic conditions. These findings suggest that S100A4 is a novel regulator of tumor-induced lymphangiogenesis.
Article
Gastroenterology & Hepatology
Shao-Jung Hsu, Chihao Zhang, Jain Jeong, Seong-il Lee, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri
Summary: This study demonstrated that enhancing meningeal lymphatic drainage can reduce neuroinflammation and ameliorate hepatic encephalopathy, suggesting a new therapeutic strategy for the treatment of HE.
Review
Medicine, Research & Experimental
Wenjing Xu, Natalie R. Harris, Kathleen M. Caron
Summary: The lymphatic system is receiving increasing attention for its role in diseases and drug delivery. Despite identified crucial lymphatic genes with therapeutic potential, effective targeted therapeutics for human lymphatic pathologies are lacking. Promising therapeutic targets for modulating lymphangiogenesis or lymphatic function are being explored for future clinical applications.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Physiology
Xiaoning Wang, Xiaojuan Ge, Yinyin Qin, Dong Liu, Changsheng Chen
Summary: This study reveals the role of IFI30 in vascular development during zebrafish embryogenesis. IFI30 deficiency results in incomplete CVP formation and impaired cell behaviors of endothelial cells and macrophages. The findings provide insight into the function of IFI30 in angiogenesis under physiological and pathological conditions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Rene Haegerling, Malou Van Zanten, Rose Yinghan Behncke, Sascha Ulferts, Nils R. Hansmeier, Bruno Maerkl, Christian Witzel, Bernard Ho, Vaughan Keeley, Katie Riches, Sahar Mansour, Kristiana Gordon, Pia Ostergaard, Peter S. Mortimer
Summary: Superficial erythematous cutaneous vascular malformations may have a lymphatic origin rather than a blood vascular origin. Biopsy is necessary for accurate diagnosis. Port-wine birthmarks are cystic lesions that may indicate lymphatic malformation, while erythematous telangiectasias are expanded but nonmalformed lymphatic structures. The presence of erythrocytes accessing lymphatics through lympho-venous shunts explains the red color.
Review
Biochemistry & Molecular Biology
Aditya Jain, Phillip S. Ang, Matthew J. Matrongolo, Max A. Tischfield
Summary: Meningeal lymphatic vessels play a crucial role in maintaining CNS homeostasis and have been extensively studied in humans, non-human primates, and rodents. Recent studies have explored their growth, development, and changes in injury, disease, or aging, leading to the development of potential therapeutic approaches. Further research is needed to fully understand and harness the therapeutic potential of meningeal lymphatics.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell Biology
Christophe Ravaud, Nikita Ved, David G. Jackson, Joaquim Miguel Vieira, Paul R. Riley
Summary: Recent advances in understanding the lymphatic system have changed our views on its importance, as it plays a crucial role in immune cell regulation in addition to transport functions. Interfering with these processes can have deleterious effects, and understanding the interaction between immune cells and lymphatic endothelium is vital for improving heart function. Promoting lymphangiogenesis is now a prime therapeutic target for reducing inflammation and oedema in ischemic heart disease.
Article
Multidisciplinary Sciences
Fan-Wei Meng, Jun-Tao Yu, Jin-Yuan Chen, Peng-Fei Yang
Summary: The study characterized the tissue repair response after penetrating traumatic brain injury in mice by examining tissue morphology and the expression of lymphatic-specific markers. The findings suggest a clearance mechanism involving lymphangiogenesis, with the appearance of new lymphatic cells in damaged brain tissue. Further research is needed to clarify the origin of these cells and their role in brain tissue repair.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Bronwyn Berkeley, Michelle Nga Huen Tang, Mairi Brittan
Summary: Myocardial infarction leads to irreversible ischemic injury, and advances in early reperfusion strategies have reduced short-term mortality. However, survivors face an increased risk of heart failure and death. Understanding the mechanisms of vascular expansion and function in myocardial infarction can inform future therapeutic strategies.
JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Melanie Jannaway, Drishya Iyer, Diandra M. Mastrogiacomo, Kunyu Li, Derek C. Sung, Ying Yang, Mark L. Kahn, Joshua P. Scallan
Summary: Research shows that the loss of Flt4 specifically in lymphatic cells inhibits the formation of specialized button junctions in multiple tissues and impairs interstitial absorption. Knockdown of FLT4 in human lymphatic endothelial cells results in disrupted NOTCH1 expression and activation, while overexpression of the NOTCH1 intracellular domain in Flt4 knockout vessels rescues the formation of button junctions and absorption of interstitial molecules. These findings reveal the importance of VEGFR3 and NOTCH1 signaling in the development of button junctions during postnatal development and may have clinical implications for lymphatic diseases with impaired VEGFR3 signaling.
