Article
Dentistry, Oral Surgery & Medicine
Marco Mascitti, Lucrezia Togni, Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Lorenzo Lo Muzio, Corrado Rubini, Andrea Santarelli, Giuseppe Troiano
Summary: Tumor budding is found to be a reliable prognostic factor in oral tongue squamous cell carcinoma (OTSCC), but a standardized scoring system is lacking. This study aims to evaluate the prognostic role of tumor budding in 211 OTSCC patients. The results confirm the predictive value of tumor budding in disease-specific survival.
Article
Pathology
Kochli Channappa Niranjan, Monica Raj, Kaveri Hallikeri
Summary: Tumor budding and CD44 expression are of prognostic significance in OSCC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Article
Pathology
Lara Alessandrini, Elisabetta Zanoletti, Diego Cazzador, Marta Sbaraglia, Leonardo Franz, Giulia Tealdo, Anna Chiara Frigo, Stella Blandamura, Piero Nicolai, Antonio Mazzoni, Gino Marioni
Summary: This study highlights the significant role of tumor budding in the prognosis of TBSCC, showing associations with tumor invasion, lymph node metastasis, disease-free survival, and overall survival. Further research is needed to confirm these findings in larger prospective studies.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Dentistry, Oral Surgery & Medicine
S. Y. Yang, S. H. Li, J. L. Liu, X. Q. Sun, Y. Y. Cen, R. Y. Ren, S. C. Ying, Y. Chen, Z. H. Zhao, W. Liao
Summary: This study developed a deep learning model to assist pathologists in diagnosing oral squamous cell carcinoma (OSCC), demonstrating improved diagnostic accuracy and speed in both junior and senior pathologists.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Oncology
Li-Yu Lee, Cheng-Han Yang, Yu-Chieh Lin, Yu-Han Hsieh, Yung-An Chen, Margaret Dah-Tsyr Chang, Yen-Yin Lin, Chun-Ta Liao
Summary: The study developed a deep learning-based human-enhanced tool, called Domain-KEY algorithm, for identifying perineural invasion (PNI) in digital slides. The algorithm was able to accurately detect PNI in patients with oral cavity squamous cell carcinoma (OCSCC) and provide rapid diagnostic results.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Yeoun Eun Sung, Min-Sik Kim, Youn Soo Lee
Summary: This study evaluated risk factors in oral squamous cell carcinoma using image analysis, with significant differences in prognosis found between low-, intermediate-, and high-risk groups. The high-risk groups were associated with poor survival even within different tumor-node-metastasis stages, suggesting a possible descriptive model for prognosis prediction based on pathological and imaging findings regardless of TNM stage.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Dentistry, Oral Surgery & Medicine
Linfeng Zhang, Mingfei Wang, Wenhao Ren, Shaoming Li, Keqian Zhi, Ling Gao, Jingjing Zheng
Summary: This systematic review comprehensively evaluates the clinicopathological and prognostic value of dysregulated expression of circRNAs in OSCC, and suggests that circRNAs may serve as candidate biomarkers for the prognosis and clinicopathology of OSCC.
Article
Oncology
Yuri Noda, Mitsuaki Ishida, Yasuhiro Ueno, Takuo Fujisawa, Hiroshi Iwai, Koji Tsuta
Summary: Histological predictors of extranodal extension (ENE) in oral squamous cell carcinoma (OSCC) were determined through routine histopathological examination. The tumor microenvironment status, including desmoplastic reaction, tumor budding, and tumor-infiltrating lymphocytes, was significantly associated with ENE presence. These histological features can serve as useful predictors for ENE.
Review
Cell Biology
Yanhui Lu, Zhichao Zheng, Yunyi Yuan, Janak L. Pathak, Xuechao Yang, Lijing Wang, Zhitong Ye, William C. Cho, Mingtao Zeng, Lihong Wu
Summary: Oral cancer, primarily oral squamous cell carcinoma, remains a challenge to treat with high rates of metastasis. Exosomes play a crucial role in the tumorigenesis and progression of oral squamous cell carcinoma, and show potential for clinical application in treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Jiwei Sun, Qingming Tang, Shaoling Yu, Mengru Xie, Wenhao Zheng, Guangjin Chen, Ying Yin, Xiaofei Huang, Keqi Wo, Haoqi Lei, Junyuan Zhang, Qian Wan, Lili Chen
Summary: This study reveals that F. nucleatum, a tumor-resident bacterium, accumulates in invasive margins of OSCC tissues and promotes the formation of tumor-associated macrophages (TAMs). Mechanistically, F. nucleatum triggers the GalNAc-Autophagy-TBC1D5 signaling, leading to GLUT1 aggregation in the plasma membrane and the deposition of extracellular lactate. Targeting this process may provide a distinct clinical strategy for patients with advanced OSCC.
