Review
Oncology
Mallory G. McKeon, Jean-Nicolas Gallant, Young J. Kim, Suman R. Das
Summary: Certain viruses, such as human papillomavirus (HPV) and Epstein-Barr virus (EBV), are associated with the development of head and neck cancer. This study reviews the mechanisms by which these viruses cause cellular transformation and chronic inflammation, and examines the interplay between viruses, cellular transformation, inflammation, and the local host microbiome in head and neck cancer.
Review
Biochemistry & Molecular Biology
Piero Giuseppe Meliante, Carla Petrella, Marco Fiore, Antonio Minni, Christian Barbato
Summary: The treatment of unresectable or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) traditionally relied on chemotherapy or radiotherapy, but with suboptimal outcomes. The introduction of immunotherapy has significantly improved HNSCC treatment, but long-term results are still uncertain. This review focuses on therapeutic vaccines for HNSCC treatment, gathering existing evidence and summarizing ongoing clinical trials. Encouraging results and ongoing experiments bring hope for potential paradigm shifts in HNSCC therapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Article
Virology
Julien Lupo, Mansour Tsougaev, Stephane Blachier, Guillaume Chovelon, Aurelie Truffot, Corentin Leroy, Joris Giai, Olivier Epaulard, Raphaele Germi, Patrice Morand
Summary: This study compared the performance of two immunoassays for detecting serological markers of EBV infection. The results showed a high agreement between the two methods, but differences were found in sensitivity and detection rates for early primary infection and past infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Oncology
Santiago Cabezas-Camarero, Pedro Perez-Segura
Summary: Head and neck cancer is the sixth most common type of solid tumor with a poor prognosis. Liquid biopsy, which studies different tumor components in body fluids, can aid in earlier diagnosis and accurate monitoring during treatment. This manuscript provides an in-depth review of the role of liquid biopsy in head and neck cancer and discusses future prospects.
Article
Biochemistry & Molecular Biology
Maria Elena Reyes, Louise Zanella, Ismael Riquelme, Kurt Buchegger, Barbara Mora-Lagos, Pablo Guzman, Patricia Garcia, Juan C. Roa, Carmen Gloria Ili, Priscilla Brebi
Summary: This study aimed to investigate the frequency and genetic diversity of EBV in gastric cancer (GC) patients in southern Chile. The study found that 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology. The results provide important information for epidemiological follow-up of different EBV subtypes that may cause GC in southern Chile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yin Luo, Yitong Liu, Chengkun Wang, Runliang Gan
Summary: Epstein-Barr virus is closely associated with multiple human cancers, mainly lymphomas and carcinomas. The virus can induce oncogenesis through activating various signaling pathways in host cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Senyao Shao, Lars Uwe Scholtz, Sarah Gendreizig, Laura Martinez-Ruiz, Javier Florido, Germaine Escames, Matthias Schuermann, Carsten Hain, Leonie Hose, Almut Mentz, Pascal Schmidt, Menghang Wang, Peter Goon, Michael Wehmeier, Frank Brasch, Jorn Kalinowski, Felix Oppel, Holger Sudhoff
Summary: This study characterized primary cell populations isolated from human papillomavirus positive head and neck squamous cell carcinoma (HNSCC) tissue. These primary HNSCC cell cultures showed delayed formation of spheroids and exhibited strong expression of B- and T-lymphocytes markers, while the expression of epithelial and mesenchymal markers could not be detected. The study also revealed the presence of Epstein-Barr-virus (EBV)-infected tumor-infiltrating B-lymphocytes in the primary cell cultures.
Review
Oncology
Patricia Bott, Ilske Oschlies, Andreas Radeloff, Maureen Loewenthal
Summary: EBV-positive mucocutaneous ulcer (EBV-MCU) is a rare lymphoproliferative B-cell disease that needs to be distinguished from head and neck squamous cell carcinoma by early biopsy. This study provides a review of the current literature and a recommendation for EBV-MCU management. A total of 181 cases were identified and summarized, and it was found that EBV-MCU is predominantly caused by immunosuppressive drug therapy. Most cases can achieve complete remission by reducing immunosuppressive therapy.
Review
Oncology
Mike Dorothea, Jia Xie, Stephanie Pei Tung Yiu, Alan Kwok Shing Chiang
Summary: This review summarizes the oncogenic roles of Epstein-Barr virus (EBV) lytic proteins, which are expressed during the latent and lytic replication cycles of the virus, and categorizes them based on the cancer hallmarks displayed. The oncogenic properties of several EBV lytic proteins are postulated by comparing the evolutionary conserved oncogenic mechanisms in other herpesviruses and oncoviruses.
