Article
Cell Biology
Wen-Jing Yang, Lin Shi, Xiao-Min Wang, Guo-Wang Yang
Summary: The study showed significantly increased HPSE expression in various cancers, correlated with poor prognosis and immune infiltration levels. In breast cancer, high HPSE expression was associated with multiple clinicopathological features, and promoted immune cell infiltration and tumor microenvironment alterations.
Article
Biochemistry & Molecular Biology
Upasana Ray, Prabhu Thirusangu, Ling Jin, Yinan Xiao, Christopher L. Pathoulas, Julie Staub, Courtney L. Erskine, Keith Dredge, Edward Hammond, Matthew S. Block, Scott H. Kaufmann, Jamie N. Bakkum-Gamez, Viji Shridhar
Summary: PG545 is a highly sulfated small molecule that inhibits heparanase and disrupts signaling mediated by heparan-binding-growth factors. It induces DNA damage in ovarian cancer cells by inducing DNA single- and double-strand breaks, reducing RAD51 expression, and inhibiting homologous recombination repair. PG545 also synergizes with PARP inhibitors in ovarian cancer cell lines and primary cultures of patient-derived ascites samples. In addition, it shows increased antitumor effects and survival in xenograft and immunocompetent syngeneic OC models. Targeting DEK-HSPG interactions through PG545 may inhibit DNA repair and sensitize cells to PARP inhibitors.
Review
Virology
Nadjet Lebsir, Fabien Zoulim, Boyan Grigorov
Summary: Heparanase-1 is an important enzyme involved in viral infections and cancer, and its inhibitors can be used as both anti-cancer drugs and antiviral agents, potentially solving drug resistance issues in current antiretroviral therapies.
Article
Pharmacology & Pharmacy
Lutan Zhou, Ronghua Yin, Na Gao, Huifang Sun, Dingyuan Chen, Ying Cai, Lin Ren, Lian Yang, Zhili Zuo, Hongbin Zhang, Jinhua Zhao
Summary: nHG and its derivatives extracted from sea cucumber demonstrate the ability to inhibit heparanase activity and show inhibitory effects on various cancer-related cells and angiogenesis. In addition, they exhibit practical antimetastatic effects in a metastatic mouse model.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Jose Pablo Leone, Michael J. Hassett, Julieta Leone, Sara M. Tolaney, Carlos T. Vallejo, Bernardo A. Leone, Eric P. Winer, Nancy U. Lin
Summary: This study compares the proportions of pathologic complete response (pCR) between male breast cancer (MaBC) and female breast cancer (FBC) in neoadjuvant chemotherapy (NAC), and finds that FBC has higher pCR rates. Furthermore, pCR is associated with survival rates in both MaBC and FBC.
Article
Medicine, General & Internal
Timothy J. Whelan, Sally Smith, Sameer Parpia, Anthony W. Fyles, Anita Bane, Fei-Fei Liu, Eileen Rakovitch, Lynn Chang, Christiaan Stevens, Julie Bowen, Sawyna Provencher, Valerie Theberge, Anna Marie Mulligan, Zuzana Kos, Mohamed A. Akra, K. David Voduc, Tarek Hijal, Ian S. Dayes, Gregory Pond, James R. Wright, Torsten O. Nielsen, Mark N. Levine
Summary: Among women with T1N0 grade 1 or 2 luminal A breast cancer who had undergone breast-conserving surgery and received endocrine therapy, the incidence of local recurrence at 5 years was low without radiotherapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cell Biology
Yiyuan Yang, Fengyan Yuan, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Fen Xiao, Qiao Liu, Jie Liu, Yujing Zhang, Xing Yu
Summary: Heparanase (HPSE) is an enzyme that degrades heparan sulfate proteoglycans, and its activity is associated with tumor growth and angiogenesis. In this review, the roles and mechanisms of HPSE in cancer progression are systematically reviewed. Additionally, potential therapeutic strategies targeting HPSE, including HPSE inhibitors in clinical trials, are discussed.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tianqun Lang, Zhong Zheng, Xin Huang, Yiran Liu, Yihui Zhai, Pengcheng Zhang, Yaping Li, Qi Yin
Summary: A new combination therapy strategy using a specific cell and drug carrier to enhance drug concentration in tumors, alleviate immunosuppression, increase the infiltration and activity of CD8(+) T cells, suppress lung metastasis, and prolong the survival of mice.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Kamil Demircan, Qian Sun, Ylva Bengtsson, Petra Seemann, Johan Vallon-Christersson, Martin Malmberg, Lao H. Saal, Lisa Ryd, Waldemar B. Minich, Ake Borg, Jonas Manjer, Lutz Schomburg
Summary: The presence of SELENOP autoantibodies in breast cancer patients is associated with poor prognosis, particularly in patients with low selenium levels. These autoantibodies may disrupt the transport function of SELENOP, leading to an increased risk of recurrence and mortality.