Article
Dentistry, Oral Surgery & Medicine
Jia Kang, Ming Su, Qiaoshi Xu, Chong Wang, Xiaohong Yuan, Zhengxue Han
Summary: The objective of this study was to evaluate the prognostic value of TSR and TB in OTSCC and establish a predictive model for the outcome of OTSCC patients. The results indicated that TSR was an independent risk factor for the prognosis of OTSCC patients and patients with stroma-rich had a worse long-term prognosis. The risk model combining TSR and TB showed valuable predictive power for the outcome of OTSCC patients.
Article
Medicine, General & Internal
Anum Kazmi, Zia Abbas, Zohra Saleem, Safdar Haider, Waqas Ahmed Farooqui, Shaheen Ahmed
Summary: The objective of this study was to evaluate the levels of salivary matrix metalloproteinases (MMP-8) in oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) for early stage diagnosis using a non-invasive method. The study found that MMP-8 levels were underexpressed in OSCC and OSF patients compared to controls, indicating an inverse relationship between MMP-8 levels and OSCC and OSF.
Article
Engineering, Environmental
Chuanhui Song, Xinyu Zhang, Zichen Cao, Zheng Wei, Meng Zhou, Yufeng Wang, Shengwei Han, Yu Cai, Wei Han
Summary: Immunotherapy is hindered by the immune suppression caused by high cholesterol concentration in the tumor microenvironment. To address this issue, researchers have developed a cholesterol-regulate nanoplatform that can reduce cholesterol levels and activate the immune system to enhance the effectiveness of tumor immunotherapy. Both in vitro and in vivo experiments have demonstrated that this nanoplatform can effectively kill tumor cells, regulate cholesterol levels, and stimulate the immune system, providing a new strategy for overcoming immune suppression in the tumor microenvironment and paving the way for adjuvant immunotherapy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Oncology
Lucrezia Togni, Vito Carlo Alberto Caponio, Nicoletta Zerman, Giuseppe Troiano, Khrystyna Zhurakivska, Lorenzo Lo Muzio, Andrea Balercia, Marco Mascitti, Andrea Santarelli
Summary: Tumor budding is an independent prognostic factor in various solid cancers, including oral squamous cell carcinoma. It can predict poor survival outcomes and has potential applications in daily pathological practice. However, further research and validation are needed due to the lack of standardized assessment methods.
Article
Ophthalmology
Marina Knudsen Kirkegaard, Marthe Minderman, Lene Dissing Sjo, Steven T. Pals, Patrick R. G. Eriksen, Steffen Heegaard
Summary: This study aimed to reclassify ocular adnexal large B-cell lymphomas (OA-LBCLs) and investigate the prevalence and association of MYD88 and CD79B mutations with clinical parameters. The results revealed that OA-LBCL mainly consists of two subtypes, and MYD88 mutations, as well as cMYC/BCL2 double-expressor DLBCL, are associated with poor prognosis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Luc-Matthieu Fornecker, Julien Lazarovici, Igor Aurer, Rene-Olivier Casasnovas, Anne-Claire Gac, Christophe Bonnet, Krimo Bouabdallah, Pierre Feugier, Lena Specht, Lysiane Molina, Mohamed Touati, Cecile Borel, Aspasia Stamatoullas, Emmanuelle Nicolas-Virelizier, Laurent Pascal, Pieternella Lugtenburg, Nicola Di Renzo, Thierry Vander Borght, Alexandra Traverse-Glehen, Peggy Dartigues, Martin Hutchings, Annibale Versari, Michel Meignan, Massimo Federico, Marc Andre
Summary: This study evaluated the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in early-stage unfavorable Hodgkin lymphoma. The results showed that BV-AVD had a higher PET-negative rate compared to ABVD after two cycles. High total metabolic tumor volume was associated with shorter progression-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Allergy
Christian Korsgaard Pedersen, Christiane Haase, Kasper Aanaes, Christian von Buchwald, Vibeke Backer
Summary: Patient reported outcome measures (PROMs) are important in assessing global airway disease caused by type-2 inflammation, as they provide insights into patients' perspective on symptoms, treatment, disease control, and possible comorbidity. This review investigates newly developed PROMs for global airway disease and provides an overview of commonly used PROMs in managing the condition.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Veterinary Sciences
Annika Linde, John Tegzes, Tonatiuh Melgarejo, Dominique Griffon, Vet Med
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2023)
Article
Oncology
Emmanouil Terzidis, Jeppe Friborg, Ivan R. Vogelius, Giedrius Lelkaitis, Christian von Buchwald, Anders B. Olin, Helle H. Johannesen, Barbara M. Fischer, Irene Wessel, Jacob H. Rasmussen
Summary: This study aimed to evaluate the mismatch between tumor volumes defined from PET/MRI hybrid imaging and pathology, and its potential clinical impact. The results showed a mismatch between imaging and pathological defined tumor volumes in all patients. However, after the addition of a clinical 5 mm margin, the entire pathological volume was fully encompassed in the imaging-defined tumor volume in most patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Respiratory System
Tobias Todsen, Martin G. Tolsgaard, Thomas Benfield, Fredrik Folke, Kathrine K. Jakobsen, Niels Tobias Gredal, Annette K. Ersboll, Christian von Buchwald, Nikolai Kirkby
Summary: This study compared the detection rate of SARS-CoV-2 using nasopharyngeal swab (NPS), oropharyngeal swab (OPS), and saliva specimen collection. The results showed that OPS had the highest detection rate, while saliva sampling had the lowest. OPS sampling had higher detection rate and lower discomfort compared to NPS. Although saliva sampling had the lowest detection rate, it was the least costly.
