Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Xiang Li, Yunhui Zhang, Congying Zhao, Bowei Zhang, Bo Peng, Yan Zhang, Jin Wang, Shuo Wang
Summary: This study demonstrates that Epigallocatechin-3-gallate (EGCG) has positive effects on insulin resistance and gut microbial dysbiosis induced by Bisphenol A (BPA), providing a potential treatment for chronic BPA-induced metabolic toxicity.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Multidisciplinary Sciences
Pengpeng Zhang, Wei Wu, Chunyu Du, Xiang Ji, Yaling Wang, Qiu Han, Hiaxia Xu, Cencen Li, Yongjie Xu
Summary: In this study, primary WAT and BAT SVF cells were isolated and induced to adipogenic differentiation in the presence or absence of EGCG. RNA-seq was used to analyze the gene regulation by EGCG in these two distinct adipose tissues and identify the key differences. The findings of this study have significant implications for obesity-related clinical and basic research.
Article
Chemistry, Applied
Jianyong Zhang, Hongchun Cui, Jiahuan Qiu, Xiaoqing Wang, Yixin Zhong, Caiping Yao, Lanying Yao, Qunxiong Zheng, ChunHua Xiong
Summary: This study aimed to improve the stability and bioavailability of EGCG in aqueous solutions and in vivo by preparing EGCG glycosylated arachin nanoparticles and EGCG glycosylated casein nanoparticles. The results showed that the DPPH scavenging activity of the nanoparticles was stable within temperature range of 25-70 degrees Celsius. EGCG enhanced the crosslinking effect of molecular particles in the glycosylation complexes solution. The glycosylated protein nanoparticles were stable to acid-base and enzymolysis in simulated gastrointestinal fluid.
Article
Biochemistry & Molecular Biology
Suchisnigdha Datta, Dona Sinha
Summary: This study found that the combination of epigallocatechin-3-gallate (EGCG) and doxorubicin (Dox) can overcome the resistance of lung cancer cells to chemotherapy drugs, and increase drug internalization, cell-cycle arrest and cell death, thereby improving the therapeutic efficacy.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Plant Sciences
Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai, Yan Xu
Summary: The combination of EGCG with Vc and glycerol could effectively increase its stability and uric acid-lowering activity, which sheds light on the development and application of EGCG in the fields of food and medicine.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Han Li, Jiaojiao Li, Meng Wang, Weiyue Feng, Fuping Gao, Ying Han, Yijie Shi, Zhongying Du, Qing Yuan, Peng Cao, Xiayan Wang, Xueyun Gao, Kai Cao, Liang Gao
Summary: Identifying effective reversal agents to overcome multidrug resistance is crucial for improving tumor chemotherapy. In this study, a metal cluster-based probe called clusterbody was developed for flow sorting-assisted single-cell mass spectrometry analysis. The clusterbody, synthesized through biomimetic mineralization, selectively recognizes an efflux pump protein and enables high-throughput cell sorting based on fluorescence emitted by the probe. Protein abundance at the single-cell level is determined through precise signal amplification using laser ablation inductively coupled plasma mass spectrometry, allowing quantitative evaluation of reversal agent treatment. This work provides a new approach to identify reversal agents and sheds light on developing combined or synergetic tumor therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Juan Wang, Liyan Qiu
Summary: In this study, a pH-responsive drug-induced self-assembled nanovesicle was developed based on an amphiphilic copolymer for the simultaneous delivery of doxorubicin hydrochloride (DOX·HCl) and chloroquine (CQ). The nanovesicle exhibited excellent delivery performance both in vitro and in vivo, and CQ enhanced the efficacy of DOX·HCl by inhibiting autophagy. Therefore, this study provides a promising strategy for precise combination therapy.
Article
Chemistry, Applied
Xin Luo, Jiankang Lu, Yongyan Wu, Wenshan Duan, Fengping An, Qun Huang, Lei Chen, Shaofeng Wei
Summary: The potential allergenicity of amandin was reduced by binding it with EGCG using different methods, such as alkaline, free radical, ultrasound-assisted alkaline, and ultrasound-assisted free radical methods. The binding of amandin to EGCG was found to be covalent or non-covalent, and was mainly through cysteine and glutamate residues. This study provides a new method and theoretical basis for developing hypoallergenic almond food.
