Article
Immunology
Qin Yang, Jingyun Guo, Jiehuang Zheng, Yan Chen, Binhua Zou, Ruopeng Li, Zongbao Ding, Yiyuan Wang, Lihong Li, Ziye Chen, Lixia Mo, Qinghe Liang, Fengsheng Chen, Xiaojuan Li
Summary: In this study, the researchers found that polyphyllin VII (PP7), isolated from the Chinese herb Paris polyphylla, can inhibit breast cancer-induced bone destruction and promote osteoblast formation. PP7 inhibited osteoclast formation induced by MDA-MB-231 cells and downregulated the activation of c-Fos and NFATc1 signaling. This study suggests that PP7 has the potential to be used for preventing and treating bone destruction in breast cancer patients with bone metastases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenxin He, Xiankun Cao, Kewei Rong, Xiaojun Chen, Shuai Han, An Qin
Summary: The combination of the anti-cancer agent DZNep and the Akt inhibitor AZD3463 can prevent skeletal complications and inhibit breast cancer progression by suppressing Akt signaling.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Tao Zheng, Zhengjun Lin, Guangyao Jiang, Hongxuan Chen, Yaocheng Yang, Xiangbin Zeng
Summary: Breast cancer is the most prevalent cancer in females, with metastatic bone disease being a major complication. Pogostone has been found to inhibit osteoclast differentiation and bone resorption, as well as suppress invasion and migration of breast cancer cells. These findings suggest that pogostone could be a potential drug for the treatment of breast cancer-associated bone metastasis.
Article
Engineering, Biomedical
Yichuan Pang, Li Su, Yao Fu, Fan Jia, Chenxi Zhang, Xiankun Cao, Wenxin He, Xueqian Kong, Jiake Xu, Jie Zhao, An Qin
Summary: This study targeted the proprotein convertase furin in breast cancer bone metastasis using bone-targeting superparamagnetic iron oxide (SPIO) nanoparticles, effectively inhibiting both osteoclastic bone resorption and breast cancer invasion. The system shows promise as a therapeutic and diagnostic strategy for breast cancer bone metastasis.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Eun-Ryeong Hahm, Su-Hyeong Kim, Subrata K. Pore, Sivapar V. Mathan, Rana P. Singh, Shivendra V. Singh
Summary: This study demonstrates that the combination of BITC and ZA synergistically inhibits osteoclast differentiation induced by conditioned media from breast cancer cells. This combination also leads to a significant increase in several antiosteoclastogenic cytokines and downregulation of genes in multiple signaling pathways.
MOLECULAR CARCINOGENESIS
(2023)
Article
Pharmacology & Pharmacy
Jianbo He, Kai Chen, Tiancheng Deng, Jiewei Xie, Kunjing Zhong, Jinbo Yuan, Ziyi Wang, Zhifeng Xiao, Ronghe Gu, Delong Chen, Xiaojuan Li, Dingkun Lin, Jiake Xu
Summary: RH shows significant anti-catabolic effects by inhibiting osteoclastogenesis and bone resorption, potentially through suppressing Nox1 expression, enhancing antioxidant enzyme activity, and inhibiting MAPKs, NF-kappa B, and intracellular Ca2+ oscillation pathways. These findings suggest RH could be a promising natural small molecule for treating osteoporosis by inhibiting excessive osteoclast activity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yajun Wang, Zeyuan Zhong, Miao Ma, Yannan Zhao, Chongjing Zhang, Zhi Qian, Biyun Wang
Summary: Ailanthone, a natural compound found in the Chinese herbal medicine Ailanthus altissima, has been discovered to inhibit bone metastasis of breast cancer. It exerts its effect by reducing cell differentiation, decreasing bone destruction, and inhibiting the activation of signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tao Li, Guangyao Jiang, Xuantao Hu, Daishui Yang, Tingting Tan, Zhi Gao, Zhuoyuan Chen, Cheng Xiang, Shizhen Li, Zhengxiao Ouyang, Xiaoning Guo
Summary: Punicalin inhibits osteoclast formation and bone resorption by suppressing the NF-κB signaling pathway, showing potential in suppressing breast cancer-induced bone metastasis and promoting apoptosis of breast cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang, Zhe Chen, Xuan Lv, Zan Huang, Yuanlong Xie, Lin Cai
Summary: This study elucidates the importance of the Bhlhe40 gene in osteoclast differentiation and osteoporosis, and identifies the Bhlhe40/c-Fos/Nfatc1 axis as a mechanism involved in regulating osteoclastogenesis. Modulating Bhlhe40 may rescue osteoporosis caused by estrogen deficiency and aging, potentially providing a new therapeutic strategy for the treatment of osteoporosis.
CELL AND BIOSCIENCE
(2022)
Article
Endocrinology & Metabolism
Junsong Chen, Wenke Xu, Kaiyuan Song, Lin-Tai Da, Xin Zhang, Mengyao Lin, Xiaowu Hong, Sheng Zhang, Fang Guo
Summary: Breast cancer is a deadly disease among females, with lung and bone metastasis posing a serious threat. Identification of novel molecular mediators for treating bone metastases is crucial. In a mouse model of breast cancer bone metastasis, a combination of AEP inhibitor and epirubicin inhibited metastasis and reduced osteolytic lesions by inhibiting osteoclast differentiation and EMT. These findings suggest that this combination has therapeutic potential for preventing bone metastasis in breast cancer.
