Review
Behavioral Sciences
Dylan J. Terstege, Jonathan R. Epp
Summary: Alzheimer's disease is the most common form of dementia, with a greater impact on women. Recent research suggests that the balance between excitatory and inhibitory activity in the brain is a strong predictor of cognitive impairments in Alzheimer's disease. This mini-review examines the effects of sex and age-related factors on the function of a specific type of inhibitory neurons called parvalbumin-expressing interneurons. It emphasizes the importance of presenting sex-stratified data in Alzheimer's disease research.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Cell Biology
Concetta Scimone, Luigi Donato, Simona Alibrandi, Concetta Alafaci, Angela D'Ascola, Sergio Vinci, Rosalia D'Angelo, Antonina Sidoti
Summary: This study reveals the importance of epitranscriptomic modifications in gene expression regulation and suggests the involvement of altered epitranscriptome profile in the development of CCM. These findings provide new insights for further investigation into the pathogenesis of CCM.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Neurosciences
Jordi A. Matias-Guiu, Vanesa Pytel, Laura Hernandez-Lorenzo, Nikil Patel, Katie A. Peterson, Jorge Matias-Guiu, Peter Garrard, Fernando Cuetos
Summary: The study adapted and validated the Spanish version of MLSE for PPA diagnosis, showing excellent internal consistency and discriminative properties. MLSE performed well in distinguishing PPA patients from healthy controls and differentiating between clinical variants.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Chemistry, Analytical
Salvatore Petralia, Antonella Vigilanza, Emanuele Sciuto, Michele Maffia, Antonella Romanini, Sabrina Conoci
Summary: The study investigated single nucleotide polymorphisms in the MC1R gene using a miniaturized silicon-based microarray-chip, showing good sensitivity and high confidence level, paving the way for future development of portable genetic assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Neurosciences
Qian Zhang, Jian Li, Ling Weng
Summary: This study aimed to identify and verify potential aging-related genes associated with Alzheimer's disease using bioinformatics analysis. Five ARDEGs (GFAP, PDGFRB, PLOD1, MAP4K4, and NFKBIA) were obtained, with biological functions related to aging, cellular senescence, and Ras protein signal transduction regulation. The diagnostic ability of these genes in discriminating AD from control samples demonstrated a favorable diagnostic value, with elevated mRNA expression levels in AD patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Physiology
Zikang Hao, Kerui Liu, Lu Zhou, Ping Chen
Summary: In disproportionate to the severity of Alzheimer's disease (AD) and the large number of patients, finding the exact treatment and prevention for AD is still being explored. Exercise has been suggested as an effective and cost-effective means of preventing and treating AD, so current research is focused on exploring its effectiveness. However, due to the complexity of AD's specific pathogenesis, there are various hypotheses and mechanisms that need to be explored for exercise interventions in AD.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Clinical Neurology
Jakub P. Hlavka, Jeffrey C. Yu, Darius N. Lakdawalla
Summary: This study presents a crosswalk between MMSE and TICS, providing a comparable cognitive measurement tool for adults aged 65 and older.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Tianyu Zhao, Tangsheng Zhong, Meishuang Zhang, Yang Xu, Ming Zhang, Li Chen
Summary: This study used bioinformatics and Mendelian randomization to explore the correlation between obesity and Alzheimer's disease (AD) and found the key targets of obesity-induced AD. The results revealed that the association between obesity and AD is mainly due to the polymorphism of the APOE gene rather than adipose tissue distribution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Grazia Maria Liuzzi, Tania Petraglia, Tiziana Latronico, Aniello Crescenzi, Rocco Rossano
Summary: The increase in life expectancy has led to the emergence of age-related diseases, including neurodegenerative diseases. Oxidative stress, caused by an imbalance of reactive oxygen species, contributes to these diseases. Dietary supplementation with antioxidant-containing foods, such as edible mushrooms, can enhance antioxidant defenses and prevent age-related neurological diseases.
Article
Psychiatry
Xiaoyue Li, Yelei Zhang, Xinyu Chen, Hongwei Yuan, Zhiqiang Wang, Guoqiang Wang, Kai Zhang, Huanzhong Liu
Summary: The study revealed that certain polymorphisms of the APOE gene are associated with an increased risk of DAT in women, while a different polymorphism of the BIN1 gene is linked to a decreased risk of DAT in men among the Chinese Han population.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Cell Biology
Eugene Lin, Po-Hsiu Kuo, Wan-Yu Lin, Yu-Li Liu, Albert C. Yang, Shih-Jen Tsai
Summary: The study suggests that genetic variants in dopamine receptor-related loci may influence cognitive aging individually and through gene-physical activity interactions. Three novel genes associated with cognitive aging were identified: ZBTB20, NCAM1, and TTC12. Additionally, interplays between physical activity and these three novel genes were found.