Article
Multidisciplinary Sciences
Casper de Boer, Zachary Armstrong, Vincent A. J. Lit, Uri Barash, Gijs Ruijgrok, Ilanit Boyango, Merle M. Weitzenberg, Sybrin P. Schroder, Alexi J. C. Sarris, Nico J. Meeuwenoord, Pedro Bule, Yasmine Kayal, Neta Ilan, Jeroen D. C. Codee, Israel Vlodavsky, Herman S. Overkleeft, Gideon J. Davies, Liang Wu
Summary: Research has shown that by developing effective HPSE inhibitors, extracellular HPSE activity can be reduced, thereby reducing the aggressiveness of cancer and potentially controlling pathological HPSE-driven malignancies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Kun Li, Guangqing Tan, Xin Zhang, Weiyu Lu, Jingyi Ren, Yuewen Si, Enoch Appiah Adu-Gyamfi, Fangfang Li, Yingxiong Wang, Biao Xie, Meijiao Wang
Summary: EIF4G1 is identified as a potential prognostic biomarker and therapeutic target for breast cancer, as it may regulate the tumor microenvironment and affect metastasis and overall survival in breast cancer patients.
Review
Biochemistry & Molecular Biology
Elisabetta Kuhn, Donatella Gambini, Luca Despini, Dario Asnaghi, Letterio Runza, Stefano Ferrero
Summary: Traditionally, lymphovascular invasion (LVI) has been considered an important pathological feature of malignancy, including breast carcinoma, and is associated with worse prognosis. However, there is inconsistency in interpretation among pathologists, leading to significant interobserver variability and scarce reproducibility. Nonetheless, in selected cases, the presence of LVI impacts adjuvant therapy.
Article
Medicine, Research & Experimental
Honghao Yu, Wenchang Lv, Yufang Tan, Xiao He, Yiping Wu, Min Wu, Qi Zhang
Summary: This study established a predictive signature based on necroptosis-related genes to evaluate the prognosis of breast cancer patients and identify those who will benefit from immunotherapy. The signature not only predicts the progression and metastasis of breast cancer, but also regulates inflammatory response and tumor microenvironment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yuqi Zhang, Qiao-Li Wang, Erwei Zeng, Wei He, Kamila Czene
Summary: This study found that family history of breast cancer is associated with prognosis. Patients with a family history of breast cancer had better outcomes in the first 5 years after diagnosis in the overall cohort and the ER-positive subgroup, while those with an early-onset family history had worse survival. These findings suggest that family history may have a significant impact on the prognosis of breast cancer patients.
Article
Oncology
Yifeng Shi, Linnea T. Olsson, Katherine A. Hoadley, Benjamin C. Calhoun, J. S. Marron, Joseph Geradts, Marc Niethammer, Melissa A. Troester
Summary: Approaches for rapidly identifying patients at high risk of early breast cancer recurrence are needed. Image-based methods for prescreening tumor slides stained with hematoxylin and eosin (H&E) could provide temporal and financial efficiency. Deep learning was leveraged to extract image information and train a model to identify recurrence. Our image model identified 70% of early-recurrent low-intermediate grade tumors, providing complementary information for predicting early recurrence compared to existing markers.
