Article
Oncology
Elahe Abdollahi, Hossein Mozdarani, Behrooz Z. Alizadeh
Summary: Identifying the radiosensitivity of cells before radiotherapy in breast cancer patients allows appropriate treatment regimens and reduces side effects. Blood samples were collected from 60 breast cancer patients and 20 healthy women to predict cellular radiosensitivity using a G2-chromosomal assay. Negative results were found in 20 patients with radiosensitivity, and further molecular studies were conducted. Expression levels of circ-FOXO3 and miR-23a in peripheral blood mononuclear cells were examined, and Receiver Operating Characteristic curves were plotted. Both circ-FOXO3 and miR-23a showed potential as biomarkers for predicting breast cancer and cellular radiosensitivity.
Article
Fisheries
Hongyan Yu, Xuewen Jia, Huiqin Niu, Lingli Xie, Biao Du, Yifan Pang, Xiaoyan Xu, Jiale Li
Summary: miRNAs have a key role in the autophagy process and have been found to indirectly modulate immune function. This study confirmed that miR-23a can simultaneously down-regulate autophagy in grass carp by targeting ATG3 and ATG12. Additionally, it was found that miR-23a levels decreased while ATG3 and ATG12 mRNA levels increased in kidney and intestine after infection by Aeromonas hydrophila. Furthermore, miR-23a was found to affect various immune functions in grass carp, including antimicrobial capacity and cellular activities. These findings provide important insights into the role of autophagy-related miRNAs in teleost defense and immune mechanisms against pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Zeng, Xin Wei, Yang-Li He, Ji-Xiong Chen, Wen-Ting Lin
Summary: In this study, the researchers investigated the role of TFAP2C in cell autophagy during myocardial ischemia/reperfusion (MI/R) injury. They found that TFAP2C inhibited autophagy and improved cell injury caused by MI/R by mediating the miR-23a-5p/SFRP5/Wnt5a axis. These findings suggest that TFAP2C could be a potential therapeutic target for treating MI/R injury.
Article
Biochemistry & Molecular Biology
Lin Zhu, Fengchun Wang, Wenhui Fan, Zhi Jin, Chao Teng, Jianxin Zhang
Summary: NEAT1 is upregulated in breast tumors and cell lines, and silencing NEAT1 sensitizes breast cancer cells to Taxol. miR-23a-3p is downregulated in breast cancer and acts as a tumor suppressor. In Taxol-resistant MDA-MB-231 breast cancer cells, NEAT1 is significantly increased and miR-23a-3p is downregulated, with FOXA1 identified as a target of miR-23a-3p.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Multidisciplinary Sciences
Simone Agostini, Elisabetta Bolognesi, Roberta Mancuso, Ivana Marventano, Lorenzo Agostino Citterio, Franca Rosa Guerini, Mario Clerici
Summary: The concentration of specific miRNAs (miR-27b-3p, miR-181a-5p, and miR-23a-3p) was found to be associated with a SNAP-25 polymorphism. In vitro experiments confirmed that miR-181a-5p and miR-23a-3p regulate SNAP-25 gene and protein expression, while miR-27b-3p does not. These findings suggest the potential use of miR-181a-5p and miR-23a-3p as biomarkers or therapeutic targets for diseases involving altered SNAP-25 expression.
Article
Medicine, Research & Experimental
Marianna Abate, Angela Lombardi, Amalia Luce, Manuela Porru, Carlo Leonetti, Marco Bocchetti, Virginia Campani, Giuseppe De Rosa, Sossio Fabio Graziano, Valeria Nele, Francesco Cardile, Federica Zito Marino, Renato Franco, Andrea Ronchi, Marianna Scrima, Rossella Sperlongano, Roberto Alfano, Gabriella Misso, Evzen Amler, Michele Caraglia, Silvia Zappavigna
Summary: This study demonstrates that nanodiamonds can effectively deliver miRNA to inhibit tumor development and progression. The nanodiamonds have excellent biocompatibility, and the miR-34a conjugated with nanodiamonds can effectively inhibit cancer cell proliferation and migration. Furthermore, the miR-34a-conjugated nanodiamonds exhibit remarkable anti-tumor effects in mouse models.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Immunology
Qiuya Yu, Lei Chu, Yongxing Li, Quanyi Wang, Juanjuan Zhu, Chen Wang, Shufang Cui
Summary: The study reveals that during HSV-1 infection, miR-23a and miR-23b directly regulate cGAS expression through interaction with lncRNA Oasl2-209, and in the autoimmune disease model, miR-23a/b can mitigate self DNA-induced autoinflammatory responses.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hye Min Kim, Ja Seung Koo
Summary: Patient morbidity and mortality are significantly increased in metastatic breast cancer. The metastasis process of breast cancer is very complicated and controlled by various factors. Autophagy is an important regulatory factor affecting metastasis in breast cancer, involving cell mobility, metabolic adaptation, tumor dormancy, and cancer stem cells. In this article, we discuss the effects of autophagy on breast cancer metastasis and evaluate the potential use of autophagy modulators for metastasis treatment.
