Review
Oncology
Jan Bures, Darina Kohoutova, Jan Skrha, Bohus Bunganic, Ondrej Ngo, Stepan Suchanek, Pavel Skrha, Miroslav Zavoral
Summary: Pancreatic ductal adenocarcinoma is a serious malignancy and a leading cause of cancer-related deaths worldwide. There are no effective screening methods available so far. Impaired glucose metabolism is present in about 3/4 of patients. This paper proposed a distinct approach to older subjects with new-onset diabetes mellitus with possible pancreatic cancer, aiming to improve the current unsatisfactory situation in diagnostics and subsequent poor outcomes of treatment.
Article
Endocrinology & Metabolism
Hee Seung Lee, Wonjeong Chae, Min Je Sung, Jiyoung Keum, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eun-Cheol Park, Chung Mo Nam, Sung-In Jang, Seungmin Bang
Summary: This study aimed to investigate the differences in incidence of pancreatic cancer between new-onset diabetes mellitus (NODM) and long-standing DM (LSDM). The results showed that the risk of pancreatic cancer was higher in the group with diabetes compared to the non-diabetes group, and the risk was higher in the NODM group than in the LSDM group, especially in men and patients in their 50s.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Louise Wang, Frank Scott, Ben Boursi, Kim A. Reiss, Sankey Williams, Henry Glick, Yu-Xiao Yang
Summary: A risk-tailored early detection strategy targeting NoD patients with a minimum predicted 3-year PDAC risk of 1.0% to 2.0% may be cost-effective.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medical Laboratory Technology
Jieying Liu, Junling Fu, Ziyan Xie, Lu Ding, Dongmei Wang, Miao Yu, Qian Zhang, Ting Xie, Xinhua Xiao
Summary: Novel serum metabolic biomarkers were identified to distinguish maturity-onset diabetes of the young (MODY) and explore its mechanism. Four significantly fluctuated metabolites were found between groups, and glycerophosphocholine was selected as a diagnostic biomarker. The combination of metabolites also showed good diagnostic value.
CLINICA CHIMICA ACTA
(2023)
Article
Oncology
Rui Zhao, Shuai Ren, Changyin Li, Kai Guo, Zipeng Lu, Lei Tian, Jian He, Kai Zhang, Yingying Cao, Shijia Liu, Donghui Li, Zhongqiu Wang
Summary: This study identified metabolic features of pancreatic ductal adenocarcinoma (PDAC) and discovered potential early detection biomarkers for PDAC through tissue and serum metabolomics analysis. The identified biomarker panel showed promising performance in distinguishing PDAC from benign pancreatic neoplasms and healthy controls, especially when combined with carbohydrate antigen 19-9 (CA19-9).
Review
Oncology
Claudia Mellenthin, Vasile Daniel Balaban, Ana Dugic, Stephane Cullati
Summary: New onset diabetes patients are at high risk for pancreatic cancer. Important risk factors for pancreatic cancer in this group include age, family history, gallstones/pancreatitis, and weight loss/rapidly increasing glycemia.
Article
Oncology
Naomi R. M. Schwartz, Lynn M. Matrisian, Eva E. Shrader, Ziding Feng, Suresh Chari, Joshua A. Roth
Summary: This study evaluated the cost-effectiveness of CT screening for pancreatic cancer in patients with new-onset diabetes and found that risk-based screening in this population is likely to be cost-effective in the United States. However, a sufficient number of screen-detected pancreatic cancer cases need to be resectable to achieve lower cost per quality-adjusted life-year gained.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Biochemical Research Methods
Lenka Michalkova, Stepan Hornik, Jan Sykora, Lucie Habartova, Vladimir Setnicka, Bohus Bunganic
Summary: Through H-1 NMR metabolomic analysis, the association between pancreatic cancer and type 2 diabetes mellitus was identified, leading to the establishment and testing of a panel of metabolites for disease identification. A prediction model was also developed and tested on recent-onset diabetes mellitus patients, showing potential for identifying individuals at risk for developing pancreatic cancer.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Patrick C. Barko, Stanley I. Rubin, Kelly S. Swanson, Maureen A. McMichael, Marcella D. Ridgway, David A. Williams
Summary: Exocrine pancreatic insufficiency (EPI) is a digestive disorder in dogs caused by insufficient secretion of digestive enzymes. In this study, untargeted metabolomics analysis was used to identify metabolic disturbances associated with EPI. 114 serum metabolites were found to differ significantly between dogs with EPI and healthy controls, suggesting malnourishment, micronutrient deficiencies, altered gut microbiome composition, and intestinal inflammation in dogs with EPI.
