Review
Medicine, General & Internal
Xuhua Wang, Zhaoyuan Chen, Huaqiang Zhou, Wuyang Liu, Jiaquan Luo
Summary: LncRNA LOXL1-AS1 is overexpressed in cancer and is closely associated with shorter overall survival, lymph node metastasis, and distant metastasis.
Review
Medicine, General & Internal
Xuhua Wang, Zhaoyuan Chen, Huaqiang Zhou, Wuyang Liu, Jiaquan Luo
Summary: The lncRNA HEIH is overexpressed in various cancers and is associated with poor clinical outcomes. A meta-analysis found that high HEIH expression is correlated with shorter overall survival and advanced clinicopathological features in cancer patients.
Article
Environmental Sciences
Baocai Lu, Xiao Li, Wenjie Miao, Qi Liu, Ruixue Li, Can Cui, Qingzu Gao, Rong Lian
Summary: ZFAS1 is highly expressed in laryngeal cancer and associated with lymph node metastasis and clinical stages. It promotes proliferation, invasion, and expression of N-cadherin and Vimentin, while suppressing E-cadherin expression in LC cells. ZFAS1 stabilizes RBFOX2 protein expression by binding to it and regulates alternative splicing of MENA, affecting cell functions and malignant progression of laryngeal cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Mohammad Javad Kamali, Atefe Abak, Hamed Shoorei, Mohammad Taheri
Summary: ZFAS1, a long non-coding RNA located on chromosome 20q13.13, is involved in the development of both neoplastic and non-neoplastic disorders, and is considered an oncogene in almost all types of cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Uttam Sharma, Tushar Singh Barwal, Akanksha Khandelwal, Akshay Malhotra, Manjit Kaur Rana, Amrit Pal Singh Rana, Evgeny N. Imyanitov, Karen M. Vasquez, Aklank Jain
Summary: The expression of ZFAS1 is significantly downregulated in TNBC patients, promoting cell proliferation and colonization by affecting cell cycle-dependent kinase inhibitors and epithelial/mesenchymal markers. ZFAS1 may function as a tumor-suppressor lncRNA and provide a new therapeutic target for TNBC patients.
Article
Medicine, General & Internal
Hao Hua, Jie Wang, Pingyong Zhong, Tinggang Mou, Pan Liu, Fei Xie
Summary: A newly discovered long non-coding RNA, LINC00675, is associated with tumor progression and poor prognosis. High expression of LINC00675 was found to be significantly correlated with poor overall survival, tumor node metastasis stage, and distant metastasis in cancer patients, suggesting its potential as a biomarker for evaluating prognosis. Further studies are needed to confirm the clinical value of LINC00675 in cancers.
Review
Medicine, General & Internal
Pingyong Zhong, Hao Hua, Shun Chen, Zhidan Zhu, Fei Xie
Summary: AGAP2-AS1 overexpression is associated with shortened overall survival in various cancers, indicating its potential as a promising predictor for clinical outcomes.
Review
Medicine, General & Internal
Yuanyang He, Zheng Chen, Jingyu He
Summary: LINC00473 was found to be associated with unfavorable prognosis and various clinicopathological factors in human cancers, suggesting its potential as a prognostic marker.
Article
Pathology
Lu Tang, Qing-Mei Liu, Shuang Zhang, Jun Zhou
Summary: In this study, a meta-analysis and bioinformatics analysis were conducted to explore the correlation between LncRNA NR2F1-AS1 and cancer prognosis. The results showed that upregulation of LncRNA NR2F1-AS1 was associated with poor prognosis and advanced clinicopathologic features of tumor patients.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Genetics & Heredity
Guangyao Lin, Yongzhou Wang, Li Deng, Tao Ye
Summary: This study found that BBOX1-AS1 is closely associated with the clinicopathological characteristics and prognosis of cancer, and it could serve as a promising biomarker.
FRONTIERS IN GENETICS
(2023)
Article
Genetics & Heredity
Yongfeng Wang, Xianglai Jiang, Dongzhi Zhang, Yuanbin Zhao, Xiaoyong Han, Lihui Zhu, Jingyao Ren, Yubin Liu, Jiarong You, Haolan Wang, Hui Cai
Summary: The overexpression of DUXAP8 is associated with poor overall survival in malignant cancers and is linked to tumor mutational burden, microsatellite instability, and mismatch repair-related genes, suggesting it may serve as a prognostic biomarker and therapeutic target.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Huishan Wang, Yuli Chen, Yanwen Liu, Qiuhui Li, Jing Luo, Li Wang, Yuanyuan Chen, Chen Sang, Wen Zhang, Xianxiu Ge, Zhifeng Yao, Lin Miao, Xianghua Liu
Summary: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths globally. This study reveals that ZFAS1 is overexpressed in CRC and positively correlated with tumor size and metastasis. ZFAS1 binds to PABP2 to stabilize SREBP1 mRNA accumulation, promoting lipid accumulation in CRC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Oncology
Shao-pu Hu, Meng-xue Ge, Lei Gao, Min Jiang, Kai-wen Hu
Summary: The dysregulation of HCP5 is significantly associated with prognosis and clinicopathological features in various cancers, indicating it may serve as a potential prognostic biomarker and therapeutic target in multiple human cancers.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Qiang Shu, Xiaoling Liu, Jushu Yang, Tinggang Mou, Fei Xie
Summary: This study demonstrates that high expression of lncRNA FOXP4-AS1 is significantly associated with unfavorable overall survival and poor disease-free survival in patients with malignant tumors. Additionally, lncRNA FOXP4-AS1 expression is correlated with tumor size, alpha-fetoprotein levels, lymph node metastasis, and age in cancer patients.
Article
Oncology
Yanping Lyu, Shuangfeng Yang, Xuejie Lyu, Yuan-Liang Wang, Shumi Ji, Shuling Kang, Yu Jiang, Jianjun Xiang, Chenzhou He, Peixin Li, Baoying Liu, Chuancheng Wu
Summary: This study reveals the association between genetic polymorphism of lncRNA and the prognosis of gastric cancer, suggesting that it can serve as a predictor for GC prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)