Article
Chemistry, Medicinal
Hui Zhang, Minghui Li, Jing Zhang, Yanbing Shen, Qi Gui
Summary: This study revealed that circ-XIAP and TPD52 were upregulated, while miR-1182 was downregulated in DTX-resistant PCa. Circ-XIAP promoted DTX resistance by regulating the miR-1182/TPD52 axis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Xiaohong Han, Yangyang Pan, Jiangfeng Fan, Meng Wang, Libin Wang, Jinglei Wang, Seth Yaw Afedo, Ling Zhao, Yaying Wang, Tian Zhao, Tongxiang Zhang, Rui Zhang, Yan Cui, Sijiu Yu
Summary: Apoptosis and autophagy in granulosa cells (GCs) play important roles in follicular development and atresia. LncRNA MEG3, miR-23a and apoptosis signal-regulating kinase 1 (ASK-1) are involved in this process. This study found that ASK1 and JNK expression levels were higher in Tertiary follicles compared to Secondary follicles and Graafian follicles. Overexpression of LncRNA MEG3 decreased miR-23a levels and increased ASK1/JNK axis expression, promoting apoptosis and attenuating autophagy in yak GCs. The effects of LncRNA MEG3 on miR-23a levels and ASK1/JNK axis-mediated apoptosis and autophagy were reversed by FSH or LH in yak GCs.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Jee Won Park, Yesol Kim, Soo-Been Lee, Chae Won Oh, Eun Ji Lee, Je Yeong Ko, Jong Hoon Park
Summary: Autophagy flux differs between luminal and triple-negative breast cancers. miR-181a regulates autophagy-related proteins ATG5 and ATG2B, which are associated with cancer stemness in TNBC. Curcumin promotes autophagy flux and attenuates cancer stemness in TNBC.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Zhang, Yu Sun, Hanzi Xu, Yaqian Shi, Rong Shen, Fang Teng, Juan Xu, Xuemei Jia
Summary: Ovarian cancer is the second leading cause of death in women with gynecological malignancy in China. Circular RNAs, specifically hsa_circ_0007444, play a role in inhibiting ovarian cancer progression by interacting with AGO2 and sponging miR-23a-3p, ultimately upregulating DICER1 expression, which is a tumor suppressor in ovarian cancer. The downregulation of hsa_circ_0007444 in ovarian cancer tissues and cell lines leads to enhanced cell proliferation, invasion, migration, and decreased apoptosis. In vivo experiments also confirm that hsa_circ_0007444 inhibits tumor growth and lung metastasis in mouse models.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Multidisciplinary Sciences
Ming Sun, Haijian Guo
Summary: MiR-18a-5p (miR-18a) has been identified as a potential biomarker for breast cancer risk, but its role in breast cancer progression remains unclear. In this study, we investigated the effect of miR-18a on MCF-7 cell proliferation, migration, and invasion under inflammation-related stimulus. We found that lipopolysaccharide (LPS) increased miR-18a expression in MCF-7 cells, and inhibition of miR-18a suppressed cell proliferation, migration, and invasion induced by LPS. Furthermore, LPS exposure promoted autophagy in MCF-7 cells, and autophagy inhibition repressed cell proliferation induced by LPS. Our findings suggest that miR-18a expression alteration is mediated by autophagy in LPS-exposed MCF-7 cells, providing insights into the pathogenesis of inflammatory-induced breast cancer progression in the tumor microenvironment.
