Article
Cell Biology
Neus Bota-Rabassedas, Priyam Banerjee, Yichi Niu, Wenjian Cao, Jiayi Luo, Yuanxin Xi, Xiaochao Tan, Kuanwei Sheng, Young-Ho Ahn, Sieun Lee, Edwin Roger Parra, Jaime Rodriguez-Canales, Jacob Albritton, Michael Weiger, Xin Liu, Hou-Fu Guo, Jiang Yu, B. Leticia Rodriguez, Joshua J. A. Firestone, Barbara Mino, Chad J. Creighton, Luisa M. Solis, Pamela Villalobos, Maria Gabriela Raso, Daniel W. Sazer, Don L. Gibbons, William K. Russell, Gregory D. Longmore, Ignacio I. Wistuba, Jing Wang, Harold A. Chapman, Jordan S. Miller, Chenghang Zong, Jonathan M. Kurie
Summary: Cancer cells alter cancer-associated fibroblasts through specific secretory programs and repulsion processes, promoting cancer cell metastasis and sensitivity to pro-metastatic signals from fibroblasts.
Article
Biochemistry & Molecular Biology
Shreya Kumar, Grace E. Mulia, Marxa L. Figueiredo
Summary: Combination therapy of chemotherapy and immunotherapy shows potential as a novel therapeutic strategy for treating bone-metastatic prostate cancer, with reduced chemotherapy-associated toxicity, enhanced sensitivity to immunotherapy, and improved bone quality.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, Research & Experimental
Ran Zhang, Feng Liu
Summary: This study established CAF gene signatures that accurately predict the prognosis of prostate cancer patients undergoing radiotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Sheng-Fan Su, Hao Ho, Jia-Hua Li, Ming-Fang Wu, Hsu-Chieh Wang, Hsiang-Yuan Yeh, Shuenn-Wen Kuo, Huei-Wen Chen, Chao-Chi Ho, Ker-Chau Li
Summary: The study investigates the clinicopathologic impact of DNA methylation in the tumor microenvironment, focusing on cancer-associated fibroblasts. A methylation index (MIND) was developed to discriminate between normal fibroblasts and cancer-associated fibroblasts, showing potential in detecting premalignancy and predicting tumor recurrence across multiple lung cancer cohorts. This suggests that the malignancy level of the tumor microenvironment can be effectively graded by this index, providing valuable information for cancer prognosis and personalized medicine.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Jiahua Pan, Zehua Ma, Bo Liu, Hongyang Qian, Xiaoguang Shao, Jiazhou Liu, Qi Wang, Wei Xue
Summary: In this study, two distinct subtypes of CAFs with different molecular characteristics and biological functions were identified in the prostate cancer microenvironment. Similar CAFs were also found in bone metastatic prostate cancer lesions. The transcriptional factor regulatory network associated with CAFs-C1 was found to be related to castration resistance and poor prognosis, as well as treatment resistance to immune checkpoint inhibitors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
XuKai Liu, JiZu Tang, LiQiang Peng, HaiBo Nie, YuanGuang Zhang, Pan Liu
Summary: Dysregulation of autophagy in cancer-associated fibroblasts has been shown to contribute to the malignant phenotypes of human tumors. This study investigated the role of CAFs autophagy in prostate cancer. Results demonstrated that CAFs had higher levels of autophagy compared to normal fibroblasts. Furthermore, inhibition of autophagy in CAFs suppressed the proliferation, migration, and invasion capabilities of PCa cells. Silencing of ATG5 in CAFs also inhibited fibroblast autophagy and suppressed malignant phenotypes of PCa cells. These findings suggest that CAFs play a promotive role in PCa through ATG5-dependent autophagy, providing a novel mechanism for PCa progression.