Article
Chemistry, Applied
Qing-Qing Ye, Gen-Sheng Chen, Weichun Pan, Qing-Qing Cao, Liang Zeng, Jun-Feng Yin, Yong-Quan Xu
Summary: The study focused on the contribution of EGCG to astringency, the impact of mucin as a protein, and developed a predictive model to estimate the intensity of EGCG astringency.
Article
Biochemistry & Molecular Biology
Adriana Elena Bulboaca, Alina Silvia Porfire, Vasile Rus, Cristina Ariadna Nicula, Corneliu Angelo Bulboaca, Sorana D. Bolboaca
Summary: This study aimed to evaluate the effect of liposomal epigallocatechin-gallate (LEGCG) compared with epigallocatechin-gallate (EGCG) solution on hepatic toxicity induced by gentamicin administration in rats. The results showed that LEGCG had better efficacy than EGCG in improving the oxidant/antioxidant balance, reducing inflammation, and protecting the liver from gentamicin-induced damage.
Article
Agriculture, Multidisciplinary
Han Peng, Fereidoon Shahidi
Summary: In this study, ester derivatives of epigallocatechin gallate (EGCG) were synthesized and their antioxidant efficacy was evaluated. The results showed that the lipophilicity of the EGCG derivatives increased with the increasing chain length of the acyl group, which affected their antioxidant performance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Qiang Peng, Ruoping Wang, Qian Zhang, Honghan Yuan, Xiaofang Luo, Wanzhen Lin, Junpeng Shi, Liang Song, Maochun Hong, Yun Zhang
Summary: The emergence of multidrug-resistant bacteria poses a serious threat to human health, and developing new antibacterial strategies is crucial. Recently, a pH-responsive targeted nanomaterial called ZEI@GCS has shown great potential in improving the bioavailability of the antibacterial agent EGCG. It also allows for evaluating the therapeutic outcome in mice.
ACS MATERIALS LETTERS
(2023)
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Zejian Xu, Guancheng Shan, Nairong Hao, Lianwei Li, Tian Lan, Yabo Dong, Jiayu Wen, Ran Tian, Yan Zhang, Lianzhou Jiang, Xiaonan Sui
Summary: This study presents a strategy to tailor soy protein-derived amyloid fibrils (SAFs) into hydrogels using (-)-epigallocatechin-3-gallate (EGCG). EGCG can cleave SAFs and induce the formation of branched chains, leading to gel-like structures. SAFs-EGCG complexes show superior antibacterial activity and are non-toxic to human cells.
Article
Oncology
Xing-Guo Tang, Ke Lin, Shun-Wen Guo, Yi Rong, Dan Chen, Zhe-Sheng Chen, Feng-Feng Ping, Jin-Quan Wang
Summary: This study confirmed that the increment-Ru1/Dox combination had a synergistic effect in inhibiting tumor growth in a mouse xenograft model. It was found that this combination treatment promoted tumor cell apoptosis and reduced cardiac fibrosis and iron accumulation caused by doxorubicin. Further investigation revealed that doxorubicin regulated iron accumulation via the ferroptosis pathway and the expression of lipid peroxidation-related proteins. Therefore, the increment-Ru1/Dox combination therapy shows promise in reducing the toxic side effects of doxorubicin, especially cardiac injury.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2023)
Review
Pharmacology & Pharmacy
Lei Zhang, Biwei Ye, Zhuo Chen, Zhe-Sheng Chen
Summary: Chemotherapy is an important method for treating cancer, but multi-drug resistance (MDR) is a major reason for its failure. Almost all anti-tumor drugs develop drug resistance over time, reducing their effectiveness in killing cancer cells. Chemoresistance can lead to rapid cancer recurrence and patient death.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Physics, Multidisciplinary
Jiuxiang Zhang, Zhesheng Chen, Jonathan Caillaux, Yannick Klein, Andrea Gauzzi, Azzedine Bendounan, Amina Taleb-Ibrahimi, Luca Perfetti, Evangelos Papalazarou, Marino Marsi
Summary: Time-resolved ARPES provides a method to investigate the band structure and dynamics of excited electronic states in solids. Understanding the orbital character of bands near the Fermi level is crucial for explaining exotic phenomena in quantum materials. By conducting polarization-dependent time-and angle-resolved photoemission spectroscopy and analyzing the photoelectron yield for different crystal orientations, we determine the orbital character of bands above and below the chemical potential in the Dirac semimetal BaNiS2. Our results demonstrate the significance of controlling and understanding matrix elements' effects in time-resolved photoemission spectroscopy for the study of quantum materials.
EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS
(2023)
Article
Chemistry, Multidisciplinary
Jiuxiang Zhang, Thibault Daniel Pierre Sohier, Michele Casula, Zhesheng Chen, Jonathan Caillaux, Evangelos Papalazarou, Luca Perfetti, Luca Petaccia, Azzedine Bendounan, Amina Taleb-Ibrahimi, David Santos-Cottin, Yannick Klein, Andrea Gauzzi, Marino Marsi
Summary: In the Dirac semimetal BaNiS2, the Dirac nodes can be moved along the Gamma-M symmetry line in reciprocal space by varying the concentration of adsorbed K atoms. This peculiar feature offers a promising tool for engineering Dirac states at surfaces, interfaces, and heterostructures, as demonstrated by first-principles calculations considering the effect of charge transfer gap.
Article
Biochemistry & Molecular Biology
Gao-Jie Ye, Chao-Yun Cai, Zhuo-Xun Wu, Qiu-Xu Teng, Jing-Quan Wang, Zhe-Sheng Chen, Bo Wang
Summary: Three series of phenylurea indole derivatives were synthesized with potent inhibitory activities on ABCG2. Four phenylurea indole derivatives with extended 7C system showed the most potent ABCG2 inhibition and no inhibition on ABCB1. Further investigation on two compounds revealed that they increased the accumulation of mitoxantrone in ABCG2-overexpressing cells and stimulated the ATP hydrolysis of ABCG2 transporter.
BIOORGANIC CHEMISTRY
(2023)
Article
Oncology
Ruikun Lin, Lei Zhang, Biwei Ye, Yanan Wang, Yi-Dong Li, Hsu Jason, Wenzhen Liu, Ping Hu, Jincan Chen, Zhe-Sheng Chen, Zhuo Chen
Summary: Our study demonstrates a novel approach to treat multidrug resistance in cancer by targeting and inhibition of P-gp using a nanoparticle system. In vitro and in vivo experiments showed that this nanoparticle system significantly enhanced the efficacy of chemotherapy, reversed drug resistance, inhibited cell proliferation, induced apoptosis, and prevented cancer cell metastasis, with no apparent toxicity.
Review
Pharmacology & Pharmacy
Jia Fu, Wei Qin, Lu-Qi Cao, Zhe-Sheng Chen, Hui-Ling Cao
Summary: This review summarizes the applications and immobilization methods of receptor chromatography, which is widely used for high-throughput separation and accurate drug screening. The review focuses on screening active compounds in natural products, as well as the design and application of receptor chromatography in drug-receptor interactions.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Juan Jin, Yuhao Xie, Jin-Shi Zhang, Jing-Quan Wang, Shi-Jie Dai, Wen-fang He, Shou-Ye Li, Charles R. Ashby Jr, Zhe-Sheng Chen, Qiang He
Summary: Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer, and targeted therapy with Sunitinib has become the main treatment option due to the lack of efficacy in radiation therapy and chemotherapy. However, many patients develop resistance to Sunitinib within months of therapy. In this review, we discuss the molecular mechanisms of Sunitinib resistance, strategies to overcome it, and potential predictive biomarkers.
