Journal
ONCOTARGET
Volume 8, Issue 56, Pages 96384-96395Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.21466
Keywords
MICA; MICB; prognosis; cancer; meta-analysis
Categories
Funding
- Nation Key Research and Development Program of China [2016YFC1303800]
- Key Laboratory Construction Project of Science and Technology Department [20170622011JC]
- Development and Reform Commission of Jilin Province [2014N147, 2017C022]
- Science and Technology Department of Natural Science Fund Project in Jilin Province [20150101176JC]
Ask authors/readers for more resources
Purpose: MHC class I chain related-proteins A (MICA) and B (MICB) are natural killer group 2D ligands that mediate tumor surveillance. Several studies have suggested that MICA/B levels predict clinical outcomes in patients with cancer; however, this remains contentious. Here, we present a systematic review and meta-analysis of available studies of the prognostic value of MICA/B in cancer. Materials and Methods: We searched PubMed, Embase, Clinicaltrials. gov, and Cochrane Library to identify studies published from inception to July 2017 that assessed MICA/B in patients with cancer. The hazard ratio (HR) and 95% confidence interval (CI) of MICA/B were extracted for overall survival (OS) analysis. Results: A total of 19 studies comprising 2,588 patients with 10 different types of cancer were included in the study. Low sMICA/B levels were found associated with significantly longer OS (HR = 1.65, 95% CI [1.42-1.92], P < 0.00001). Patients with cancers of digestive system that exhibited high MICA/B expression had significantly longer OS in (HR = 0.56, 95% CI [0.39-0.80], P = 0.002) compared with those with lower MICA/B expression (I-2 = 35%, P = 0.18). Conclusions: Serum soluble MICA/B represents a potential prognostic marker in various human cancers. High cell-surface MICA/B expression in cancers of the digestive system was found associated with increased survival.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available