Article
Immunology
Eva Pastille, Tabea Fassnacht, Alexandra Adamczyk, Nhi Ngo Thi Phuong, Jan Buer, Astrid M. Westendorf
Summary: In this study, the research team found that blocking TLR4 signaling during the inflammatory phases of CAC can significantly reduce the development and progression of colonic tumors, as well as decrease inflammation levels, providing a novel approach to impede CAC development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Syrina F. Mehrabi, Souvik Ghatak, Lubna M. Mehdawi, Geriolda Topi, Shakti Ranjan Satapathy, Anita Sjolander
Summary: The study found that high levels of CD66b and BDNF are associated with poor prognosis in colon cancer patients, and are strongly positively correlated with CysLT(1). These three proteins can potentially serve as a combined biomarker for colon cancer patients.
Review
Biochemistry & Molecular Biology
Michelle Temby, Theresa L. Boye, Jacqueline Hoang, Ole H. Nielsen, John Gubatan
Summary: This article reviews the role of kinase signaling pathways in colitis-associated colon cancer, including MAPK, CDK, autophagy-activated kinases, JAK-STAT, and other kinases. It also discusses the involvement of JAK-STAT signaling in the pathogenesis of inflammatory bowel disease (IBD) and the potential use of JAK inhibitors for treating IBD.
Review
Immunology
Luying He, Qianming Kang, Ka Iong Chan, Yang Zhang, Zhangfeng Zhong, Wen Tan
Summary: In this study, we reviewed the immunomodulatory role of matrix metalloproteinases (MMPs) in colitis-associated cancer (CAC) and discussed relevant clinical applications. We analyzed over 300 pharmacological studies retrieved from PubMed and the Web of Science, focusing on MMPs, cancer, colitis, CAC, and immunomodulation. MMPs are involved in various processes in CAC, such as cell proliferation, cell differentiation, angiogenesis, ECM remodeling, and the inflammatory response. They also affect the immune system by modulating immune cell differentiation and activity, as well as the recruitment of macrophages and neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Junjie Liang, Caiyi Yang, Pengcheng Li, Meiling Zhang, Xueqian Xie, Xuting Xie, Yunliang Chen, Qing Wang, Lian Zhou, Xia Luo
Summary: Astragaloside IV activates PPAR gamma signaling and reduces DNA damage to inhibit the occurrence of CAC.
Article
Cell Biology
Bo-Ram Jin, Hyo-Jung Kim, Seo-Ah Sim, Minho Lee, Hyo-Jin An
Summary: The study found that Western diet exacerbates the development and progression of colon cancer, inducing inflammation, hyperplasia, and tumorigenicity through the activation of STAT3 and NF-kappa B signaling. Additionally, the anti-obesity agent orlistat can improve survival rates, alleviate symptoms of CAC, and suppress tumor progression by inhibiting inflammation and activating STAT3 and NF-kappa B.
Article
Pharmacology & Pharmacy
Kilia Y. Liu, Qianyue Wang, Cindy H. Nakatsu, Yava Jones-Hall, Qing Jiang
Summary: Combining aspirin and gamma T has been shown to be more effective in suppressing colorectal cancer compared to using either compound alone. This combination also alleviates the adverse effects caused by aspirin and improves gut microbiota. The study provides a new strategy for the prevention and treatment of colorectal cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wang Lin, Wang Rui, Wei Guang-yi, Zhang Rui-ping, Zhu Ying, Wang Zhe, Wang Shu-mei, Du Guan-hua
Summary: The study found that cryptotanshinone can significantly alleviate 5-FU/CPT-11 induced colitis in mice with colitis associated colon cancer by regulating lipid metabolism associated with fecal bacteria.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Blanca E. Callejas, Graham A. D. Blyth, Nicholas Jendzjowsky, Arthur Wang, Anshu Babbar, Konstantin Koro, Richard J. A. Wilson, Margaret M. Kelly, Eduardo R. Cobo, Derek M. McKay
Summary: The study investigated the effects of M(IL4) treatment on different disease models, including colitis, colorectal cancer, and airway inflammation. It was found that M(IL4) treatment had anti-inflammatory effects and improved the severity of colitis, while not exacerbating other conditions or diseases such as colorectal tumorigenesis. Overall, the data suggest that systemic delivery of M(IL4) did not worsen disease in the tested models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xue-jun Wang, Dan Zhang, Yan-ting Yang, Xiao-ying Li, Hong-na Li, Xiao-peng Zhang, Jun-yi Long, Yun-qiong Lu, Li Liu, Guang Yang, Jie Liu, Jue Hong, Huan-gan Wu, Xiao-peng Ma
Summary: This study found that miR-222-3p reduces oxidative stress in IECs by targeting BRG1 to activate the Nrf2/HO-1 signaling pathway, thereby reducing colonic inflammation and tumorigenesis in UC and CAC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Marica Cariello, Roberta Zerlotin, Emanuela Pasculli, Elena Piccinin, Claudia Peres, Emanuele Porru, Aldo Roda, Raffaella Maria Gadaleta, Antonio Moschetta
Summary: The activation of intestinal FXR can prevent both inflammation- and genetically-driven colorectal tumorigenesis by modulating the size and composition of bile acid pool, providing new possibilities for the therapeutic management of intestinal inflammation and tumorigenesis.