Article
Oncology
Christoph Roderburg, Sarah Krieg, Andreas Krieg, Tom Luedde, Karel Kostev, Sven H. Loosen
Summary: Patients with infectious mononucleosis have a higher incidence of certain types of cancer, especially tumors of the hematopoietic and lymphoid tissues. The study findings support the role of EBV in the development of different malignancies.
Article
Oncology
Xiaoxia Jia, Ting Guo, Zhemin Li, Meng Zhang, Yi Feng, Bin Dong, Zhongwu Li, Ying Hu, Ziyu Li, Xiaofang Xing, Shuqin Jia, Jiafu Ji
Summary: Epstein-Barr virus-associated gastric cancer patients are characterized by younger age, low-differentiated adenocarcinoma, and less vascular invasion. Increased infiltration of immune cells affects patient prognosis, particularly in EBVaGC patients with higher CD3(+) T lymphocyte density, leading to longer survival.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Elham Jafari Maskouni, Tasnim Jamalvandi, Farbod Tabatabaei, Sepideh Bourenjan Shirazi, Hasan Saadati, Arash Letafati, Mahdiyeh Hosseini, Saeed Motlaghzadeh, Zohreh Khalesi, Pouya Moradi, Sepideh Saeb, Najmeh Sheikh, Elaheh Fozouni, Alireza Khatami, Alireza Homayouni Baker, Zahra Keyvanlou, Vahid Tamrchi, Ahmad Tavakoli, Saied Ghorbani
Summary: The aim of this study was to investigate the prevalence of Epstein-Barr virus (EBV) infection in colorectal cancer (CRC) and its potential association. A systematic literature search was conducted, and meta-analysis was performed on the selected articles. The results showed that EBV infection is associated with CRC and may be a potential risk factor for its development.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Fransenio Clark, Anna Gil, Ishwor Thapa, Nuray Aslan, Dario Ghersi, Liisa K. K. Selin
Summary: Older people have difficulty controlling infection with common viruses, and changes in T cell receptor (TCR) repertoires may contribute to waning immunity with age. There are differences in TCR usage between young and older individuals, particularly in the alpha and beta repertoires. Both young and older individuals have cross-reactive T cell responses to the common viruses, but the specific features of these responses differ.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elena Muscolino, Laura-Marie Luoto, Wolfram Brune
Summary: Protein folding can be disrupted by various factors, leading to the formation of protein aggregates. While cells typically prevent or degrade aggregates, they may serve as a defense mechanism during viral infections. Some viruses exploit aggregate formation to promote replication or evade immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Nelli T. Suominen, Anna J. Jaakola, Michel Roger, Marie-Claude Faucher, Kari J. Syrjanen, Seija E. Grenman, Stina M. Syrjanen, Karolina Louvanto
Summary: The study shows that the polymorphism of HLA-G plays a significant role in oral HPV infection in men, specific HLA-G alleles may affect infection and outcomes, while possibly being associated with self-reported allergies.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Stina Syrjanen, Tim Waterboer, Marjut Rintala, Michael Pawlita, Kari Syrjanen, Karolina Louvanto, Seija Grenman
Summary: By analyzing serum samples of infants during the first 36 months of their life, we assessed the dynamics of human papillomavirus (HPV) serology. The study found that there is a high concordance between maternal and infant HPV antibody levels, indicating the transfer of maternal antibodies. At 1 month, a significant percentage of infants tested positive for HPV antibodies. Children born to HPV-seronegative mothers showed seroconversion to several HPV genotypes during early infancy. Maternal history of hand warts and oral warts were identified as significant predictors for infants' seroconversion to low-risk HPV.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Salla Vuorinen, Kari Syrjanen, Tim Waterboer, Seija Grenman, Stina Syrjanen, Karolina Louvanto
Summary: The study found that high-level or persistent HPV antibodies acquired naturally do not significantly influence the outcomes of genital or oral HPV infections in young, non-vaccinated women.
Article
Engineering, Chemical
Erika Saaskilahti, Stina Syrjanen, Vuokko Loimaranta, Karolina Louvanto
Summary: Hinokitiol has anti-tumor activity on HPV positive and negative cell lines, inhibiting metabolic activity and DNA synthesis in all carcinoma cell lines, with a more significant effect on HPV-positive cell lines. It induces G1 cell cycle arrest and upregulation of p21 expression, showing potential in preventing the progression of immortalized cells towards malignancy and influencing HPV-associated lesion progression by downregulating E6 and E7 expression.
