Review
Oncology
Jun Peng, Jinfeng Liu, Huining Liu, Yan Huang, Yingchun Ren
Summary: MicroRNAs play an important role in the overall survival of patients with small cell lung cancer, serving as potential prognostic markers and providing valuable information for treatment strategies.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Yan Huang, Min Gu, Yiting Tang, Zhiqiang Sun, Judong Luo, Zhe Li
Summary: The research identified potential noninvasive and simple markers, including miRNA-100, miRNA-155, miRNA-21, miRNA-34a, miRNA-195, and miR-let-7, for disease prognosis in patients with laryngeal cancer. Dysregulated microRNAs were observed in 5307 patients with laryngeal cancer, showing an association with patient outcomes.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Masahisa Ohtsuka, Kazuya Iwamoto, Atsushi Naito, Mitsunobu Imasato, Satoshi Hyuga, Yujiro Nakahara, Manabu Mikamori, Kenta Furukawa, Jeongho Moon, Tadafumi Asaoka, Kentaro Kishi, Awad Shamma, Hiroki Akamatsu, Tsunekazu Mizushima, Hirofumi Yamamoto
Summary: MicroRNAs (miRNAs) show potential as noninvasive biomarkers for gastrointestinal cancer (GIC) due to their stability in blood and association with GIC status. Research on miRNAs is crucial for early detection and treatment improvement in GIC patients.
Review
Medicine, General & Internal
Jie Yang, Xue-Song Yang, Shao-Wei Fan, Xiao-Yu Zhao, Chao Li, Zheng-Yao Zhao, Hui-Juan Pei, Lu Qiu, Xin Zhuang, Chuan-Hua Yang
Summary: The meta-analysis indicates that the expression levels of circulating miRNAs are associated with overall survival in heart failure patients, with certain miRNAs serving as strong prognostic biomarkers. Low expression levels of specific miRNAs could potentially lead to worse patient outcomes.
Review
Oncology
Yan-Ling Chen, Xiao-Lin Liu, Ling Li
Summary: The meta-analysis showed that lower miR-34a expression is significantly associated with poorer overall survival and disease-free/progression-free/recurrence-free survival in gastrointestinal cancer patients. The expression level of miR-34a is relatively lower in patients with lymph node metastasis, and decreased miR-34a expression is linked to poor tumor differentiation and late TNM stage. MiR-34a may serve as a new factor for prognosis prediction and progression in gastrointestinal cancers.
Review
Medicine, General & Internal
Yuming Yao, Xiang Zhu, Weixin Liu, Jiayi Jiang, Han Jiang
Summary: Detecting circulating tumor cells (CTCs) can predict the prognosis of patients with gastrointestinal tumors and contribute to personalized treatment plans.
Review
Oncology
Hua-Yang Pang, Xiu-Feng Chen, Meng-Hua Yan, Li-Hui Chen, Zhi-Xiong Chen, Shou-Ru Zhang, Hao Sun
Summary: This study investigated the value of the advanced lung cancer inflammation index (ALI) in evaluating postoperative complications (POCs) and survival outcomes in patients with gastrointestinal (GI) cancer. The results showed that patients in the low ALI group had an increased incidence of POCs, worse overall survival, and decreased disease-free survival compared to those in the high ALI group. Therefore, ALI could serve as a valuable predictor of POCs and long-term outcomes in patients with GI cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Codrin-Constantin Burlacu, Daniela Ciobanu, Andrei-Vlad Badulescu, Vlad-Florin Chelaru, Andrei-Otto Mitre, Bogdan Capitanescu, Dirk M. Hermann, Aurel Popa-Wagner
Summary: Stroke is the second leading cause of death and disability, with limited therapeutic strategies. Blood-based biomarkers, such as microRNAs and exosomes, are recognized as useful tools to predict prognosis in patients with stroke. This systematic review identified 72 circulating biomarkers with prognostic value in stroke recovery, including 68 miRNAs predictive for motor recovery and seven biomarkers predictive for cognitive recovery. The most significant correlations were found with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. Serum miR-9 and neutrophil miR-29b were identified as promising biomarkers for further studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yongjuan Ye, Guozhi Wu, Hao Yuan, Ya Zheng, Yuping Wang, Qinghong Guo
Summary: The lymphocyte/C-reactive protein (LCR) level is associated with the clinical outcomes in patients with upper gastrointestinal cancers, with lower LCR levels indicating worse prognosis. More high-quality studies are needed to validate these findings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yanyan Hu, Zhongjian Liu, Hui Tang
Summary: This meta-analysis investigated the association between TDO2 expression and clinical features and prognosis in malignant tumor patients. The results indicated that overexpression of TDO2 was associated with poor overall survival, progression-free survival, TNM stage, and regional lymph node metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bo Zhang, Zhenmei Chen, Baorui Tao, Chenhe Yi, Zhifei Lin, Yitong Li, Weiqing Shao, Jing Lin, Jinhong Chen
Summary: This study demonstrates the significant value of m(6)A miRNAs in cancer detection. By developing a serum diagnostic signature based on m(6)A target miRNAs, it enables mass detection of multiple cancer types with high accuracy and sensitivity in distinguishing different cancer types.
Review
Oncology
Elmira Gheytanchi, Fatemeh Tajik, Mahdieh Razmi, Sadegh Babashah, William Chi Shing Cho, Kiarash Tanha, Maryam Sahlolbei, Roya Ghods, Zahra Madjd
Summary: This meta-analysis suggests that circulating exosomal microRNAs have prognostic value in gastrointestinal cancers. Both up-regulated and down-regulated exomiRs are associated with differentiation, TNM stage, lymph node metastasis, distant metastasis, overall survival, and disease/relapse/progression-free survival in GI cancer patients. These findings indicate that circulating exomiRs could serve as potential prognostic biomarkers in GI cancers.
CANCER CELL INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Shilpi Singh, Waseem Raza, Shahnaz Parveen, Abha Meena, Suaib Luqman
Summary: miRNAs, as non-coding nucleotide sequences, play a crucial role in cancer development, with evidence suggesting that their deregulation is associated with tumorigenesis. Flavonoids are known to modulate miRNAs expression, potentially serving as chemopreventive agents by targeting miRNAs involved in cancer progression. While extensively studied in pre-clinical settings, more research is needed to explore the clinical implications of flavonoids in targeting miRNAs for cancer prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Oncology
Xu-Rui Liu, Lian-Lian Wang, Bin Zhang, Xiao-Yu Liu, Zi-Wei Li, Bing Kang, Chao Yuan, Zheng-Qiang Wei, Dong Peng
Summary: This study aimed to evaluate the independent predictive value of the advanced lung cancer inflammation index (ALI) for the prognosis of gastrointestinal cancer patients after surgical resection. Through a comprehensive analysis of various types of gastrointestinal cancers, including colorectal cancer, gastric cancer, esophageal cancer, liver cancer, cholangiocarcinoma, and pancreatic cancer, it was found that ALI could predict the overall survival, disease-free survival, and cancer-specific survival of patients. Particularly, ALI had a significant predictive role in patients with colorectal cancer and gastric cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Lin Dai, Zilin Huang, Wang Li
Summary: This study comprehensively analyzed the expression patterns of PD-1 ligands in seven types of gastrointestinal cancers, providing insights for further research in cancer immunity and development.
FRONTIERS IN ONCOLOGY
(2021)