Article
Medicine, Research & Experimental
Jianxiu Wang, Guiling Dong, Weifeng Chi, Yingying Nie
Summary: The study found that miR-96 plays a promoting role in acute myocardial infarction (AMI) by directly targeting XIAP to affect anti-apoptotic function, providing a new therapeutic target for AMI treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Ahmadpour, Somayeh Igder, Hossein Babaahmadi-Rezaei, Ehsan Khalili, Malek Kanani, Vahid Soleimani, Ghorban Mohammadzadeh
Summary: The promoter hypermethylation of miR-125a leads to its decreased expression in breast cancer, while overexpression of miR-125a can reduce autophagy. These findings provide a new therapeutic approach for the treatment of breast cancer.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Tao Xu, Yanling Yang, Xing Huang, Jianhong Ren, Ting Xu, Wei Xie
Summary: Thyroid disease affects approximately 200 million people worldwide and is often associated with elevated blood lipid levels. A study on cynomolgus monkeys revealed that the changes in TSH and T3/T4 levels were correlated with lipid accumulation, with perturbations in numerous lipid species. The administration of SNA001 showed comparable effects on TSH, T3/T4 levels, and lipid profiles as the reference rhTSH (Thyrogen(R)), indicating a need for further exploration into the delayed responses observed in lipid levels after TSH stimulation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Enliang Li, Xing Huang, Gang Zhang, Tingbo Liang
Summary: This study systematically investigated the potential effectiveness of a novel pancreatic cancer immunotherapy targeting RTKs, and revealed the function of MET in PD-L1 regulation as well as the combined therapeutic efficacy of MET and PD-L1 in pancreatic cancer. Results showed that MET is a pancreatic cancer-specific RTK significantly associated with prognosis and positively correlated with PD-L1 levels. The study also demonstrated that MET deficiency facilitates lymphocyte infiltration into pancreatic tumors and verified significant benefits of combining MET inhibition with PD-1/PD-L1 blockage in mouse models of pancreatic cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Xiaozhen Zhang, Xing Huang, Jian Xu, Enliang Li, Mengyi Lao, Tianyu Tang, Gang Zhang, Chengxiang Guo, Xiaoyu Zhang, Wen Chen, Dipesh Kumar Yadav, Xueli Bai, Tingbo Liang
Summary: The study reveals that NEK2 phosphorylates PD-L1 to maintain stability, impacting the efficacy of immunotherapy in pancreatic cancer, while NEK2 deficiency enhances lymphocyte infiltration and sensitivity to immunotherapy. Inhibiting NEK2 can enhance PD-L1 blockade, potentially improving the effectiveness of pancreatic cancer treatment.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Xing Huang, Gang Zhang, Tingbo Liang
Summary: The lack of the TGFB signaling pathway in CD4(+) helper T cells induces remodeling of intratumoral vascular tissue, preventing tumor cells from receiving necessary nutrients and ultimately causing tumor cell death due to starvation. Blocking TGFB promotes tissue healing, leading to an effective anticancer immune response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Yu-ting Shen, Xing Huang, Gang Zhang, Bo Jiang, Cheng-jun Li, Zheng-sheng Wu
Summary: ERα, ERβ, and PGR proteins were found to be differentially expressed in ovarian and uterine cancers, correlating with tumor stage and grade. In addition, the mRNA expression levels of ESR1, ESR2, and PGR were significantly associated with immunomodulators and immune cells. This suggests that ESR1, ESR2, and PGR could serve as potential prognostic markers and therapeutic targets for various cancers.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Cheng-Xiang Guo, Xing Huang, Jian Xu, Xiao-Zhen Zhang, Yi-Nan Shen, Ting-Bo Liang, Xue-Li Bai
Summary: This review summarizes the recent combinations of targeted therapies and immunotherapies, highlighting the synergistic effects on anti-tumor immunity for rapid tumor regression and durable response, while also addressing the associated clinical challenges.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Oncology
Lingyue Liu, Xing Huang, Fukang Shi, Jinyuan Song, Chengxiang Guo, Jiaqi Yang, Tingbo Liang, Xueli Bai
Summary: Pancreatic cancer has a high mortality rate and immunotherapy with anti-PD-(L)1 has limited efficacy. This review explores the combination of chemotherapy, radiotherapy, targeted therapy, and immunotherapy with anti-PD-(L)1 in pancreatic cancer treatment. It also suggests future directions for optimizing combination therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Xing Huang, Gang Zhang, Tingbo Liang