Article
Microbiology
Johanna Laakso, Tytti Vuorinen, Jaana Rautava, Katja Kero, Stina Syrjanen, Veijo Hukkanen
Summary: This study evaluated the HSV seroprevalence and seroconversion among pregnant women and their spouses in Finland over a six-year follow-up period. Results showed a higher overall HSV seroprevalence in women compared to their spouses, with similar seroconversion rates between spouses. Factors associated with HSV seropositivity varied between women and male spouses, with women's age and history of genital warts being significant factors, while male spouses' HSV seropositivity was linked to the practice of oral sex.
Article
Virology
Tiina Pirttila, Stina Syrjanen, Karolina Louvanto, Vuokko Loimaranta
Summary: Oral infections with high-risk HPV genotypes are associated with certain head and neck squamous cell carcinomas. Such infections can result from oral sex or horizontal transmission from mouth to mouth. In these cases, saliva can serve as a vehicle for HPV transmission. However, the prevalence and dynamics of salivary HPV antibodies in healthy non-vaccinated individuals are not well-known, and the role of salivary antibodies in protection against oral HPV infection is unclear. This study evaluated the levels and correlation of oral HPV16 infection and HPV16L1 and E7 specific antibody levels in saliva and serum samples among 39 women, 13 of whom had persistent oral HPV16 infection.
Article
Multidisciplinary Sciences
Hanna K. Laine, Tim Waterboer, Kari Syrjanen, Seija Grenman, Karolina Louvanto, Stina Syrjanen
Summary: This study analyzed the seroprevalence and antibody levels of BKPyV and JCPyV in 327 pregnant women and their 132 spouses in Finland. The results showed that BKPyV and JCPyV infections were common in married couples, with slightly higher prevalence in women and stable antibody levels.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Virology
Tina Dalianis, Christian von Buchwald, Anders Nasman, Stina Syrjanen
Article
Medicine, General & Internal
Niina Kuusisto, Jussi Hirvonen, Auli Suominen, Stina Syrjanen, Sisko Huumonen, Pekka Vallittu, Ilpo Kinnunen
Summary: The study assessed the frequency and location of artifacts in cone beam computed tomography (CBCT) images used to confirm chronic rhinosinusitis (CRS). It was found that large dental fillings or crowns, as well as endodontic fillings, were the main origins of the artifacts. The presence of artifacts might lead to difficulties in diagnosing apical periodontitis (AP) and could also affect the diagnosis of CRS.
Article
Immunology
Nelli T. Suominen, Tiina H. Luukkaala, Claudie Laprise, Marjut A. Haataja, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study aimed to determine whether vertical human papillomavirus (HPV) transmission occurs from parents to their offspring before or during birth. The study included 321 mothers, 134 fathers, and their 321 newborn offspring. The results showed statistically significant genotype-specific HPV concordance between mother-newborn and father-newborn pairs, suggestive for vertical HPV transmission, but transmission from the father to the newborn remains uncertain.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Helmi Suominen, Nelli Suominen, Kari Syrjaenen, Tim Waterboer, Seija Grenman, Stina Syrjaenen, Karolina Louvanto
Summary: This study found that a second pregnancy does not have a significant impact on HPV antibody levels, but it may influence serological outcomes, especially in ongoing second pregnancies.
Article
Genetics & Heredity
Vivian Reinhold, Stina Syrjanen, Minna Kankuri-Tammilehto
Summary: This study reports a severe case of oligodontia in a female patient with the EDA gene variant c.742-2A>G. The results strongly suggest that this variant is pathogenic and the oligodontia in the patient is exceptionally severe. Early identification of this variant is crucial for planning adequate treatment and follow-up.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Pediatrics
Hanna K. Laine, Tim Waterboer, Kari Syrjanen, Seija Grenman, Karolina Louvanto, Stina Syrjanen
Summary: BK (BKPyV) and JC (JCPyV) polyomaviruses are common in infants, with high correlation of antibody levels between mother-infant pairs. The correlation differs between father-child pairs and may be related to predisposition to allergies.
Article
Orthopedics
Vivian Reinhold, Antti Saarinen, Eetu Suominen, Stina Syrjanen, Minna Kankuri-Tammilehto
Summary: This case report describes a NF1 patient with symptoms of dystrophic scoliosis and breast cancer. A novel pathogenic variant in NF1 gene was identified. This study highlights the importance of genetic counseling and multidisciplinary consultation for NF1 patients.
ORTHOPEDIC RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Nelli T. Suominen, Michel Roger, Marie-Claude Faucher, Kari J. Syrjaenen, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study evaluated the importance of human leukocyte antigen (HLA)-G alleles in father-to-child human papillomavirus (HPV) transmission during the perinatal period. The results showed that HLA-G allele concordance was associated with the father's urethral and child's oral high-risk HPV concordance at birth. In addition, HLA-G allele concordance increased the risk of father's oral and child's postpartum oral any- and high-risk HPV concordance.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