Article
Oncology
Giovanni Vitale, Michele Caraglia, Volker Jung, Joern Kamradt, Davide Gentilini, Maria Teresa Di Martino, Alessandra Dicitore, Marianna Abate, Pierosandro Tagliaferri, Annalisa Itro, Matteo Ferro, Raffaele Balsamo, Marco De Sio, Gaetano Facchini, Luca Persani, Kai Schmitt, Matthias Saar, Michael Stoeckle, Gerhard Unteregger, Silvia Zappavigna
Summary: This study found differential gene expression profiles between prostate-cancer associated fibroblasts (PCAF) and prostate non-cancer associated fibroblasts (PNAF), suggesting that these differences may contribute to functional alterations in adjacent prostate cancer cells.
Review
Oncology
Zimu Wang, Jiaxin Liu, Hairong Huang, Mingxiang Ye, Xinying Li, Ranpu Wu, Hongbing Liu, Yong Song
Summary: Studies have shown that MAFs play a crucial role in tumor metastasis and therapeutic resistance, making them a promising therapeutic target for metastatic cancer.
BIOMARKER RESEARCH
(2021)
Article
Oncology
Jinfei Li, Shuangyi Chen, Yuxuan Liao, Hongyi Wang, Dawei Zhou, Bo Zhang
Summary: This study found a close association between arecoline, cuproptosis, and CAFs, which might play an important role in the metastasis of OSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Marcia S. Brose, Bruce Robinson, Steven Sherman, Jolanta Krajewska, Chia-Chi Lin, Fernanda Vaisman, Ana Hoff, Erika Hitre, Daniel W. Bowles, Jorge Hernando, Leonardo Faoro, Kamalika Banerjee, Jennifer W. Oliver, Bhumsuk Keam, Jaume Capdevila
Summary: Patients with radioiodine-refractory differentiated thyroid cancer who have previously undergone VEGFR-targeted therapy and have no available standard of care were evaluated in this study for the tyrosine kinase inhibitor cabozantinib. Results showed that cabozantinib significantly prolonged progression-free survival, potentially offering a new treatment option for these patients.
Article
Biochemistry & Molecular Biology
Tyler Risom, David R. Glass, Inna Averbukh, Candace C. Liu, Alex Baranski, Adam Kagel, Erin F. McCaffrey, Noah F. Greenwald, Belen Rivero-Gutierrez, Siri H. Strand, Sushama Varma, Alex Kong, Leeat Keren, Sucheta Srivastava, Chunfang Zhu, Zumana Khair, Deborah J. Veis, Katherine Deschryver, Sujay Vennam, Carlo Maley, E. Shelley Hwang, Jeffrey R. Marks, Sean C. Bendall, Graham A. Colditz, Robert B. West, Michael Angelo
Summary: This study used MIBI-TOF and antibody staining methods to analyze the changes in the tumor microenvironment (TME) between DCIS and IBC. Four coordinated transitions between TME states were identified. The study also found that myoepithelial disruption was more advanced in DCIS patients who did not develop IBC, suggesting a potential protective effect against recurrence.
Article
Medicine, Research & Experimental
Qian Li, Xuejiao Lv, Chunyong Han, Yu Kong, Zhongye Dai, Dawei Huo, Ting Li, Dapeng Li, Wei Li, Xing Wang, Qian Zhao, Jie Ming, Wen Yang, Yang Chen, Xudong Wu
Summary: This study investigates the transcriptomic and epigenomic features of NFs and CAFs associated with breast cancer metastasis, and identifies signature genes and enhancers specific to CAFs. The study demonstrates the importance of activated JUN in remodeling enhancers and maintaining the activation of CAF-specific enhancers, leading to breast cancer invasiveness. These findings provide insights into stroma cell transformation and support the potential of stroma-targeting strategy in cancer treatment.
Review
Biochemistry & Molecular Biology
Jasmine S. Owen, Aled Clayton, Helen B. Pearson
Summary: The continuous remodeling of the tumor microenvironment (TME) is critical for prostate tumor growth, progression, and drug-resistance. Cancer-associated fibroblasts (CAFs) are key players in TME and mediate various oncogenic events. Understanding fibroblast heterogeneity, recruitment, and differential functions can help in developing new therapies and biomarkers for prostate cancer patients.