Review
Immunology
Shun-Shun Wang, Xin-Xu Zhu, Xin-Yi Wu, Wen-Wu Zhang, Yang-Dong Ding, Sheng-Wei Jin, Pu-Hong Zhang
Summary: Physiological activity depends on the blood and lymphatic vasculatures, which have complementary roles in maintaining homeostasis and immune responses. Inflammation is the initial response to injury and has important functions in protecting and restoring the body. Research has shown that blood and lymphatic vessels are crucial in various inflammatory diseases. Changes in the permeability of these vessels lead to angiogenesis and lymphangiogenesis during inflammation. The interaction between blood and lymphatic vessels determines the progression or resolution of inflammation. This review discusses the changes in these vascular systems during inflammation, the different scenarios of angiogenesis and lymphangiogenesis at different sites, and the potential of targeting these systems for inflammation therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Mehmet Can Ucar, Edouard Hannezo, Emmi Tiilikainen, Inam Liaqat, Emma Jakobsson, Harri Nurmi, Kari Vaahtomeri
Summary: The authors reveal that developing lymphatic capillary networks utilize complementary branching strategies to optimize tissue coverage through a combination of experimental and theoretical approaches.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Catherine L. Ly, Jinyeon Shin, Noa Schwartz, Theresa T. Lu, Sagrario Ortega, Babak J. Mehrara
Summary: The study shows that intracellular modulation of the VEGF-C signaling pathway can induce the formation of functional lymphatic networks without off-target effects and inflammation.
Article
Cardiac & Cardiovascular Systems
Natalie R. Harris, Natalie R. Nielsen, John B. Pawlak, Amir Aghajanian, Krsna Rangarajan, D. Stephen Serafin, Gregory Farber, Danielle M. Dy, Nathan P. Nelson-Maney, Wenjing Xu, Disha Ratra, Sophia H. Hurr, Li Qian, Joshua P. Scallan, Kathleen M. Caron
Summary: This study reveals the essential role of VE-cadherin in the development and maintenance of cardiac lymphatics and its impact on lymphangiogenic signaling pathways. Surprisingly, despite the regression of cardiac lymphatics, Cdh5(flox/flox);Prox1CreER(T2) mice exhibited preserved cardiac function at baseline and after myocardial infarction compared with control mice. Mechanistically, loss of VE-cadherin leads to aberrant cellular internalization of VEGFR3, impairing downstream processes such as cellular proliferation.
CIRCULATION RESEARCH
(2022)
Article
Developmental Biology
Yan Li, Chao Tang, Fan Liu, Caiying Zhu, Feng Liu, Ping Zhu, Lu Wang
Summary: This study investigates the role of DNA methyltransferase 1 (Dnmt1) in hematopoietic stem and progenitor cell (HSPC) generation. It finds that Dnmt1 is essential for HSPC generation by repressing Notch signaling through DNA methylation.
Review
Cell Biology
Yanan Sun, Huihui Wang, Taiqi Qu, Junjie Luo, Peng An, Fazheng Ren, Yongting Luo, Yixuan Li
Summary: Autophagy is a highly regulated catabolic process involving the degradation and recycling of cellular components. The mechanistic target of rapamycin (mTOR) plays a central role in autophagy regulation. While mTORC1 is well-studied and known to be acutely inhibited by rapamycin, less is known about mTORC2. Recent research suggests that mTORC2's role in autophagy is mainly through its downstream effector proteins and varies under different conditions and cellular contexts. Understanding the involvement of mTORC2 in autophagy could potentially lead to new treatment strategies for autophagy-related diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Jian Heng, Boyang Shi, Jia-Yi Zhou, Yifan Zhang, Dongyuan Ma, Yun-Gui Yang, Feng Liu
Summary: Cpeb1b-mediated cytoplasmic polyadenylation plays a crucial role in hematopoietic stem and progenitor cell development by regulating Hedgehog signaling. Cpeb1b controls hemogenic endothelium specification through the Hedgehog-Vegf-Notch axis, leading to the production of HSPCs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Jingjing He, Fangyan Chen, Sitong Wan, Yongting Luo, Junjie Luo, Shuli He, Daizhan Zhou, Peng An, Ping Zeng
Summary: Antioxidant minerals such as zinc, copper and selenium have important roles in maintaining redox balance in the body. This study aimed to investigate the relationship between these minerals and type 2 diabetes mellitus (T2DM) in Chinese populations. The results showed a negative association between serum zinc and copper concentrations and T2DM, while no association was found for serum selenium. Adequate intake of antioxidant minerals is emphasized for T2DM prevention in the Chinese population.
Article
Developmental Biology
Peng Lv, Feng Liu
Summary: Deficiencies in primitive red blood cells have detrimental effects on the survival and development of HSPCs, potentially leading to hematological malignancies.
