Article
Surgery
Ronan J. Kelly, Amir M. Ansari, Tomoharu Miyashita, Marianna Zahurak, Frank Lay, A. Karim Ahmed, Louis J. Born, Maryam K. Pezhouh, Kevan J. Salimian, Christopher Ng, Aerielle E. Matsangos, Anne-Heloise Stricker-Krongrad, Ken-ichi Mukaisho, Guy P. Marti, Christine H. Chung, Marcia I. Canto, Michelle A. Rudek, Stephen J. Meltzer, John W. Harmon
Summary: Itraconazole significantly reduces the development of esophageal adenocarcinoma and SHH expression in a preclinical animal model of Barrett's Metaplasia. In humans, BE tissue expresses higher levels of SHH, Indian Hedgehog, and bone morphogenic protein compared to normal squamous esophageal epithelium.
Article
Biology
Janani Ramachandran, Weiqiang Zhou, Anna E. Bardenhagen, Talia Nasr, Ellen R. Yates, Aaron M. Zorn, Hongkai Ji, Steven A. Vokes, Marianne E. Bronner
Summary: This study investigates the role of sonic hedgehog (SHH) in the development of the larynx and anterior foregut in mice. The results show that SHH is crucial for maintaining epithelial integrity and regulating epithelial remodeling. Mutations in SHH lead to abnormal epithelial-to-mesenchymal transition, cell movement, and cell death.
Article
Biochemistry & Molecular Biology
Jun Wu, Rong Wang, Xuechun Kan, Jinghan Zhang, Wen Sun, David Goltzman, Dengshun Miao
Summary: This study reveals that the activation of the Shh-Gli-Bmi1 signaling pathway plays a critical role in the bone anabolic action induced by p27 deficiency. Bmi1 may be an important therapeutic target for treating osteoporosis caused by the activation of p27 signaling or inactivation of sonic hedgehog signaling.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biology
Alejandro Urdiciain, Elena Erausquin, Maria V. Zelaya, Idoya Zazpe, Jose L. Lanciego, Barbara Melendez, Juan A. Rey, Miguel A. Idoate, Natalia A. Riobo-Del Galdo, Javier S. Castresana
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor with poor prognosis. HDAC6 is overexpressed in GBM and its silencing inhibits proliferation, migration, and clonogenic potential in GBM cell lines, as well as reversing the mesenchymal phenotype, decreasing autophagy, inhibiting the Sonic Hedgehog pathway, and restoring primary cilia expression. These findings suggest HDAC6 may be a promising therapeutic target for GBM treatment.
Article
Immunology
Xueting Jia, Jinan Liu, Yinxue He, Xiaofeng Huang
Summary: The cultured media of P. gingivalis can induce the malignant transformation of normal esophageal epithelium through the Sonic hedgehog pathway.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Toxicology
Mahsa Ghorbaninejad, Anna Meyfour, Samaneh Maleknia, Shabnam Shahrokh, Meghdad Abdollahpour-Alitappeh, Hamid Asadzadeh-Aghdaei
Summary: This study revealed that increased SHH signaling activity in patients with inflammatory bowel disease enhanced inflammatory responses and affected epithelial cell characteristics. Inhibiting SHH signaling may have therapeutic benefits in treating inflammatory conditions in the intestines.
TOXICOLOGY IN VITRO
(2022)
Article
Oncology
Vivien Koh, Jayati Chakrabarti, Meaghan Torvund, Nina Steele, Jennifer A. Hawkins, Yoshiaki Ito, Jiang Wang, Michael A. Helmrath, Juanita L. Merchant, Syed A. Ahmed, Asim Shabbir, Jimmy Bok Yan So, Wei Peng Yong, Yana Zavros
Summary: The study shows that PD-L1 expression in gastric cancer is mediated by Hh and mTOR signaling pathways. Patient-derived organoid/immune cell co-cultures can be used to study immunosuppressive MDSC function. DSP analysis reveals infiltration of immunosuppressive MDSCs in gastric cancer tissues.
Article
Multidisciplinary Sciences
Rachel K. Lex, Weiqiang Zhou, Zhicheng Ji, Kristin N. Falkenstein, Kaleigh E. Schuler, Kathryn E. Windsor, Joseph D. Kim, Hongkai Ji, Steven A. Vokes
Summary: The study challenges the current understanding that GLI3 repression is established before Hedgehog (HH) signaling and demonstrates that GLI3 is inert in the limb bud before HH onset. The loss of Gli3 does not increase target gene expression or accessibility, contrasting with post-HH signaling. GLI repression is established independently of HH signaling, but after its onset.