Editorial Material
Virology
Tina Dalianis, Christian von Buchwald, Anders Nasman, Stina Syrjanen
Review
Oncology
Anne Marie Lindegaard, Katrin Hakansson, Mogens Bernsdorf, Anita B. Gothelf, Claus A. Kristensen, Lena Specht, Ivan R. Vogelius, Jeppe Friborg
Summary: This systematic review examines the clinical and dosimetric benefits of adaptive radiotherapy (ART) in head and neck cancer patients. The results show that ART can effectively reduce doses to organs at risk, but the impact on toxicity and disease control is uncertain. Larger, prospective trials with well-defined control groups are needed to further investigate these findings.
Letter
Oncology
Julie Kjems, Michael R. T. Laursen, Claus A. Kristensen, Anita B. Gothelf, Mogens Bernsdorf, Lena Specht, Anne K. Berthelsen, Ivan R. Vogelius, Gitte F. Persson, Jeppe Friborg
Editorial Material
Otorhinolaryngology
Jacob P. S. Nielsen, Christian von Buchwald, Christian Gronhoj
ACTA OTO-LARYNGOLOGICA
(2023)
Review
Otorhinolaryngology
Theresa Emilia Britze, Kathrine Kronberg Jakobsen, Christian Gronhoj, Christian von Buchwald
Summary: This study reviewed the role of biomarkers in liquid biopsies and saliva samples in monitoring salivary gland cancer. Five studies identified potential biomarkers in blood and saliva samples, and concluded that further research is needed before the method can be used for diagnosis.
ACTA OTO-LARYNGOLOGICA
(2023)
Review
Oncology
Kim M. Linton, Lena Specht, Astrid Pavlovsky, Carrie A. Thompson, Eva Kimby, Daphne de Jong, Loretta J. Nastoupil, Anne-Segolene Cottereau, Carla Casulo, Clementine Sarkozy, Jessica Okosun
Summary: Follicular lymphoma, the most common indolent lymphoma in western countries, has a favorable prognosis but includes high-risk groups with poor outcomes. This review discusses recent updates in risk stratification and treatment approaches, including upfront treatment for limited and advanced stage follicular lymphoma, as well as options for relapsed, refractory disease. It also highlights the need for precise and prospective selection of optimal treatment based on varying risks, which may be achieved through a better understanding of the biology of different phenotypes and improved imaging and biomarker-based tools.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mads Lawaetz, Tina Binderup, Anders Christensen, Karina Juhl, Giedrius Lelkaitis, Eva Lykke, Line Knudsen, Christian von Buchwald, Andreas Kjaer
Summary: This study established oral squamous cell carcinoma (OSCC) PDX models and evaluated the effectiveness of [Cu-64]Cu-uPAR-PET/CT for tumor imaging in these models.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Editorial Material
Oncology
Mario A. Hermsen, Matt Lechner, Leticia Oliveira Ferrer, Annalisa Trama, Patrick Rene Gerhard Eriksen, Eva Martinez-Balibrea, Christian von Buchwald
Summary: Sinonasal cancer is a rare and heterogeneous group of tumors with poor outcomes. Due to their low incidence, collaboration between physicians and researchers is essential for advancement in clinical management and translational research. This report discusses a conference organized by EUSICA and COST Action 'IMMUNO-model' that focused on collaboration, preclinical tumor and immuno models, treatment options, genetic characterization, and cancer registry for sinonasal cancer.
Article
Medicine, Research & Experimental
Kathrine Kronberg Jakobsen, Amanda-Louise Fenger Carlander, Christian Gronhoj, Tobias Todsen, Jacob Melchiors, Natasja Paaske, Anne Kathrine ostergaard Madsen, Jens Kastrup, Annette Ekblond, Mandana Haack-Sorensen, Mohammad Farhadi, Christian Maare, Jeppe Friborg, Charlotte Duch Lynggard, Christian von Buchwald
Summary: This is a trial investigating the safety and effectiveness of allogeneic stem cell injection for treating radiation-induced hyposalivation and xerostomia in head and neck cancer patients. The study aims to evaluate changes in saliva flow rate, quality of life, and safety of the treatment.