Article
Integrative & Complementary Medicine
Shih-Yu Lee, I-Chuan Yen, Jang-Chun Lin, Min-Chieh Chung, Wei-Hsiu Liu
Summary: This study found that a new component 4-acetylantrocamol LT3 (4AALT3) from Antrodia cinnamomea can significantly inhibit proliferation and migration of glioblastoma cells in vitro, and suppress multiple signaling pathways. In addition, 4AALT3 also showed a synergistic effect with temozolomide.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Julia Penas-Martinez, Gines Luengo-Gil, Salvador Espin, Nataliya Bohdan, Carmen Ortega-Sabater, Maria Carmen Rodenas, David Zaragoza-Huesca, Maria Jose Lopez-Andreo, Carme Plasencia, Vicente Vicente, Alberto Carmona-Bayonas, Irene Martinez-Martinez
Summary: Our study reveals the versatile anti-tumor properties of prelatent antithrombin on U-87 MG glioblastoma multiforme cells, inhibiting migration and invasion while having a lesser effect on proliferation. Prelatent antithrombin down-regulated the expression of VEGFA, pSTAT3, and pERK1/2 in U-87 MG cells.
Article
Oncology
Dilara Akcora-Yildiz, Yunus Yukselten, Merve Sunguroglu, Hasan Caglar Ugur, Asuman Sunguroglu
Summary: The study revealed significantly elevated mRNA expressions of IL-33 and ADAMTS5 in GBM cells, with a positive correlation between the two. IL-33 treatment increased ADAMTS5 protein levels in a dose-dependent manner and promoted migration of GBM cells.
Article
Multidisciplinary Sciences
Yuanning Zheng, Francisco Carrillo-Perez, Marija Pizurica, Dieter Henrik Heiland, Olivier Gevaert
Summary: In this study, two deep learning models were used to predict the transcriptional subtypes and prognosis of glioblastoma (GBM) cells from histology images. The results showed consistent associations between spatial cellular organization and patient prognosis. The study also confirmed that transcriptional heterogeneity and cell-state plasticity are key factors in the development of therapeutic resistance in GBM.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Xiaosan Zhu, Shanshan Liu, Xueou Yang, Wenjun Wang, Wei Shao, Tianhai Ji
Summary: This study demonstrates that hypoxia enhances the migration and invasion of GBM through the L-Arg/P4HA1 axis, which could serve as an effective molecular marker or predictor of clinical outcomes in GBM patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Marianna Makowska, Beata Smolarz, Hanna Romanowicz
Summary: Glioblastoma multiforme (GBM) is a common, malignant brain tumor with a poor prognosis. Traditional treatments have limited success due to the tumor's infiltrating growth and resistance. The search for new therapies is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chao Yuan, Yanli Liao, Shengjie Liao, Mi Huang, Duanzhuo Li, Weibin Wu, Yi Quan, Liqiang Li, Xin Yu, Wenxia Si
Summary: This study confirmed that triptolide inhibited the progression of glioblastoma cells by transcriptionally depressing the expression of PROX1.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Hsiao-Hang Chung, Ming-Ju Hsieh, Yih-Shou Hsieh, Pei-Ni Chen, Chung-Po Ko, Nuo-Yi Yu, Chiao-Wen Lin, Shun-Fa Yang
Summary: The leaf extracts of Terminalia catappa (TCE) were found to significantly inhibit the migration and invasion abilities of GBM cell lines through regulating the p38 pathway, suggesting potential therapeutic applications for treating GBM brain tumors.