NATURE COMMUNICATIONS
(2022)
Article
Pediatrics
Haibao Zhang, Shan Xu, Dalin He, Xinyang Wang, Guodong Zhu
Summary: Autocrine SHH signaling was found in the developing urothelium, while paracrine SHH signaling was found in the developing smooth muscle layer, mediated by SMO, PTC-1, and GLI1 during human bladder development. The expression of SHH signaling components peaked at 12- and 23-weeks gestation, corresponding to different stages of urothelium and smooth muscle layer differentiation and development in the fetal bladder.
FRONTIERS IN PEDIATRICS
(2021)
Article
Plant Sciences
Yiqing Guan, Dongling Quan, Kai Chen, Liangqi Kang, Danni Yang, Huanxian Wu, Mengqiu Yan, Shaoyu Wu, Lin Lv, Guohua Zhang
Summary: The study investigates the effect of KAE therapy on extracellular matrix deposition and stimulation of EMT in vitro and in vivo. The results show that KAE can reduce blood pressure and decrease ECM components, TGF-01, and a-SMA in the kidneys of hypertension-induced rats with chronic kidney disease. In addition, KAE administration significantly suppresses proliferation, migration, and EMT in HK-2 cells treated with TGF-01.
Article
Genetics & Heredity
Manhal Abd-Alameer, Masoumeh Rajabibazl, Zahra Esmaeilizadeh, Zahra Fazeli
Summary: This study found that treating human bone marrow-mesenchymal stem cells (BM-MSCs) with SAG-dihydrochloride can increase the expression of germ cell markers, leading to improved efficiency in germ line cell generation.
Article
Health Care Sciences & Services
Constantin Busuioc, Cristina Alexandra Ciocan-Cartita, Cornelia Braicu, Oana Zanoaga, Lajos Raduly, Monica Trif, Mihai-Stefan Muresan, Calin Ionescu, Cristina Stefan, Carmen Crivii, Nadim Al Hajjar, Simona Margarit, Ioana Berindan-Neagoe
Summary: The study utilized bioinformatics approaches to investigate alterations in EMT-related genes in colon adenocarcinoma patients, identifying key gene changes related to prognosis in COAD. These findings may help develop biomarkers for recurrence prediction in COAD patients and improve risk stratification for patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Qiaosi Tang, Ashley Lento, Kensuke Suzuki, Gizem Efe, Tatiana Karakasheva, Apple Long, Veronique Giroux, Mirazul Islam, E. Paul Wileyto, Andres J. Klein-Szanto, Hiroshi Nakagawa, Adam Bass, Anil K. Rustgi
Summary: The study reveals that TP53 mutation is the most common in ESCC, while Rab11-FIP1 gene is significantly downregulated in mutant p53 tumor cells. Genetic knockdown of Rab11-FIP1 results in increased organoid size and promotes tumor cell invasion through mutant p53.
Article
Pediatrics
Pu Siyu, Wang Junxiang, Wang Qi, Zhang Yimao, Jin Shuguang
Summary: The nuclear transcription factor GLI1/GLI2 of the Shh signaling pathway plays a regulatory role in epithelial-mesenchymal transition (EMT) related to hepatic fibrosis in patients with biliary atresia (BA).
FRONTIERS IN PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Emilia J. Orzechowska-Licari, Agnieszka B. Bialkowska, Vincent W. Yang
Summary: This study reveals that upon ionizing radiation-induced injury, intestinal epithelial cells increase SHH secretion, stimulating stromal cells to secrete WNT ligands, which leads to the activation of reserve intestinal stem cells (rISCs) (marked by BMI1) and subsequent epithelial regeneration.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhou, Joy Jin, Mei Feng, Di Zhu
CURRENT PROTEIN & PEPTIDE SCIENCE
(2019)
Article
Multidisciplinary Sciences
M. Feng, J. Q. Jin, L. Xia, T. Xiao, S. Mei, X. Wang, X. Huang, J. Chen, M. Liu, C. Chen, S. Rafi, A. X. Zhu, Y. -X. Feng, D. Zhu
Article
Oncology
Lei Wang, Joy Jin, Yong Zhou, Ziqiang Tian, Biao He, Yueyan Huang, Feng Ding
Article
Respiratory System
Yong Zhou, Degui Shu, Hangdi Xu, Yuanhua Qiu, Pan Zhou, Wenjing Ruan, Guangyue Qin, Joy Jin, Hao Zhu, Kejing Ying, Wenxia Zhang, Enguo Chen
JOURNAL OF THORACIC DISEASE
(2020)
Article
Dermatology
Joy Q. Jin, Jenny M. Ahlstrom, Nathan W. Sweeney, Wilson Liao
DERMATOLOGY AND THERAPY
(2020)
Review
Biotechnology & Applied Microbiology
Joy Q. Jin, David Wu, Riley Spencer, Kareem G. Elhage, Jared Liu, Mitchell Davis, Marwa Hakimi, Sugandh Kumar, Zhi-Ming Huang, Tina Bhutani, Wilson Liao