Article
Medicine, General & Internal
Lucy Oldfield, Anthony Evans, Rohith Gopala Rao, Claire Jenkinson, Tejpal Purewal, Eftychia E. Psarelli, Usha Menon, John F. Timms, Stephen P. Pereira, Paula Ghaneh, William Greenhalf, Christopher Halloran, Eithne Costello
Summary: This study aimed to find a blood biomarker that can differentiate newly diagnosed type 2 diabetes mellitus (T2DM) patients into T2DM and PDAC-related diabetes. Through analysis of multiple sample sets, the researchers found that the combination of adiponectin and interleukin-1 receptor antagonist showed strong diagnostic potential for distinguishing T3cDM from T2DM.
Article
Public, Environmental & Occupational Health
M. J. White, A. C. Sheka, C. J. LaRocca, R. L. Irey, S. Ma, K. M. Wirth, A. Benner, J. W. Denbo, E. H. Jensen, J. S. Ankeny, S. Ikramuddin, T. M. Tuttle, J. Y. C. Hui, S. Marmor
Summary: Observational studies have shown an association between new-onset type 2 diabetes (NoD) and subsequent diagnosis of pancreatic ductal adenocarcinoma (PDAC). This study used a large administrative database to evaluate this association and found that NoD was independently associated with PDAC diagnosis within 3 years.
JOURNAL OF PUBLIC HEALTH
(2023)
Review
Endocrinology & Metabolism
Sun H. Kim, Ipsa Arora, Daniel S. Hsia, William C. Knowler, Erin LeBlanc, Eleftherios Mylonakis, Richard Pratley, Anastassios G. Pittas
Summary: There is evidence suggesting that infection with SARS-CoV-2 can lead to long-term sequelae, including diabetes. This mini-review examines the evolving literature on new-onset diabetes after COVID-19 (NODAC). Current evidence suggests that COVID-19 increases the risk of developing diabetes, but the exact causality is uncertain due to study limitations and the evolving nature of the pandemic. COVID-19 may have direct and indirect effects on pancreatic beta-cell function and insulin sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medical Laboratory Technology
Seetharaman Balasenthil, Suyu Liu, Jianliang Dai, William R. Bamlet, Gloria Petersen, Suresh T. Chari, Anirban Maitra, Nanyue Chen, Subrata Sen, Ann McNeill Killary
Summary: This study identified potential blood-based biomarkers, including tissue factor pathway inhibitor (TFPI), tenascin C (TNC-FNIII-C), and CA 19-9, for distinguishing PDAC-NOD from T2DM. The migration signature panel showed improved performance in discriminating PDAC-NOD and warrants further validation for high-risk group stratification.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Chun Zhou, Panpan He, Ziliang Ye, Yuanyuan Zhang, Yanjun Zhang, Sisi Yang, Qimeng Wu, Mengyi Liu, Jing Nie, Xianhui Qin
Summary: The study found an inverse association between serum vitamin D levels and new-onset chronic kidney disease in participants with diabetes. However, this association was not observed in participants without diabetes.
Article
Food Science & Technology
Eirini Trichia, Albert Koulman, Isobel D. Stewart, Soren Brage, Simon J. Griffin, Julian L. Griffin, Kay-Tee Khaw, Claudia Langenberg, Nicholas J. Wareham, Fumiaki Imamura, Nita G. Forouhi
Summary: The study identified metabolites associated with habitual dairy consumption and found that consuming milk, butter, and total dairy products is associated with lower risk of type 2 diabetes.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)