Article
Biochemistry & Molecular Biology
Dina Polosukhina, Kshipra Singh, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Dana M. Hardbower, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson, Lori A. Coburn
Summary: The study found that CCL11 is involved in the pathogenesis of DSS-induced colitis and contributes to colon tumorigenesis. Mice lacking CCL11 exhibited less intestinal damage and reduced cancer development in experiments, indicating the important role of CCL11 in the development of colitis and colon cancer.
Review
Gastroenterology & Hepatology
Thergiory Irrazabal, Bhupesh K. Thakur, Kenneth Croitoru, Alberto Martin
Summary: Patients with inflammatory bowel disease have increased oxidative damage, potentially leading to colon cancer, while exogenous antioxidant molecules can reduce intestinal oxidation and prevent these cancers from developing.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jelena Popov, Valentina Caputi, Nandini Nandeesha, David Avelar Rodriguez, Nikhil Pai
Summary: Ulcerative colitis (UC) is a chronic autoimmune disorder that affects the colonic mucosa. Its etiology remains unclear, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in UC pathogenesis, and the potential for modulating intestinal inflammation through microbial-targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Chi-Yu Lai, Kun-Yun Yeh, Bi-Feng Liu, Tzu-Ming Chang, Chuan-Hsun Chang, Yung-Feng Liao, Yi-Wen Liu, Guor Mour Her
Summary: miR-21 plays a crucial role in the development of CRC/CAC through the PI3K/AKT, STAT3, and PDCD4/TNF-alpha signaling networks, and may serve as a novel therapeutic target for the treatment of CRC/CAC.
Meeting Abstract
Oncology
J. Osman, S. Savari, N. K. Chandrashekar, D. Douglas, K. Bellamkonda, G. Greicius, S. Pettersson, A. Sjolander
EUROPEAN JOURNAL OF CANCER
(2015)
Article
Oncology
Kishan Bellamkonda, Naveen Kumar Chandrashekar, Janina Osman, Benson Chellakkan Selvanesan, Sayeh Savari, Anita Sjolander
Article
Oncology
Sayeh Savari, Naveen Kumar Chandrashekar, Janina Osman, Desiree Douglas, Kishan Bellamkonda, Gunilla Jonsson, Maria Juhas, Gedas Greicius, Sven Pettersson, Anita Sjolander
Article
Oncology
Kishan Bellamkonda, Shakti Ranjan Satapathy, Desiree Douglas, Naveenkumar Chandrashekar, Benson Chellakkan Selvanesan, Minghui Liu, Sayeh Savari, Gunilla Jonsson, Anita Sjolander
Article
Oncology
Robert C. Fisher, Kishan Bellamkonda, L. Alex Molina, Shao Xiang, David Liska, Samaneh K. Sarvestani, Susmita Chakrabarti, Annamarie Berg, Marda L. Jorgensen, Denise Hatala, Sugong Chen, Alexandra Aiello, Henry D. Appelman, Edward W. Scott, Emina H. Huang
Article
Oncology
Janina Osman, Kishan Bellamkonda, Qing Liu, Tommy Andersson, Anita Sjolander
ANTICANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Naveenkumar Chandrashekar, Raghunandhakumar Subramanian, Devaki Thiruvengadam
Summary: Our study aims to explore the mechanisms of the growth inhibitory effect of baicalein in human lung carcinoma. The results show that baicalein treatment suppresses cell viability and induces cell apoptosis both in vitro and in vivo, through activating antioxidant pathways and regulating cell cycle-related proteins.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Naveenkumar Chandrashekar, Anandakumar Pandi
Summary: Baicalein, a flavonoid found in Scutellaria baicalensis, has been studied for its various biological effects and has now been discovered to be effective against lung neoplasm. It has potential anti-cancer activity and could be used as a novel drug for the treatment of lung carcinoma.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Hematology
Maria Rodriguez-Zabala, Ramprasad Ramakrishnan, Katrin Reinbach, Somadri Ghosh, Leal Oburoglu, Antoni Falques-Costa, Kishan Bellamkonda, Mats Ehinger, Pablo Pena-Martinez, Noelia Puente-Moncada, Henrik Lilljebjorn, Jorg Cammenga, Cornelis Jan Pronk, Vladimir Lazarevic, Thoas Fioretos, Anna K. Hagstrom-Andersson, Niels-Bjarne Woods, Marcus Jaras
Summary: Acute myeloid leukemia (AML) is driven by leukemia stem cells (LSCs) which are resistant to therapy. This study identified GLUT1 as a critical metabolic dependency for LSCs and showed that its disruption can suppress leukemia progression and improve survival. Inhibition of GLUT1 leads to metabolic reprogramming, increased apoptosis and autophagic activity. Dual inhibition of GLUT1 and oxidative phosphorylation exhibited synergistic effects against AML.
Review
Multidisciplinary Sciences
Anandakumar Pandi, Mahto Hemanti Raghu, Naveenkumar Chandrashekar, Vanitha Manickam Kalappan
Summary: The main purpose of this review is to explore the cardioprotective mechanisms of ferulic acid against various drugs and chemicals and recommend further studies to investigate its potential protective effect.
BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES
(2022)