Review
Immunology
Boyuan Huang, Xuesong Li, Yuntao Li, Jin Zhang, Zhitao Zong, Hongbo Zhang
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive malignant tumor in the central nervous system. Immunotherapy has shown promising results in the treatment of GBM, but future developments will require an integrated approach with various treatment modalities and specific targeted therapies for the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yung-Lung Chang, Yao-Feng Li, Chung-Hsing Chou, Li-Chun Huang, Yi-Ping Wu, Ying Kao, Chia-Kuang Tsai
Summary: Diosmin, a natural flavone glycoside, demonstrated inhibitory effects on GBM cell growth, migration, and invasion, as well as modulation of autophagy and cell cycle progression. It showed limited cytotoxicity towards astrocytes and holds potential for new GBM treatment therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mark Marsland, Amiee Dowdell, Sam Faulkner, Phillip Jobling, Robert A. Rush, Craig Gedye, James Lynam, Cassandra P. Griffin, Mark Baker, Joanne Marsland, Chen Chen Jiang, Hubert Hondermarck
Summary: In this study, we investigated the expression and biological activity of proNGF in glioblastoma multiforme (GBM). The results showed that proNGF was significantly overexpressed in GBM and could stimulate cancer cell growth. Therefore, further investigations are needed to confirm the potential of proNGF as a clinical biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maya A. Dymova, Elena Kuligina, Vladimir A. Richter
Summary: This review summarizes recent advances in understanding the molecular mechanisms of therapeutic resistance of GBM, molecular characteristics of glioblastoma cells, and barriers in the brain that contribute to drug resistance. The progress in developing new targeted drugs for glioblastoma and drug delivery across the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB) is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Antoine Chartouni, Antoine Mouawad, Marc Boutros, Fouad Attieh, Nicolas Medawar, Hampig Raphael Kourie
Summary: Glioblastoma multiforme (GBM) is a deadly primary tumor of the central nervous system with a low survival rate, despite a standard treatment plan. Recent exploration of innovative and more effective treatments based on Mesenchymal Stem Cells (MSCs) shows promising results. MSCs, harvested from adipose tissue, bone marrow, and umbilical cord, can migrate towards tumors and be used for direct treatment or as delivery vehicles for anti-tumoral agents.
INVESTIGATIONAL NEW DRUGS
(2023)
Article
Oncology
Robyn A. Umans, Joelle Martin, Megan E. Harrigan, Dipan C. Patel, Lata Chaunsali, Aarash Roshandel, Kavya Iyer, Michael D. Powell, Ken Oestreich, Harald Sontheimer
Summary: Glioblastoma multiforme (GBM) is a deadly brain tumor with limited treatment options. Recent research suggests that tumor protein 53 (TP53) is a molecular regulator of System xc- (SXC) in GBM, with its expression negatively correlated with xCT expression. This finding indicates that p53 may serve as a potential therapeutic target for GBM by regulating glutamate biology.
Article
Oncology
Xiongxiong Liu, Qiqi Wang, Bingtao Liu, Xiaogang Zheng, Ping Li, Ting Zhao, Xiaodong Jin, Fei Ye, Pengcheng Zhang, Weiqiang Chen, Qiang Li
Summary: This study demonstrated that genistein can effectively inhibit radiation-induced invasion and migration of GBM cells by specifically binding to DNA-PKcs and blocking its pathway. DNA-PKcs is not only a potential target for cancer therapy, but also a reliable biomarker for predicting radiation-induced invasion and migration of GBM cells.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, Research & Experimental
Mu-Kuei Shieu, Hsin-Yu Ho, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: This study demonstrated the antimetastatic effects of narciclasine in oral cancer and identified the underlying molecular mechanisms. Narciclasine inhibits oral cancer metastasis by regulating the ERK pathway and CTSB, providing potential targets for oral cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Chun-Yu Hsieh, Chia-Yen Lin, Shian-Shiang Wang, Ying-Erh Chou, Ming-Hsien Chien, Yu-Ching Wen, Ming-Ju Hsieh, Shun-Fa Yang
Summary: This study aimed to investigate the relationship between TIMP3 genetic polymorphisms and biochemical recurrence and clinicopathological features of prostate cancer. It was found that the TIMP3 rs9619311 genetic polymorphism was significantly associated with susceptibility to biochemical recurrence of prostate cancer. Moreover, in patients with a PSA concentration under 7 ng/mL, the TIMP3 rs9619311 genetic polymorphism was associated with Gleason total score upgrade and grade group upgrade.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Oncology
Hung-Ju Chien, Chung-Jung Liu, Tsung-Ho Ying, Pei-Ju Wu, Jiunn-Wei Wang, Yi-Hsuan Ting, Yi-Hsien Hsieh, Shih-Chiang Wang
Summary: This study aimed to evaluate Timosaponin AIII (TSAIII) as a potential therapeutic approach for cervical cancer. The results showed that TSAIII suppresses cell migration, invasion, p38 activation, and uPA expression in cervical cancer. Additionally, TSAIII demonstrated antimetastatic properties and inhibited the growth of cervical cancer stem cells. These findings suggest that TSAIII may be a potential auxiliary therapy for cervical cancer.
