Review
Oncology
Biyuan Xing, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao
Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
An-Jen Chiang, Chia-Jung Li, Kuan-Hao Tsui, Chung Chang, Yuan-chin Ivan Chang, Li-Wen Chen, Tsung-Hsien Chang, Jim Jinn-Chyuan Sheu
Summary: The study found that UBE2C is highly expressed in human cervical squamous cell carcinoma (CESC) tissues and is related to clinical characteristics. In vitro experiments demonstrated that overexpression and knockdown of UBE2C respectively enhanced and reduced proliferation of cervical cancer cells. In vivo experiments showed that UBE2C regulates the expression and activity of the mTOR/PI3K/AKT pathway.
Article
Obstetrics & Gynecology
C. Acuti Martellucci, S. Nomura, D. Yoneoka, P. Ueda, J. M. L. Brotherton, K. Canfell, M. Palmer, L. Manzoli, P. Giorgi Rossi, A. De Togni, C. Palmonari, A. Califano, E. Saito, M. Hashizume, K. Shibuya
Summary: This retrospective cohort study in Italy assessed the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities detected during subsequent screenings. Results showed that women who received at least one dose of the HPV vaccine were significantly less likely to have abnormal cervical cytology. Overall, catch-up HPV vaccination almost halved the risk of cytological abnormalities in organized cervical screening programmes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Editorial Material
Oncology
Eduardo Franco
Summary: The American Cancer Society (ACS) believes that the time has come for primary human papillomavirus (HPV) screening in the United States, but it requires educating the public and healthcare providers and overcoming logistical barriers. ACS is taking the lead by utilizing its resources to promote primary HPV screening in the US and sharing best practices from other countries through its Primary HPV Screening Initiative.
Article
Oncology
Jacqueline M. Mix, Mona Saraiya, Trevor D. Thompson, Troy D. Querec, April Greek, Thomas C. Tucker, Edward S. Peters, Charles F. Lynch, Brenda Y. Hernandez, Glenn Copeland, Marc T. Goodman, Elizabeth R. Unger
Summary: The study compared HPV prevalence among high-grade cervical precancers and invasive cervical cancers before and after HPV vaccine availability. No significant reduction in vaccine-type prevalence was observed between the two studies, likely due to low HPV vaccination coverage among women in the postvaccine study. Monitoring HPV-type prevalence through population-based strategies remains important for evaluating the impact of the HPV vaccine.
Review
Virology
Kimia Sharifian, Zabihollah Shoja, Somayeh Jalilvand
Summary: In recent decades, it has become well-established that human papillomavirus can cause tumors, and research is actively investigating the genetic and environmental factors that determine whether viral infection is eliminated or develops into cancer. The microbiota has emerged as an important factor that can influence this balance by either enhancing or reducing the ability of viral infection to promote cancer. In the female reproductive system, the vaginal microbiota plays a crucial role in maintaining health and preventing pathogenic infections. A diverse vaginal microbiota with reduced abundance of Lactobacillus spp. has been found to contribute to HPV acquisition, persistence, and the development of cervical cancer. This review explores the role of normal female reproductive tract microbiota in health, the mechanisms by which dysbiosis can lead to disease through interactions with microbes, and various therapeutic approaches.
Review
Virology
Zahra Salavatiha, Mohammad Farahmand, Zabihollah Shoja, Somayeh Jalilvand
Summary: This study found varying HPV prevalence among women in Iran with different cervical cytology statuses, and suggests integrating HPV vaccines into the national vaccination programs of Iran for beneficial outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Luhan Zhang, Hong Yu, Tian Deng, Li Ling, Juan Wen, Mingfen Lv, Rongying Ou, Qiaozhi Wang, Yunsheng Xu
Summary: The study revealed that key genes involved in HPV-mediated cervical carcinogenesis include those related to DNA replication/repair and cell cycle, with significant metabolic shifts observed. FNDC3B and BPGM were identified as key genes in the transformation from normal epithelium to precancerous lesions and cervical cancer. Higher FNDC3B expression or lower BPGM expression were associated with shorter overall survival and disease-free survival in patients with cervical cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chetna Yadav, Ritu Yadav, Ravindresh Chabbra, Smiti Nanda, Shalu Ranga, Lokesh Kadian, Parul Ahuja
Summary: Cervical cancer is a common cancer in women worldwide, particularly in low- and middle-income countries. HPV plays a crucial role in its development by interfering with the host's signaling pathways. Aberrant genetic mutations, polymorphisms, and epigenetic mechanisms affect the apoptotic pathways involved in cervical carcinogenesis. Non-coding RNAs have also been implicated in epigenetic regulation of various malignancies, including cervical cancer. This review focuses on genetic and epigenetic approaches to target apoptosis and HPV genes, as well as novel drug molecules currently in clinical trials for cervical cancer treatment.