Article
Cell Biology
Xiaoli Liu, Zuwei Yin, Linping Xu, Huaimin Liu, Lifeng Jiang, Shuochuan Liu, Xu Sun
Summary: The study found that LINC01426 promotes LUAD progression by recruiting USP22 to stabilize SHH protein and activate the Hedgehog pathway.
CELL DEATH & DISEASE
(2021)
Review
Medicine, General & Internal
Linlin Liu, Xu Sun, Chenxi Yuan, Huaimin Liu
Summary: This study aims to explore the relationship between HLA-DRB1 gene polymorphism and breast cancer, providing evidence-based support. The study utilized systematic evaluation methods, searched multiple databases, and selected relevant studies. Two researchers independently conducted data extraction and quality assessment, and ultimately performed data analysis using statistical software.
Article
Biotechnology & Applied Microbiology
Yunfei Ma, Guangda Li, Mingwei Yu, Kexin Cao, Qiwei Li, Xu Sun, Guowang Yang, Xiaomin Wang
Summary: The study systematically explored the pharmacological mechanism of Radix Paeoniae Rubra (RPR) against lung cancer (LC) using network pharmacology approach, and found that Baicalein (BAI) in RPR may exert anti-tumor effects by inhibiting the proliferation, migration, and invasion of LC cells, and inducing apoptosis of LC cells.
ONCOTARGETS AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Lu Gao, Yun Ji, Lulu Wang, Meixia He, Xiaojing Yang, Yibing Qiu, Xu Sun, Zhenyu Ji, Guanrui Yang, Jianying Zhang, Shanshan Li, Liping Dai, Liguo Zhang
Summary: Piezo1 expression is upregulated in esophageal squamous cell carcinoma (ESCC) tissues and plays a role in promoting proliferation, migration, and invasion of ESCC cells, while downregulation of Piezo1 inhibits these processes and induces apoptosis. Further, Piezo1-p53-Bax-Caspase 3 axis is involved in mediating ESCC apoptosis, suggesting Piezo1 as a potential therapeutic target for ESCC.
Correction
Chemistry, Multidisciplinary
Lu Gao, Yun Ji, Lulu Wang, Meixia He, Xiaojing Yang, Yibing Qiu, Xu Sun, Zhenyu Ji, Guanrui Yang, Jianying Zhang, Shanshan Li, Liping Dai, Liguo Zhang
Article
Engineering, Biomedical
Jinghua Mu, Liguo Zhang, Can Zhang, Enxia Xu, Lulu Wang, Xinhong Liu, Guanglei Chang, Xu Sun, Chengliang Ma, Huiyu Yuan, Fei Zhao, Jinxing Gao
Summary: This study explored the effect of beta-SiAlON's Z-value on the properties of beta-SiAlON-Si3N4 composites. The results showed that an increase in the Z-value led to higher density and strength, as well as good biological performance in an aqueous environment. The addition of beta-SiAlON improved the sintering performance of beta-Si3N4 without degrading its biological properties, possibly due to the promotion of osteogenic differentiation through Si release.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Materials Science, Ceramics
Jinxing Gao, Xin Ma, Jinghua Mu, Enxia Xu, Can Zhang, Lu Gao, Chengliang Ma, Fei Zhao, Xu Sun, Liguo Zhang
Summary: The addition of CaO improved the sintering process, reduced porosity, and increased compressive strength of the beta-SiAlON ceramics. Chemical stability studies showed that CaO altered the surface chemical properties of the material. Cell culture experiments demonstrated that beta-SiAlON ceramics with CaO had good anti-cell adhesion ability.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Review
Integrative & Complementary Medicine
Lu Wang, Mingwei Yu, Yunfei Ma, Rong Tian, Xiaomin Wang
Summary: Pulmonary rehabilitation (PR) has a positive impact on the postoperative clinical status of patients with lung cancer and COPD, reducing the risk of complications, pneumonia, and length of stay.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Boran Zhang, Wenchao Dan, Ganlin Zhang, Xiaomin Wang
Summary: This study analyzed the pharmacological mechanism of Gleditsiae Spina in the treatment of high-grade serous ovarian cancer (HGSC) using network pharmacology and biological experiments. The results showed that Gleditsiae Spina has cytotoxicity on HGSC and exerts therapeutic effects by regulating multiple targets and pathways.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Oncology
Yan Li, Lifeng Jiang, Zhaocheng Zhu, Binfan Fu, Xu Sun, Yue Jiao
Summary: This study investigates the role and therapeutic potential of lncRNA SNHG16 in human lung cancer. The results show that upregulation of SNHG16 is associated with increased lung cancer cell proliferation, migration, and invasion, while downregulation of SNHG16 inhibits these processes. SNHG16 interacts with ALDH2 to exert its effects in lung cancer cells. Additionally, the expression of ALDH2 is suppressed in lung cancer tissues and cell lines. Overall, this study uncovers the molecular role of SNHG16 in regulating the development of lung cancer by interacting with ALDH2.