Review
Oncology
Patricia Fernandez-Nogueira, Gemma Fuster, Alvaro Gutierrez-Uzquiza, Pere Gascon, Neus Carbo, Paloma Bragado
Summary: Breast cancer is a major public health issue with significant impact on patients and their families. Early detection is crucial for successful treatment, as therapy resistance and metastases are critical clinical challenges. Cancer-associated fibroblasts play a key role in therapy resistance and metastasis, highlighting the importance of targeting CAFs for overcoming resistance and preventing metastases. Advances in biomarkers and genetic analysis have allowed for personalized treatment strategies in breast cancer management.
Article
Oncology
Natalie Walterskirchen, Catharina Mueller, Cristiano Ramos, Stephan Zeindl, Simone Stang, Daniela Herzog, Monika Sachet, Vanessa Schimek, Lukas Unger, Vasileios Gerakopoulos, Markus Hengstschlaeger, Thomas Bachleitner-Hofmann, Michael Bergmann, Helmut Dolznig, Rudolf Oehler
Summary: Fibroblasts in the tumor microenvironment play important roles in primary and metastatic colorectal cancer. This study found differences in immune modulation between primary CRC and peritoneal metastasis, with peritoneal metastasis-associated fibroblasts (MAFs) showing higher expression of CD38 and secretion of immunosuppressive factors. These findings highlight the role of MAFs in modulating the immune microenvironment in CRC metastases through an IGFBP2-dependent mechanism.
Article
Biochemistry & Molecular Biology
Manabu Kato, Veronica R. Placencio-Hickok, Anisha Madhav, Subhash Haldar, Manisha Tripathi, Sandrine Billet, Rajeev Mishra, Bethany Smith, Krizia Rohena-Rivera, Priyanka Agarwal, Frank Duong, Bryan Angara, David Hickok, Zhenqiu Liu, Neil A. Bhowmick
Editorial Material
Biochemistry & Molecular Biology
Supriya Borah, Neil A. Bhowmick
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Oncology
Chuanxia Liu, Sandrine Billet, Diptiman Choudhury, Ran Cheng, Subhash Haldar, Ana Fernandez, Shea Biondi, Zhenqiu Liu, Hongmei Zhou, Neil A. Bhowmick
Summary: Head and neck cancers diagnosed at later stages often exhibit poor outcomes. Exposure of head and neck cancer cells to mesenchymal stem cells (MSC) led to increased tumor size, proliferation rate, and motility, as well as drug resistance. RNA sequencing analysis showed upregulation of drug resistance genes in cancer cells exposed to MSC. The secretory profile of MSC indicated IL-6 as a potential mediator of epigenetic imprinting on cancer cells.
Article
Food Science & Technology
Pallavi Sharma, Arti Tyagi, Pravin Bhansali, Shubhra Pareek, Vineeta Singh, Ashal Ilyas, Rajeev Mishra, Nitesh Kumar Poddar
Summary: Saponins in herbal compounds have shown great potential as natural anti-viral remedies, with no adverse side effects.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Genetics & Heredity
Surabhi Suchanti, Bjorn J. Stephen, Sonali Awasthi, Sudhir K. Awasthi, Gyanendra Singh, Abhijeet Singh, Rajeev Mishra
Summary: This review examines the role of histone epigenetic modifications in head and neck squamous cell carcinoma (HNSCC) and explores the relationships between human papillomavirus oncoproteins and histone-modifying agents. It also discusses the potential of using these modifications as biomarkers for drug treatments.
Article
Biotechnology & Applied Microbiology
Swapnil Tripathi, Shabrin Fhatima, Dharati Parmar, Dhirendra Pratap Singh, SukhDev Mishra, Rajeev Mishra, Gyanendra Singh
Summary: This study investigates the effects of Coenzyme Q10, Biochanin A, and Phloretin on the neurotoxicity induced by arsenic and chromium. The results show that these natural compounds can alleviate the oxidative stress caused by arsenic and chromium in mice.