Article
Medicine, Research & Experimental
Okhwa Kim, Phuong Thao Tran, Minju Gal, Se Jin Lee, Sung Hun Na, Cheol Hwangbo, Jeong-Hyung Lee
Summary: The activation of RAS in breast cancer cells plays a crucial role in osteolytic bone metastasis through the exosome-mediated transfer of osteoclastogenic miRNAs. The study identifies miR-494-3p, miR-4508, and miR-6869-5p as osteoclastogenic miRNAs in exosomes secreted by RAS-activated breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lidia Ibanez, Josep Nacher-Juan, Maria Carmen Terencio, Maria Luisa Ferrandiz, Maria Jose Alcaraz
Summary: Osteostatin inhibits the differentiation of human osteoclasts and does not affect their resorptive ability. It also controls the differentiation of human osteoclasts by downregulating NFATc1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
He Yang, Li Jian, Qian Jin, Kang Xia, Wang Cai-Ru, Sheng Jun, Huang Chen, Wang Wei, Song Ben-Jing, Li Shi-Hong, Long Shi-Wei, Wu Juan, Zheng Wei
Summary: This study reveals the essential role of CCL7-CCR1 signaling in the recruitment of OCPs in the early bone metastasis of CRC. Targeting CCL7 or CCR1 could restore bone volume, suggesting a potential therapeutic target.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Lakshana Sadu, R. Hari Krishnan, R. L. Akshaya, Udipt Ranjan Das, Sneha Satishkumar, N. Selvamurugan
Summary: Exosomes play a crucial role in bone remodeling and breast cancer bone metastasis, and have the potential to serve as biomarkers or delivery vehicles for the diagnosis and treatment of breast cancer bone metastasis.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Rahul Rimal, Prachi Desai, Andrea Bonnin Marquez, Karina Sieg, Yvonne Marquardt, Smriti Singh
Summary: By constructing a multi-cellular breast cancer model involving various cell types, the study investigated the influence of bone cells on primary tumors and metastasis events, revealing potential regulatory factors in the process.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Hui Li, Juyang Jiao, Shutao Zhang, Haozheng Tang, Xinhua Qu, Bing Yue
Summary: The purpose of this study was to develop a predictive model for length of stay (LOS) after total knee arthroplasty (TKA). Risk factors that could affect LOS were identified, and machine learning models were found to have better predictive performance compared to logistic regression models.
JOURNAL OF KNEE SURGERY
(2022)
Article
Engineering, Environmental
Hongtao Yang, Xinhua Qu, Minqi Wang, Houwen Cheng, Bo Jia, Jianfeng Nie, Kerong Dai, Yufeng Zheng
Summary: The study demonstrates the potential of high-strength biodegradable Zn-Li alloy implants for high load-bearing applications in orthopedic surgeries. The implants facilitated complete fracture healing within 6 months, with the osteogenic activity of the Zn-Li alloy validated.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Haozheng Tang, Xinhua Qu, Wenkai Zhang, Xuan Chen, Shutao Zhang, Yang Xu, Hongtao Yang, You Wang, Jianping Yang, Wei-en Yuan, Bing Yue
Summary: In this study, an ultra-micro photosensitizer, AgB nanodots, were used to efficiently clear multidrug-resistant bacteria MRSA through photothermal therapy, photodynamic therapy, and Ag+ ion sterilization. The AgB nanodots were found to enhance host immunogenicity and establish immunological memory in a murine model, providing a novel platform for the effective treatment of postoperative infection and a systematic immunotherapeutic strategy to combat persistent infections, thereby reducing the incidence of recurrence.
ADVANCED MATERIALS
(2022)
Article
Endocrinology & Metabolism
Jingke Du, Zihao He, Mingming Xu, Xinhua Qu, Junqi Cui, Shuangyan Zhang, Shuhong Zhang, Hanjun Li, Zhifeng Yu
Summary: Cold temperature activates the sympathetic nervous system (SNS) to induce bone loss by altering bone remodeling. Brown adipose tissue (BAT), which is influenced by the SNS in cold environments, has been found to have a positive relationship with bone mass. This study showed that bone volume can be restored after cold exposure due to enlarged BAT, which has a beneficial effect on bone mass by facilitating osteogenesis and suppressing osteoclastogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jialian Xu, Jindou Ji, Juyang Jiao, Liangjun Zheng, Qimin Hong, Haozheng Tang, Shutao Zhang, Xinhua Qu, Bing Yue
Summary: The self-repair of cartilage and subchondral bone is challenging due to the vasculature defects, complex gradients, and layered zonal architecture. However, three-dimensional (3D) printing technology provides a new strategy for bone-cartilage interface regeneration, offering rapid and accurate molding and personalized therapy. Challenges still remain, such as determining the optimal bioink concentrations and finding biomaterials with dual bioactivities.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Bin'en Nie, Shicheng Huo, Xinhua Qu, Jingjing Guo, Xi Liu, Qimin Hong, You Wang, Jianping Yang, Bing Yue
Summary: The bone-and-bacteria dual-targeted nanoparticles show excellent targeting efficacy and antibacterial properties for bone infection treatment.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Shutao Zhang, Xinhua Qu, Juyang Jiao, Haozheng Tang, Minqi Wang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: Felodipine has antibacterial effects against MRSA, biofilm, and persisters. It can inhibit the expression of proteins associated with aminoglycoside resistance, eradicate formed biofilms and kill persisters. Felodipine also reduces MRSA virulence and modulates bacterial metabolism. It inhibits the growth of persisters by binding to a protease. In a mouse infection model, felodipine in combination with gentamicin alleviates bacterial burden and inflammation.
