Journal
ONCOTARGET
Volume 8, Issue 26, Pages 43470-43480Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16478
Keywords
long non-coding RNA; melanoma; biomarkers; cancer therapy
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Metastatic melanoma of the skin has a high mortality despite the recent introduction of targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as transcripts of more than 200 nucleotides in length that lack protein-coding potential. There is growing evidence that lncRNAs play an important role in gene regulation, including oncogenesis. We present 13 lncRNA genes involved in the pathogenesis of cutaneous melanoma through a variety of pathways and molecular interactions. Some of these lncRNAs are possible biomarkers or therapeutic targets for malignant melanoma.
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