Review
Instruments & Instrumentation
Bjorn John Stephen, Surabhi Suchanti, Devendra Jain, Harshdeep Dhaliwal, Vikram Sharma, Ramandeep Kaur, Rajeev Mishra, Abhijeet Singh
Summary: This study highlights the current state of design and development of biosensors for detecting pathogens associated with neglected tropical diseases (NTDs). The researchers discuss the potential of electrochemical DNA biosensors as effective and affordable diagnostic tools for NTDs, reviewing the available literature. They analyze the components and modifications of these biosensors, as well as the use of nanomaterials to improve sensitivity and specificity. The study also considers the future impact of these techniques on mass screening for NTDs.
Article
Biotechnology & Applied Microbiology
Rajeev Mishra, Subhash Haldar, Shea Biondi, Vikash Kumar Bhari, Gyanendra Singh, Neil A. Bhowmick
Summary: Telomere length is primarily regulated by the enzyme telomerase, but it can also be epigenetically regulated. Shorter telomere length in cancer cells and cancer-associated stromal cells is strongly associated with prostate cancer metastasis and death. This study investigates the role of TGF-beta signaling in regulating telomere length in prostate fibroblast cells and finds that it regulates telomere length through increased expression of the histone methyltransferase Suv39h1. Understanding the regulation of telomere length in stromal cells holds significant prospects for prostate cancer treatment, diagnosis, and prognosis.
Editorial Material
Oncology
Manish Thiruvalluvan, Neil A. Bhowmick
Article
Oncology
Hayato Muranaka, Andrew Hendifar, Arsen Osipov, Natalie Moshayedi, Veronica Placencio-Hickok, Nicholas Tatonetti, Aleksandr Stotland, Sarah Parker, Jennifer Van Eyk, Stephen J. Pandol, Neil A. Bhowmick, Jun Gong
Summary: Pancreatic cancer is a deadly disease, and finding biomarkers for predicting chemotherapy response is crucial for improving the prognosis of advanced patients. By analyzing plasma metabolites, this study found that the levels of intermediate metabolites in multiple metabolic pathways were statistically different in patients with different responses to chemotherapy. The study demonstrates the feasibility of plasma metabolomics in assessing the effect of enteral feeding as the primary source of nutrition, and suggests that metabolic signatures specific to different chemotherapy regimens could be predictive of patient response.
Article
Oncology
Le Zhang, Yueyuan Zheng, Wenwen Chien, Benjamin Ziman, Sandrine Billet, H. Phillip Koeffler, De-Chen Lin, Neil A. Bhowmick
Summary: ARID1A deficiency enhances tumor immune response and promotes CD8(+) T cell recruitment and cytolytic activity in esophageal adenocarcinoma (EAC). Additionally, ARID1A regulates fatty acid metabolism genes, influencing CD8(+) T cell recruitment and cytolytic activity.
Proceedings Paper
Materials Science, Multidisciplinary
Bjorn John Stephen, Rajeev Mishra, Madan Mohan Sharma, Abhijeet Singh
Summary: N-acetylcysteine (NAC) is a major antioxidant and anti-inflammatory agent, but its poor bioavailability has been a challenge. Encapsulating NAC in PLGA nanoparticles can enhance drug effectiveness and control drug concentration.
MATERIALS TODAY-PROCEEDINGS
(2021)
Proceedings Paper
Materials Science, Multidisciplinary
Surabhi Suchanti, Abhijeet Singh, Rajeev Mishra
Summary: The development of environmentally-friendly technologies for material synthesis is crucial for exploring their biological applications. Plant-extract synthesized nanoparticles, with well-defined characteristics, have shown promise in various technological applications. These biologically-synthesized nanoparticles, particularly those from medicinal plants, have been found to be more pharmacologically active than chemically-synthesized nanoparticles, and are being investigated for their potential role in epigenetic modification in cancer therapy.
MATERIALS TODAY-PROCEEDINGS
(2021)
Article
Biochemistry & Molecular Biology
Vikas Kumar Bhari, Durgesh Kumar, Surendra Kumar, Rajeev Mishra
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2020)
Review
Pharmacology & Pharmacy
Bjorn John Stephen, Surabhi Suchanti, Rajeev Mishra, Abhijeet Singh
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
(2020)