BIOACTIVE MATERIALS
(2022)
Article
Surgery
Zhengyu Cai, Xinhua Qu, Yaochao Zhao, Zhiguo Yuan, Liangjun Zheng, Teng Long, Qiuying Yao, Bing Yue, You Wang
Summary: This study conducted a clinical trial of the world's first totally modular polyetheretherketone (PEEK) total knee arthroplasty (TKA) to determine bone density values around the prosthesis, reconstructing a three-dimensional model. Results showed excellent CT compatibility of the PEEK knee joint prosthesis and the ability to assess periprosthetic bone volume changes using Hounsfield units (HU) after CT scans. The assessment may potentially guide future improvements in knee prosthesis alignment techniques and artificial knee prosthesis designs.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Xinhua Qu, Minqi Wang, Miaochen Wang, Haozheng Tang, Shutao Zhang, Hongtao Yang, Weien Yuan, You Wang, Jianping Yang, Bing Yue
Summary: This study proposes a novel antimicrobial system to address the challenges of refractory Staphylococcus aureus-related implant infection. The system provides a continuous, prolonged antibacterial effect at the site of infection and significantly reduces immunosuppression, thereby restoring the antimicrobial immune response.
ADVANCED MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Zhen Liu, Weiwei Xin, Jindou Ji, Jialian Xu, Liangjun Zheng, Xinhua Qu, Bing Yue
Summary: Three-dimensional (3D) printing has been used in medical research and practice for several years. Hydrogels, as the most advantageous biological raw materials for 3D printing, have shown significant potential in orthopedics. They can promote tissue repair and prevent infection. However, there are still some challenges associated with hydrogel materials that need to be addressed through a multi-disciplinary approach.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yihan Wang, Shutao Zhang, Bin'en Nie, Xinhua Qu, Bing Yue
Summary: This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial purposes, including surface-coating modifications, controlled release of antimicrobials, blending modifications, and 3D printing technology. The aim is to provide an in-depth understanding and optimize the design of PEEK orthopedic implants.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Bo Jia, Zechuan Zhang, Yifu Zhuang, Hongtao Yang, Yu Han, Qiang Wu, Xiufeng Jia, Yanhui Yin, Xinhua Qu, Yufeng Zheng, Kerong Dai
Summary: Implant-related infections caused by drug-resistant bacteria are a major challenge in orthopedic surgery. This study focuses on the antibacterial and osteogenic properties of Zn alloys, specifically the Zn-Li-Ag ternary alloy, which showed significant bactericidal effects on MRSA and improved mechanical properties. In vivo experiments on a rat femoral model demonstrated the alloy's effectiveness in controlling infection and promoting bone retention.
Article
Engineering, Biomedical
Hongtao Yang, Bo Jia, Xinhua Qu, Kerong Dai, Yufeng Zheng
Summary: The addition of a small amount of gadolinium can modify the degradation behavior and microstructure of zinc, leading to more uniform degradation and improved bone regeneration and implant integration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Orthopedics
Haozheng Tang, Jialian Xu, Wei'en Yuan, You Wang, Bing Yue, Xinhua Qu
Summary: This study aimed to evaluate and unify diagnostic criteria for periprosthetic joint infection (PJI) and found that laboratory-based synovial alpha-defensin and synovial calprotectin are the two best independent preoperative diagnostic tests for PJI. A cut off of 70% for synovial PMN% and tighter cut-offs for synovial WBC and serum CRP could have a better diagnostic accuracy for non-IA patients with chronic PJI.
ORTHOPAEDIC SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Juyang Jiao, Qimin Hong, Dachen Zhang, Minqi Wang, Haozheng Tang, Jingzhou Yang, Xinhua Qu, Bing Yue
Summary: Porous tantalum scaffolds with three different porosities (60%, 70%, and 80%) were prepared using laser powder bed fusing technique to investigate the effects on the adhesion, proliferation, and osteogenic differentiation of rat mesenchymal stem cells in vitro. The in vivo bone ingrowth and osseointegration effects of each scaffold were evaluated in a rat femoral bone defect model. The results showed that scaffolds with 70% and 80% porosity exhibited better osteogenic proliferation and differentiation capacity, as well as bone ingrowth, suggesting that the 3D printed trabecular tantalum scaffold with 70% porosity could be the optimal choice for implant design.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