JOURNAL OF ONCOLOGY
(2022)
Review
Integrative & Complementary Medicine
Fangfang Ma, Hewei Zhang, Bingxue Li, Duanhong Yang, Peiyu Cheng, Mingwei Yu, Dechun Dai, Xun Li, Xiaomin Wang
Summary: The aim of this study was to evaluate the efficacy and safety of traditional Chinese medicine (TCM) for postviral olfactory dysfunction (PVOD). Six randomized controlled trials (RCTs) involving 467 patients were selected. TCM plus olfactory training and/or drug therapy (OTDT) decreased QOD-P and appeared to increase the treatment success rate compared to no treatment. TCM plus drug therapy appeared to increase the effective rate compared to drug therapy alone. However, further high-quality RCTs are still needed due to the lack of sufficient evidence.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2023)
Article
Pathology
Bingtan Kong, Jie Zhou, Hao Wang, Yinan Li, Yuancan Pan, Hui Zhu, Qing Zhang, Qingsheng Fan, Xiaomin Wang, Ganlin Zhang
Summary: The histopathological growth pattern (HGP) reflects the interaction between cancer cells and surrounding tissues and has a predictive value in liver metastases. This study focuses on investigating HGP and its evolution in primary liver cancer using a rabbit model. The study found that tumor growth follows an exponential pattern and metastasis occurs after reaching a specific stage of development. The components of HGPs change with tumor growth, with the decrease and increase of desmoplastic HGP (dHGP) and replacement HGP (rHGP) respectively. The expression of HIF1A and VEGF is correlated with collagen deposition and dHGP, while CD31 is not. The findings suggest that HGP evolution is a two-way switch and HIF1A-VEGF may play a key role in the formation of dHGP.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Medicine, General & Internal
Jiayun Nian, Xu Sun, Wenjie Zhao, Xiaomin Wang
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy and safety of acupuncture in the treatment of leukopenia after chemotherapy. The results showed that acupuncture can increase white blood cell count, reduce the incidence of myelosuppression, and improve clinical treatment effectiveness.
Article
Oncology
Yun-Fei Ma, Guang-Da Li, Xu Sun, Xiao-Xiao Li, Yu Gao, Chong Gao, Ke-Xin Cao, Guo-Wang Yang, Ming-Wei Yu, Xiao-Min Wang
Summary: FAM107A expression is decreased in prostate adenocarcinoma and is significantly associated with poor survival outcomes. It may be related to immune cells and various signaling pathways, serving as an independent risk factor for progression-free survival in PRAD.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Yun Ji, Lu Gao, Can Zhang, Xu Sun, Liping Dai, Zhenyu Ji, Jianying Zhang, Zhida Zhang, Wei Cao, Yang Zhao, Liguo Zhang
Summary: This study identified 10 hub genes and 3 prognostic indicators of gastric cancer through differential gene expression analysis. The upregulation of these genes in GC tissue and their correlation with tumor-infiltrating immune cell levels suggest they could be valuable indicators for future diagnosis and treatment of GC.
