Antihyperalgesic, Antiallodynic, and Antinociceptive Effects of Cebranopadol, a Novel Potent Nociceptin/Orphanin FQ and Opioid Receptor Agonist, after Peripheral and Central Administration in Rodent Models of Neuropathic Pain

Nociceptin/orphanin FQ receptor expression in clinical pain disorders and functional effects in cultured neurons

(2016) Praveen Anand et al.   PAIN

Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates

(2015) H Ding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanical hyperalgesia in rats with diabetic polyneuropathy is selectively inhibited by local peripheral nociceptin/orphanin FQ receptor and µ-opioid receptor agonism

(2015) Klaus Schiene et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists

(2014) W Schröder et al.   BRITISH JOURNAL OF PHARMACOLOGY

Axial Low Back Pain: One Painful Area – Many Perceptions and Mechanisms

(2013) Matti Förster et al.   PLoS One

Targeting pain and inflammation by peripherally acting opioids

(2013) Christoph Stein   Frontiers in Pharmacology

Self-reported pain severity, quality of life, disability, anxiety and depression in patients classified with ‘nociceptive’, ‘peripheral neuropathic’ and ‘central sensitisation’ pain. The discriminant validity of mechanisms-based classifications of low back (±leg) pain

(2011) Keith M. Smart et al.   MANUAL THERAPY

Antinociceptive Effects of Nociceptin/Orphanin FQ Administered Intrathecally in Monkeys

(2009) Mei-Chuan Ko et al.   JOURNAL OF PAIN

Behavioral Effects of a Synthetic Agonist Selective for Nociceptin/Orphanin FQ Peptide Receptors in Monkeys

(2009) Mei-Chuan Ko et al.   NEUROPSYCHOPHARMACOLOGY

Tapentadol, but not morphine, selectively inhibits disease-related thermal hyperalgesia in a mouse model of diabetic neuropathic pain

(2009) Thomas Christoph et al.   NEUROSCIENCE LETTERS