Review
Genetics & Heredity
Zubo Wu, Suyuan Wu, Tao Liang
Summary: The association between two NLRP3 gene polymorphisms and susceptibility to autoimmune diseases is controversial, with rs35829419 showing no significant association but potentially protective effect in rheumatoid arthritis, and rs10754558 significantly reducing the risk of AIDs, especially in Latin American individuals.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Meng Feng, Shuping Zhou, Tong Liu, Yong Yu, Qinghong Su, Xiaofan Li, Min Zhang, Xiao Xie, Tingting Liu, Wei Lin
Summary: IL-35 is an essential regulatory factor in autoimmune uveitis, and its specific SNP sites change may be correlated to disease susceptibility and clinical symptoms, especially in patients with Vogt-Koyanagi-Harada syndrome.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Genetics & Heredity
Chuncheng Yi, Tiandong Li, Yajing Shen, Peng Wang, Liping Dai, Jianxiang Shi, Keyan Wang, Changqing Sun, Hua Ye
Summary: This meta-analysis suggests a significant association between ERCC1 rs11615, ERCC1 rs3212986, ERCC2 rs1799793, and ERCC5 rs17655 and CRC susceptibility. However, larger and well-designed studies are needed to confirm these results due to the limited sample size and influence of genetic background.
FRONTIERS IN GENETICS
(2022)
Article
Computer Science, Interdisciplinary Applications
Hezhe Qiao, Lin Chen, Fan Zhu
Summary: The study introduces a ranking convolutional neural network (rankCNN) method to predict MMSE through multi-classification, which outperforms other state-of-the-art methods on both ADNI-1 and ADNI-2 datasets. The proposed model achieved RMSE of 2.238 and 2.434 at baseline on the two datasets, demonstrating high prediction accuracy.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Psychology, Clinical
Chiao-Erh Chang, Jui Wang, Yi-Ting Lin, Chih-Chiang Chiu, Ming-Hsien Hsieh, Ming-Chyi Huang, Mong-Liang Lu, Hsi-Chung Chen, Wei J. Chen, Po-Hsiu Kuo
Summary: This study compared the clinical features, psychosocial characteristics, and comorbidity patterns between the unipolar mania (UM) and depressive-manic (D-M) subgroups. The results showed that compared to the D-M group, the UM group had more psychotic symptoms, a higher proportion of morningness chronotype, better sleep quality, higher extraversion, lower neuroticism, and less harm avoidance personality traits. Additionally, different lifetime comorbidity patterns were observed between the two groups.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Yun-Ling Chen, Po-Hsiu Kuo
Summary: Objective depression and perceived stress are important risk factors for adolescent suicidal behaviors. This study examined the joint effects of parenting styles on suicidal ideation (SI) and attempt (SA) in early adolescents, while considering individual factors, and evaluated the role of social support in mitigating the risk. The results showed that depression, father's low care and high authoritarian parenting styles, and low acceptance and high authoritarian parenting styles were strong risk factors, while overall social support was a protective factor for SI and SA in early adolescents. Perceived stress and mother's low care and high authoritarian parenting style were also identified as risk factors for SI. Overall, family and social factors should be considered in suicidal prevention and interventions for early adolescents.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yen-Feng Lin, Wen-Hai Chou, Tung-Hsia Liu, Chiu-Ping Fang, Hsiang-Wei Kuo, Po-Hsiu Kuo, Shih-Jen Tsai, Sheng-Chang Wang, Ren-Hua Chung, Hsiao-Hui Tsou, Andrew C. H. Chen, Yu-Li Liu
Summary: The study found that the gene encoding the GABRD subunit of the GABA-A receptor is associated with amphetamine use in heroin dependent patients under MMT in Taiwan. Two genetic variants in the GABRD, rs2889475 and rs2376805, were found to be associated with the positive urine amphetamine test. The CC genotype carriers of rs2889475 showed a four times higher risk of amphetamine use than those with TT genotype, while the GG genotype carriers of rs2376805 showed a three times higher risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Tien-Wei Hsu, Chih-Sung Liang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Evidence suggests that childhood and adolescent cancer survivors have an increased long-term risk of major psychiatric disorders. However, it remains unclear whether these associations vary for different types of cancers.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychiatry
Hsin-Jung Tsai, Wei-Cheng Yang, Shih-Jen Tsai, Ching-Hua Lin, Albert C. Yang
Summary: Major depressive disorder has a significant impact on global healthcare resources. Antidepressants are commonly used as the first-line treatment, but brain stimulation therapy may be necessary for non-responders. Digital phenotyping can help predict treatment effectiveness for patients with major depressive disorder.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Che-Sheng Chu, Kai-Lin Huang, Ya-Mei Bai, Tung-Ping Su, Shih-Jen Tsai, Tzeng-Ji Chen, Ju-Wei Hsu, Chih-Sung Liang, Mu-Hong Chen