Article
Cell Biology
Chu-Che Lee, Jen-Pi Tsai, Hsiang-Lin Lee, Yung-Jen Chen, Yong-Syuan Chen, Yi-Hsien Hsieh, Jin-Cherng Chen
Summary: In this study, Timosaponin AIII (TSAIII) was found to inhibit the growth of glioma cells by inducing cell death, mitochondrial dysfunction, and autophagy activation. The results suggest that TSAIII exhibits antitumor effects and may have potential as a therapy for glioma.
Article
Chemistry, Medicinal
Je-Chiuan Ye, Yih-Shou Hsieh, Pei-Ni Chen, Jer-Yuh Liu, Yi-Hsien Hsieh
Summary: Our study shows that PKCa regulates the PA and MMPs systems in liver cancer cells through the p38 MAPK signaling pathway, promoting cell progression. MMP-1 and u-PA play critical roles in this pathway, and targeting these genes may be a potential treatment approach for liver cancer.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Environmental Sciences
Pei-Ju Wu, Hui-Ling Chiou, Yi-Hsien Hsieh, Chia-Liang Lin, Hsiang-Lin Lee, I-Chun Liu, Tsung-Ho Ying
Summary: Licoricidin, an active compound of Glycyrrhiza uralensis, was found to significantly inhibit cell viability and induce apoptosis in cervical cancer cells. It also triggered endoplasmic reticulum stress and upregulated the protein expression of GRP78 (Bip), CHOP, and IRE1 alpha, ultimately leading to immunogenic cell death. These findings suggest that Licoricidin may be a potential inducer of immunotherapy in advanced cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ming-Ju Hsieh, Hsin-Yu Ho, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mosleh Mohammad Abomughaid, Ming-Chang Hsieh, Mu-Kuan Chen
Summary: The study investigates the anticancer activities of a natural compound called semilicoisoflavone B (SFB) in oral squamous cell carcinoma (OSCC). Results show that SFB reduces cell viability by targeting the cell cycle and inducing apoptosis. It also inhibits several signaling pathways and downregulates survivin expression. Overall, the study suggests that SFB has potential as a therapeutic agent for human OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Kuan-Chun Hsueh, Po-Chung Ju, Yi-Hsien Hsieh, Shih-Chi Su, Chao-Bin Yeh, Chiao-Wen Lin
Summary: HO-3867 triggers cell cycle arrest and apoptotic responses in liver cancer, possibly involving p38-mediated activation of caspase cascades.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Tsai-Kun Wu, Tung-Wei Hung, Yong-Syuan Chen, Ying-Ru Pan, Yi-Hsien Hsieh, Jen-Pi Tsai
Summary: Corosolic acid inhibits the migration and invasion of renal cell carcinoma cells by reducing MMP2 expression and stimulating ERK1/2 phosphorylation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Chun Sun, Chia-Liang Lin, Tzong-Huei Lee, Chia-Hao Chang, Ann-Zhi Ong, Yen-Hsiu Yeh, Chen-Lin Yu, Guang-Wei Chen, Yi-Hsien Hsieh, Shih-Wei Wang
Summary: In this study, Chaetoglobosin A (ChA) was identified as a potent and selective antitumor agent in human colorectal cancer (CRC). ChA inhibited CRC cell growth and induced apoptotic cell death through mitochondrial intrinsic and caspase-dependent pathways. The expression of Heme oxygenase-1 (HO-1) was found to be associated with ChA-induced cell death, and inhibition of HO-1 increased the sensitivity of CRC cells to ChA.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Jia-Sin Yang, Chia-Hsuan Chou, Yi-Hsien Hsieh, Peace Wun-Ang Lu, Ya-Chiu Lin, Shun-Fa Yang, Ko-Hsiu Lu
Summary: The study found that Morin can suppress the migration and invasion capabilities of human osteosarcoma cells, playing an anti-metastatic role by reducing uPA expression. Therefore, Morin may be a potential drug candidate for the treatment of human osteosarcoma.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Huang-Ming Hu, Hsiang-Lin Lee, Chung-Jung Liu, Yi-Hsien Hsieh, Yong-Syuan Chen, Kuan-Chun Hsueh
Summary: The study found that MTA2 regulates HCC progression through the MTA2-FAK-MMP7 pathway. PTK7, as a downstream factor of MTA2, affects the migration and invasion abilities of HCC cells by regulating MMP7 expression. The expression level of PTK7 is correlated with tumor stage, grade, and overall survival in HCC patients, and may have diagnostic value for HCC patients.
ENVIRONMENTAL TOXICOLOGY
(2023)