Review
Biochemistry & Molecular Biology
Yi Xia, Xu Zhang, Peng An, Junjie Luo, Yongting Luo
Summary: Vascular remodeling, characterized by abnormal proliferation, migration, and apoptosis of vascular smooth muscle cells (VSMCs), is a common pathological feature of many cardiovascular diseases. Emerging evidence suggests that mitochondria, as the energy center of VSMCs, play a crucial role in vascular remodeling. Maintaining mitochondrial homeostasis in VSMCs may provide a potential therapeutic target for preventing and treating pathologic vascular remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Genetics & Heredity
Chunxia Zhang, Yi Zhang
Summary: Using new techniques, Liu et al. found that human maternal mRNAs undergo global poly(A) tail mediated remodeling during the oocyte-to-embryo transition (OET), identified the enzymes involved, and demonstrated the essentiality of remodeling for embryo cleavage.
TRENDS IN GENETICS
(2023)
Article
Nutrition & Dietetics
Lin Zhu, Peng An, Wenting Zhao, Yi Xia, Jingyi Qi, Junjie Luo, Yongting Luo
Summary: Low zinc can reduce the development of thoracic aortic dissection triggered by vascular inflammation. It achieves this by reducing the infiltration of macrophages, inhibiting the expression of inflammatory cytokines, suppressing the phenotype switch of vascular smooth muscle cells, and ultimately improving the progression of thoracic aortic dissection.
Review
Developmental Biology
Suwei Gao, Yifan Zhang, Feng Liu
Summary: For a long time, it was believed that self-renewing and multipotent hematopoietic stem cells (HSCs) were the main contributors to both embryonic and adult hematopoiesis. However, recent studies have shown that native hematopoiesis is not solely driven by hierarchical differentiation of HSCs, but rather by hematopoietic progenitor cells (HPCs). These findings help redefine our understanding of the cellular origins of embryonic and adult hematopoiesis and highlight the differences in revealing HSC potential versus HSC fate using different approaches.
Article
Developmental Biology
Ying Li, Can Li, Mengyao Liu, Shicheng Liu, Feng Liu, Lu Wang
Summary: This article investigates the role of RBP protein Csde1 in regulating HSPC generation during zebrafish early development. By modulating the activity of the Wnt/f3-catenin signaling pathway, Csde1 ensures the proper production of HSPCs.
Article
Cell Biology
Xuan Wang, Yuting Ji, Jingyi Qi, Shuaishuai Zhou, Sitong Wan, Chang Fan, Zhenglong Gu, Peng An, Yongting Luo, Junjie Luo
Summary: Cervical cancer is a deadly disease in women, and mitochondrial-mediated ferroptosis (MMF) has been identified as a key factor in its development. By investigating the mitochondria transmembrane candidates, researchers discovered that mitochondrial carrier 1 (MTCH1) plays a central role in MMF in cervical cancers. MTCH1 deficiency disrupted mitochondrial oxidative phosphorylation and increased mitochondrial reactive oxygen species (ROS), leading to ferroptosis. Targeting MTCH1 in combination with Sorafenib effectively inhibited cervical cancer growth by inducing ferroptosis in a mouse xenograft model. These findings provide insights into the mechanisms of MMF and offer a potential therapeutic target for cervical cancer.
CELL DEATH & DISEASE
(2023)
Editorial Material
Nutrition & Dietetics
Junjie Luo, Yongting Luo
Article
Nutrition & Dietetics
Shuaishuai Zhou, Zi Wang, Yanling Hao, Peng An, Junjie Luo, Yongting Luo
Summary: Dandelion polysaccharides may play an important role in attenuating atherosclerosis by antioxidative and anti-inflammatory effects.
Article
Engineering, Biomedical
Zhongqian Liu, Shijie Mao, Yubin Hu, Feng Liu, Xiaowei Shao
Summary: This study developed an alginate hydrogel-based method to efficiently induce astrocytic differentiation from human neural stem cells, which significantly promoted differentiation within three days compared to conventional tissue culture materials. The regulatory mechanism underlying the enhanced differentiation was investigated, revealing the involvement of stretch-activated ion channels and a mechanosensitive transcription coactivator. These findings provide novel insights into the mechanism of astrocytic development through mechanical regulation.
MATERIALS TODAY BIO
(2023)
Article
Cell Biology
Jun Xia, Mengyao Liu, Caiying Zhu, Shicheng Liu, Lanlan Ai, Dongyuan Ma, Ping Zhu, Lu Wang, Feng Liu
Summary: Using single-cell multi-omics, lineage tracing and functional assays, it was discovered that hematopoietic stem and progenitor cells (HSPCs) originate from heterogeneous hemogenic endothelial cells (HECs) during zebrafish embryogenesis. The study revealed the importance of Spi2 in the endothelial-to-hematopoietic transition process and identified molecular determinants of HSPC heterogeneity. These findings provide a foundation for new strategies for inducing lineage-primed HSPCs for transplantation in vitro.