DRUG RESISTANCE UPDATES
(2023)
Review
Pharmacology & Pharmacy
Jiaqi Xuan, Weiguo Feng, Jiaye Wang, Ruichen Wang, Bowen Zhang, Letao Bo, Zhe-Sheng Chen, Hui Yang, Leming Sun
Summary: The long-term use of antibiotics leading to drug resistance has become a major concern. As the problem worsens, infections caused by multiple bacteria are increasing rapidly and posing serious threats to human health. Antimicrobial peptides (AMPs) offer a promising alternative to traditional antibiotics as they exhibit strong antimicrobial activity and unique mechanisms against drug-resistant bacterial infections. Current research on AMPs focuses on integrating new technologies, such as modifying the amino acid structure and exploring different delivery methods. This article provides valuable insights into the properties, mechanisms, and advancements of AMPs in combating drug-resistant bacterial infections.
DRUG RESISTANCE UPDATES
(2023)
Article
Oncology
Ruixiang Guo, Huiru Dai, Fuweijian Liu, Minling Liu, Xueying Li, Tingwei Li, Jiehao Liao, Zhe-Sheng Chen, Yuchen Liu, Shuo Fang
Summary: LEF1 has been found to be significantly associated with high histological grade in hepatocellular carcinoma (HCC) and its overexpression is correlated with poor prognosis. LEF1 may regulate the cell cycle, WNT signaling pathway, and NOTCH signaling pathway in HCC. It could serve as a potential drug target for HCC.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2023)
Article
Pharmacology & Pharmacy
Congying Gao, Lei Zhang, Yun Xu, Xiangyu Ma, Peilei Chen, Zhe-Sheng Chen, Liuya Wei
Summary: In this study, the potent histone deacetylase inhibitor I13 was assessed for its effect on chronic myeloid leukemia (CML) cells harboring T315I-mutated and wild-type BCR-ABL. I13 showed strong activity against both types of cells, inducing cell differentiation and suppressing proliferation by causing cell cycle G0/G1-phase accumulation. It was found that I13 blocked the CML signaling pathway by depleting BCR-ABL, resulting in cell differentiation. These findings highlight I13 as a BCR-ABL modulator for overcoming drug resistance caused by T315I-mutated BCR-ABL and have implications for CML therapy development.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Longyang Liu, Chunlin Chen, Ping Liu, Jing Li, Zhanjun Pang, Jiayu Zhu, Zhongqiu Lin, Haixu Zhou, Yingying Xie, Tiancai Lan, Zhe-Sheng Chen, Zhaoyang Zeng, Weiyi Fang
Summary: In this study, the expression and function of MYH10 in serous ovarian cancer (SOC) were investigated. It was found that MYH10 is associated with the invasive capacity and cisplatin resistance of SOC cells. Further experiments revealed that MYH10 interacts with MYH9 to promote tumorigenesis, progression, and cisplatin resistance in SOC. Clinical samples also showed elevated expression of MYH10 in SOC samples, which correlated positively with MYH9 expression. Co-expression of MYH10+/MYH9+ was identified as an independent prognostic factor for SOC patient survival.
Editorial Material
Immunology
Jingxian Chen, Zhesheng Chen, Barkat Ali Khan, Kaijian Hou
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Letao Bo, Youyou Wang, Yidong Li, John N. D. Wurpel, Zoufang Huang, Zhe-Sheng Chen
Summary: The survival rate for pediatric cancers has significantly improved in recent years. Conventional chemotherapy is crucial, especially in low- and middle-income countries with limited access to advanced treatments. Despite the expanded FDA approval of chemotherapy drugs for children, patients still face side effects and multidrug resistance remains a major challenge. This review focuses on the severe side effects of pediatric chemotherapy, mechanisms of multidrug resistance, and potential therapeutic options offered by drug transporters in pediatric tumors.
Article
Fisheries
Peng Xu, Kuopeng Cui, Liming Chen, Shaoshu Chen, Zheng Wang
Summary: This study evaluated the potential of Bifidobacterium animalis subsp. lactis BLa80 as a probiotic for Japanese seabass aquaculture. The results showed that BLa80 supplementation improved survival, accelerated growth, enhanced antioxidant capacity, reduced apoptosis, and altered the gut microbiota structure of juvenile Japanese seabass.
AQUACULTURE INTERNATIONAL
(2023)