Summary: The cases and deaths related to pancreatic cancer are on the rise globally, posing a significant global health concern. The heterogeneous nature of pancreatic cancer within and between tumors has been identified as a critical factor contributing to its poor prognosis. However, there is a lack of precise management strategies for this complex disease. Subtyping pancreatic tumors based on their molecular characteristics shows promise in improving the accuracy of treatment decisions, but its feasibility and potential flaws need further exploration.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Oncology
Tianyu Tang, Xing Huang, Gang Zhang, Minghao Lu, Zhengtao Hong, Meng Wang, Junming Huang, Xiao Zhi, Tingbo Liang
Summary: This study demonstrates that LTX-315 can enhance lymphocyte infiltration and induce an antitumor immune response by inhibiting PD-L1 expression in pancreatic tumors. ATP11B is identified as a potential target of LTX-315 and a critical regulator in maintaining PD-L1 expression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Tianyu Tang, Xing Huang, Gang Zhang, Tingbo Liang
Summary: Oncolytic peptides are highly effective in remodeling the tumor microenvironment and enhancing anticancer immunity by inducing immunogenic cell death. A recent study shows that LTX-315 inhibits PD-L1 expression via ATP11B, thereby enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. This commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, as well as the potential issues and directions in cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Tianyu Tang, Xing Huang, Minghao Lu, Gang Zhang, Xu Han, Tingbo Liang
Summary: Cancer cell metabolism and immunosuppressive tumor microenvironment are influenced by the aberrant expression of CD73. CD73 facilitates the recruitment of Treg cells to pancreatic tumors, leading to an immunosuppressive microenvironment. CD73 transcriptionally upregulates CCL5 through tumor cell-autocrine adenosine-Adora2a signaling-mediated activation of the p38-STAT1 axis. This study highlights the importance of CD73-adenosine metabolism in pancreatic cancer immunosuppression in a tumor-autonomous and -autocrine manner.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Chengxiang Guo, Junlei Zhang, Xin Huang, Yiwen Chen, Jianpeng Sheng, Xing Huang, Junhui Sun, Wenbo Xiao, Ke Sun, Shunliang Gao, Risheng Que, Yan Shen, Min Zhang, Jian Wu, Xueli Bai, Tingbo Liang
Summary: A study found that preoperative drug-eluting bead transarterial chemoembolization (DEB-TACE) plus sintilimab could be an effective treatment approach before surgery for patients with HCC of BCLC stage A exceeding the Milan criteria or BCLC stage B.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Gang Zhang, Tianyu Tang, Yinfeng Chen, Xing Huang, Tingbo Liang
Summary: mRNA vaccines have shown remarkable efficacy in preventing and treating diseases, particularly in the case of COVID-19. This comprehensive review examines the technical aspects of mRNA vaccines, including design, synthesis, delivery, and adjuvant technologies. It provides a systematic analysis of representative mRNA vaccines used in various diseases and explores their potential in different therapeutic areas. The review also discusses current challenges and future directions for the advancement and utilization of mRNA vaccines.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Medicine, General & Internal
Xing Huang, Gang Zhang, Tian Yu Tang, Xiang Gao, Ting Bo Liang
Summary: Pancreatic cancer vaccines offer multifaceted advantages, with personalized mRNA vaccines showing promising potential as a cutting-edge option for precise treatment. Further research and development in this area is warranted.
MILITARY MEDICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Tian-Yu Tang, Xing Huang, Gang Zhang, Ming-Hao Lu, Ting-Bo Liang
Summary: Cholangiocarcinoma is a highly aggressive tumor that currently lacks effective treatment options. A recent study has proposed an immunotherapeutic strategy using mRNA vaccines, with a focus on selecting suitable patients and identifying potent antigens. However, further research is needed to better understand the immunogenic antigens and onco-immunological characteristics of cholangiocarcinoma for future clinical applications.
MILITARY MEDICAL RESEARCH
(2022)