Summary: We investigated the risk of suicide in patients diagnosed with sleep apnea and found that they are more likely to attempt suicide compared to those without sleep apnea.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shih-Jen Tsai, Ju-Wei Hsu, Kai-Lin Huang, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: This study investigated the difference in periodontitis risk between adolescents with autism spectrum disorder (ASD) and those without ASD. The results showed that adolescents with ASD were more likely to develop periodontitis compared to those without ASD. ASD can be considered as an independent risk factor for subsequent periodontitis development.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2023)
Article
Psychiatry
Jiajia Zhao, Chu-Chung Huang, Yajuan Zhang, Yuchen Liu, Shih-Jen Tsai, Ching-Po Lin, Chun-Yi Zac Lo
Summary: This study reveals the widespread connectivity abnormalities in both structural and functional brain circuits in individuals with schizophrenia. The abnormal signal transfer along the white matter pathways is found to be significantly associated with psychotic symptoms and illness duration in schizophrenia. This work supports the dysconnectivity hypothesis of schizophrenia and emphasizes the critical role of white matter networks in the pathophysiology of this disorder.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Jun-Ding Zhu, Yung-Fu Wu, Shih-Jen Tsai, Ching-Po Lin, Albert C. C. Yang
Summary: Brain-age prediction models were constructed using multimodal MRI, and deviations in aging trajectories in different brain regions of participants with schizophrenia were examined. The results showed accelerated aging in most gray matter regions, especially in the frontal lobe, temporal lobe, and insula. Deviations in aging trajectories were also observed in some white matter tracts. However, no accelerated brain aging was found in functional connectivity maps. These findings provide insights into the neuropathology of schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Shiau-Shian Huang, Yu-Hsiang Yu, His-Han Chen, Chia-Chun Hung, Yao-Ting Wang, Chieh Hsin Chang, Syu-Jyun Peng, Po-Hsiu Kuo
Summary: This study found that the functional connectivity (FC) of major depressive disorder (MDD) patients was worse than that of controls at baseline, but improved after treatment. Responders showed better FC in the high-frequency bands than non-responders, both before and after treatment.
Article
Psychiatry
Che-Sheng Chu, Shu-Li Cheng, Ya-Mei Bai, Tung-Ping Su, Shih-Jen Tsai, Tzeng-Ji Chen, Fu-Chi Yang, Mu-Hong Chen, Chih-Sung Liang
Summary: Individuals with dementia who have multiple comorbidities such as fractures, urinary and pulmonary infections, upper gastrointestinal bleeding, and nasogastric intubation face a higher risk of mortality within 5 years compared to those with cancer or cardiometabolic comorbidities.
PSYCHIATRY INVESTIGATION
(2023)
Article
Psychiatry
Cheng-Ta Li, Chih-Ming Cheng, Hui-Ching Lin, Skye Hsin-Hsieh Yeh, Jia-Shyun Jeng, Hui-Ting Wu, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Paul B. Fitzgerald
Summary: This double-blind, sham-controlled study aimed to investigate the antidepressant efficacy of 2 daily prolonged intermittent theta-burst stimulation (piTBS) sessions for treating major depressive disorder (MDD) patients. The results showed that the piTBS group had significantly more responders at week 2 than the sham group, but there was no evidence to support that longer piTBS treatment duration resulted in more rapid or better antidepressant effects. Longer treatment duration did not result in stronger placebo effects.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Tien-Wei Hsu, Mu-Hong Chen, Ya-Mei Bai, Wen-Han Chang, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Shih-Jen Tsai, Chih-Sung Liang
Summary: This study aimed to examine the risk of T1D, MDD, ADHD, and ASD in first-degree relatives of T1D patients. The results showed that FDRs of individuals with T1D had a higher risk of T1D and MDD compared to controls. Stratified by sex and kinship, female FDRs had an increased risk of MDD, while male FDRs had an increased risk of ADHD. Furthermore, FDRs of individuals with T1D and DKA had a higher risk of MDD and ADHD.
ACTA DIABETOLOGICA
(2023)
Article
Psychiatry
Chen-Lan Shen, Shih-Jen Tsai, Ching-Po Lin, Albert C. C. Yang
Summary: This study examined the structural and functional brain abnormalities in patients with schizophrenia, and found that these abnormalities progress at different rates and in different brain areas throughout the course of the illness. Using MRI scanning, the study found that in the early stages of schizophrenia, there were only limited functional abnormalities in certain brain regions, but as the illness progressed, the abnormalities spread to wider brain areas and also involved gray matter density. In the third decade of the illness, structural connectivity abnormalities affecting almost all white matter tracts emerged.
Article
Psychiatry
Jun-Ding Zhu, Shih-Jen Tsai, Ching-Po Lin, Yi-Ju Lee, Albert C. Yang
Summary: Brain-age prediction is a novel approach for assessing deviated brain aging trajectories in different diseases. This study aimed to investigate the presence of declined brain structures in schizophrenia using brain volume, cortical thickness, and fractional anisotropy as features. The results showed that individuals with schizophrenia had larger brain age gaps compared to healthy controls across different illness durations.