Article
Oncology
Chameera Ekanayake Weeramange, Danhua Shu, Kai Dun Tang, Jyotsna Batra, Rahul Ladwa, Lizbeth Kenny, Sarju Vasani, Ian H. Frazer, Riccardo Dolcetti, Jonathan J. Ellis, Richard A. Sturm, Paul Leo, Chamindie Punyadeera
Summary: The risk of human papillomavirus (HPV)-positive head and neck cancer (HNC) is associated with distinct human leukocyte antigen (HLA) variants, some of which are shared by both cervical cancer and HPV-positive HNC. Several previous genome-wide association studies were replicated in this study, but the associations were limited to the HPV-positive HNC group.
Article
Multidisciplinary Sciences
Xun Shangguan, Jianli He, Zehua Ma, Weiwei Zhang, Yiyi Ji, Kai Shen, Zhiying Yue, Wenyu Li, Zhixiang Xin, Quan Zheng, Ying Cao, Jiahua Pan, Baijun Dong, Jinke Cheng, Qi Wang, Wei Xue
Summary: The study reveals the crucial role of SUMOylation in regulating the binding of hexokinase 2 to mitochondria, impacting metabolic reprogramming and chemotherapy response in prostate cancer cells.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Ryan C. Lintao, Leslie Faye T. Cando, Glenmarie Angelica S. Perias, Ourlad Alzeus G. Tantengco, Ian Kim B. Tabios, Clarissa L. Velayo, Sheriah Laine M. de Paz-Silava
Summary: There has been a significant increase in cervical cancer incidence among women in the Philippines, with a high prevalence of HPV infection. The prevention and treatment of cervical cancer in the Philippines are inadequate, and the HPV vaccination rate is low.
FRONTIERS IN MEDICINE
(2022)
Review
Infectious Diseases
Marc Arbyn, Marie Simon, Eliana Peeters, Lan Xu, Chris J. L. M. Meijer, Johannes Berkhof, Kate Cuschieri, Jesper Bonde, Anja Ostrbenk Vanlencak, Fang-Hui Zhao, Remila Rezhake, Murat Gultekin, Joakim Dillner, Silvia de Sanjose, Karen Canfell, Peter Hillemanns, Maribel Almonte, Nicolas Wentzensen, Mario Poljak
Summary: This study updated the list of high-risk HPV assays that fulfill the international validation criteria, with only 11 DNA assays meeting the requirements for cervical cancer screening using clinician-collected specimens, while other tests partially fulfilled the validation criteria.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Oncology
Crispin Kahesa, Louise T. Thomsen, Ditte S. Linde, Bariki Mchome, Johnson Katanga, Patricia Swai, Rachel Manongi, Myassa Kjaerem, Thomas Iftner, Marianne Waldstrom, Julius Mwaiselage, Vibeke Rasch, Susanne K. Kjaer
Summary: This study from Tanzania compared nine HPV-based cervical cancer screening strategies and suggested that HPV testing alone, or HPV testing with extended genotyping or increased viral load cut-offs, may improve cervical cancer screening in Sub-Saharan Africa.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Virology
Sadhana M. Gupta, Himangi Warke, Hemangi Chaudhari, Padmaja Mavani, Rajshree D. Katke, Shilpa C. Kerkar, Jayanti Mania-Pramanik
Summary: This study aimed to evaluate HPV E6/E7 oncogene expression as markers for early identification of cervical cancer risk in women with minor cytological abnormalities and negative cytology. The results showed that E6 and E7 transcripts could serve as sensitive early predictors of cervical cancer risk.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Karin Hoppe-Seyler, Felicitas Bossler, Claudia Lohrey, Julia Bulkescher, Frank Roesl, Lars Jansen, Arnulf Mayer, Peter Vaupel, Matthias Duerst, Felix Hoppe-Seyler
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Review
Virology
Karin Hoppe-Seyler, Julia Maendl, Svenja Adrian, Bianca J. Kuhn, Felix Hoppe-Seyler
Review
Biochemistry & Molecular Biology