Summary: This article summarizes single-cell studies on psoriasis and psoriatic arthritis, highlighting the unique transcriptional profiles and cellular interactions involved. Through analyses of 22 single-cell studies, it has been found that a small subpopulation of cells can have a significant impact on disease pathogenesis. Multiple cell types identified through scRNA-seq play supporting roles in psoriasis pathogenesis, contrasting with the traditional focus on IL-23/IL-17 signaling among dendritic cells and T cells. Immune cell states are dynamic, with psoriatic subpopulations abnormally re-activating and differentiating into inflammatory phenotypes depending on surrounding signaling cues. Comparison of circulating immune cells with resident skin/joint cells has revealed specific T cell clonotypes associated with the disease. Finally, machine learning models show great promise in identifying biomarkers for diagnosing clinically ambiguous rashes and early-stage psoriatic arthritis.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2022)
Article
Medicine, General & Internal
Jing Qian, Zeeshan Haq, Daphne Yang, Joy Q. Jin, Jay M. Stewart
Summary: This study examined the impact of diabetes mellitus disease duration on optical coherence tomography angiography parameters in diabetic patients without diabetic retinopathy. The findings suggest that as the disease duration increases, there is a gradual decrease in retinal vessel density and vessel length density, as well as changes in the area of the foveal avascular zone.
Review
Dermatology
Joy Q. Jin, Kareem G. Elhage, Riley K. Spencer, Mitchell S. Davis, Marwa Hakimi, Tina Bhutani, Wilson Liao
Summary: A systematic review of 27 Mendelian randomization studies on psoriasis (PSO) and psoriatic arthritis (PSA) revealed causal relationships between PSO/PSA and exposures such as smoking, obesity, cardiovascular disease, and Crohn's disease. In addition, PSO was found to be causally associated with several comorbidities. These findings have important implications for preventive counseling and precision medicine.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Dermatology
Joy Q. Jin, Allison S. Dobry
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Health Care Sciences & Services
Joy Q. Jin, Riley K. Spencer, Vidhatha Reddy, Tina Bhutani, Wilson Liao
Summary: Deucravacitinib, a new oral medication for treating psoriasis, has shown good clinical efficacy and no severe adverse effects in patients with moderate-to-severe psoriasis.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2023)
Article
Dermatology
Joy Q. Jin, Angel Cronin, Carla Roberts-Toler, Samuel Yeroushalmi, Edward Hadeler, Riley K. Spencer, Kareem G. Elhage, George Gondo, Elizabeth B. Wallace, Soumya M. Reddy, George Han, Jessica Kaffenberger, Mitchell S. Davis, Marwa Hakimi, Jose U. Scher, April W. Armstrong, Tina Bhutani, Robert R. Mclean, Wilson Liao
Summary: This study investigated psoriasis patients with poor response to multiple biologic agents and identified characteristics associated with multiple biologic failure (MBF). The results showed that about 6% of patients met the criteria for MBF, and certain characteristics such as female sex, shorter psoriasis duration, and prior nonbiologic systemic therapy use were associated with MBF. The findings provide valuable insights for identifying patients who may require more frequent follow-up.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Letter
Dermatology
Joy Q. Jin, Kareem G. Elhage, Riley K. Spencer, Mitchell S. Davis, Marwa Hakimi, Tina Bhutani, Wilson Liao
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Dermatology
Riley K. Spencer, Joy Q. Jin, Kareem G. Elhage, Mitchell S. Davis, Wilson Liao, Tina Bhutani
Summary: Tapinarof is a novel topical medication that has shown beneficial effects in treating plaque psoriasis. It improves the condition through various mechanisms and provides a highly effective and safe non-steroidal treatment option for adults with moderate-to-severe psoriasis.
PSORIASIS-TARGETS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mei Feng, Zhongen Wu, Yan Zhou, Zhuang Wei, Enming Tian, Shenglin Mei, Yuanyuan Zhu, Chenglong Liu, Fenglian He, Huiyu Li, Cao Xie, Joy Jin, Jibin Dong, Dehua Yang, Ker Yu, Junbin Qian, Diether Lambrechts, Ming-Wei Wang, Di Zhu
Summary: The study shows that inhibition of BCL9 can reduce tumor growth, promote CD8(+) T cell infiltration into tumors, and enhance response to anti-PD-1 treatment. The mechanism of BCL9 involves regulation of CD155-CD226 and CD155-CD96 checkpoints.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)