Karin Hoppe-Seyler, Felicitas Bossler, Julia A. Braun, Anja L. Herrmann, Felix Hoppe-Seyler
TRENDS IN MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Yu-Hsien Lien, Dhani Ram Mahato, Felix Hoppe-Seyler, Wolfgang B. Fischer
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2020)
Article
Microbiology
Felicitas Bossler, Bianca J. Kuhn, Thomas Guenther, Stephen J. Kraemer, Prajakta Khalkar, Svenja Adrian, Claudia Lohrey, Angela Holzer, Mitsugu Shimobayashi, Matthias Duerst, Arnulf Mayer, Frank Roesl, Adam Grundhoff, Jeroen Krijgsveld, Karin Hoppe-Seyler, Felix Hoppe-Seyler
Article
Oncology
Julia A. Braun, Anja L. Herrmann, Johanna Blase, Kristin Frensemeier, Julia Bulkescher, Martin Scheffner, Bruno Galy, Karin Hoppe-Seyler, Felix Hoppe-Seyler
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Karin Hoppe-Seyler, Anja L. Herrmann, Antonia Daeschle, Bianca J. Kuhn, Tobias D. Strobel, Claudia Lohrey, Julia Bulkescher, Jeroen Krijgsveld, Felix Hoppe-Seyler
Summary: The study reveals that Metformin can effectively suppress the expression of HPV oncogenes in HPV-positive cancer cells, leading to a reversible proliferative halt without inducing senescence completely.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Anja L. Herrmann, Bianca J. Kuhn, Angela Holzer, Jeroen Krijgsveld, Karin Hoppe-Seyler, Felix Hoppe-Seyler
Summary: The iron-chelating drug ciclopirox (CPX) shows potential for treating cancer, specifically cervical cancer, by inducing senescence or apoptosis in cancer cells, affecting their therapy response differently. This study explores the cellular decision-making between senescence and apoptosis in cervical cancer cells. CPX in combination with glycolysis inhibitors synergistically blocks cervical cancer proliferation by modulating OXPHOS factors and glucose availability-dependent responses, providing a rationale for future treatment strategies.
Article
Oncology
Kristin Frensemeier, Angela Holzer, Karin Hoppe-Seyler, Felix Hoppe-Seyler
Summary: This study reveals that the expression of tumor suppressor protein Dkk1 is strongly restrained in HPV-positive cervical cancer cells through the continuous expression of the viral E6 oncogene, leading to increased resistance to Cisplatin-induced apoptosis. The repression of Dkk1 is not linked to Wnt pathway activation but rather the diminished stimulation of JNK signaling, which is required for efficient apoptosis induction by Cisplatin.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cell Biology
Dongyun Yang, Tobias D. Strobel, Julia Bulkescher, Claudia Tessmer, Ilse Hofmann, Felix Hoppe-Seyler, Karin Hoppe-Seyler
Summary: The FAM57A gene has an important regulatory role in cervical cancer cells, with its protein expression being influenced by cell density, hypoxia, and inhibition of HPV gene expression. Inhibition of FAM57A leads to significant suppression of proliferation and migration in cervical cancer cells.
Article
Oncology
Ann-Kathrin Daum, Jessica Dittmann, Lars Jansen, Sven Peters, Uta Dahmen, Julia Heger, Felix Hoppe-Seyler, Alexandra Gille, Joachim H. Clement, Ingo B. Runnebaum, Matthias Durst, Claudia Backsch
Summary: The study found that ITIH5 has a significant inhibitory effect on the growth and invasiveness of cervical cancer tumor spheres under three-dimensional cell culture conditions. Immunohistochemical analysis revealed that overexpression of ITIH5 led to an increase in apoptotic cells, while it did not affect the sensitivity of cervical MCTS to cytostatic drug treatment.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Felicitas Bossler, Karin Hoppe-Seyler, Felix Hoppe-Seyler
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)